iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089076

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39

Genbank Nucleotide ID

AAQR03151915

Gene Name

CIAO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000006874.2	ENSOGAT00000006880.2	ENSOGAP00000006154.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.90e-45	148.9	192	222
UBD/Beta-Prp	5.90e-62	209.5	13	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtl 90
           +h++s++  +++ p ++lla+ + d++i++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
           688999999999*********************9877654566689******************************99999******** PP
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtl 175
           +ghe++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl
   Q: 102  EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCYATL 190
           *********************************9987776566*********************************99777544999** PP
   S: 176  tgghtdsvyslsfdsngkelvsgsldgtvklw 207
           +g h++ v sl+fd++g++l+s+s+d+tv++w
   Q: 191  EG-HESTVWSLAFDPSGQRLASCSDDRTVRIW 221
           99.***************************** PP

Organism

Otolemur garnettii

Functional Description
(View)

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Protein Sequence
(Fasta)

MKDSLVLLSR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCCCATC TCCTCACCCT GCGCCGGGCA GCCATGAAAG ACTCGCTGGT GCTGCTGAGT 60
CGTGTCCCGG CGCACCCGGA CTCTCGCTGC TGGTTTCTAG CTTGGAACCC CGCGGGCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000874	Aegilops tauschii	42.66	4.00e-67	249.00
IUUC-Aml-001317	Ailuropoda melanoleuca	95.58	0.00e+00	627.00
IUUC-Atr-003029	Amborella trichopoda	51.32	3.00e-93	334.00
IUUC-Apl-004042	Anas platyrhynchos	77.27	1.00e-55	207.00
IUUC-Aly-006458	Arabidopsis lyrata	48.12	1.00e-85	309.00
IUUC-Ath-006671	Arabidopsis thaliana	48.12	1.00e-85	309.00
IUUC-Ago-007820	Ashbya gossypii	40.94	8.00e-61	227.00
IUUC-Acl-008042	Aspergillus clavatus	32.09	9.00e-50	191.00
IUUC-Afl-008639	Aspergillus flavus	32.86	1.00e-52	200.00
IUUC-Afu-008899	Aspergillus fumigatus	35.80	4.00e-49	188.00
IUUC-Ani-009453	Aspergillus nidulans	32.49	3.00e-51	196.00
IUUC-Ang-009758	Aspergillus niger	34.91	1.00e-51	196.00
IUUC-Aor-010212	Aspergillus oryzae	32.86	1.00e-52	200.00
IUUC-Ate-010314	Aspergillus terreus	33.33	2.00e-53	202.00
IUUC-Ame-010676	Astyanax mexicanus	77.54	6.00e-158	549.00
IUUC-Bgr-012095	Blumeria graminis	30.19	2.00e-38	153.00
IUUC-Bta-012884	Bos taurus	94.69	2.00e-178	617.00
IUUC-Bci-013622	Botrytis cinerea	32.56	1.00e-37	150.00
IUUC-Bdi-014614	Brachypodium distachyon	48.22	1.00e-84	306.00
IUUC-Bol-016439	Brassica oleracea	47.35	1.00e-83	303.00
IUUC-Bra-016830	Brassica rapa	46.31	3.00e-82	298.00
IUUC-Cel-018709	Caenorhabditis elegans	40.37	1.00e-63	236.00
IUUC-Cja-019822	Callithrix jacchus	96.17	0.00e+00	630.00
IUUC-Cfa-020823	Canis familiaris	96.17	0.00e+00	630.00
IUUC-Cre-022811	Chlamydomonas reinhardtii	48.21	3.00e-79	288.00
IUUC-Csa-023754	Chlorocebus sabaeus	97.05	0.00e+00	635.00
IUUC-Cin-025395	Ciona intestinalis	57.31	3.00e-116	411.00
IUUC-Csv-025943	Ciona savignyi	55.26	2.00e-111	395.00
IUUC-Cgl-026435	Colletotrichum gloeosporioides	30.87	2.00e-36	146.00
IUUC-Cne-026939	Cryptococcus neoformans	31.76	3.00e-49	189.00
IUUC-Cme-027239	Cyanidioschyzon merolae	40.51	2.00e-43	169.00
IUUC-Dre-028172	Danio rerio	76.65	5.00e-156	543.00
IUUC-Dno-029472	Dasypus novemcinctus	94.20	1.00e-150	525.00
IUUC-Dor-031134	Dipodomys ordii	84.66	1.00e-151	529.00
IUUC-Dse-031535	Dothistroma septosporum	30.33	4.00e-46	178.00
IUUC-Dme-032020	Drosophila melanogaster	58.86	3.00e-118	417.00
IUUC-Eca-033700	Equus caballus	96.46	0.00e+00	629.00
IUUC-Eeu-035010	Erinaceus europaeus	93.51	4.00e-176	610.00
IUUC-Fca-036309	Felis catus	88.53	6.00e-173	599.00
IUUC-Fal-037243	Ficedula albicollis	73.95	5.00e-85	306.00
IUUC-Fox-038058	Fusarium oxysporum	32.99	1.00e-43	171.00
IUUC-Fso-038459	Fusarium solani	35.76	3.00e-39	155.00
IUUC-Gmo-039375	Gadus morhua	75.52	4.00e-141	493.00
IUUC-Ggr-040002	Gaeumannomyces graminis	35.11	7.00e-41	161.00
IUUC-Gga-040294	Gallus gallus	78.29	8.00e-129	452.00
IUUC-Gac-042499	Gasterosteus aculeatus	74.78	1.00e-139	489.00
IUUC-Gma-043543	Glycine max	49.26	8.00e-88	317.00
IUUC-Ggo-045181	Gorilla gorilla	97.05	0.00e+00	635.00
IUUC-Hsa-046528	Homo sapiens	97.05	0.00e+00	635.00
IUUC-Hvu-047341	Hordeum vulgare	57.45	6.00e-56	209.00
IUUC-Itr-048790	Ictidomys tridecemlineatus	97.35	0.00e+00	635.00
IUUC-Kpa-049353	Komagataella pastoris	37.36	2.00e-56	213.00
IUUC-Lch-049763	Latimeria chalumnae	80.24	6.00e-162	563.00
IUUC-Lpe-051500	Leersia perrieri	44.20	4.00e-80	291.00
IUUC-Loc-052021	Lepisosteus oculatus	80.84	4.00e-154	537.00
IUUC-Lma-053331	Leptosphaeria maculans	34.75	1.00e-54	208.00
IUUC-Laf-054558	Loxodonta africana	93.51	2.00e-177	614.00
IUUC-Mcc-055374	Macaca mulatta	96.76	0.00e+00	632.00
IUUC-Meu-056042	Macropus eugenii	77.59	1.00e-113	402.00
IUUC-Mor-057187	Magnaporthe oryzae	31.58	6.00e-40	158.00
IUUC-Mtr-058072	Medicago truncatula	48.52	3.00e-87	315.00
IUUC-Mla-059108	Melampsora laricipopulina	31.36	4.00e-52	198.00
IUUC-Mga-059370	Meleagris gallopavo	64.62	1.00e-100	358.00
IUUC-Mvi-060495	Microbotryum violaceum	37.37	2.00e-57	216.00
IUUC-Mmr-060902	Microcebus murinus	97.35	0.00e+00	636.00
IUUC-Mdo-062510	Monodelphis domestica	92.63	2.00e-170	591.00
IUUC-Mmu-063575	Mus musculus	94.99	6.00e-180	622.00
IUUC-Mac-065322	Musa acuminata	50.74	2.00e-90	325.00
IUUC-Mpu-065925	Mustela putorius furo	96.46	0.00e+00	635.00
IUUC-Mlu-067755	Myotis lucifugus	95.58	0.00e+00	627.00
IUUC-Nfi-068327	Neosartorya fischeri	31.83	3.00e-49	189.00
IUUC-Ncr-068845	Neurospora crassa	33.23	3.00e-32	132.00
IUUC-Nle-069406	Nomascus leucogenys	94.69	8.00e-178	615.00
IUUC-Opr-070416	Ochotona princeps	76.11	1.00e-134	472.00
IUUC-Ont-071936	Oreochromis niloticus	76.56	6.00e-145	506.00
IUUC-Oan-073452	Ornithorhynchus anatinus	92.12	5.00e-75	273.00
IUUC-Ocu-074791	Oryctolagus cuniculus	95.87	0.00e+00	631.00
IUUC-Oba-075636	Oryza barthii	48.96	2.00e-87	315.00
IUUC-Obr-076742	Oryza brachyantha	47.90	1.00e-75	276.00
IUUC-Ogl-077766	Oryza glaberrima	48.96	2.00e-87	315.00
IUUC-Ogu-079039	Oryza glumaepatula	48.96	8.00e-88	317.00
IUUC-Oin-079315	Oryza indica	48.63	1.00e-76	279.00
IUUC-Olo-080669	Oryza longistaminata	43.49	1.00e-79	290.00
IUUC-Ome-081490	Oryza meridionalis	48.96	1.00e-87	316.00
IUUC-Oni-082572	Oryza nivara	48.96	2.00e-87	315.00
IUUC-Opu-083732	Oryza punctata	49.11	1.00e-87	316.00
IUUC-Oru-084763	Oryza rufipogon	48.96	2.00e-87	315.00
IUUC-Osa-085372	Oryza sativa	48.96	2.00e-87	315.00
IUUC-Ola-087379	Oryzias latipes	73.82	9.00e-140	489.00
IUUC-Olu-087801	Ostreococcus lucimarinus	36.01	2.00e-44	172.00
IUUC-Oar-090022	Ovis aries	94.69	1.00e-178	618.00
IUUC-Ptr-090809	Pan troglodytes	97.05	0.00e+00	635.00
IUUC-Pan-091685	Papio anubis	97.05	0.00e+00	641.00
IUUC-Psi-093046	Pelodiscus sinensis	87.83	1.00e-166	578.00
IUUC-Pma-094181	Petromyzon marinus	64.09	2.00e-132	464.00
IUUC-Pno-094882	Phaeosphaeria nodorum	34.95	1.00e-54	207.00
IUUC-Ppa-095172	Physcomitrella patens	47.38	9.00e-85	306.00
IUUC-Pfo-096396	Poecilia formosa	72.40	7.00e-140	489.00
IUUC-Pab-098427	Pongo abelii	96.46	0.00e+00	627.00
IUUC-Pop-100016	Populus trichocarpa	51.03	1.00e-90	326.00
IUUC-Pca-101048	Procavia capensis	94.40	3.00e-178	617.00
IUUC-Ppe-102050	Prunus persica	48.00	7.00e-87	313.00
IUUC-Pva-103117	Pteropus vampyrus	95.28	4.00e-180	623.00
IUUC-Pgr-103307	Puccinia graminis	33.56	1.00e-56	214.00
IUUC-Ptt-103938	Puccinia triticina	38.06	5.00e-49	187.00
IUUC-Pte-104315	Pyrenophora teres	33.33	2.00e-55	209.00
IUUC-Pyt-104825	Pyrenophora triticirepentis	32.61	2.00e-54	206.00
IUUC-Rno-105523	Rattus norvegicus	94.69	5.00e-180	623.00
IUUC-Sce-106297	Saccharomyces cerevisiae	42.27	2.00e-64	239.00
IUUC-Sha-106981	Sarcophilus harrisii	92.49	3.00e-143	500.00
IUUC-Sja-107715	Schizosaccharomyces japonicus	38.92	4.00e-56	212.00
IUUC-Spo-108214	Schizosaccharomyces pombe	40.43	1.00e-56	214.00
IUUC-Smo-109034	Selaginella moellendorffii	46.48	4.00e-82	297.00
IUUC-Sit-110663	Setaria italica	49.85	6.00e-89	320.00
IUUC-Sly-110898	Solanum lycopersicum	47.38	4.00e-83	301.00
IUUC-Stu-112647	Solanum tuberosum	51.13	2.00e-70	258.00
IUUC-Sbi-114288	Sorghum bicolor	47.51	1.00e-84	306.00
IUUC-Sre-115065	Sporisorium reilianum	44.05	3.00e-76	278.00
IUUC-Ssc-115960	Sus scrofa	89.32	6.00e-178	616.00
IUUC-Tru-118382	Takifugu rubripes	71.51	7.00e-147	513.00
IUUC-Tsy-119585	Tarsius syrichta	87.61	1.00e-160	558.00
IUUC-Tni-120133	Tetraodon nigroviridis	75.45	5.00e-144	503.00
IUUC-Tca-121167	Theobroma cacao	49.26	3.00e-82	298.00
IUUC-Tre-122119	Trichoderma reesei	29.10	2.00e-40	160.00
IUUC-Tvi-122407	Trichoderma virens	32.47	7.00e-40	157.00
IUUC-Tae-125748	Triticum aestivum	47.51	6.00e-81	294.00
IUUC-Tur-126682	Triticum urartu	48.52	9.00e-68	249.00
IUUC-Tme-127095	Tuber melanosporum	35.86	5.00e-61	228.00
IUUC-Tbe-128004	Tupaia belangeri	97.35	0.00e+00	637.00
IUUC-Ttr-129284	Tursiops truncatus	92.40	1.00e-172	598.00
IUUC-Uma-129527	Ustilago maydis	43.58	1.00e-75	277.00
IUUC-Vda-129854	Verticillium dahliae	31.54	1.00e-37	150.00
IUUC-Vpa-130681	Vicugna pacos	97.41	5.00e-50	191.00
IUUC-Vvi-131004	Vitis vinifera	53.45	5.00e-88	317.00
IUUC-Xtr-131928	Xenopus tropicalis	81.31	1.00e-153	535.00
IUUC-Xma-134290	Xiphophorus maculatus	71.22	3.00e-136	478.00
IUUC-Yli-134364	Yarrowia lipolytica	44.02	2.00e-67	249.00
IUUC-Zma-135658	Zea mays	48.96	2.00e-85	309.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence