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Tag Content
iUUCD ID IUUC-Bta-013437
Ensembl Protein ID ENSBTAP00000001725.5
UniProt Accession Q05B87; FRDA_BOVIN
Genbank Protein ID AAI22621.1
Protein Name Frataxin, mitochondrial; Frataxin intermediate form; Frataxin mature form
Genbank Nucleotide ID BC122620
Gene Name FXN; FRDA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000001306.5 ENSBTAT00000001725.5 ENSBTAP00000001725.5
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 74.76 5.00e-75 278.00 IUUC-Hsa-046921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity).
 Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity).
Protein Sequence
(Fasta)
MWTLGRRSVA SFLPRSALPG FAPTRAGAPR PAKDLSLSGL PGLRIGTAKA PARSQSSLSL 60
RCLNQTLDVK KQSVCWINLR TAGTLGDAGT LDDTTYERLA EETLDSLAEF FEDLADKPYT 120
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Protein Fasta Sequence


>IUUC-Bta-013437|UBD,UBD/Other/Other|Bos taurus
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Nucleotide Sequence
(Fasta)
GCCGCCGCAG ATCACAAAGA GCATGTGGAC GCTCGGGCGC CGCTCGGTTG CCAGTTTCCT 60
GCCCCGCTCC GCGCTCCCGG GCTTTGCCCC TACCCGTGCC GGGGCCCCGC GGCCGGCGAA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013437|UBD,UBD/Other/Other|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS
PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2
Pfam

PF01491--Frataxin_Cyay
PRINTS

PR00904--FRATAXIN
SMART

SM01219--Frataxin_Cyay
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0007628--P:adult walking behavior
GO:0009060--P:aerobic respiration
GO:0006879--P:cellular iron ion homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0034599--P:cellular response to oxidative stress
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0007005--P:mitochondrion organization
GO:0040015--P:negative regulation of multicellular organism growth
GO:0046621--P:negative regulation of organ growth
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0006119--P:oxidative phosphorylation
GO:1904234--P:positive regulation of aconitate hydratase activity
GO:0030307--P:positive regulation of cell growth
GO:0008284--P:positive regulation of cell proliferation
GO:1904231--P:positive regulation of succinate dehydrogenase activity
GO:0019230--P:proprioception
GO:0016540--P:protein autoprocessing
GO:0010722--P:regulation of ferrochelatase activity
GO:0010039--P:response to iron ion
KEGG bta:505694
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002122 Ailuropoda melanoleuca 76.47 2.00e-85 308.00
IUUC-Apl-003853 Anas platyrhynchos 83.47 3.00e-57 213.00
IUUC-Aca-005026 Anolis carolinensis 70.06 1.00e-61 228.00
IUUC-Aly-006200 Arabidopsis lyrata 46.15 6.00e-19 86.70
IUUC-Ath-007033 Arabidopsis thaliana 46.15 5.00e-19 87.00
IUUC-Ago-007707 Ashbya gossypii 47.57 2.00e-18 84.00
IUUC-Acl-008146 Aspergillus clavatus 37.69 5.00e-18 84.30
IUUC-Afl-008501 Aspergillus flavus 43.82 6.00e-15 73.90
IUUC-Afu-008851 Aspergillus fumigatus 38.14 2.00e-17 82.00
IUUC-Ani-009129 Aspergillus nidulans 32.48 1.00e-11 63.20
IUUC-Ang-009557 Aspergillus niger 36.92 3.00e-17 81.60
IUUC-Ate-010486 Aspergillus terreus 37.69 5.00e-18 84.00
IUUC-Bgr-012108 Blumeria graminis 44.04 2.00e-15 75.10
IUUC-Bci-013810 Botrytis cinerea 53.25 2.00e-15 75.50
IUUC-Bdi-014226 Brachypodium distachyon 44.35 2.00e-23 102.00
IUUC-Bol-015092 Brassica oleracea 46.15 2.00e-19 88.20
IUUC-Bra-017945 Brassica rapa 47.73 8.00e-19 86.30
IUUC-Cel-018466 Caenorhabditis elegans 50.46 4.00e-25 106.00
IUUC-Cja-019306 Callithrix jacchus 75.00 6.00e-77 279.00
IUUC-Cfa-020063 Canis familiaris 75.36 2.00e-82 298.00
IUUC-Cpo-021325 Cavia porcellus 69.34 6.00e-78 283.00
IUUC-Cre-022889 Chlamydomonas reinhardtii 51.06 2.00e-20 92.40
IUUC-Csa-023739 Chlorocebus sabaeus 75.71 2.00e-85 307.00
IUUC-Cho-024324 Choloepus hoffmanni 74.88 5.00e-76 276.00
IUUC-Cgl-026402 Colletotrichum gloeosporioides 46.49 2.00e-19 88.60
IUUC-Cne-027094 Cryptococcus neoformans 39.51 4.00e-13 67.80
IUUC-Cme-027112 Cyanidioschyzon merolae 46.67 5.00e-13 66.60
IUUC-Dre-028813 Danio rerio 66.67 4.00e-44 170.00
IUUC-Dno-029949 Dasypus novemcinctus 84.56 3.00e-55 206.00
IUUC-Dse-031482 Dothistroma septosporum 39.47 1.00e-17 82.40
IUUC-Dme-031608 Drosophila melanogaster 54.10 1.00e-33 135.00
IUUC-Ete-032937 Echinops telfairi 96.88 3.00e-13 67.40
IUUC-Eca-033899 Equus caballus 87.10 4.00e-65 239.00
IUUC-Fca-036579 Felis catus 78.53 2.00e-66 244.00
IUUC-Fox-037940 Fusarium oxysporum 39.41 5.00e-24 103.00
IUUC-Fso-038465 Fusarium solani 51.75 6.00e-24 103.00
IUUC-Ggr-040089 Gaeumannomyces graminis 46.15 1.00e-21 96.30
IUUC-Gga-040910 Gallus gallus 70.81 4.00e-64 236.00
IUUC-Gma-044349 Glycine max 43.80 7.00e-24 103.00
IUUC-Ggo-044854 Gorilla gorilla 75.24 3.00e-72 264.00
IUUC-Hsa-046921 Homo sapiens 74.76 1.00e-71 262.00
IUUC-Hvu-047142 Hordeum vulgare 45.61 8.00e-24 103.00
IUUC-Kpa-049187 Komagataella pastoris 40.35 5.00e-15 73.60
IUUC-Lch-050614 Latimeria chalumnae 70.45 1.00e-54 205.00
IUUC-Lpe-051184 Leersia perrieri 42.11 5.00e-23 100.00
IUUC-Loc-052083 Lepisosteus oculatus 69.49 3.00e-47 180.00
IUUC-Lma-053209 Leptosphaeria maculans 40.37 2.00e-15 75.10
IUUC-Laf-054090 Loxodonta africana 73.68 3.00e-82 297.00
IUUC-Meu-056814 Macropus eugenii 75.51 3.00e-65 239.00
IUUC-Mor-057169 Magnaporthe oryzae 47.83 2.00e-21 95.50
IUUC-Mpo-057483 Magnaporthe poae 45.97 4.00e-23 100.00
IUUC-Mtr-058166 Medicago truncatula 48.57 2.00e-19 88.60
IUUC-Mla-059015 Melampsora laricipopulina 40.65 5.00e-19 86.70
IUUC-Mvi-060356 Microbotryum violaceum 52.13 9.00e-21 93.20
IUUC-Mdo-062658 Monodelphis domestica 78.91 3.00e-66 244.00
IUUC-Mmu-063470 Mus musculus 68.25 2.00e-76 278.00
IUUC-Mac-065327 Musa acuminata 51.43 3.00e-24 104.00
IUUC-Mpu-065761 Mustela putorius furo 84.97 1.00e-70 258.00
IUUC-Mlu-067175 Myotis lucifugus 74.65 2.00e-86 311.00
IUUC-Nfi-068535 Neosartorya fischeri 38.14 2.00e-17 82.00
IUUC-Ncr-068966 Neurospora crassa 44.53 4.00e-23 100.00
IUUC-Opr-070533 Ochotona princeps 56.21 9.00e-34 135.00
IUUC-Oan-073024 Ornithorhynchus anatinus 80.54 5.00e-59 220.00
IUUC-Ocu-074451 Oryctolagus cuniculus 72.81 2.00e-77 282.00
IUUC-Oba-075540 Oryza barthii 44.35 4.00e-23 100.00
IUUC-Obr-076285 Oryza brachyantha 42.98 5.00e-23 101.00
IUUC-Ogl-077827 Oryza glaberrima 44.35 4.00e-23 100.00
IUUC-Ogu-078491 Oryza glumaepatula 44.35 3.00e-23 101.00
IUUC-Oin-080149 Oryza indica 44.74 4.00e-23 100.00
IUUC-Olo-080318 Oryza longistaminata 42.50 3.00e-21 93.60
IUUC-Oni-083037 Oryza nivara 44.74 5.00e-23 100.00
IUUC-Opu-083448 Oryza punctata 44.74 2.00e-23 101.00
IUUC-Oru-084793 Oryza rufipogon 44.74 5.00e-23 100.00
IUUC-Osa-086032 Oryza sativa 44.74 5.00e-23 100.00
IUUC-Ola-086956 Oryzias latipes 63.28 8.00e-44 169.00
IUUC-Olu-087806 Ostreococcus lucimarinus 39.09 6.00e-16 76.60
IUUC-Oga-089029 Otolemur garnettii 77.99 1.00e-82 298.00
IUUC-Oar-089471 Ovis aries 95.39 3.00e-109 387.00
IUUC-Pan-092091 Papio anubis 75.71 1.00e-85 308.00
IUUC-Psi-093193 Pelodiscus sinensis 76.62 6.00e-68 249.00
IUUC-Pma-094540 Petromyzon marinus 62.71 2.00e-41 160.00
IUUC-Pno-094873 Phaeosphaeria nodorum 42.02 7.00e-17 80.50
IUUC-Ppa-095343 Physcomitrella patens 45.45 2.00e-17 82.40
IUUC-Pfo-097093 Poecilia formosa 64.10 1.00e-42 166.00
IUUC-Pab-098781 Pongo abelii 92.77 5.00e-30 122.00
IUUC-Pop-098983 Populus trichocarpa 40.60 3.00e-22 97.80
IUUC-Pca-100872 Procavia capensis 67.30 5.00e-60 223.00
IUUC-Ppe-101711 Prunus persica 49.44 2.00e-19 88.60
IUUC-Pva-102256 Pteropus vampyrus 77.73 3.00e-86 310.00
IUUC-Pgr-103607 Puccinia graminis 41.46 1.00e-20 92.80
IUUC-Pte-104220 Pyrenophora teres 36.44 3.00e-14 70.50
IUUC-Pyt-104562 Pyrenophora triticirepentis 36.44 6.00e-15 73.60
IUUC-Rno-105021 Rattus norvegicus 65.88 2.00e-74 271.00
IUUC-Sce-106182 Saccharomyces cerevisiae 47.89 7.00e-15 73.20
IUUC-Sha-107279 Sarcophilus harrisii 78.23 3.00e-66 244.00
IUUC-Sja-107819 Schizosaccharomyces japonicus 44.44 5.00e-21 93.60
IUUC-Spo-108197 Schizosaccharomyces pombe 40.65 4.00e-20 90.50
IUUC-Smo-108810 Selaginella moellendorffii 53.57 5.00e-21 92.40
IUUC-Sit-110256 Setaria italica 44.95 1.00e-22 99.80
IUUC-Sly-111448 Solanum lycopersicum 43.86 1.00e-21 96.30
IUUC-Stu-112702 Solanum tuberosum 43.86 7.00e-22 96.70
IUUC-Sbi-113956 Sorghum bicolor 40.37 8.00e-25 106.00
IUUC-Sre-115024 Sporisorium reilianum 37.96 3.00e-17 81.30
IUUC-Ssc-116034 Sus scrofa 83.26 6.00e-96 342.00
IUUC-Tgu-117503 Taeniopygia guttata 77.62 2.00e-58 217.00
IUUC-Tsy-119166 Tarsius syrichta 65.16 7.00e-45 172.00
IUUC-Tni-120703 Tetraodon nigroviridis 45.13 1.00e-22 99.40
IUUC-Tca-121473 Theobroma cacao 46.39 3.00e-19 87.80
IUUC-Tre-122241 Trichoderma reesei 47.46 2.00e-20 91.70
IUUC-Tvi-122347 Trichoderma virens 45.61 8.00e-19 86.70
IUUC-Tae-124560 Triticum aestivum 45.63 2.00e-22 99.00
IUUC-Tur-126452 Triticum urartu 46.79 2.00e-23 102.00
IUUC-Tme-127205 Tuber melanosporum 48.96 6.00e-19 85.50
IUUC-Ttr-128186 Tursiops truncatus 86.17 3.00e-88 317.00
IUUC-Uma-129523 Ustilago maydis 35.04 1.00e-15 76.30
IUUC-Vda-129793 Verticillium dahliae 46.49 5.00e-21 94.00
IUUC-Vpa-130040 Vicugna pacos 89.10 1.00e-78 284.00
IUUC-Vvi-131588 Vitis vinifera 40.15 1.00e-19 89.40
IUUC-Yli-134631 Yarrowia lipolytica 38.52 9.00e-19 86.30
IUUC-Zma-135478 Zea mays 46.90 6.00e-25 107.00
Created Date 25-Jun-2017

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