iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ppe-101315

Ensembl Protein ID

EMJ15833

UniProt Accession

M5X2S7; M5X2S7_PRUPE

Genbank Protein ID

EMJ15833.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

KB639078

Gene Name

UBP14; PRUPE_ppa001521mg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PRUPE_ppa001521mg	EMJ15833	EMJ15833

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-54	184.8	312	806
UBD/Alpha-Helix/UBA	8.90e-16	57.9	623	663

Active Site

Position(s)	Description	Evidence
321	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
769	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkekln.eenpkepkgellkslqklfeel......................wkskkkavsprellkalk 78
           tGl NlgN+CYm +++Q+ ++++++ + + ++++ kl+ e++p +p+ +l ++l+kl + l                      +ksk++ + pr+++++++
   Q: 312  TGLVNLGNSCYMAATMQVVFSTHSFYSGYYKNQSLKLAfEKAPADPTVDLNMQLTKLAHGLlsgkysipvaegkddpnatattTKSKQEGIPPRMFKAVIA 412
           7**************************999977777662456789999*************9********9999999998865599*************** PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           + ++efs+++qqDa Ef+ ++ldq+e++                              k +    + F++ ++++i c + +  +  +   + lsl++p +
   Q: 413  ASHPEFSSMRQQDALEFFLHFLDQVERAH---------------------------AGKPEADPARSFKFGIEDRILCSSGKVAY-NRRLDYILSLNIPLH 485
           **************************998...........................45566667899***********8776666.334455666666655 PP
   S: 180  eetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
             t+ke                              l+ cL+sf+++ee+++   +y++  k+k++a+k+ +l+++P++L+lh+ +f + e +++++k++ 
   Q: 486  AATNKEeleafqklkaekisegkevssdeivrprvPLEACLASFSSPEEIQD---FYSTALKAKTTAVKSGGLTSFPDYLVLHMRKF-VMEVGWVPKKLDV 582
           55555567999***************************************97...********************************.67889******** PP
   S: 252  kvefpleLdlspfcts................................................................................peekq 272
           +v++p+ +d+s++ ++                                                                                +    
   Q: 583  YVDVPDIIDISHMRSKglqpgeellpegvpgeeeepnkpvadesivsqlvsmgfshlhcqkaaintsntgveeamnwllshmddpdidapiseggqN---- 679
           ***********99999999999999999988887777777777777777777777777776666666666666666666666665555555555550.... PP
   S: 273  ke....................................................................kkkYeLiavvvHsG.slssGHYvayvknekg 304
            +                                                                      kY+Li++v+H G s+++GHYva++ + +g
   Q: 680  -VvdqskvdmllsfgfqedvartalkasggdiekatdwifnnpdasvstdmdattsenaptaadtglpdgGGKYRLIGIVSHIGtSTQCGHYVAHIFK-DG 778
           .0555555666666666666666666666666666666777777777777777778888889999999999***************************.9* PP
   S: 305  kWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +W+ f+D+kV ++   +  +   + +Y++f++r
   Q: 779  RWVIFNDDKVGASV--NTPK---DMGYLYFFER 806
           **********9982..3333...7999999987 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +de+++ qlv+MGF+  ++++a  ++ n  +e+A+++Ll++
   Q: 623  ADESIVSQLVSMGFSHLHCQKAAINTsNTGVEEAMNWLLSH 663
           69*************************************97 PP

Organism

Prunus persica

Protein Sequence
(Fasta)

MLNPMDLLRS NLSRVRIPEP TNRIYKQECC ISFDTPRSEG GLFVDMNTFL AFGKECVGWN 60
YNKTGNPVYL HIKQTKVLVP EDRPLKKPTL MALGVDGGFD NNEPEYEETH SIVLLPDYVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTTGCAG AGAGCGATGT TAAACCCCAT GGACTTGCTC CGATCCAATC TCTCCCGGGT 60
TCGGATCCCG GAGCCCACCA ATCGCATCTA CAAGCAAGAA TGCTGCATAT CTTTCGACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pper:PRUPE_ppa001521mg

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	64.18	0.00e+00	1013.00
IUUC-Aml-002104	Ailuropoda melanoleuca	46.85	0.00e+00	744.00
IUUC-Atr-002580	Amborella trichopoda	70.95	0.00e+00	1226.00
IUUC-Apl-003712	Anas platyrhynchos	44.88	0.00e+00	679.00
IUUC-Aca-005368	Anolis carolinensis	48.14	0.00e+00	773.00
IUUC-Aly-005727	Arabidopsis lyrata	78.26	0.00e+00	1265.00
IUUC-Ath-006974	Arabidopsis thaliana	78.01	0.00e+00	1263.00
IUUC-Ago-007890	Ashbya gossypii	28.45	3.00e-74	272.00
IUUC-Acl-008057	Aspergillus clavatus	33.71	6.00e-114	404.00
IUUC-Afl-008547	Aspergillus flavus	35.21	2.00e-109	388.00
IUUC-Afu-008805	Aspergillus fumigatus	33.25	3.00e-103	368.00
IUUC-Ani-009441	Aspergillus nidulans	35.11	3.00e-99	355.00
IUUC-Ang-009720	Aspergillus niger	33.82	2.00e-107	382.00
IUUC-Aor-010111	Aspergillus oryzae	32.97	4.00e-117	414.00
IUUC-Ate-010531	Aspergillus terreus	31.32	2.00e-97	349.00
IUUC-Ame-011470	Astyanax mexicanus	41.70	0.00e+00	667.00
IUUC-Bgr-012183	Blumeria graminis	31.89	2.00e-102	366.00
IUUC-Bta-013179	Bos taurus	47.08	0.00e+00	751.00
IUUC-Bci-013858	Botrytis cinerea	33.45	7.00e-118	417.00
IUUC-Bdi-014904	Brachypodium distachyon	69.54	0.00e+00	1125.00
IUUC-Bol-015296	Brassica oleracea	76.89	0.00e+00	1263.00
IUUC-Bra-017939	Brassica rapa	77.71	0.00e+00	1268.00
IUUC-Cel-018625	Caenorhabditis elegans	33.17	2.00e-110	392.00
IUUC-Cja-019063	Callithrix jacchus	46.85	0.00e+00	744.00
IUUC-Cfa-020976	Canis familiaris	48.50	0.00e+00	761.00
IUUC-Cpo-022265	Cavia porcellus	48.38	0.00e+00	764.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.64	2.00e-114	405.00
IUUC-Csa-024078	Chlorocebus sabaeus	43.76	0.00e+00	688.00
IUUC-Cho-024522	Choloepus hoffmanni	35.94	2.00e-129	456.00
IUUC-Cin-025411	Ciona intestinalis	42.44	5.00e-174	603.00
IUUC-Csv-026347	Ciona savignyi	41.93	3.00e-173	601.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.11	1.00e-100	359.00
IUUC-Cne-026831	Cryptococcus neoformans	35.18	9.00e-119	420.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.80	7.00e-53	201.00
IUUC-Dre-027982	Danio rerio	43.94	0.00e+00	660.00
IUUC-Dno-029034	Dasypus novemcinctus	47.31	0.00e+00	754.00
IUUC-Dor-030130	Dipodomys ordii	38.71	3.00e-110	391.00
IUUC-Dse-031467	Dothistroma septosporum	35.77	4.00e-118	417.00
IUUC-Dme-032075	Drosophila melanogaster	44.42	0.00e+00	663.00
IUUC-Ete-032865	Echinops telfairi	44.03	0.00e+00	672.00
IUUC-Eca-034059	Equus caballus	46.98	0.00e+00	746.00
IUUC-Eeu-035304	Erinaceus europaeus	44.74	0.00e+00	674.00
IUUC-Fca-035515	Felis catus	47.08	0.00e+00	752.00
IUUC-Fal-037271	Ficedula albicollis	48.12	0.00e+00	715.00
IUUC-Fox-037745	Fusarium oxysporum	35.67	3.00e-119	421.00
IUUC-Fso-038158	Fusarium solani	34.80	1.00e-116	413.00
IUUC-Gmo-039071	Gadus morhua	44.54	0.00e+00	664.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.54	3.00e-108	385.00
IUUC-Gga-041215	Gallus gallus	44.03	0.00e+00	690.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.52	0.00e+00	673.00
IUUC-Gma-043614	Glycine max	81.16	0.00e+00	1290.00
IUUC-Ggo-044602	Gorilla gorilla	47.08	0.00e+00	752.00
IUUC-Hsa-045959	Homo sapiens	47.08	0.00e+00	752.00
IUUC-Hvu-047563	Hordeum vulgare	67.75	0.00e+00	874.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.08	0.00e+00	751.00
IUUC-Kpa-049156	Komagataella pastoris	30.74	5.00e-101	361.00
IUUC-Lch-049648	Latimeria chalumnae	47.66	0.00e+00	755.00
IUUC-Lpe-051523	Leersia perrieri	68.13	0.00e+00	1125.00
IUUC-Loc-052072	Lepisosteus oculatus	42.66	0.00e+00	677.00
IUUC-Lma-053216	Leptosphaeria maculans	34.48	6.00e-106	379.00
IUUC-Laf-054327	Loxodonta africana	46.96	0.00e+00	752.00
IUUC-Mcc-055443	Macaca mulatta	47.31	0.00e+00	754.00
IUUC-Meu-056298	Macropus eugenii	50.17	4.00e-157	547.00
IUUC-Mor-057106	Magnaporthe oryzae	34.22	2.00e-113	402.00
IUUC-Mpo-057589	Magnaporthe poae	32.93	2.00e-108	386.00
IUUC-Mtr-058680	Medicago truncatula	81.72	0.00e+00	1328.00
IUUC-Mla-058903	Melampsora laricipopulina	33.29	1.00e-108	386.00
IUUC-Mga-059972	Meleagris gallopavo	42.40	0.00e+00	635.00
IUUC-Mvi-060476	Microbotryum violaceum	31.62	7.00e-97	347.00
IUUC-Mmr-060575	Microcebus murinus	47.08	0.00e+00	749.00
IUUC-Mdo-062183	Monodelphis domestica	47.56	0.00e+00	753.00
IUUC-Mmu-063592	Mus musculus	47.20	0.00e+00	753.00
IUUC-Mac-065446	Musa acuminata	69.05	0.00e+00	1167.00
IUUC-Mpu-066082	Mustela putorius furo	48.38	0.00e+00	759.00
IUUC-Mlu-067345	Myotis lucifugus	46.92	0.00e+00	744.00
IUUC-Nfi-068558	Neosartorya fischeri	34.10	2.00e-113	402.00
IUUC-Ncr-068960	Neurospora crassa	31.81	6.00e-99	354.00
IUUC-Nle-070173	Nomascus leucogenys	48.50	0.00e+00	761.00
IUUC-Opr-070556	Ochotona princeps	46.91	0.00e+00	764.00
IUUC-Ont-071502	Oreochromis niloticus	45.37	0.00e+00	679.00
IUUC-Oan-072959	Ornithorhynchus anatinus	54.91	2.00e-70	258.00
IUUC-Ocu-074861	Oryctolagus cuniculus	48.62	0.00e+00	772.00
IUUC-Oba-075109	Oryza barthii	68.64	0.00e+00	1118.00
IUUC-Obr-076292	Oryza brachyantha	69.38	0.00e+00	1118.00
IUUC-Ogl-077065	Oryza glaberrima	70.25	0.00e+00	1160.00
IUUC-Ogu-078776	Oryza glumaepatula	68.40	0.00e+00	1130.00
IUUC-Oin-080048	Oryza indica	69.88	0.00e+00	1144.00
IUUC-Olo-080711	Oryza longistaminata	66.79	0.00e+00	1029.00
IUUC-Ome-081506	Oryza meridionalis	68.14	0.00e+00	1038.00
IUUC-Oni-082320	Oryza nivara	66.75	0.00e+00	1110.00
IUUC-Opu-083801	Oryza punctata	68.89	0.00e+00	1101.00
IUUC-Oru-085139	Oryza rufipogon	66.63	0.00e+00	1103.00
IUUC-Osa-085713	Oryza sativa	70.37	0.00e+00	1164.00
IUUC-Ola-086951	Oryzias latipes	42.92	0.00e+00	657.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.78	9.00e-162	563.00
IUUC-Oga-088625	Otolemur garnettii	46.90	0.00e+00	749.00
IUUC-Oar-089995	Ovis aries	46.56	0.00e+00	741.00
IUUC-Ptr-090640	Pan troglodytes	46.26	0.00e+00	750.00
IUUC-Pan-091974	Papio anubis	46.97	0.00e+00	747.00
IUUC-Psi-093509	Pelodiscus sinensis	44.43	0.00e+00	713.00
IUUC-Pma-094242	Petromyzon marinus	49.35	7.00e-108	382.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.58	2.00e-101	362.00
IUUC-Ppa-095901	Physcomitrella patens	65.08	0.00e+00	1099.00
IUUC-Pfo-097148	Poecilia formosa	45.45	0.00e+00	687.00
IUUC-Pab-098672	Pongo abelii	41.53	1.00e-180	625.00
IUUC-Pop-098855	Populus trichocarpa	84.16	0.00e+00	1310.00
IUUC-Pca-100738	Procavia capensis	44.01	1.00e-142	499.00
IUUC-Pva-102154	Pteropus vampyrus	46.72	0.00e+00	742.00
IUUC-Pgr-103343	Puccinia graminis	33.29	5.00e-97	347.00
IUUC-Ptt-103928	Puccinia triticina	28.90	6.00e-92	331.00
IUUC-Pte-104306	Pyrenophora teres	32.97	3.00e-98	352.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.13	7.00e-103	367.00
IUUC-Rno-105801	Rattus norvegicus	47.31	0.00e+00	754.00
IUUC-Sce-106304	Saccharomyces cerevisiae	30.44	3.00e-68	252.00
IUUC-Sha-107635	Sarcophilus harrisii	48.08	0.00e+00	751.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.44	8.00e-92	330.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.41	4.00e-105	375.00
IUUC-Smo-108848	Selaginella moellendorffii	61.12	0.00e+00	989.00
IUUC-Sit-110728	Setaria italica	71.11	0.00e+00	1179.00
IUUC-Sly-111523	Solanum lycopersicum	76.67	0.00e+00	1288.00
IUUC-Sar-113733	Sorex araneus	47.19	2.00e-97	349.00
IUUC-Sbi-114419	Sorghum bicolor	71.64	0.00e+00	1178.00
IUUC-Sre-115225	Sporisorium reilianum	32.99	2.00e-103	369.00
IUUC-Ssc-115686	Sus scrofa	46.61	0.00e+00	746.00
IUUC-Tgu-116591	Taeniopygia guttata	43.96	0.00e+00	710.00
IUUC-Tru-118350	Takifugu rubripes	42.87	0.00e+00	665.00
IUUC-Tsy-119278	Tarsius syrichta	40.20	3.00e-170	591.00
IUUC-Tni-120658	Tetraodon nigroviridis	43.24	0.00e+00	646.00
IUUC-Tca-121585	Theobroma cacao	83.62	0.00e+00	1342.00
IUUC-Tre-122043	Trichoderma reesei	34.88	2.00e-113	402.00
IUUC-Tvi-122303	Trichoderma virens	34.57	1.00e-115	410.00
IUUC-Tae-123798	Triticum aestivum	68.43	0.00e+00	1132.00
IUUC-Tur-126732	Triticum urartu	64.24	0.00e+00	1060.00
IUUC-Tme-126909	Tuber melanosporum	34.40	5.00e-106	377.00
IUUC-Tbe-127261	Tupaia belangeri	39.08	4.00e-116	411.00
IUUC-Ttr-128295	Tursiops truncatus	39.32	2.00e-167	582.00
IUUC-Uma-129599	Ustilago maydis	32.99	2.00e-109	389.00
IUUC-Vda-129688	Verticillium dahliae	33.78	1.00e-107	382.00
IUUC-Vpa-130170	Vicugna pacos	38.31	2.00e-151	528.00
IUUC-Vvi-131116	Vitis vinifera	83.91	0.00e+00	1326.00
IUUC-Xtr-131953	Xenopus tropicalis	45.01	0.00e+00	723.00
IUUC-Xma-133837	Xiphophorus maculatus	45.63	0.00e+00	689.00
IUUC-Yli-134510	Yarrowia lipolytica	33.62	4.00e-102	364.00
IUUC-Zma-135786	Zea mays	71.02	0.00e+00	1136.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence