iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131962

UUCD1 version

UUC-XeT-00966

Ensembl Protein ID

ENSXETP00000031497.2

UniProt Accession

Q6P1W0; DTL_XENTR

Genbank Protein ID

CAJ81765.1; AAH64851.1

Protein Name

Denticleless protein homolog

Genbank Nucleotide ID

CR848464; BC064851

Gene Name

dtl; cdt2; l2dtl; TEgg011o17.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000014394.2	ENSXETT00000031497.2	ENSXETP00000031497.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-36	123.1	359	392

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH  +vt++a+  sd t ++++sdD+t++vW+l+
   Q: 359  GHCQEVTSVAWcqSDfTKIATCSDDNTVRVWRLK 392
           89******************************86 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.

Protein Sequence
(Fasta)

MLFRSVVNKP RLGCRQRGVP FTHPLQSLLQ CYQCAKHDEH TSYGELGAAV PPFGCAFSTV 60
PDMSHVLAVA NEEGIVRLYD TECRDVQRLV VKEFMAHTNA VFDIAWVPGE HKLVTASGDQ 120

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Nucleotide Sequence
(Fasta)

CGGGCTGTGT GAGGGGAAGG AGTGCAGGAG CGGAGCTCTC CCTTGGGGCC TTTATCGCTG 60
CTGTTACTGC TTGGATCCGC ATCTGCCATA GCTGAGATCT CATTCATTCC TCGCCATGTT 120

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Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xtr:395039

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002111	Ailuropoda melanoleuca	56.42	0.00e+00	718.00
IUUC-Atr-003097	Amborella trichopoda	36.24	3.00e-62	232.00
IUUC-Apl-004088	Anas platyrhynchos	58.82	0.00e+00	783.00
IUUC-Aca-004732	Anolis carolinensis	54.30	0.00e+00	701.00
IUUC-Aly-005686	Arabidopsis lyrata	33.82	8.00e-59	221.00
IUUC-Ath-006970	Arabidopsis thaliana	34.65	3.00e-58	219.00
IUUC-Acl-008219	Aspergillus clavatus	23.45	3.00e-23	103.00
IUUC-Afu-008784	Aspergillus fumigatus	26.27	3.00e-24	107.00
IUUC-Ani-009304	Aspergillus nidulans	26.75	5.00e-17	82.80
IUUC-Ang-009842	Aspergillus niger	24.67	4.00e-24	106.00
IUUC-Aor-009883	Aspergillus oryzae	25.40	2.00e-21	97.40
IUUC-Ate-010454	Aspergillus terreus	28.52	1.00e-20	94.00
IUUC-Ame-010949	Astyanax mexicanus	47.46	4.00e-172	597.00
IUUC-Bta-012333	Bos taurus	56.93	0.00e+00	728.00
IUUC-Bci-013733	Botrytis cinerea	23.92	2.00e-20	94.40
IUUC-Bdi-014494	Brachypodium distachyon	34.66	2.00e-56	213.00
IUUC-Bol-015301	Brassica oleracea	34.99	7.00e-58	218.00
IUUC-Bra-017384	Brassica rapa	35.44	6.00e-57	214.00
IUUC-Cel-018498	Caenorhabditis elegans	27.90	1.00e-36	147.00
IUUC-Cja-019534	Callithrix jacchus	56.07	0.00e+00	734.00
IUUC-Cfa-020847	Canis familiaris	57.01	0.00e+00	726.00
IUUC-Cpo-021695	Cavia porcellus	55.96	0.00e+00	740.00
IUUC-Cre-022762	Chlamydomonas reinhardtii	30.69	5.00e-43	170.00
IUUC-Csa-023748	Chlorocebus sabaeus	55.69	0.00e+00	731.00
IUUC-Cho-024445	Choloepus hoffmanni	64.44	3.00e-136	479.00
IUUC-Cgl-026664	Colletotrichum gloeosporioides	24.06	5.00e-18	86.30
IUUC-Cne-027008	Cryptococcus neoformans	22.48	4.00e-17	84.30
IUUC-Dre-027536	Danio rerio	47.46	1.00e-167	582.00
IUUC-Dno-030035	Dasypus novemcinctus	54.26	0.00e+00	720.00
IUUC-Dor-030814	Dipodomys ordii	62.62	1.00e-71	264.00
IUUC-Dse-031354	Dothistroma septosporum	25.11	5.00e-29	122.00
IUUC-Dme-031691	Drosophila melanogaster	41.55	4.00e-81	295.00
IUUC-Ete-032814	Echinops telfairi	52.86	1.00e-138	486.00
IUUC-Eca-033332	Equus caballus	56.42	0.00e+00	721.00
IUUC-Fca-035571	Felis catus	56.42	0.00e+00	721.00
IUUC-Fal-037421	Ficedula albicollis	57.12	0.00e+00	764.00
IUUC-Fox-038069	Fusarium oxysporum	22.40	4.00e-19	89.40
IUUC-Gmo-039365	Gadus morhua	59.75	7.00e-160	556.00
IUUC-Gga-041153	Gallus gallus	58.00	0.00e+00	771.00
IUUC-Gac-041984	Gasterosteus aculeatus	46.95	5.00e-170	590.00
IUUC-Gma-042679	Glycine max	34.37	2.00e-54	206.00
IUUC-Ggo-044419	Gorilla gorilla	56.22	0.00e+00	734.00
IUUC-Hsa-045862	Homo sapiens	55.33	0.00e+00	742.00
IUUC-Hvu-047728	Hordeum vulgare	34.82	3.00e-59	222.00
IUUC-Itr-048786	Ictidomys tridecemlineatus	56.99	0.00e+00	746.00
IUUC-Lch-050616	Latimeria chalumnae	53.40	0.00e+00	671.00
IUUC-Lpe-051222	Leersia perrieri	35.75	2.00e-59	223.00
IUUC-Loc-052564	Lepisosteus oculatus	52.21	0.00e+00	649.00
IUUC-Lma-053098	Leptosphaeria maculans	23.11	2.00e-23	103.00
IUUC-Laf-053892	Loxodonta africana	56.56	0.00e+00	713.00
IUUC-Mcc-055854	Macaca mulatta	55.69	0.00e+00	733.00
IUUC-Mor-057144	Magnaporthe oryzae	26.26	3.00e-15	77.00
IUUC-Mpo-057501	Magnaporthe poae	28.03	2.00e-12	67.40
IUUC-Mtr-058510	Medicago truncatula	35.54	2.00e-56	213.00
IUUC-Mla-058823	Melampsora laricipopulina	24.38	1.00e-22	100.00
IUUC-Mga-060128	Meleagris gallopavo	59.41	0.00e+00	778.00
IUUC-Mvi-060475	Microbotryum violaceum	32.54	2.00e-44	173.00
IUUC-Mmr-061331	Microcebus murinus	56.85	0.00e+00	724.00
IUUC-Mdo-063020	Monodelphis domestica	55.95	0.00e+00	762.00
IUUC-Mmu-063713	Mus musculus	54.23	0.00e+00	701.00
IUUC-Mac-064653	Musa acuminata	34.77	3.00e-60	226.00
IUUC-Mpu-066490	Mustela putorius furo	56.68	0.00e+00	721.00
IUUC-Mlu-067900	Myotis lucifugus	56.83	0.00e+00	722.00
IUUC-Nfi-068433	Neosartorya fischeri	26.05	2.00e-24	107.00
IUUC-Ncr-068776	Neurospora crassa	29.89	7.00e-24	105.00
IUUC-Nle-069675	Nomascus leucogenys	53.18	0.00e+00	667.00
IUUC-Opr-070769	Ochotona princeps	45.21	2.00e-86	313.00
IUUC-Ont-071441	Oreochromis niloticus	46.92	7.00e-165	573.00
IUUC-Oan-072757	Ornithorhynchus anatinus	57.42	0.00e+00	739.00
IUUC-Ocu-074670	Oryctolagus cuniculus	56.85	0.00e+00	738.00
IUUC-Oba-075844	Oryza barthii	35.41	7.00e-57	214.00
IUUC-Obr-076625	Oryza brachyantha	36.31	2.00e-60	226.00
IUUC-Ogl-077771	Oryza glaberrima	35.41	7.00e-57	214.00
IUUC-Ogu-078475	Oryza glumaepatula	33.71	4.00e-49	189.00
IUUC-Oin-079958	Oryza indica	35.41	6.00e-57	214.00
IUUC-Olo-080311	Oryza longistaminata	35.08	4.00e-49	188.00
IUUC-Ome-081985	Oryza meridionalis	34.84	8.00e-56	211.00
IUUC-Oni-082921	Oryza nivara	35.41	6.00e-57	214.00
IUUC-Opu-083174	Oryza punctata	35.73	6.00e-59	221.00
IUUC-Oru-084338	Oryza rufipogon	35.41	5.00e-57	215.00
IUUC-Osa-085609	Oryza sativa	47.67	7.00e-22	97.10
IUUC-Olu-087907	Ostreococcus lucimarinus	28.57	1.00e-31	130.00
IUUC-Oga-088358	Otolemur garnettii	57.40	0.00e+00	750.00
IUUC-Oar-089994	Ovis aries	56.25	0.00e+00	724.00
IUUC-Ptr-091338	Pan troglodytes	56.58	0.00e+00	744.00
IUUC-Pan-091759	Papio anubis	55.62	0.00e+00	726.00
IUUC-Psi-093211	Pelodiscus sinensis	58.91	0.00e+00	689.00
IUUC-Pma-094588	Petromyzon marinus	58.06	1.00e-95	342.00
IUUC-Pno-094964	Phaeosphaeria nodorum	29.10	5.00e-22	99.40
IUUC-Ppa-095159	Physcomitrella patens	38.23	5.00e-64	238.00
IUUC-Pfo-096592	Poecilia formosa	45.16	8.00e-149	520.00
IUUC-Pab-098597	Pongo abelii	46.07	2.00e-146	512.00
IUUC-Pop-099255	Populus trichocarpa	36.54	3.00e-60	226.00
IUUC-Pca-100593	Procavia capensis	60.64	1.00e-136	479.00
IUUC-Ppe-101333	Prunus persica	30.57	9.00e-55	207.00
IUUC-Pva-102283	Pteropus vampyrus	53.95	0.00e+00	666.00
IUUC-Pgr-103383	Puccinia graminis	28.68	2.00e-23	103.00
IUUC-Ptt-103974	Puccinia triticina	27.08	2.00e-20	93.60
IUUC-Pte-104329	Pyrenophora teres	23.63	4.00e-25	109.00
IUUC-Pyt-104424	Pyrenophora triticirepentis	26.55	1.00e-23	104.00
IUUC-Rno-105720	Rattus norvegicus	54.05	0.00e+00	694.00
IUUC-Sha-106891	Sarcophilus harrisii	53.04	0.00e+00	691.00
IUUC-Sja-107723	Schizosaccharomyces japonicus	29.44	2.00e-32	133.00
IUUC-Spo-108060	Schizosaccharomyces pombe	24.19	8.00e-23	101.00
IUUC-Sit-109862	Setaria italica	35.71	2.00e-58	220.00
IUUC-Sly-111468	Solanum lycopersicum	33.25	1.00e-59	223.00
IUUC-Stu-112346	Solanum tuberosum	32.58	2.00e-56	213.00
IUUC-Sar-113734	Sorex araneus	67.28	1.00e-81	297.00
IUUC-Sbi-114076	Sorghum bicolor	35.29	3.00e-60	225.00
IUUC-Ssc-115561	Sus scrofa	56.93	0.00e+00	727.00
IUUC-Tgu-117011	Taeniopygia guttata	57.00	0.00e+00	753.00
IUUC-Tru-118411	Takifugu rubripes	45.91	1.00e-161	563.00
IUUC-Tsy-119367	Tarsius syrichta	49.11	2.00e-168	586.00
IUUC-Tni-120301	Tetraodon nigroviridis	60.68	9.00e-151	526.00
IUUC-Tca-121265	Theobroma cacao	32.77	6.00e-59	221.00
IUUC-Tre-121997	Trichoderma reesei	24.41	4.00e-19	89.70
IUUC-Tvi-122292	Trichoderma virens	24.20	2.00e-20	94.00
IUUC-Tae-125188	Triticum aestivum	33.43	5.00e-59	221.00
IUUC-Tur-126794	Triticum urartu	31.85	6.00e-45	174.00
IUUC-Tme-127090	Tuber melanosporum	25.83	1.00e-19	90.50
IUUC-Tbe-127646	Tupaia belangeri	66.43	2.00e-166	579.00
IUUC-Ttr-128171	Tursiops truncatus	57.10	0.00e+00	736.00
IUUC-Uma-129525	Ustilago maydis	21.40	7.00e-18	85.90
IUUC-Vda-129871	Verticillium dahliae	23.53	5.00e-20	92.80
IUUC-Vpa-130554	Vicugna pacos	71.96	4.00e-90	325.00
IUUC-Vvi-131698	Vitis vinifera	30.66	5.00e-59	221.00
IUUC-Xma-133803	Xiphophorus maculatus	47.30	2.00e-163	568.00
IUUC-Zma-135693	Zea mays	34.59	9.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence