iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118454

UUCD1 version

UUC-TaR-00109

Ensembl Protein ID

ENSTRUP00000005136.1

UniProt Accession

H2RYB5; H2RYB5_TAKRU

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Gene Name

wdr4; WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002237.1	ENSTRUT00000005166.1	ENSTRUP00000005136.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-07	32.9	187	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf..sd..tllvsGsdDgtikvWDlrtgvllk 37
             v++l +  ++  + l+sGs+Dgtik+WD+  g+ l+
   Q: 187  QFVSAL-LvpPThpRWLLSGSGDGTIKLWDYEHGRRLQ 223
           555555.246333577**************99888776 PP

Organism

Takifugu rubripes

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MAALGFSGSW LIFSCGTKLV AVDTTQSREA FVFDCSSAEK KPKSRKDEDS GAAEETGSDR 60
VLAFCTSPSG KLLALTDDSK RLVLFTCEPS WRCISTRFVV RRCTALQFSN AEDALLVADK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCTC TCGGCTTCAG TGGATCCTGG TTGATCTTCA GCTGCGGCAC CAAACTGGTG 60
GCTGTCGACA CCACGCAGAG CAGGTCAGTT CGGCCAGAAC CGGCTCGTTC GCGCTGCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043527--C:tRNA methyltransferase complex
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	26.37	2.00e-09	56.60
IUUC-Atr-002431	Amborella trichopoda	37.07	6.00e-14	69.70
IUUC-Apl-003975	Anas platyrhynchos	45.48	9.00e-85	306.00
IUUC-Aca-005170	Anolis carolinensis	40.23	3.00e-67	248.00
IUUC-Aly-005769	Arabidopsis lyrata	31.80	2.00e-26	113.00
IUUC-Ath-006733	Arabidopsis thaliana	31.71	4.00e-26	112.00
IUUC-Acl-008151	Aspergillus clavatus	25.93	2.00e-18	87.00
IUUC-Afl-008518	Aspergillus flavus	31.05	7.00e-18	84.70
IUUC-Afu-009102	Aspergillus fumigatus	26.29	3.00e-18	86.30
IUUC-Ani-009442	Aspergillus nidulans	27.18	3.00e-20	93.20
IUUC-Aor-010133	Aspergillus oryzae	31.05	3.00e-18	86.30
IUUC-Ate-010465	Aspergillus terreus	24.36	2.00e-17	83.60
IUUC-Ame-010613	Astyanax mexicanus	53.56	2.00e-112	399.00
IUUC-Bgr-012067	Blumeria graminis	34.76	6.00e-19	89.00
IUUC-Bta-012788	Bos taurus	44.39	3.00e-81	295.00
IUUC-Bdi-014458	Brachypodium distachyon	32.34	5.00e-18	85.50
IUUC-Bol-016398	Brassica oleracea	33.20	1.00e-27	117.00
IUUC-Bra-016644	Brassica rapa	35.65	5.00e-27	117.00
IUUC-Cpo-021963	Cavia porcellus	43.92	7.00e-80	290.00
IUUC-Csa-024148	Chlorocebus sabaeus	42.63	6.00e-70	258.00
IUUC-Cne-026834	Cryptococcus neoformans	35.50	2.00e-23	103.00
IUUC-Dre-028427	Danio rerio	53.67	2.00e-114	405.00
IUUC-Dno-028881	Dasypus novemcinctus	39.22	8.00e-67	247.00
IUUC-Dor-030522	Dipodomys ordii	43.80	2.00e-80	292.00
IUUC-Dme-032136	Drosophila melanogaster	35.50	4.00e-23	102.00
IUUC-Fca-035833	Felis catus	47.09	2.00e-78	286.00
IUUC-Fal-037497	Ficedula albicollis	45.75	3.00e-87	315.00
IUUC-Gga-040547	Gallus gallus	45.66	2.00e-85	309.00
IUUC-Gac-041761	Gasterosteus aculeatus	63.03	9.00e-135	473.00
IUUC-Gma-043722	Glycine max	31.75	5.00e-23	102.00
IUUC-Ggo-045340	Gorilla gorilla	43.97	9.00e-76	277.00
IUUC-Hsa-046403	Homo sapiens	44.50	1.00e-76	280.00
IUUC-Hvu-047643	Hordeum vulgare	30.17	1.00e-19	90.50
IUUC-Itr-048103	Ictidomys tridecemlineatus	45.45	2.00e-87	315.00
IUUC-Kpa-049283	Komagataella pastoris	33.71	5.00e-20	92.00
IUUC-Lch-050682	Latimeria chalumnae	44.97	2.00e-92	332.00
IUUC-Lpe-050712	Leersia perrieri	29.16	4.00e-24	105.00
IUUC-Loc-052599	Lepisosteus oculatus	50.64	4.00e-112	397.00
IUUC-Laf-054390	Loxodonta africana	44.27	9.00e-83	300.00
IUUC-Mcc-054747	Macaca mulatta	44.77	4.00e-75	275.00
IUUC-Mtr-058600	Medicago truncatula	35.50	3.00e-27	115.00
IUUC-Mla-059129	Melampsora laricipopulina	29.55	1.00e-16	80.50
IUUC-Mga-059876	Meleagris gallopavo	44.19	2.00e-84	306.00
IUUC-Mvi-060359	Microbotryum violaceum	31.52	2.00e-13	71.20
IUUC-Mmr-061518	Microcebus murinus	43.80	7.00e-80	290.00
IUUC-Mac-065625	Musa acuminata	33.62	2.00e-23	103.00
IUUC-Nfi-068402	Neosartorya fischeri	26.44	2.00e-18	87.40
IUUC-Nle-069914	Nomascus leucogenys	42.78	6.00e-69	254.00
IUUC-Ont-071555	Oreochromis niloticus	60.53	2.00e-133	469.00
IUUC-Oan-072951	Ornithorhynchus anatinus	44.17	3.00e-81	295.00
IUUC-Ocu-074679	Oryctolagus cuniculus	42.63	2.00e-73	269.00
IUUC-Oba-075355	Oryza barthii	24.47	2.00e-13	70.50
IUUC-Obr-076769	Oryza brachyantha	28.00	8.00e-26	111.00
IUUC-Ogl-077168	Oryza glaberrima	28.35	2.00e-26	113.00
IUUC-Ogu-078275	Oryza glumaepatula	24.27	7.00e-14	72.00
IUUC-Oin-079207	Oryza indica	28.35	2.00e-26	113.00
IUUC-Oni-082437	Oryza nivara	24.50	6.00e-13	68.60
IUUC-Opu-084031	Oryza punctata	28.00	2.00e-24	107.00
IUUC-Oru-084380	Oryza rufipogon	24.47	3.00e-13	69.70
IUUC-Osa-085327	Oryza sativa	28.35	3.00e-26	112.00
IUUC-Ola-086716	Oryzias latipes	58.42	1.00e-116	412.00
IUUC-Olu-087708	Ostreococcus lucimarinus	27.01	1.00e-15	77.80
IUUC-Oar-090239	Ovis aries	44.44	1.00e-81	296.00
IUUC-Ptr-090851	Pan troglodytes	43.97	1.00e-75	277.00
IUUC-Pan-092558	Papio anubis	42.78	4.00e-70	258.00
IUUC-Psi-093792	Pelodiscus sinensis	40.37	6.00e-79	287.00
IUUC-Ppa-095757	Physcomitrella patens	32.56	9.00e-23	101.00
IUUC-Pfo-096465	Poecilia formosa	58.72	1.00e-130	459.00
IUUC-Pab-097722	Pongo abelii	46.05	8.00e-78	284.00
IUUC-Pop-098979	Populus trichocarpa	33.33	7.00e-22	98.20
IUUC-Pca-100753	Procavia capensis	40.48	4.00e-51	195.00
IUUC-Ppe-101515	Prunus persica	33.62	1.00e-22	100.00
IUUC-Sja-107780	Schizosaccharomyces japonicus	27.09	5.00e-13	68.90
IUUC-Spo-108251	Schizosaccharomyces pombe	27.45	6.00e-15	75.10
IUUC-Smo-108938	Selaginella moellendorffii	33.60	2.00e-25	110.00
IUUC-Sit-110020	Setaria italica	31.18	8.00e-26	111.00
IUUC-Sly-111543	Solanum lycopersicum	38.38	4.00e-24	105.00
IUUC-Stu-111925	Solanum tuberosum	33.20	5.00e-24	105.00
IUUC-Sbi-114061	Sorghum bicolor	29.55	8.00e-24	104.00
IUUC-Tgu-117321	Taeniopygia guttata	44.77	9.00e-79	286.00
IUUC-Tni-119894	Tetraodon nigroviridis	75.41	1.00e-149	522.00
IUUC-Tca-121746	Theobroma cacao	32.79	1.00e-25	110.00
IUUC-Tae-124459	Triticum aestivum	29.51	2.00e-20	93.20
IUUC-Tur-126254	Triticum urartu	26.41	5.00e-13	68.60
IUUC-Tbe-127683	Tupaia belangeri	57.32	2.00e-24	106.00
IUUC-Ttr-129056	Tursiops truncatus	41.98	6.00e-74	271.00
IUUC-Vvi-131428	Vitis vinifera	33.05	1.00e-22	100.00
IUUC-Xma-133605	Xiphophorus maculatus	57.44	4.00e-129	454.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence