iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106819

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01004072

Gene Name

HECTD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018873.1	ENSSHAT00000022477.1	ENSSHAP00000022299.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-102	342.8	393	730

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f y++++ ++++ + +      ++ + F+++G+l+g+a++++  ld++
   Q: 393  GDLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFAYHKDSLCHWFSSYKC-----DNYSEFRLVGILMGLAVYNSITLDIR 476
           799************************************************9976655.....789*********************** PP
   S: 92   lsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVt 166
           +++++yk+ll+               +++++dl +++pel++ l+e++++ + ++ee  +  tf+v +e++g +k+++Lkp+G++ipVt
   Q: 477  FPPCCYKKLLSPpivpsdqntpvgicSVTIDDLYQIMPELAHGLTELLSY-DGNVEED-FYSTFQVFQEEFGVIKSYNLKPSGDKIPVT 563
           ***********9666666666666555***********************.6788885.****************************** PP
   S: 167  neNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevlee 255
           n+N++eYv+l+v++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l+++t+y+g y +++ +i++Fw+v+ +
   Q: 564  NQNRKEYVQLYVDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRNTQYDG-YVKTDLTIRYFWDVVLG 651
           *********************************************************************76.***************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k d+s+++lP ++TCfn+L+LP+Y++k++lk+kL++ i++++gF+l+
   Q: 652  FPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKhDTSTNWLPVAHTCFNQLCLPPYKNKKELKQKLIIGISNSEGFGLE 730
           ****************************...9999989999**************************************985 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

VERGAKGQLS TFSSFISTVS QKKDVAGKRS SPTQLVTPNV KNVRDLPPIC LDVRQKQRLS 60
IDSLSTEMKA SIPPEPVLPI RTKTMKDFQE DVEKVKSSGE WKEVHDFYLT TFDSFLELSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAAAGAG GAGCCAAAGG CCAGCTTTCT ACTTTCAGCA GTTTCATTTC AACTGTTAGC 60
CAGAAGAAAG ATGTGGCTGG AAAGAGAAGT TCACCCACAC AACTTGTTAC ACCTAACGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	90.60	0.00e+00	1367.00
IUUC-Apl-003589	Anas platyrhynchos	86.73	0.00e+00	1289.00
IUUC-Aca-004350	Anolis carolinensis	81.92	0.00e+00	1207.00
IUUC-Ago-007908	Ashbya gossypii	35.66	4.00e-81	296.00
IUUC-Acl-008288	Aspergillus clavatus	35.80	2.00e-96	347.00
IUUC-Afl-008402	Aspergillus flavus	34.11	9.00e-89	321.00
IUUC-Afu-008762	Aspergillus fumigatus	35.08	3.00e-94	340.00
IUUC-Ani-009176	Aspergillus nidulans	35.49	3.00e-91	330.00
IUUC-Ang-009791	Aspergillus niger	36.30	8.00e-92	332.00
IUUC-Aor-009921	Aspergillus oryzae	33.94	2.00e-88	320.00
IUUC-Ate-010295	Aspergillus terreus	36.32	4.00e-99	356.00
IUUC-Ame-010660	Astyanax mexicanus	82.27	9.00e-153	532.00
IUUC-Bgr-011981	Blumeria graminis	32.62	3.00e-92	333.00
IUUC-Bta-012945	Bos taurus	90.27	0.00e+00	1335.00
IUUC-Bci-013697	Botrytis cinerea	34.32	3.00e-81	297.00
IUUC-Cja-019263	Callithrix jacchus	89.24	0.00e+00	1313.00
IUUC-Cfa-020486	Canis familiaris	93.19	0.00e+00	1242.00
IUUC-Cpo-021755	Cavia porcellus	89.73	0.00e+00	1333.00
IUUC-Csa-023814	Chlorocebus sabaeus	90.45	0.00e+00	1261.00
IUUC-Cho-024980	Choloepus hoffmanni	73.84	0.00e+00	1061.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	42.83	2.00e-96	347.00
IUUC-Dre-028551	Danio rerio	77.12	0.00e+00	1148.00
IUUC-Dno-029497	Dasypus novemcinctus	89.73	0.00e+00	1218.00
IUUC-Dor-030867	Dipodomys ordii	78.63	0.00e+00	1137.00
IUUC-Dse-031239	Dothistroma septosporum	29.99	6.00e-90	325.00
IUUC-Ete-032902	Echinops telfairi	76.41	0.00e+00	1109.00
IUUC-Eca-033678	Equus caballus	90.82	0.00e+00	1355.00
IUUC-Eeu-035262	Erinaceus europaeus	75.69	0.00e+00	1016.00
IUUC-Fca-035590	Felis catus	91.23	0.00e+00	1374.00
IUUC-Fal-037123	Ficedula albicollis	82.99	0.00e+00	1223.00
IUUC-Fox-037941	Fusarium oxysporum	40.74	8.00e-100	358.00
IUUC-Fso-038388	Fusarium solani	41.39	5.00e-101	362.00
IUUC-Gmo-039553	Gadus morhua	65.73	0.00e+00	836.00
IUUC-Ggr-040110	Gaeumannomyces graminis	32.93	4.00e-99	356.00
IUUC-Gga-040406	Gallus gallus	86.58	0.00e+00	1321.00
IUUC-Gac-042141	Gasterosteus aculeatus	76.27	0.00e+00	1107.00
IUUC-Ggo-045504	Gorilla gorilla	88.83	0.00e+00	1318.00
IUUC-Hsa-045786	Homo sapiens	89.59	0.00e+00	1324.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	86.34	0.00e+00	1184.00
IUUC-Kpa-049152	Komagataella pastoris	32.44	4.00e-73	269.00
IUUC-Lch-049824	Latimeria chalumnae	81.04	0.00e+00	1101.00
IUUC-Loc-052173	Lepisosteus oculatus	80.00	0.00e+00	1185.00
IUUC-Laf-054017	Loxodonta africana	91.86	0.00e+00	1286.00
IUUC-Mcc-055713	Macaca mulatta	90.05	0.00e+00	1310.00
IUUC-Meu-056212	Macropus eugenii	83.58	3.00e-122	432.00
IUUC-Mor-057045	Magnaporthe oryzae	36.33	9.00e-89	322.00
IUUC-Mla-059187	Melampsora laricipopulina	44.07	2.00e-87	316.00
IUUC-Mga-059884	Meleagris gallopavo	80.03	0.00e+00	1172.00
IUUC-Mmr-061344	Microcebus murinus	90.14	0.00e+00	1337.00
IUUC-Mdo-062653	Monodelphis domestica	93.61	0.00e+00	1368.00
IUUC-Mmu-063775	Mus musculus	87.67	0.00e+00	1243.00
IUUC-Mpu-066069	Mustela putorius furo	92.46	0.00e+00	1263.00
IUUC-Mlu-067925	Myotis lucifugus	90.41	0.00e+00	1323.00
IUUC-Nfi-068439	Neosartorya fischeri	35.41	4.00e-95	342.00
IUUC-Ncr-068903	Neurospora crassa	30.68	2.00e-94	340.00
IUUC-Nle-070046	Nomascus leucogenys	89.37	0.00e+00	1326.00
IUUC-Opr-071085	Ochotona princeps	77.52	5.00e-135	474.00
IUUC-Ont-072126	Oreochromis niloticus	74.73	0.00e+00	1159.00
IUUC-Oan-072933	Ornithorhynchus anatinus	89.52	0.00e+00	1180.00
IUUC-Ocu-073800	Oryctolagus cuniculus	93.06	0.00e+00	1254.00
IUUC-Ola-086988	Oryzias latipes	76.31	0.00e+00	1109.00
IUUC-Oga-088117	Otolemur garnettii	93.12	0.00e+00	1090.00
IUUC-Oar-089371	Ovis aries	90.00	0.00e+00	1313.00
IUUC-Ptr-090551	Pan troglodytes	88.58	0.00e+00	1286.00
IUUC-Pan-092067	Papio anubis	90.55	0.00e+00	1315.00
IUUC-Psi-092963	Pelodiscus sinensis	87.11	0.00e+00	1253.00
IUUC-Pfo-096562	Poecilia formosa	72.58	0.00e+00	1116.00
IUUC-Pab-098680	Pongo abelii	90.00	0.00e+00	1327.00
IUUC-Pca-100986	Procavia capensis	73.54	0.00e+00	850.00
IUUC-Pva-102219	Pteropus vampyrus	76.23	0.00e+00	1001.00
IUUC-Pgr-103315	Puccinia graminis	35.87	3.00e-94	339.00
IUUC-Ptt-103736	Puccinia triticina	41.61	1.00e-92	334.00
IUUC-Rno-105270	Rattus norvegicus	88.08	0.00e+00	1243.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.10	6.00e-70	258.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.41	5.00e-85	308.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	31.61	9.00e-85	308.00
IUUC-Sar-113134	Sorex araneus	81.37	0.00e+00	1169.00
IUUC-Ssc-115441	Sus scrofa	91.10	0.00e+00	1346.00
IUUC-Tgu-117166	Taeniopygia guttata	85.48	0.00e+00	1247.00
IUUC-Tsy-118898	Tarsius syrichta	77.49	0.00e+00	1046.00
IUUC-Tre-122108	Trichoderma reesei	39.26	8.00e-89	322.00
IUUC-Tvi-122644	Trichoderma virens	39.44	4.00e-94	339.00
IUUC-Tme-127004	Tuber melanosporum	34.96	4.00e-102	366.00
IUUC-Tbe-127292	Tupaia belangeri	74.38	0.00e+00	1012.00
IUUC-Ttr-128352	Tursiops truncatus	86.44	0.00e+00	1267.00
IUUC-Vda-129969	Verticillium dahliae	40.79	2.00e-92	334.00
IUUC-Vpa-130218	Vicugna pacos	87.76	0.00e+00	949.00
IUUC-Xtr-132594	Xenopus tropicalis	79.59	0.00e+00	1158.00
IUUC-Xma-134157	Xiphophorus maculatus	75.65	0.00e+00	1036.00
IUUC-Yli-134470	Yarrowia lipolytica	34.95	6.00e-76	279.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence