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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045685
UUCD1 version UUC-HoS-00185
Ensembl Protein ID ENSP00000403524.3
UniProt Accession Q7Z569; B4DRM1; B9EGS8; O43238; O75341; BRAP_HUMAN
Genbank Protein ID AAC24200.1; AAP93638.1; BAG61333.1; EAW97972.1; AAI36699.1; AAI36700.1; AAB88538.1
Protein Name BRCA1-associated protein; BRAP2; Impedes mitogenic signal propagation; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63
Genbank Nucleotide ID AF035620; AY332222; AK299326; AC002996; BC136698; BC136699; AF035950
Gene Name BRAP; RNF52
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000089234.15 ENST00000419234.8 ENSP00000403524.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16757328; 19091743; 19152073
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.60e-06 30.1 264 304
UBD/ZnF/ZnF_UBP 4.60e-24 86.1 316 376
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle++++     l++ C+H fh +Clq+w           +CP+Cr
   Q: 264  CTVCLERMDESvngILTTLCNHSFHSQCLQRW--------DDTTCPVCR 304
           9*******77333366777*************........8889****8 PP
   

   UBD/ZnF/ZnF_UBP
   S: 2    kcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhplvlslstlsvycYacddyvhr 62
           kc +c+ +enlW+cL+cg++gCGRyv+ Ha kH+eetqh ++++l + +v++Ya+d+yvhr
   Q: 316  KCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHR 376
           8**********************************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
 Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Protein Sequence
(Fasta)
MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII 60
HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045685|E3,RING;UBD,ZnF_UBP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGACGGCG GCCGGGAGGC GGAAGTGGAG GTTGTTGTGG CTCCGAGGGC TGTTCGAGGA 60
GCTGCTGCTG CTGAGGCGGC GGCAACTGCA TTGAGGTGGT GGCGGCGCTG CCGGCCCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045685|E3,RING;UBD,ZnF_UBP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011422--BRAP2
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50089--ZF_RING_2
PS50271--ZF_UBP
Pfam

PF07576--BRAP2
PF13639--zf-RING_2
PF02148--zf-UBP
SMART

SM00184--RING
SM00290--ZnF_UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0000151--C:ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0008139--F:nuclear localization sequence binding
GO:0003676--F:nucleic acid binding
GO:0000166--F:nucleotide binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000165--P:MAPK cascade
GO:0009968--P:negative regulation of signal transduction
GO:0016567--P:protein ubiquitination
GO:0007265--P:Ras protein signal transduction
KEGG hsa:8315
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000519 Aegilops tauschii 30.72 1.00e-52 201.00
IUUC-Aml-002229 Ailuropoda melanoleuca 96.11 0.00e+00 1127.00
IUUC-Atr-002785 Amborella trichopoda 38.63 1.00e-91 330.00
IUUC-Apl-004048 Anas platyrhynchos 91.17 0.00e+00 926.00
IUUC-Aca-005133 Anolis carolinensis 84.83 0.00e+00 944.00
IUUC-Aly-006306 Arabidopsis lyrata 38.81 6.00e-77 281.00
IUUC-Ath-007604 Arabidopsis thaliana 35.04 4.00e-80 291.00
IUUC-Ago-007905 Ashbya gossypii 36.43 8.00e-71 261.00
IUUC-Acl-008310 Aspergillus clavatus 32.35 1.00e-66 247.00
IUUC-Afl-008497 Aspergillus flavus 31.92 2.00e-61 229.00
IUUC-Afu-008830 Aspergillus fumigatus 31.43 3.00e-64 239.00
IUUC-Ani-009485 Aspergillus nidulans 31.72 8.00e-68 251.00
IUUC-Ang-009603 Aspergillus niger 37.80 2.00e-65 243.00
IUUC-Aor-009935 Aspergillus oryzae 32.37 2.00e-65 243.00
IUUC-Ate-010485 Aspergillus terreus 32.20 6.00e-69 255.00
IUUC-Ame-011516 Astyanax mexicanus 84.93 0.00e+00 745.00
IUUC-Bgr-011985 Blumeria graminis 27.35 2.00e-46 181.00
IUUC-Bta-013203 Bos taurus 96.64 0.00e+00 1141.00
IUUC-Bci-013788 Botrytis cinerea 33.84 1.00e-53 204.00
IUUC-Bdi-014763 Brachypodium distachyon 35.58 2.00e-81 296.00
IUUC-Bol-015518 Brassica oleracea 34.41 1.00e-77 285.00
IUUC-Bra-017435 Brassica rapa 34.51 7.00e-78 284.00
IUUC-Cel-018194 Caenorhabditis elegans 36.99 6.00e-110 391.00
IUUC-Cja-018948 Callithrix jacchus 98.20 0.00e+00 1121.00
IUUC-Cfa-020377 Canis familiaris 97.30 0.00e+00 1173.00
IUUC-Cpo-021930 Cavia porcellus 94.35 0.00e+00 1090.00
IUUC-Cre-022571 Chlamydomonas reinhardtii 41.99 2.00e-57 215.00
IUUC-Csa-023554 Chlorocebus sabaeus 98.52 0.00e+00 984.00
IUUC-Cho-025045 Choloepus hoffmanni 92.77 1.00e-137 483.00
IUUC-Cin-025326 Ciona intestinalis 43.42 2.00e-111 396.00
IUUC-Csv-026232 Ciona savignyi 43.88 4.00e-114 405.00
IUUC-Cgl-026587 Colletotrichum gloeosporioides 30.89 3.00e-60 226.00
IUUC-Cne-026980 Cryptococcus neoformans 35.94 6.00e-51 196.00
IUUC-Cme-027262 Cyanidioschyzon merolae 35.10 1.00e-60 228.00
IUUC-Dre-028521 Danio rerio 77.44 0.00e+00 914.00
IUUC-Dno-029291 Dasypus novemcinctus 95.78 0.00e+00 1118.00
IUUC-Dor-030231 Dipodomys ordii 86.66 0.00e+00 1019.00
IUUC-Dse-031234 Dothistroma septosporum 32.75 1.00e-56 214.00
IUUC-Dme-032095 Drosophila melanogaster 44.33 3.00e-121 429.00
IUUC-Ete-032227 Echinops telfairi 83.24 0.00e+00 635.00
IUUC-Eca-034404 Equus caballus 97.00 0.00e+00 1153.00
IUUC-Eeu-035030 Erinaceus europaeus 77.59 1.00e-132 466.00
IUUC-Fca-035428 Felis catus 97.17 0.00e+00 1144.00
IUUC-Fal-037435 Ficedula albicollis 90.96 0.00e+00 973.00
IUUC-Fox-037733 Fusarium oxysporum 32.50 3.00e-61 230.00
IUUC-Fso-038427 Fusarium solani 33.10 1.00e-60 228.00
IUUC-Gmo-038817 Gadus morhua 75.22 0.00e+00 855.00
IUUC-Ggr-039949 Gaeumannomyces graminis 28.97 4.00e-56 213.00
IUUC-Gga-040929 Gallus gallus 89.52 0.00e+00 989.00
IUUC-Gac-041893 Gasterosteus aculeatus 75.80 0.00e+00 882.00
IUUC-Gma-043119 Glycine max 35.70 3.00e-82 298.00
IUUC-Ggo-045106 Gorilla gorilla 99.09 0.00e+00 922.00
IUUC-Hvu-047475 Hordeum vulgare 33.58 5.00e-35 141.00
IUUC-Itr-048406 Ictidomys tridecemlineatus 95.76 0.00e+00 1107.00
IUUC-Kpa-049175 Komagataella pastoris 35.46 6.00e-65 241.00
IUUC-Lch-050408 Latimeria chalumnae 81.09 0.00e+00 990.00
IUUC-Lpe-050777 Leersia perrieri 31.26 6.00e-70 258.00
IUUC-Loc-052160 Lepisosteus oculatus 66.73 0.00e+00 724.00
IUUC-Lma-053095 Leptosphaeria maculans 34.62 3.00e-79 290.00
IUUC-Laf-053497 Loxodonta africana 95.12 0.00e+00 1145.00
IUUC-Mcc-055381 Macaca mulatta 99.12 0.00e+00 1176.00
IUUC-Meu-056402 Macropus eugenii 71.37 0.00e+00 674.00
IUUC-Mor-057002 Magnaporthe oryzae 30.31 3.00e-61 230.00
IUUC-Mpo-057508 Magnaporthe poae 26.34 2.00e-54 207.00
IUUC-Mtr-058619 Medicago truncatula 35.31 5.00e-69 254.00
IUUC-Mla-058901 Melampsora laricipopulina 34.40 3.00e-73 270.00
IUUC-Mga-059667 Meleagris gallopavo 95.15 0.00e+00 914.00
IUUC-Mvi-060229 Microbotryum violaceum 29.68 3.00e-64 239.00
IUUC-Mmr-060881 Microcebus murinus 86.75 0.00e+00 970.00
IUUC-Mdo-062573 Monodelphis domestica 91.56 0.00e+00 996.00
IUUC-Mmu-063656 Mus musculus 90.88 0.00e+00 1089.00
IUUC-Mac-065512 Musa acuminata 37.34 1.00e-81 297.00
IUUC-Mpu-065816 Mustela putorius furo 97.17 0.00e+00 1150.00
IUUC-Mlu-067225 Myotis lucifugus 95.59 0.00e+00 1151.00
IUUC-Nfi-068534 Neosartorya fischeri 32.08 2.00e-65 244.00
IUUC-Ncr-068801 Neurospora crassa 28.16 2.00e-59 224.00
IUUC-Nle-069258 Nomascus leucogenys 99.23 0.00e+00 1085.00
IUUC-Opr-070877 Ochotona princeps 81.45 0.00e+00 907.00
IUUC-Ont-072141 Oreochromis niloticus 76.27 0.00e+00 885.00
IUUC-Oan-072961 Ornithorhynchus anatinus 91.40 0.00e+00 1037.00
IUUC-Ocu-074020 Oryctolagus cuniculus 94.28 0.00e+00 957.00
IUUC-Oba-075084 Oryza barthii 31.47 3.00e-70 259.00
IUUC-Obr-076840 Oryza brachyantha 36.05 7.00e-80 291.00
IUUC-Ogl-077880 Oryza glaberrima 42.38 5.00e-79 288.00
IUUC-Ogu-078968 Oryza glumaepatula 31.47 1.00e-70 260.00
IUUC-Oin-079200 Oryza indica 42.38 4.00e-79 288.00
IUUC-Olo-080753 Oryza longistaminata 34.59 2.00e-61 230.00
IUUC-Ome-081756 Oryza meridionalis 31.47 2.00e-70 259.00
IUUC-Oni-082434 Oryza nivara 31.47 3.00e-70 259.00
IUUC-Opu-083262 Oryza punctata 31.67 7.00e-69 254.00
IUUC-Oru-084381 Oryza rufipogon 31.47 1.00e-70 260.00
IUUC-Osa-085760 Oryza sativa 47.94 2.00e-71 262.00
IUUC-Ola-087390 Oryzias latipes 74.06 0.00e+00 829.00
IUUC-Olu-087694 Ostreococcus lucimarinus 31.83 1.00e-58 220.00
IUUC-Oga-088612 Otolemur garnettii 97.00 0.00e+00 1122.00
IUUC-Oar-089988 Ovis aries 96.46 0.00e+00 1135.00
IUUC-Ptr-090637 Pan troglodytes 99.83 0.00e+00 1202.00
IUUC-Pan-092506 Papio anubis 98.94 0.00e+00 1172.00
IUUC-Psi-093026 Pelodiscus sinensis 89.83 0.00e+00 954.00
IUUC-Pno-094779 Phaeosphaeria nodorum 32.15 7.00e-58 218.00
IUUC-Ppa-095731 Physcomitrella patens 40.22 6.00e-95 341.00
IUUC-Pfo-096725 Poecilia formosa 77.03 0.00e+00 861.00
IUUC-Pab-098413 Pongo abelii 99.48 0.00e+00 770.00
IUUC-Pop-099538 Populus trichocarpa 37.87 1.00e-81 297.00
IUUC-Pca-100130 Procavia capensis 83.22 0.00e+00 969.00
IUUC-Ppe-101843 Prunus persica 37.58 1.00e-86 313.00
IUUC-Pva-102752 Pteropus vampyrus 92.06 0.00e+00 1078.00
IUUC-Pgr-103478 Puccinia graminis 39.11 3.00e-77 283.00
IUUC-Ptt-103921 Puccinia triticina 38.57 1.00e-71 264.00
IUUC-Pte-104032 Pyrenophora teres 34.31 1.00e-75 278.00
IUUC-Pyt-104480 Pyrenophora triticirepentis 33.08 6.00e-74 272.00
IUUC-Rno-106037 Rattus norvegicus 75.97 0.00e+00 880.00
IUUC-Sce-106310 Saccharomyces cerevisiae 31.35 5.00e-61 229.00
IUUC-Sha-106752 Sarcophilus harrisii 89.36 0.00e+00 1034.00
IUUC-Sja-107665 Schizosaccharomyces japonicus 37.31 4.00e-83 302.00
IUUC-Spo-108042 Schizosaccharomyces pombe 34.17 4.00e-73 269.00
IUUC-Ssl-108504 Sclerotinia sclerotiorum 30.26 4.00e-53 202.00
IUUC-Smo-109399 Selaginella moellendorffii 38.19 7.00e-90 324.00
IUUC-Sit-110251 Setaria italica 38.70 3.00e-88 319.00
IUUC-Sly-111563 Solanum lycopersicum 37.78 3.00e-77 282.00
IUUC-Stu-112294 Solanum tuberosum 38.27 9.00e-81 293.00
IUUC-Sar-113080 Sorex araneus 79.30 9.00e-149 519.00
IUUC-Sbi-113915 Sorghum bicolor 38.51 5.00e-85 308.00
IUUC-Sre-114897 Sporisorium reilianum 36.55 3.00e-59 223.00
IUUC-Ssc-115369 Sus scrofa 98.91 8.00e-113 398.00
IUUC-Tgu-116710 Taeniopygia guttata 87.63 0.00e+00 1025.00
IUUC-Tru-117941 Takifugu rubripes 76.06 0.00e+00 865.00
IUUC-Tsy-118902 Tarsius syrichta 82.49 3.00e-105 375.00
IUUC-Tni-120587 Tetraodon nigroviridis 75.62 0.00e+00 900.00
IUUC-Tca-121425 Theobroma cacao 38.08 5.00e-89 322.00
IUUC-Tre-121874 Trichoderma reesei 30.37 5.00e-60 226.00
IUUC-Tvi-122266 Trichoderma virens 36.68 9.00e-61 228.00
IUUC-Tae-123517 Triticum aestivum 35.70 3.00e-80 292.00
IUUC-Tur-126467 Triticum urartu 32.86 1.00e-52 200.00
IUUC-Tme-127096 Tuber melanosporum 36.26 1.00e-59 224.00
IUUC-Tbe-128012 Tupaia belangeri 89.86 0.00e+00 897.00
IUUC-Ttr-128388 Tursiops truncatus 96.82 0.00e+00 1150.00
IUUC-Uma-129610 Ustilago maydis 34.23 6.00e-57 216.00
IUUC-Vda-129830 Verticillium dahliae 29.03 3.00e-56 213.00
IUUC-Vpa-130171 Vicugna pacos 96.62 0.00e+00 1166.00
IUUC-Vvi-131063 Vitis vinifera 42.26 6.00e-82 298.00
IUUC-Xtr-132313 Xenopus tropicalis 81.93 0.00e+00 1003.00
IUUC-Xma-133303 Xiphophorus maculatus 76.01 0.00e+00 854.00
IUUC-Yli-134669 Yarrowia lipolytica 31.95 5.00e-65 241.00
IUUC-Zma-135783 Zea mays 37.39 2.00e-82 300.00
Created Date 25-Jun-2017

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