iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045869

Ensembl Protein ID

ENSP00000343479.5

UniProt Accession

Q14596; Q13173; Q15026; Q5J7Q8; Q96GB6; Q9NRF7; NBR1_HUMAN

Genbank Protein ID

CAA54274.1; BAA06417.2; AAS15047.1; EAW60946.1; AAH09808.1; AAF74119.1; AAA93228.1

Protein Name

Next to BRCA1 gene 1 protein; Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B

Genbank Nucleotide ID

X76952; D30756; AY450308; AC060780; BC009808; AF227189; U25764

Gene Name

NBR1; 1A13B; KIAA0049; M17S2; MIG19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000188554.13	ENST00000341165.10	ENSP00000343479.5
ENSG00000188554.13	ENST00000542611.5	ENSP00000437545.1
ENSG00000188554.13	ENST00000589872.1	ENSP00000467816.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	23649778
ULD/UDP/UFD/PB1	PB1	18234223

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.0021	19.8	921	955
ULD/UDP/UFD/PB1	3.60e-18	67.2	4	84

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGF.dreealqaLraa.nnnleaAveyLl 39
           ++ l eMGF dr+++l+ L  + +n l++++e+L 
   Q: 921  MAHLFEMGFcDRQLNLRLLKKHnYNILQVVTELLQ 955
           67899*****************9999999999985 PP

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqk 83
           +v+++v++k+ei+sf ++ +++++++d++++v+   +++ +++++kY De+++ v+++s+ ++++a+++++++ ++l++++++
   Q: 4    QVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKV--SFDLNTIQIKYLDEENEEVSINSQGEYEEALKMAVKQGNQLQMQVHE 84
           6899******************************..*********************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Protein Sequence
(Fasta)

MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS 60
QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAATTGCT GTACCAAGGT CAGAATCGCC ACCTGAGGCC TGAATATCAG CGTAAGATAG 60
TGTCCAAAGC AGTCTTAAGA AGAGGTCCCA TTACCCCACT CTTTCCGCCC TAATGGAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032350--N_BRCA1_central
IPR033513--NBR1
IPR000270--PB1_dom
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF16158--N_BRCA1_IG
PF00564--PB1
PF00569--ZZ

SMART

SM00666--PB1
SM00291--ZnF_ZZ

Gene Ontology

GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0031430--C:M band
GO:0016020--C:membrane
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0000407--C:pre-autophagosomal structure
GO:0051019--F:mitogen-activated protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0016236--P:macroautophagy
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0051259--P:protein oligomerization
GO:0030500--P:regulation of bone mineralization
GO:0032872--P:regulation of stress-activated MAPK cascade

KEGG

hsa:4077

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002028	Ailuropoda melanoleuca	88.89	0.00e+00	1230.00
IUUC-Atr-003106	Amborella trichopoda	37.19	1.00e-14	75.10
IUUC-Apl-003851	Anas platyrhynchos	59.38	0.00e+00	959.00
IUUC-Aca-005281	Anolis carolinensis	60.82	0.00e+00	733.00
IUUC-Acl-008033	Aspergillus clavatus	26.67	2.00e-17	84.70
IUUC-Afl-008503	Aspergillus flavus	24.41	7.00e-15	76.30
IUUC-Afu-008992	Aspergillus fumigatus	27.64	5.00e-17	83.60
IUUC-Ani-009220	Aspergillus nidulans	25.50	4.00e-16	80.50
IUUC-Ang-009700	Aspergillus niger	30.77	7.00e-11	62.80
IUUC-Aor-010141	Aspergillus oryzae	24.41	6.00e-15	76.30
IUUC-Ate-010391	Aspergillus terreus	27.24	2.00e-15	78.60
IUUC-Ame-010904	Astyanax mexicanus	44.56	2.00e-135	476.00
IUUC-Bgr-011970	Blumeria graminis	23.97	7.00e-14	73.20
IUUC-Bta-013030	Bos taurus	83.94	0.00e+00	1618.00
IUUC-Bci-013961	Botrytis cinerea	28.46	2.00e-10	62.00
IUUC-Bol-015840	Brassica oleracea	37.50	4.00e-14	73.60
IUUC-Bra-017383	Brassica rapa	38.33	6.00e-15	76.30
IUUC-Cja-019576	Callithrix jacchus	87.63	0.00e+00	1702.00
IUUC-Cfa-021030	Canis familiaris	86.17	0.00e+00	1602.00
IUUC-Cpo-021386	Cavia porcellus	63.56	0.00e+00	1077.00
IUUC-Cre-022856	Chlamydomonas reinhardtii	34.62	1.00e-03	40.80
IUUC-Csa-023265	Chlorocebus sabaeus	96.59	0.00e+00	1775.00
IUUC-Cho-024901	Choloepus hoffmanni	66.11	1.00e-168	586.00
IUUC-Cin-025280	Ciona intestinalis	28.57	2.00e-09	55.80
IUUC-Cne-027045	Cryptococcus neoformans	45.28	1.00e-09	58.90
IUUC-Dre-028204	Danio rerio	42.57	2.00e-139	490.00
IUUC-Dno-028885	Dasypus novemcinctus	85.43	0.00e+00	1603.00
IUUC-Dse-031315	Dothistroma septosporum	28.46	1.00e-11	65.50
IUUC-Eca-033409	Equus caballus	85.71	0.00e+00	1643.00
IUUC-Fca-035407	Felis catus	85.85	0.00e+00	1628.00
IUUC-Fal-037400	Ficedula albicollis	57.24	0.00e+00	985.00
IUUC-Fox-037767	Fusarium oxysporum	23.79	1.00e-15	79.30
IUUC-Fso-038322	Fusarium solani	31.97	3.00e-12	67.80
IUUC-Gmo-039454	Gadus morhua	35.72	6.00e-108	385.00
IUUC-Gga-040430	Gallus gallus	59.69	0.00e+00	1030.00
IUUC-Gac-042114	Gasterosteus aculeatus	44.25	0.00e+00	657.00
IUUC-Gma-044280	Glycine max	38.33	3.00e-16	80.90
IUUC-Ggo-045643	Gorilla gorilla	98.54	0.00e+00	1358.00
IUUC-Itr-048172	Ictidomys tridecemlineatus	87.01	0.00e+00	1652.00
IUUC-Lch-050238	Latimeria chalumnae	55.84	0.00e+00	715.00
IUUC-Loc-052860	Lepisosteus oculatus	43.99	5.00e-142	498.00
IUUC-Lma-053158	Leptosphaeria maculans	29.01	5.00e-12	66.60
IUUC-Laf-054460	Loxodonta africana	84.71	0.00e+00	1668.00
IUUC-Mcc-055768	Macaca mulatta	94.83	0.00e+00	1758.00
IUUC-Meu-056136	Macropus eugenii	70.71	0.00e+00	811.00
IUUC-Mor-057101	Magnaporthe oryzae	24.07	6.00e-16	80.10
IUUC-Mtr-058592	Medicago truncatula	39.66	1.00e-14	75.50
IUUC-Mga-059507	Meleagris gallopavo	63.80	0.00e+00	822.00
IUUC-Mvi-060452	Microbotryum violaceum	37.19	3.00e-14	74.70
IUUC-Mmr-060796	Microcebus murinus	90.37	0.00e+00	1582.00
IUUC-Mdo-062214	Monodelphis domestica	79.42	0.00e+00	1118.00
IUUC-Mmu-063788	Mus musculus	87.37	0.00e+00	1202.00
IUUC-Mpu-066809	Mustela putorius furo	86.16	0.00e+00	1588.00
IUUC-Mlu-067887	Myotis lucifugus	85.06	0.00e+00	1618.00
IUUC-Nfi-068336	Neosartorya fischeri	27.64	2.00e-18	88.60
IUUC-Nle-069230	Nomascus leucogenys	97.10	0.00e+00	1781.00
IUUC-Opr-070848	Ochotona princeps	87.29	0.00e+00	748.00
IUUC-Ont-071913	Oreochromis niloticus	45.21	3.00e-143	503.00
IUUC-Oan-073479	Ornithorhynchus anatinus	48.11	2.00e-168	586.00
IUUC-Ocu-074112	Oryctolagus cuniculus	85.47	0.00e+00	1666.00
IUUC-Ola-087486	Oryzias latipes	38.07	2.00e-137	483.00
IUUC-Oga-088832	Otolemur garnettii	86.61	0.00e+00	1609.00
IUUC-Oar-090088	Ovis aries	83.45	0.00e+00	1590.00
IUUC-Ptr-090790	Pan troglodytes	97.72	0.00e+00	1826.00
IUUC-Pan-092523	Papio anubis	96.69	0.00e+00	1775.00
IUUC-Psi-093398	Pelodiscus sinensis	64.76	0.00e+00	834.00
IUUC-Pno-095009	Phaeosphaeria nodorum	26.10	7.00e-17	83.20
IUUC-Pfo-097491	Poecilia formosa	41.69	2.00e-148	520.00
IUUC-Pab-098775	Pongo abelii	94.53	0.00e+00	1745.00
IUUC-Pca-100690	Procavia capensis	83.68	0.00e+00	800.00
IUUC-Ppe-101351	Prunus persica	40.48	8.00e-17	82.80
IUUC-Pva-102582	Pteropus vampyrus	85.98	0.00e+00	852.00
IUUC-Pgr-103390	Puccinia graminis	39.09	1.00e-10	62.80
IUUC-Ptt-103754	Puccinia triticina	39.62	2.00e-14	74.30
IUUC-Pte-104190	Pyrenophora teres	24.64	3.00e-15	77.80
IUUC-Pyt-104763	Pyrenophora triticirepentis	25.00	6.00e-16	80.10
IUUC-Rno-105543	Rattus norvegicus	81.39	0.00e+00	1472.00
IUUC-Sha-106861	Sarcophilus harrisii	79.54	0.00e+00	1131.00
IUUC-Sly-111749	Solanum lycopersicum	38.21	1.00e-16	81.60
IUUC-Stu-111924	Solanum tuberosum	40.16	1.00e-17	85.50
IUUC-Sar-113740	Sorex araneus	76.01	0.00e+00	1342.00
IUUC-Ssc-116108	Sus scrofa	85.51	0.00e+00	1668.00
IUUC-Tgu-117185	Taeniopygia guttata	57.82	0.00e+00	986.00
IUUC-Tru-117980	Takifugu rubripes	37.82	1.00e-119	424.00
IUUC-Tsy-119265	Tarsius syrichta	90.17	0.00e+00	862.00
IUUC-Tni-120728	Tetraodon nigroviridis	43.06	1.00e-179	624.00
IUUC-Tca-120994	Theobroma cacao	34.11	1.00e-15	78.60
IUUC-Tre-122001	Trichoderma reesei	25.09	6.00e-15	76.60
IUUC-Tme-127010	Tuber melanosporum	27.07	3.00e-10	61.20
IUUC-Tbe-127236	Tupaia belangeri	85.88	0.00e+00	1648.00
IUUC-Ttr-128229	Tursiops truncatus	91.00	0.00e+00	866.00
IUUC-Vpa-130650	Vicugna pacos	86.01	8.00e-133	467.00
IUUC-Vvi-131325	Vitis vinifera	37.21	2.00e-18	88.20
IUUC-Xtr-132375	Xenopus tropicalis	50.00	5.00e-174	605.00
IUUC-Xma-134007	Xiphophorus maculatus	41.04	4.00e-146	512.00
IUUC-Zma-134921	Zea mays	39.29	3.00e-16	80.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence