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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106360
UUCD1 version UUC-SaC-00011
Ensembl Protein ID YGL116W
UniProt Accession P26309; D6VU31; CDC20_YEAST
Genbank Protein ID CAA42058.1; CAA96824.1; BAA03957.1; DAA07992.1
Protein Name APC/C activator protein CDC20; Cell division control protein 20
Genbank Nucleotide ID X59428; Z72638; D16506; BK006941
Gene Name CDC20; YGL116W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL116W YGL116W YGL116W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 16648845; 17889668
E3 adaptor/Cullin RING/APC_C/CDC20 CDC20 16648845; 19197151; 17889668; 18538651; 12737808
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-22 76.7 384 416
E3 adaptor/Cullin RING/APC_C/CDC20 7.00e-130 431.2 249 560
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
    Ht++v++l++ sd l+sG++D+t+++WD+rt
   Q: 384 HTGEVCGLSYkSDgLQLASGGNDNTVMIWDTRT 416
    9**********99788**************998 PP
   


   E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl.tghsarvga 101
    pe++ldap ++ddfylnLl+Ws+knvla+aL++++ylw+a+tgdvs l+d+ e+++++sv+w+++++++++G+++g++ei+Dve+++ +rt+ +g r+g+
   Q: 249 PERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDF-ENTTICSVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMrSGLGVRIGS 349
    689************************************************.9999************************************99******** PP
   S: 102 LsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavkaiawsPwqkslLasGGGtaD 203
    LsW ++++++Gsr+gei+++dvr+k++ +st+++h+ evCGl++++d+ +LasGGnDn+v++wd+++s P++++k+h+aavka++w+P+++++LasGGG++D
   Q: 350 LSWLDTLIATGSRSGEIQINDVRIKQHIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTSLPQFSKKTHTAAVKALSWCPYSPNILASGGGQTD 451
    ****************************************************************************************************** PP
   S: 204 rcikfwntltgalleeidtgsqvcsllwskks.........kelvsthGfaenkitlwkypslskvae.lkgheaRvlslalspdgeaivtaagDetlrfwk 295
    ++i+fwn++tga++ +i+tgsqv+sl+w++++ ke+v+t G++en+i++++y+++ kvae +++heaR+++++lspdg++++t++gDe+l+f+k
   Q: 452 KHIHFWNSITGARVGSINTGSQVSSLHWGQSHtstnggmmnKEIVATGGNPENAISVYNYETKFKVAEvVHAHEARICCSQLSPDGTTLATVGGDENLKFYK 553
    ******************************999***********************************99******************************** PP
   S: 296 lfdkkka 302
    +fd++++
   Q: 554 IFDPRCT 560
    ***9876 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
Protein Sequence
(Fasta)
MPESSRDKGN AAISGNRSVL SIASPTKLNI LSSDWSRNQG KVSKNSLKRS SSLNIRNSKR 60
PSLQASANSI YSRPKITIGA PPLIRRDSSF FKDEFDAKKD KATFSAYSSR SYPTIGSESV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Sce-106360|E3,WD_repeat;E3,CDC20|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCAGAAA GCTCTAGAGA TAAGGGAAAT GCAGCAATTA GCGGTAACCG TTCTGTACTT 60
TCTATTGCGT CCCCAACAAA GCTAAACATA CTATCTTCCG ATTGGTCCAG AAACCAAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106360|E3,WD_repeat;E3,CDC20|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0033597--C:mitotic checkpoint complex
GO:0034399--C:nuclear periphery
GO:0010997--F:anaphase-promoting complex binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0045732--P:positive regulation of protein catabolic process
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0051441--P:positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle
GO:0040020--P:regulation of meiotic nuclear division

KEGG sce:YGL116W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007962 Ashbya gossypii 56.12 1.00e-177 613.00
IUUC-Acl-008043 Aspergillus clavatus 44.69 2.00e-90 324.00
IUUC-Afl-008593 Aspergillus flavus 45.34 4.00e-90 323.00
IUUC-Afu-008793 Aspergillus fumigatus 44.16 2.00e-89 320.00
IUUC-Ani-009158 Aspergillus nidulans 45.34 2.00e-90 324.00
IUUC-Ang-009786 Aspergillus niger 45.23 1.00e-89 322.00
IUUC-Aor-010163 Aspergillus oryzae 45.34 4.00e-90 323.00
IUUC-Ate-010479 Aspergillus terreus 44.81 4.00e-90 323.00
IUUC-Bgr-012059 Blumeria graminis 47.38 2.00e-100 357.00
IUUC-Bci-013607 Botrytis cinerea 46.53 1.00e-98 352.00
IUUC-Cgl-026465 Colletotrichum gloeosporioides 43.39 3.00e-98 350.00
IUUC-Cne-026872 Cryptococcus neoformans 40.89 6.00e-81 292.00
IUUC-Dre-028026 Danio rerio 45.17 8.00e-78 282.00
IUUC-Dse-031391 Dothistroma septosporum 46.30 2.00e-96 344.00
IUUC-Fox-037850 Fusarium oxysporum 47.49 5.00e-98 349.00
IUUC-Fso-038375 Fusarium solani 44.89 3.00e-98 350.00
IUUC-Ggr-039864 Gaeumannomyces graminis 45.16 4.00e-97 346.00
IUUC-Lma-052998 Leptosphaeria maculans 44.62 2.00e-94 338.00
IUUC-Mor-057277 Magnaporthe oryzae 45.53 5.00e-94 336.00
IUUC-Mpo-057624 Magnaporthe poae 44.67 5.00e-94 336.00
IUUC-Mla-059066 Melampsora laricipopulina 39.12 5.00e-77 279.00
IUUC-Mvi-060422 Microbotryum violaceum 40.18 3.00e-81 293.00
IUUC-Nfi-068375 Neosartorya fischeri 44.42 1.00e-89 322.00
IUUC-Ncr-068951 Neurospora crassa 46.03 7.00e-96 342.00
IUUC-Pno-094809 Phaeosphaeria nodorum 45.19 4.00e-95 340.00
IUUC-Pop-098890 Populus trichocarpa 41.78 3.00e-79 286.00
IUUC-Pgr-103627 Puccinia graminis 38.36 5.00e-73 266.00
IUUC-Pte-104142 Pyrenophora teres 44.68 2.00e-93 334.00
IUUC-Pyt-104693 Pyrenophora triticirepentis 44.94 7.00e-94 335.00
IUUC-Sja-107919 Schizosaccharomyces japonicus 49.33 8.00e-104 368.00
IUUC-Spo-108075 Schizosaccharomyces pombe 43.74 2.00e-99 353.00
IUUC-Ssl-108507 Sclerotinia sclerotiorum 46.02 2.00e-97 348.00
IUUC-Sre-114976 Sporisorium reilianum 40.72 3.00e-69 254.00
IUUC-Tru-118184 Takifugu rubripes 39.52 6.00e-66 242.00
IUUC-Tni-120474 Tetraodon nigroviridis 42.01 2.00e-70 257.00
IUUC-Tre-122211 Trichoderma reesei 46.84 2.00e-97 347.00
IUUC-Tvi-122531 Trichoderma virens 46.83 1.00e-95 342.00
IUUC-Tme-126905 Tuber melanosporum 44.72 2.00e-95 341.00
IUUC-Uma-129318 Ustilago maydis 41.92 1.00e-70 258.00
IUUC-Vda-129993 Verticillium dahliae 44.80 2.00e-97 347.00
IUUC-Vvi-131277 Vitis vinifera 40.77 7.00e-78 281.00
IUUC-Yli-134501 Yarrowia lipolytica 42.66 5.00e-100 356.00
Created Date 25-Jun-2017

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