iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068427

Ensembl Protein ID

CADNFIAP00001250

UniProt Accession

A1D3C5; RSP5_NEOFI

Genbank Protein ID

EAW22918.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase RSP5

Genbank Nucleotide ID

DS027688

Gene Name

NFIA_016110; hulA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00001289	CADNFIAT00001289	CADNFIAP00001250

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-126	420.6	484	815

Active Site

Position(s)	Description	Evidence
784	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  
   Q: 484  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIG 575
           689*********************************************************9.89***************************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegik 187
           +fyk++l+kk+sl+d+e vd++l+++l++ ++n   die   l+ltfsv++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++
   Q: 576  AFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDN---DIEGV-LELTFSVDDEKFGERRTIDLKPGGRDIPVTNENKAEYVELVTEWKIVKRVE 664
           *******************************99...9***8.*************************************************** PP
   S: 188  eqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfa 280
           eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++++iq+Fw+v++++++e+++++LqF+Tg+sr+P++Gf+
   Q: 665  EQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQESDEVIQNFWKVVRSWDAEQKSRLLQFTTGTSRIPVNGFK 756
           ************************************************76.****************************************** PP
   S: 281  elk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +l+    pr+f+i+k+++++ lP+s+TCfn+L+LP+Y+s+e+l++k+ +A+eet gF++
   Q: 757  DLQgsdgPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKSYETLEHKMSIAVEETLGFGQ 815
           *********************************************************86 PP

Organism

Neosartorya fischeri

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MGSNLPAQPN LRLTIIAADG LYKRDVFRFP DPFAVATVGG EQTHTTSVIK KTLNPYWNEM 60
FDLRVNEDSI LAIQIFDQKK FKKKDQGFLG VINVRIGDVI DLQMGGDEML TRDLKKSNDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTCCA ATCTGCCTGC GTAAGTTTCG CCCCTCCCTA CCTGGACTGG CACCAGAGAA 60
GCGAAATCTG TCTGCGTCGA GTGCGTATGA GGACGAAAAG ACTAACAAGT GGATGCATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

KEGG

nfi:NFIA_016110

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	49.16	5.00e-158	550.00
IUUC-Apl-003893	Anas platyrhynchos	48.66	9.00e-156	542.00
IUUC-Aca-005338	Anolis carolinensis	47.98	7.00e-157	546.00
IUUC-Ago-007742	Ashbya gossypii	66.10	0.00e+00	1015.00
IUUC-Acl-008273	Aspergillus clavatus	94.93	0.00e+00	1470.00
IUUC-Afl-008713	Aspergillus flavus	93.33	0.00e+00	1444.00
IUUC-Afu-009103	Aspergillus fumigatus	96.19	0.00e+00	1500.00
IUUC-Ani-009259	Aspergillus nidulans	89.42	0.00e+00	1439.00
IUUC-Ang-009738	Aspergillus niger	92.70	0.00e+00	1466.00
IUUC-Aor-010053	Aspergillus oryzae	95.99	1.00e-176	610.00
IUUC-Ate-010529	Aspergillus terreus	94.00	0.00e+00	1489.00
IUUC-Ame-010810	Astyanax mexicanus	52.47	2.00e-146	511.00
IUUC-Bgr-012148	Blumeria graminis	74.02	0.00e+00	1113.00
IUUC-Bta-012679	Bos taurus	49.16	3.00e-158	550.00
IUUC-Bci-013785	Botrytis cinerea	74.67	0.00e+00	1189.00
IUUC-Cel-018299	Caenorhabditis elegans	45.71	8.00e-151	525.00
IUUC-Cja-018732	Callithrix jacchus	48.66	2.00e-158	551.00
IUUC-Cfa-021226	Canis familiaris	49.16	6.00e-158	550.00
IUUC-Cpo-021671	Cavia porcellus	49.16	5.00e-158	550.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.86	3.00e-154	537.00
IUUC-Cho-024695	Choloepus hoffmanni	48.48	9.00e-159	552.00
IUUC-Cin-025212	Ciona intestinalis	49.69	2.00e-143	501.00
IUUC-Csv-026256	Ciona savignyi	49.39	6.00e-142	495.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	73.92	0.00e+00	1121.00
IUUC-Cne-026849	Cryptococcus neoformans	63.88	0.00e+00	996.00
IUUC-Dre-027770	Danio rerio	52.47	2.00e-147	514.00
IUUC-Dno-029466	Dasypus novemcinctus	49.16	4.00e-158	550.00
IUUC-Dor-030138	Dipodomys ordii	47.99	2.00e-153	534.00
IUUC-Dse-031241	Dothistroma septosporum	75.37	0.00e+00	1212.00
IUUC-Dme-032041	Drosophila melanogaster	46.50	3.00e-146	510.00
IUUC-Ete-033145	Echinops telfairi	45.82	2.00e-145	508.00
IUUC-Eca-033445	Equus caballus	49.16	6.00e-158	549.00
IUUC-Eeu-035247	Erinaceus europaeus	48.49	2.00e-157	547.00
IUUC-Fca-036384	Felis catus	48.57	2.00e-159	555.00
IUUC-Fal-037604	Ficedula albicollis	46.84	5.00e-152	530.00
IUUC-Fox-037774	Fusarium oxysporum	72.97	0.00e+00	1133.00
IUUC-Fso-038393	Fusarium solani	72.34	0.00e+00	1110.00
IUUC-Gmo-039674	Gadus morhua	52.47	4.00e-146	510.00
IUUC-Ggr-040107	Gaeumannomyces graminis	71.86	0.00e+00	1151.00
IUUC-Gga-040703	Gallus gallus	48.16	3.00e-155	540.00
IUUC-Gac-042020	Gasterosteus aculeatus	49.25	5.00e-157	546.00
IUUC-Ggo-045332	Gorilla gorilla	48.42	6.00e-158	550.00
IUUC-Hsa-045968	Homo sapiens	48.42	4.00e-158	550.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	48.32	2.00e-158	551.00
IUUC-Kpa-049273	Komagataella pastoris	67.12	0.00e+00	1045.00
IUUC-Lch-050443	Latimeria chalumnae	48.67	5.00e-157	546.00
IUUC-Loc-052662	Lepisosteus oculatus	52.47	3.00e-143	501.00
IUUC-Lma-052980	Leptosphaeria maculans	73.08	0.00e+00	692.00
IUUC-Laf-053850	Loxodonta africana	49.16	7.00e-158	549.00
IUUC-Mcc-055821	Macaca mulatta	48.42	2.00e-158	551.00
IUUC-Meu-055953	Macropus eugenii	40.54	5.00e-119	420.00
IUUC-Mor-057097	Magnaporthe oryzae	74.15	0.00e+00	1164.00
IUUC-Mpo-057442	Magnaporthe poae	69.28	0.00e+00	1026.00
IUUC-Mla-058996	Melampsora laricipopulina	63.32	0.00e+00	986.00
IUUC-Mga-059362	Meleagris gallopavo	47.24	6.00e-154	536.00
IUUC-Mvi-060395	Microbotryum violaceum	79.42	0.00e+00	825.00
IUUC-Mmr-061061	Microcebus murinus	47.79	3.00e-160	558.00
IUUC-Mdo-062173	Monodelphis domestica	46.54	1.00e-153	535.00
IUUC-Mmu-064136	Mus musculus	49.16	3.00e-158	550.00
IUUC-Mpu-066765	Mustela putorius furo	49.16	5.00e-158	550.00
IUUC-Mlu-067565	Myotis lucifugus	49.16	1.00e-157	548.00
IUUC-Ncr-068918	Neurospora crassa	73.48	0.00e+00	1111.00
IUUC-Nle-069225	Nomascus leucogenys	47.96	4.00e-159	554.00
IUUC-Opr-071044	Ochotona princeps	48.49	3.00e-157	547.00
IUUC-Ont-071664	Oreochromis niloticus	47.00	1.00e-146	512.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.43	2.00e-150	525.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.01	2.00e-157	547.00
IUUC-Ola-087467	Oryzias latipes	48.17	9.00e-156	542.00
IUUC-Oga-088460	Otolemur garnettii	49.16	4.00e-158	550.00
IUUC-Oar-090198	Ovis aries	48.66	2.00e-158	551.00
IUUC-Ptr-090939	Pan troglodytes	48.42	4.00e-158	550.00
IUUC-Pan-092284	Papio anubis	48.42	3.00e-158	550.00
IUUC-Psi-093645	Pelodiscus sinensis	48.49	3.00e-157	547.00
IUUC-Pma-094364	Petromyzon marinus	52.05	1.00e-143	501.00
IUUC-Pno-095118	Phaeosphaeria nodorum	74.09	0.00e+00	1187.00
IUUC-Pfo-097145	Poecilia formosa	47.37	6.00e-152	530.00
IUUC-Pab-098088	Pongo abelii	48.42	2.00e-158	551.00
IUUC-Pca-100568	Procavia capensis	45.42	5.00e-138	484.00
IUUC-Pva-102354	Pteropus vampyrus	49.16	1.00e-157	548.00
IUUC-Pgr-103620	Puccinia graminis	77.96	0.00e+00	804.00
IUUC-Ptt-103806	Puccinia triticina	78.78	0.00e+00	691.00
IUUC-Pte-104016	Pyrenophora teres	75.42	0.00e+00	1195.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.42	0.00e+00	1195.00
IUUC-Rno-105318	Rattus norvegicus	49.16	3.00e-158	550.00
IUUC-Sce-106289	Saccharomyces cerevisiae	75.38	0.00e+00	927.00
IUUC-Sha-107482	Sarcophilus harrisii	47.75	2.00e-153	534.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	65.88	0.00e+00	1033.00
IUUC-Spo-108171	Schizosaccharomyces pombe	66.91	0.00e+00	1044.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	75.67	0.00e+00	1180.00
IUUC-Sar-113761	Sorex araneus	48.15	1.00e-157	548.00
IUUC-Sre-114929	Sporisorium reilianum	70.70	0.00e+00	881.00
IUUC-Ssc-115368	Sus scrofa	44.29	1.00e-148	518.00
IUUC-Tgu-117130	Taeniopygia guttata	48.49	8.00e-156	542.00
IUUC-Tru-118610	Takifugu rubripes	54.73	2.00e-154	538.00
IUUC-Tsy-119492	Tarsius syrichta	48.17	2.00e-156	545.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.99	1.00e-150	525.00
IUUC-Tre-122203	Trichoderma reesei	72.22	0.00e+00	1110.00
IUUC-Tvi-122595	Trichoderma virens	72.46	0.00e+00	1133.00
IUUC-Tme-126897	Tuber melanosporum	69.70	0.00e+00	1045.00
IUUC-Tbe-127793	Tupaia belangeri	47.84	2.00e-132	464.00
IUUC-Ttr-128235	Tursiops truncatus	53.09	2.00e-148	518.00
IUUC-Uma-129332	Ustilago maydis	71.62	0.00e+00	844.00
IUUC-Vda-129753	Verticillium dahliae	70.57	0.00e+00	1071.00
IUUC-Vpa-130503	Vicugna pacos	50.73	3.00e-139	488.00
IUUC-Xtr-132859	Xenopus tropicalis	48.66	1.00e-158	551.00
IUUC-Xma-133797	Xiphophorus maculatus	48.51	9.00e-159	552.00
IUUC-Yli-134668	Yarrowia lipolytica	74.76	0.00e+00	947.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence