iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093504

Ensembl Protein ID

ENSPSIP00000006024.1

UniProt Accession

K7FDB4; K7FDB4_PELSI

Genbank Protein ID

ENSPSIP00000006024

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

AGCU01135965

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000005532.1	ENSPSIT00000006059.1	ENSPSIP00000006024.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.30e-43	143.4	341	376
UBD/Beta-Prp	5.40e-45	153.8	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++   +d  l+sGs D+++k+WD+r+++
   Q: 341  HTGWVTSVKWsptHDQQLISGSLDNVVKIWDTRSCK 376
           ***********755588**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++v t++gh++ v s+ +s   + + s+s+d ti++wd+etg   + tl+g++ v n++++++ ++ l+sGs+Dr +rlWd +t++ 
   Q: 246  TRTPVATFSGHTEAVSSVLWSD-AEEICSASWDHTIKIWDVETGGLKS-TLTGNK-VFNSISYSQLCRRLASGSTDRHIRLWDPRTKDG 331
           678999***************9.99**********************9.***987.99**************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v+s++++++  ++l+sgsld+ vk+wd +  +  ++ l +h+d v++v+ + +  +l+sg++D+ ++ +
   Q: 332  SLVLlslTS-HTGWVTSVKWSPTHdQQLISGSLDNVVKIWDTRsCKAPLYDLAAHEDKVLCVEWT-EAGLLLSGGADNKLYSY 412
           444444387.************999******************54566****************9.999********999876 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQARFFT GNRKYVVDDV PFSIPAASEI TDLSNIINKL LEAKHEVHKY VEFDFLVKGQ 60
FLRMSLVKHM EVENISTEEV VEIEYVEKYT APQPEECMFH DDWISSIEAT EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCTACTA ATCGCTGGCG GAGTATTCGA TCTGCGCGGC CGCGCCGGCA GAGTGACGGC 60
AGCTCCGAGA CACGTGTTCT CTGGGCTCTG TCGCCTGTGA GGTGCGCCGC GCCGGCATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

KEGG

pss:102444857

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	31.19	2.00e-54	206.00
IUUC-Aml-001997	Ailuropoda melanoleuca	87.32	0.00e+00	663.00
IUUC-Atr-002544	Amborella trichopoda	32.30	6.00e-52	197.00
IUUC-Apl-003981	Anas platyrhynchos	90.43	0.00e+00	651.00
IUUC-Aca-004370	Anolis carolinensis	88.00	0.00e+00	725.00
IUUC-Aly-006455	Arabidopsis lyrata	33.74	5.00e-55	207.00
IUUC-Ath-006669	Arabidopsis thaliana	32.92	3.00e-50	192.00
IUUC-Ago-007864	Ashbya gossypii	28.86	2.00e-34	139.00
IUUC-Acl-008177	Aspergillus clavatus	30.95	1.00e-34	140.00
IUUC-Afl-008617	Aspergillus flavus	29.41	3.00e-33	135.00
IUUC-Afu-008752	Aspergillus fumigatus	29.49	1.00e-31	130.00
IUUC-Ani-009136	Aspergillus nidulans	30.59	8.00e-33	134.00
IUUC-Ang-009701	Aspergillus niger	28.90	3.00e-32	132.00
IUUC-Aor-009884	Aspergillus oryzae	29.41	8.00e-33	134.00
IUUC-Ate-010472	Aspergillus terreus	31.10	6.00e-20	90.90
IUUC-Ame-011432	Astyanax mexicanus	78.01	0.00e+00	660.00
IUUC-Bgr-012218	Blumeria graminis	28.34	2.00e-32	133.00
IUUC-Bta-012829	Bos taurus	87.94	0.00e+00	691.00
IUUC-Bci-013953	Botrytis cinerea	30.00	5.00e-35	142.00
IUUC-Bdi-014351	Brachypodium distachyon	33.02	3.00e-50	192.00
IUUC-Bol-015618	Brassica oleracea	33.77	2.00e-52	199.00
IUUC-Bra-017876	Brassica rapa	33.50	4.00e-54	205.00
IUUC-Cel-018569	Caenorhabditis elegans	32.52	2.00e-47	183.00
IUUC-Cja-019468	Callithrix jacchus	86.29	0.00e+00	663.00
IUUC-Cfa-020471	Canis familiaris	86.52	0.00e+00	681.00
IUUC-Cpo-022260	Cavia porcellus	87.00	0.00e+00	673.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.20	2.00e-35	142.00
IUUC-Csa-023989	Chlorocebus sabaeus	86.76	0.00e+00	669.00
IUUC-Cho-024426	Choloepus hoffmanni	84.76	9.00e-141	493.00
IUUC-Cin-025789	Ciona intestinalis	44.60	4.00e-95	341.00
IUUC-Cne-027063	Cryptococcus neoformans	24.69	2.00e-18	86.70
IUUC-Dre-027907	Danio rerio	78.96	0.00e+00	672.00
IUUC-Dno-029225	Dasypus novemcinctus	86.29	0.00e+00	681.00
IUUC-Dor-031082	Dipodomys ordii	73.29	6.00e-151	526.00
IUUC-Dse-031308	Dothistroma septosporum	29.46	4.00e-33	135.00
IUUC-Dme-032189	Drosophila melanogaster	40.78	6.00e-89	320.00
IUUC-Ete-032247	Echinops telfairi	81.80	0.00e+00	632.00
IUUC-Eca-034285	Equus caballus	86.76	0.00e+00	682.00
IUUC-Eeu-035322	Erinaceus europaeus	77.14	4.00e-166	577.00
IUUC-Fca-036114	Felis catus	87.00	0.00e+00	687.00
IUUC-Fal-036891	Ficedula albicollis	90.68	4.00e-176	610.00
IUUC-Fox-037965	Fusarium oxysporum	26.23	2.00e-31	129.00
IUUC-Fso-038244	Fusarium solani	26.21	1.00e-29	123.00
IUUC-Gmo-039040	Gadus morhua	76.36	0.00e+00	651.00
IUUC-Gga-040610	Gallus gallus	87.47	0.00e+00	715.00
IUUC-Gac-042117	Gasterosteus aculeatus	77.30	0.00e+00	643.00
IUUC-Gma-043146	Glycine max	35.00	1.00e-59	223.00
IUUC-Ggo-045179	Gorilla gorilla	86.76	0.00e+00	663.00
IUUC-Hsa-046114	Homo sapiens	87.23	0.00e+00	665.00
IUUC-Hvu-047331	Hordeum vulgare	32.13	4.00e-50	191.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	87.47	0.00e+00	689.00
IUUC-Kpa-049304	Komagataella pastoris	30.00	4.00e-42	165.00
IUUC-Lch-050655	Latimeria chalumnae	76.70	7.00e-141	493.00
IUUC-Lpe-051675	Leersia perrieri	34.76	1.00e-55	210.00
IUUC-Loc-052868	Lepisosteus oculatus	81.32	0.00e+00	675.00
IUUC-Lma-053258	Leptosphaeria maculans	26.60	1.00e-30	129.00
IUUC-Laf-053993	Loxodonta africana	86.29	0.00e+00	684.00
IUUC-Mcc-055128	Macaca mulatta	70.69	9.00e-148	515.00
IUUC-Meu-056501	Macropus eugenii	75.60	4.00e-150	523.00
IUUC-Mor-057114	Magnaporthe oryzae	26.77	1.00e-24	107.00
IUUC-Mtr-058367	Medicago truncatula	34.29	2.00e-55	209.00
IUUC-Mla-059107	Melampsora laricipopulina	25.81	6.00e-25	108.00
IUUC-Mga-059745	Meleagris gallopavo	85.41	0.00e+00	691.00
IUUC-Mvi-060362	Microbotryum violaceum	27.62	2.00e-30	126.00
IUUC-Mdo-062257	Monodelphis domestica	82.90	0.00e+00	689.00
IUUC-Mmu-063546	Mus musculus	85.82	0.00e+00	681.00
IUUC-Mac-065540	Musa acuminata	30.71	6.00e-50	191.00
IUUC-Mpu-066284	Mustela putorius furo	87.23	0.00e+00	689.00
IUUC-Mlu-067241	Myotis lucifugus	86.29	0.00e+00	685.00
IUUC-Nfi-068260	Neosartorya fischeri	29.92	6.00e-32	131.00
IUUC-Ncr-068719	Neurospora crassa	26.06	3.00e-24	106.00
IUUC-Nle-068981	Nomascus leucogenys	86.76	0.00e+00	663.00
IUUC-Opr-071218	Ochotona princeps	78.14	3.00e-175	607.00
IUUC-Ont-071646	Oreochromis niloticus	78.15	0.00e+00	655.00
IUUC-Oan-073453	Ornithorhynchus anatinus	87.47	0.00e+00	724.00
IUUC-Ocu-074008	Oryctolagus cuniculus	86.76	0.00e+00	686.00
IUUC-Oba-075712	Oryza barthii	29.57	7.00e-40	157.00
IUUC-Obr-076721	Oryza brachyantha	33.17	6.00e-55	207.00
IUUC-Ogl-077229	Oryza glaberrima	33.41	4.00e-55	208.00
IUUC-Ogu-078977	Oryza glumaepatula	29.57	4.00e-40	158.00
IUUC-Oin-079683	Oryza indica	33.41	2.00e-55	209.00
IUUC-Olo-080291	Oryza longistaminata	28.72	1.00e-25	110.00
IUUC-Ome-081834	Oryza meridionalis	33.41	2.00e-56	213.00
IUUC-Oni-082507	Oryza nivara	32.30	2.00e-51	196.00
IUUC-Opu-083396	Oryza punctata	33.41	1.00e-55	210.00
IUUC-Oru-085220	Oryza rufipogon	32.13	6.00e-51	194.00
IUUC-Osa-085767	Oryza sativa	33.41	2.00e-55	209.00
IUUC-Ola-087420	Oryzias latipes	78.72	0.00e+00	662.00
IUUC-Olu-087740	Ostreococcus lucimarinus	28.43	2.00e-34	139.00
IUUC-Oga-088264	Otolemur garnettii	85.34	0.00e+00	678.00
IUUC-Oar-089335	Ovis aries	87.47	0.00e+00	687.00
IUUC-Ptr-091320	Pan troglodytes	87.23	0.00e+00	665.00
IUUC-Pan-092833	Papio anubis	86.76	0.00e+00	668.00
IUUC-Pma-094189	Petromyzon marinus	69.81	4.00e-169	587.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.91	1.00e-32	134.00
IUUC-Ppa-095429	Physcomitrella patens	33.49	2.00e-58	219.00
IUUC-Pfo-096337	Poecilia formosa	76.60	0.00e+00	657.00
IUUC-Pab-097571	Pongo abelii	87.23	0.00e+00	665.00
IUUC-Pop-099977	Populus trichocarpa	33.41	3.00e-57	215.00
IUUC-Pca-100394	Procavia capensis	82.64	5.00e-179	619.00
IUUC-Ppe-101848	Prunus persica	35.71	3.00e-57	215.00
IUUC-Pva-102921	Pteropus vampyrus	87.04	3.00e-104	371.00
IUUC-Pgr-103637	Puccinia graminis	28.11	7.00e-32	131.00
IUUC-Ptt-103781	Puccinia triticina	29.46	7.00e-32	131.00
IUUC-Pte-104135	Pyrenophora teres	27.01	1.00e-32	135.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.59	2.00e-32	132.00
IUUC-Rno-105114	Rattus norvegicus	85.34	0.00e+00	683.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.74	5.00e-39	155.00
IUUC-Sha-107122	Sarcophilus harrisii	84.18	0.00e+00	661.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.01	3.00e-44	172.00
IUUC-Spo-108134	Schizosaccharomyces pombe	30.37	9.00e-37	147.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	30.24	4.00e-36	145.00
IUUC-Smo-108720	Selaginella moellendorffii	32.46	9.00e-52	197.00
IUUC-Sit-110311	Setaria italica	33.93	6.00e-54	204.00
IUUC-Sly-111023	Solanum lycopersicum	32.01	9.00e-51	194.00
IUUC-Stu-112778	Solanum tuberosum	34.52	2.00e-56	212.00
IUUC-Sar-113596	Sorex araneus	71.87	2.00e-154	538.00
IUUC-Sbi-114193	Sorghum bicolor	33.68	2.00e-53	202.00
IUUC-Sre-115002	Sporisorium reilianum	24.14	4.00e-10	59.30
IUUC-Ssc-116066	Sus scrofa	87.47	0.00e+00	686.00
IUUC-Tgu-117048	Taeniopygia guttata	89.63	0.00e+00	648.00
IUUC-Tsy-119573	Tarsius syrichta	55.02	2.00e-112	398.00
IUUC-Tni-119820	Tetraodon nigroviridis	75.41	0.00e+00	640.00
IUUC-Tca-121605	Theobroma cacao	34.86	2.00e-57	215.00
IUUC-Tre-121947	Trichoderma reesei	27.23	3.00e-31	129.00
IUUC-Tvi-122481	Trichoderma virens	27.66	3.00e-33	136.00
IUUC-Tae-125861	Triticum aestivum	31.43	1.00e-54	206.00
IUUC-Tur-126586	Triticum urartu	31.88	2.00e-52	199.00
IUUC-Tme-126900	Tuber melanosporum	30.73	4.00e-43	168.00
IUUC-Tbe-127736	Tupaia belangeri	64.82	2.00e-129	455.00
IUUC-Ttr-129041	Tursiops truncatus	75.89	1.00e-171	595.00
IUUC-Vpa-130260	Vicugna pacos	87.23	0.00e+00	687.00
IUUC-Vvi-131009	Vitis vinifera	34.52	2.00e-55	209.00
IUUC-Xtr-132083	Xenopus tropicalis	81.32	0.00e+00	665.00
IUUC-Xma-133094	Xiphophorus maculatus	75.89	0.00e+00	652.00
IUUC-Yli-134531	Yarrowia lipolytica	24.28	1.00e-17	84.30
IUUC-Zma-135509	Zea mays	32.38	4.00e-53	201.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence