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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106375
Ensembl Protein ID YGR267C
UniProt Accession P51601; D6VV45; GCH1_YEAST
Genbank Protein ID CAA87397.1; CAA63975.1; CAA69198.1; CAA97297.1; AAT93012.1; CAA89826.1; DAA08356.1
Protein Name GTP cyclohydrolase 1; GTP cyclohydrolase I
Genbank Nucleotide ID Z47201; X94314; Y07893; Z73052; AY692993; Z49756; BK006941
Gene Name FOL2; YGR267C; G9349
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGR267C YGR267C YGR267C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 57.53 5.00e-67 251.00 IUUC-Hsa-046907
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.
 GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.
Protein Sequence
(Fasta)
MHNIQLVQEI ERHETPLNIR PTSPYTLNPP VERDGFSWPS VGTRQRAEET EEEEKERIQR 60
ISGAIKTILT ELGEDVNREG LLDTPQRYAK AMLYFTKGYQ TNIMDDVIKN AVFEEDHDEM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106375|UBD,UBD/Other/Other|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCATAACA TCCAATTAGT GCAAGAGATA GAAAGACATG AAACCCCGTT AAACATTAGA 60
CCTACCTCTC CATACACTTT AAACCCTCCT GTCGAGAGAG ATGGGTTTTC TTGGCCAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106375|UBD,UBD/Other/Other|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0289--Folate biosynthesis
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom
PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2
Pfam

PF01227--GTP_cyclohydroI
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0046656--P:folic acid biosynthetic process
GO:0009396--P:folic acid-containing compound biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process
KEGG sce:YGR267C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002530 Amborella trichopoda 41.56 1.00e-28 119.00
IUUC-Apl-004135 Anas platyrhynchos 70.00 2.00e-64 236.00
IUUC-Aca-005252 Anolis carolinensis 64.80 4.00e-66 241.00
IUUC-Aly-006454 Arabidopsis lyrata 41.76 4.00e-29 120.00
IUUC-Ath-006744 Arabidopsis thaliana 41.21 6.00e-29 119.00
IUUC-Ago-007744 Ashbya gossypii 79.83 1.00e-101 359.00
IUUC-Acl-008058 Aspergillus clavatus 66.98 3.00e-85 306.00
IUUC-Afl-008668 Aspergillus flavus 68.06 1.00e-86 310.00
IUUC-Afu-008935 Aspergillus fumigatus 66.97 3.00e-86 309.00
IUUC-Ani-009207 Aspergillus nidulans 67.13 1.00e-84 304.00
IUUC-Ang-009686 Aspergillus niger 67.71 6.00e-86 308.00
IUUC-Aor-010202 Aspergillus oryzae 68.61 5.00e-91 325.00
IUUC-Ate-010518 Aspergillus terreus 68.16 3.00e-90 322.00
IUUC-Ame-010958 Astyanax mexicanus 59.62 1.00e-69 253.00
IUUC-Bgr-012060 Blumeria graminis 57.48 6.00e-71 258.00
IUUC-Bta-012416 Bos taurus 65.36 4.00e-67 245.00
IUUC-Bci-013811 Botrytis cinerea 56.39 1.00e-74 270.00
IUUC-Bdi-014794 Brachypodium distachyon 39.51 8.00e-24 102.00
IUUC-Bol-015182 Brassica oleracea 42.20 2.00e-30 124.00
IUUC-Bra-016764 Brassica rapa 41.38 2.00e-29 121.00
IUUC-Cel-018345 Caenorhabditis elegans 65.95 6.00e-72 261.00
IUUC-Cja-019848 Callithrix jacchus 69.85 5.00e-56 207.00
IUUC-Cfa-020630 Canis familiaris 66.48 1.00e-68 250.00
IUUC-Cpo-021420 Cavia porcellus 69.46 9.00e-67 243.00
IUUC-Cre-022618 Chlamydomonas reinhardtii 43.48 1.00e-36 144.00
IUUC-Csa-023403 Chlorocebus sabaeus 61.08 9.00e-54 201.00
IUUC-Cho-024907 Choloepus hoffmanni 66.48 8.00e-69 251.00
IUUC-Cin-025120 Ciona intestinalis 63.39 6.00e-61 224.00
IUUC-Csv-026259 Ciona savignyi 62.64 6.00e-68 247.00
IUUC-Cgl-026508 Colletotrichum gloeosporioides 61.97 2.00e-78 283.00
IUUC-Cne-026810 Cryptococcus neoformans 61.24 2.00e-72 264.00
IUUC-Cme-027139 Cyanidioschyzon merolae 54.05 9.00e-53 197.00
IUUC-Dre-028815 Danio rerio 66.48 1.00e-68 250.00
IUUC-Dno-029017 Dasypus novemcinctus 67.80 3.00e-69 252.00
IUUC-Dor-030417 Dipodomys ordii 69.92 7.00e-55 203.00
IUUC-Dse-031187 Dothistroma septosporum 64.19 1.00e-85 307.00
IUUC-Dme-031615 Drosophila melanogaster 62.01 1.00e-56 210.00
IUUC-Ete-032727 Echinops telfairi 46.76 7.00e-30 121.00
IUUC-Eca-033487 Equus caballus 70.59 1.00e-55 206.00
IUUC-Eeu-034696 Erinaceus europaeus 68.86 2.00e-66 243.00
IUUC-Fca-035975 Felis catus 69.74 2.00e-26 107.00
IUUC-Fal-037439 Ficedula albicollis 70.27 6.00e-60 220.00
IUUC-Fox-037781 Fusarium oxysporum 64.32 6.00e-72 261.00
IUUC-Fso-038377 Fusarium solani 63.38 4.00e-74 269.00
IUUC-Gmo-038945 Gadus morhua 64.29 2.00e-65 239.00
IUUC-Ggr-039834 Gaeumannomyces graminis 61.03 2.00e-76 276.00
IUUC-Gga-040495 Gallus gallus 67.60 4.00e-69 251.00
IUUC-Gac-042306 Gasterosteus aculeatus 65.92 6.00e-68 248.00
IUUC-Gma-043539 Glycine max 41.14 4.00e-31 127.00
IUUC-Ggo-045597 Gorilla gorilla 55.69 4.00e-50 188.00
IUUC-Hsa-046907 Homo sapiens 68.26 5.00e-66 241.00
IUUC-Hvu-047298 Hordeum vulgare 36.68 8.00e-30 122.00
IUUC-Itr-048997 Ictidomys tridecemlineatus 65.92 3.00e-68 248.00
IUUC-Kpa-049319 Komagataella pastoris 75.98 3.00e-102 362.00
IUUC-Lch-049771 Latimeria chalumnae 67.04 1.00e-69 253.00
IUUC-Lpe-050904 Leersia perrieri 39.33 6.00e-28 116.00
IUUC-Loc-052063 Lepisosteus oculatus 67.60 3.00e-69 252.00
IUUC-Lma-053280 Leptosphaeria maculans 52.14 2.00e-61 228.00
IUUC-Laf-054214 Loxodonta africana 59.24 6.00e-69 251.00
IUUC-Mcc-054778 Macaca mulatta 68.26 4.00e-66 242.00
IUUC-Meu-056598 Macropus eugenii 68.66 5.00e-21 92.40
IUUC-Mor-056989 Magnaporthe oryzae 62.44 2.00e-76 276.00
IUUC-Mpo-057591 Magnaporthe poae 61.50 2.00e-76 276.00
IUUC-Mtr-057924 Medicago truncatula 44.52 4.00e-33 133.00
IUUC-Mla-058931 Melampsora laricipopulina 64.32 2.00e-69 253.00
IUUC-Mga-060001 Meleagris gallopavo 70.59 2.00e-56 208.00
IUUC-Mvi-060513 Microbotryum violaceum 59.91 5.00e-73 265.00
IUUC-Mmr-061725 Microcebus murinus 66.48 1.00e-68 250.00
IUUC-Mdo-062715 Monodelphis domestica 66.48 1.00e-68 251.00
IUUC-Mmu-063203 Mus musculus 68.86 2.00e-66 243.00
IUUC-Mac-065392 Musa acuminata 44.38 2.00e-34 136.00
IUUC-Mpu-066174 Mustela putorius furo 66.48 9.00e-69 251.00
IUUC-Mlu-067883 Myotis lucifugus 69.85 4.00e-56 207.00
IUUC-Nfi-068317 Neosartorya fischeri 66.97 3.00e-86 309.00
IUUC-Ncr-068822 Neurospora crassa 63.77 8.00e-76 275.00
IUUC-Nle-069231 Nomascus leucogenys 68.26 4.00e-66 241.00
IUUC-Opr-070417 Ochotona princeps 70.68 9.00e-55 203.00
IUUC-Ont-072168 Oreochromis niloticus 64.80 2.00e-67 246.00
IUUC-Oan-072690 Ornithorhynchus anatinus 71.05 1.00e-26 108.00
IUUC-Ocu-074537 Oryctolagus cuniculus 66.48 6.00e-68 248.00
IUUC-Oba-075333 Oryza barthii 39.74 2.00e-28 118.00
IUUC-Obr-076255 Oryza brachyantha 41.10 4.00e-27 112.00
IUUC-Ogl-077792 Oryza glaberrima 39.33 2.00e-28 117.00
IUUC-Ogu-078354 Oryza glumaepatula 39.33 5.00e-28 116.00
IUUC-Oin-079934 Oryza indica 34.85 8.00e-28 115.00
IUUC-Olo-080643 Oryza longistaminata 39.88 1.00e-25 108.00
IUUC-Ome-081632 Oryza meridionalis 35.90 3.00e-28 117.00
IUUC-Oni-083004 Oryza nivara 34.85 7.00e-28 116.00
IUUC-Opu-083899 Oryza punctata 35.35 8.00e-29 119.00
IUUC-Oru-084386 Oryza rufipogon 34.85 6.00e-28 116.00
IUUC-Osa-085665 Oryza sativa 39.88 5.00e-26 109.00
IUUC-Ola-086577 Oryzias latipes 67.57 1.00e-70 257.00
IUUC-Olu-087867 Ostreococcus lucimarinus 47.62 7.00e-44 167.00
IUUC-Oga-088652 Otolemur garnettii 68.86 1.00e-65 240.00
IUUC-Oar-089965 Ovis aries 65.92 3.00e-68 249.00
IUUC-Ptr-090833 Pan troglodytes 68.26 5.00e-66 241.00
IUUC-Psi-093542 Pelodiscus sinensis 68.00 5.00e-59 218.00
IUUC-Pma-094423 Petromyzon marinus 66.42 5.00e-53 197.00
IUUC-Pno-095091 Phaeosphaeria nodorum 66.96 5.00e-83 298.00
IUUC-Ppa-096013 Physcomitrella patens 42.48 5.00e-29 120.00
IUUC-Pfo-097146 Poecilia formosa 65.92 3.00e-68 249.00
IUUC-Pab-098744 Pongo abelii 68.26 5.00e-66 241.00
IUUC-Pop-099917 Populus trichocarpa 43.51 2.00e-30 124.00
IUUC-Pca-100111 Procavia capensis 66.48 1.00e-68 250.00
IUUC-Ppe-101984 Prunus persica 40.91 5.00e-28 116.00
IUUC-Pva-103078 Pteropus vampyrus 64.84 3.00e-67 246.00
IUUC-Pgr-103438 Puccinia graminis 62.70 3.00e-67 246.00
IUUC-Ptt-103875 Puccinia triticina 61.73 3.00e-67 246.00
IUUC-Pte-104180 Pyrenophora teres 66.81 1.00e-81 294.00
IUUC-Pyt-104552 Pyrenophora triticirepentis 64.05 2.00e-82 296.00
IUUC-Rno-105506 Rattus norvegicus 65.92 3.00e-68 249.00
IUUC-Sha-107585 Sarcophilus harrisii 67.65 8.00e-55 203.00
IUUC-Sja-107871 Schizosaccharomyces japonicus 63.00 2.00e-80 289.00
IUUC-Spo-108282 Schizosaccharomyces pombe 62.45 1.00e-80 290.00
IUUC-Smo-109561 Selaginella moellendorffii 43.09 1.00e-33 135.00
IUUC-Sit-110577 Setaria italica 37.79 4.00e-26 110.00
IUUC-Sly-111719 Solanum lycopersicum 41.56 2.00e-30 124.00
IUUC-Stu-112752 Solanum tuberosum 41.67 2.00e-31 128.00
IUUC-Sar-113701 Sorex araneus 64.13 3.00e-68 249.00
IUUC-Sbi-114308 Sorghum bicolor 35.64 7.00e-29 119.00
IUUC-Sre-115125 Sporisorium reilianum 58.99 4.00e-74 270.00
IUUC-Tgu-117039 Taeniopygia guttata 70.59 2.00e-56 208.00
IUUC-Tru-117939 Takifugu rubripes 58.04 8.00e-70 254.00
IUUC-Tsy-118852 Tarsius syrichta 58.65 2.00e-42 162.00
IUUC-Tni-120356 Tetraodon nigroviridis 65.36 9.00e-68 247.00
IUUC-Tca-121422 Theobroma cacao 42.86 2.00e-31 128.00
IUUC-Tre-122035 Trichoderma reesei 62.74 1.00e-77 280.00
IUUC-Tvi-122649 Trichoderma virens 63.68 2.00e-78 283.00
IUUC-Tae-124146 Triticum aestivum 36.18 4.00e-30 123.00
IUUC-Tme-127015 Tuber melanosporum 65.33 8.00e-84 301.00
IUUC-Tbe-128024 Tupaia belangeri 58.65 2.00e-42 162.00
IUUC-Ttr-128474 Tursiops truncatus 57.73 4.00e-69 252.00
IUUC-Uma-129655 Ustilago maydis 59.35 2.00e-74 271.00
IUUC-Vda-129970 Verticillium dahliae 58.12 4.00e-77 279.00
IUUC-Vpa-130564 Vicugna pacos 70.68 4.00e-55 204.00
IUUC-Vvi-131597 Vitis vinifera 43.17 7.00e-33 132.00
IUUC-Xtr-132201 Xenopus tropicalis 62.38 1.00e-69 253.00
IUUC-Xma-133679 Xiphophorus maculatus 65.92 3.00e-68 249.00
IUUC-Yli-134489 Yarrowia lipolytica 77.63 1.00e-101 360.00
IUUC-Zma-135058 Zea mays 35.32 1.00e-28 118.00
Created Date 25-Jun-2017

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