iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046545

UUCD1 version

UUC-HoS-01186

Ensembl Protein ID

ENSP00000347836.3

UniProt Accession

P62256; A4D1L6; C9JY93; P37286; Q7Z6F4; UBE2H_HUMAN

Genbank Protein ID

CAA82525.1; CAA82527.1; CAA82528.1; AAP57630.1; AAP35402.1; EAL24099.1; EAW83736.1; AAH06277.1

Protein Name

Ubiquitin-conjugating enzyme E2 H; (E3-independent) E2 ubiquitin-conjugating enzyme H; E2 ubiquitin-conjugating enzyme H; UbcH2; Ubiquitin carrier protein H; Ubiquitin-conjugating enzyme E2-20K; Ubiquitin-protein ligase H

Genbank Nucleotide ID

Z29328; Z29330; Z29331; AY302138; BT006756; AC073320; CH471070; BC006277

Gene Name

UBE2H

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000186591.11	ENST00000355621.7	ENSP00000347836.3
ENSG00000186591.11	ENST00000473814.6	ENSP00000419097.2
ENSG00000186591.11	ENST00000496698.5	ENSP00000417681.1
ENSG00000186591.11	ENST00000472396.5	ENSP00000419689.1
ENSG00000186591.11	ENST00000480245.5	ENSP00000417709.1
ENSG00000186591.11	ENST00000490974.1	ENSP00000419750.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19118899; 12840003

Classification

Family	E-value	Score	Start	End
E2/UBC	3.40e-34	119.2	31	143

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 27   ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvlls.iqsllaepnpes 116
           l+e+ v++ Gp++tpYeggv+k+++++p++YPfk+P++ f++kifhPn++e+ G+vCl++++  ++W++ +++++++ s + +lla pnp +
   Q: 31   LNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEAsGTVCLDVIN--QTWTALYDLTNIFESfLPQLLAYPNPID 120
           7899***********************************************99********9..*************66378999******* PP
   S: 117  plneeaaellkknreeykkkvre 139
           pln +aa ++ +++eeyk+k++e
   Q: 121  PLNGDAAAMYLHRPEEYKQKIKE 143
           ********************985 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

Protein Sequence
(Fasta)

MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV WKVRVDLPDK 60
YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTAGGGA GGCCGACTGA GCAGGAGTCG TCCGCTTATA GTGGAGGCTG CTAGGAGCCG 60
GTCAGAGGGT GAGTGGGGAG CAGGCGAGCG AGCCACAGCA GGCAGGAGGG AGCGTCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7328

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	60.13	1.00e-52	198.00
IUUC-Aml-001260	Ailuropoda melanoleuca	100.00	2.00e-86	311.00
IUUC-Atr-002681	Amborella trichopoda	58.06	1.00e-52	199.00
IUUC-Apl-003547	Anas platyrhynchos	99.39	2.00e-73	267.00
IUUC-Aca-005224	Anolis carolinensis	100.00	4.00e-75	273.00
IUUC-Aly-005836	Arabidopsis lyrata	57.79	6.00e-52	196.00
IUUC-Ath-007534	Arabidopsis thaliana	57.79	4.00e-52	197.00
IUUC-Ago-007727	Ashbya gossypii	60.39	2.00e-52	198.00
IUUC-Acl-008119	Aspergillus clavatus	58.82	5.00e-57	213.00
IUUC-Afl-008412	Aspergillus flavus	61.90	9.00e-47	179.00
IUUC-Afu-008925	Aspergillus fumigatus	56.98	4.00e-54	204.00
IUUC-Ani-009294	Aspergillus nidulans	57.76	3.00e-52	197.00
IUUC-Ang-009805	Aspergillus niger	62.35	6.00e-57	213.00
IUUC-Aor-010201	Aspergillus oryzae	54.38	3.00e-48	184.00
IUUC-Ate-010441	Aspergillus terreus	66.39	2.00e-47	181.00
IUUC-Ame-010807	Astyanax mexicanus	75.41	1.00e-62	231.00
IUUC-Bta-012802	Bos taurus	100.00	2.00e-86	311.00
IUUC-Bdi-014713	Brachypodium distachyon	60.78	1.00e-52	198.00
IUUC-Bol-016385	Brassica oleracea	59.33	4.00e-51	194.00
IUUC-Bra-016989	Brassica rapa	59.33	9.00e-51	192.00
IUUC-Cel-018412	Caenorhabditis elegans	67.74	3.00e-66	244.00
IUUC-Cja-019571	Callithrix jacchus	75.00	2.00e-63	234.00
IUUC-Cfa-020811	Canis familiaris	100.00	2.00e-86	311.00
IUUC-Cpo-021889	Cavia porcellus	92.35	1.00e-76	278.00
IUUC-Cre-022956	Chlamydomonas reinhardtii	58.17	6.00e-52	196.00
IUUC-Csa-023289	Chlorocebus sabaeus	100.00	2.00e-86	311.00
IUUC-Cho-024517	Choloepus hoffmanni	78.14	4.00e-56	210.00
IUUC-Cin-025571	Ciona intestinalis	62.89	5.00e-54	203.00
IUUC-Cgl-026627	Colletotrichum gloeosporioides	65.12	5.00e-52	196.00
IUUC-Cne-027006	Cryptococcus neoformans	58.21	1.00e-47	182.00
IUUC-Cme-027171	Cyanidioschyzon merolae	60.00	2.00e-53	202.00
IUUC-Dre-027450	Danio rerio	98.36	5.00e-86	310.00
IUUC-Dno-029838	Dasypus novemcinctus	100.00	2.00e-86	311.00
IUUC-Dor-031119	Dipodomys ordii	100.00	2.00e-86	311.00
IUUC-Dse-031243	Dothistroma septosporum	61.78	3.00e-57	214.00
IUUC-Dme-031807	Drosophila melanogaster	78.69	7.00e-78	282.00
IUUC-Ete-032437	Echinops telfairi	75.96	7.00e-64	236.00
IUUC-Eca-034123	Equus caballus	100.00	4.00e-80	290.00
IUUC-Eeu-034543	Erinaceus europaeus	95.59	6.00e-35	140.00
IUUC-Fca-035502	Felis catus	100.00	2.00e-86	311.00
IUUC-Fal-037054	Ficedula albicollis	100.00	8.00e-76	276.00
IUUC-Fox-037912	Fusarium oxysporum	69.70	3.00e-41	160.00
IUUC-Fso-038148	Fusarium solani	60.93	2.00e-51	194.00
IUUC-Gmo-038858	Gadus morhua	95.63	3.00e-91	327.00
IUUC-Ggr-039749	Gaeumannomyces graminis	64.57	2.00e-48	185.00
IUUC-Gga-040942	Gallus gallus	100.00	2.00e-86	311.00
IUUC-Gac-042079	Gasterosteus aculeatus	95.08	3.00e-90	323.00
IUUC-Gma-042856	Glycine max	62.75	1.00e-54	205.00
IUUC-Hvu-047746	Hordeum vulgare	60.14	2.00e-49	188.00
IUUC-Itr-048474	Ictidomys tridecemlineatus	100.00	2.00e-86	311.00
IUUC-Kpa-049144	Komagataella pastoris	65.91	8.00e-50	189.00
IUUC-Lch-050589	Latimeria chalumnae	92.90	9.00e-77	279.00
IUUC-Lpe-051335	Leersia perrieri	60.13	3.00e-52	197.00
IUUC-Loc-052829	Lepisosteus oculatus	98.91	4.00e-81	293.00
IUUC-Lma-052971	Leptosphaeria maculans	60.31	3.00e-46	178.00
IUUC-Laf-053526	Loxodonta africana	98.36	2.00e-84	304.00
IUUC-Mcc-055611	Macaca mulatta	100.00	2.00e-86	311.00
IUUC-Meu-056722	Macropus eugenii	58.79	8.00e-36	142.00
IUUC-Mor-057278	Magnaporthe oryzae	66.67	7.00e-52	196.00
IUUC-Mpo-057484	Magnaporthe poae	65.22	2.00e-46	178.00
IUUC-Mtr-058579	Medicago truncatula	59.35	2.00e-53	201.00
IUUC-Mla-058926	Melampsora laricipopulina	64.24	2.00e-57	214.00
IUUC-Mga-059801	Meleagris gallopavo	100.00	2.00e-86	311.00
IUUC-Mvi-060244	Microbotryum violaceum	61.94	6.00e-56	209.00
IUUC-Mmr-061205	Microcebus murinus	100.00	2.00e-86	311.00
IUUC-Mdo-062038	Monodelphis domestica	100.00	2.00e-43	166.00
IUUC-Mmu-063974	Mus musculus	100.00	2.00e-86	311.00
IUUC-Mac-065158	Musa acuminata	63.87	1.00e-56	212.00
IUUC-Mpu-066759	Mustela putorius furo	100.00	2.00e-86	311.00
IUUC-Mlu-067674	Myotis lucifugus	94.44	4.00e-76	276.00
IUUC-Nfi-068618	Neosartorya fischeri	62.24	7.00e-52	196.00
IUUC-Ncr-068712	Neurospora crassa	69.17	8.00e-51	192.00
IUUC-Nle-069926	Nomascus leucogenys	100.00	2.00e-86	311.00
IUUC-Opr-070598	Ochotona princeps	100.00	2.00e-86	311.00
IUUC-Ont-071893	Oreochromis niloticus	96.72	2.00e-88	318.00
IUUC-Oan-073273	Ornithorhynchus anatinus	100.00	1.00e-75	275.00
IUUC-Ocu-074357	Oryctolagus cuniculus	100.00	9.00e-79	285.00
IUUC-Oba-075055	Oryza barthii	60.13	3.00e-52	197.00
IUUC-Obr-076538	Oryza brachyantha	59.48	6.00e-52	196.00
IUUC-Ogl-077784	Oryza glaberrima	60.13	3.00e-52	197.00
IUUC-Ogu-078045	Oryza glumaepatula	60.13	3.00e-52	197.00
IUUC-Oin-079163	Oryza indica	60.13	3.00e-52	197.00
IUUC-Olo-080847	Oryza longistaminata	54.79	7.00e-44	170.00
IUUC-Ome-081586	Oryza meridionalis	55.76	8.00e-50	189.00
IUUC-Oni-082913	Oryza nivara	60.13	3.00e-52	197.00
IUUC-Opu-083651	Oryza punctata	60.13	3.00e-52	197.00
IUUC-Oru-084980	Oryza rufipogon	60.13	3.00e-52	197.00
IUUC-Osa-085334	Oryza sativa	60.14	7.00e-49	186.00
IUUC-Ola-087423	Oryzias latipes	96.72	1.00e-92	332.00
IUUC-Oga-088412	Otolemur garnettii	100.00	2.00e-86	311.00
IUUC-Oar-090282	Ovis aries	97.66	3.00e-76	277.00
IUUC-Ptr-090470	Pan troglodytes	100.00	2.00e-86	311.00
IUUC-Pan-092552	Papio anubis	100.00	2.00e-86	311.00
IUUC-Psi-093516	Pelodiscus sinensis	92.93	3.00e-77	280.00
IUUC-Pno-094800	Phaeosphaeria nodorum	68.27	8.00e-44	169.00
IUUC-Ppa-095962	Physcomitrella patens	58.71	8.00e-54	202.00
IUUC-Pfo-097374	Poecilia formosa	99.45	6.00e-86	309.00
IUUC-Pab-098112	Pongo abelii	100.00	2.00e-86	311.00
IUUC-Pop-099923	Populus trichocarpa	61.29	3.00e-54	204.00
IUUC-Pca-100436	Procavia capensis	82.39	3.00e-64	236.00
IUUC-Ppe-101144	Prunus persica	61.94	3.00e-54	204.00
IUUC-Pva-102776	Pteropus vampyrus	99.45	1.00e-84	305.00
IUUC-Pgr-103325	Puccinia graminis	63.97	2.00e-52	197.00
IUUC-Ptt-104010	Puccinia triticina	62.41	9.00e-48	182.00
IUUC-Pte-104024	Pyrenophora teres	56.40	1.00e-53	202.00
IUUC-Pyt-104715	Pyrenophora triticirepentis	64.39	4.00e-51	193.00
IUUC-Rno-105699	Rattus norvegicus	98.91	3.00e-85	307.00
IUUC-Sce-106165	Saccharomyces cerevisiae	58.82	2.00e-43	168.00
IUUC-Sha-106524	Sarcophilus harrisii	100.00	2.00e-75	275.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	61.59	2.00e-53	201.00
IUUC-Spo-108105	Schizosaccharomyces pombe	60.78	3.00e-54	204.00
IUUC-Ssl-108543	Sclerotinia sclerotiorum	55.48	3.00e-47	181.00
IUUC-Smo-108971	Selaginella moellendorffii	63.33	7.00e-56	209.00
IUUC-Sit-110211	Setaria italica	60.13	8.00e-52	197.00
IUUC-Sly-111324	Solanum lycopersicum	61.29	9.00e-55	206.00
IUUC-Stu-112525	Solanum tuberosum	60.13	2.00e-53	201.00
IUUC-Sar-113572	Sorex araneus	80.61	1.00e-50	192.00
IUUC-Sbi-113911	Sorghum bicolor	60.13	1.00e-52	198.00
IUUC-Sre-115027	Sporisorium reilianum	62.34	3.00e-58	218.00
IUUC-Ssc-116221	Sus scrofa	99.42	4.00e-78	283.00
IUUC-Tgu-116965	Taeniopygia guttata	100.00	2.00e-75	274.00
IUUC-Tru-117574	Takifugu rubripes	96.72	4.00e-80	290.00
IUUC-Tni-120422	Tetraodon nigroviridis	96.72	2.00e-80	291.00
IUUC-Tca-121140	Theobroma cacao	63.23	8.00e-56	209.00
IUUC-Tre-122110	Trichoderma reesei	64.89	1.00e-50	192.00
IUUC-Tvi-122592	Trichoderma virens	58.28	4.00e-49	187.00
IUUC-Tae-123045	Triticum aestivum	60.13	1.00e-52	198.00
IUUC-Tur-126414	Triticum urartu	59.48	4.00e-52	197.00
IUUC-Tme-127020	Tuber melanosporum	54.89	4.00e-40	157.00
IUUC-Tbe-128053	Tupaia belangeri	84.24	1.00e-55	208.00
IUUC-Ttr-128734	Tursiops truncatus	100.00	2.00e-86	311.00
IUUC-Uma-129334	Ustilago maydis	62.34	2.00e-58	218.00
IUUC-Vda-129953	Verticillium dahliae	57.74	3.00e-53	201.00
IUUC-Vpa-130729	Vicugna pacos	100.00	2.00e-75	274.00
IUUC-Vvi-131055	Vitis vinifera	60.13	7.00e-55	206.00
IUUC-Xtr-132368	Xenopus tropicalis	98.91	1.00e-85	308.00
IUUC-Xma-133864	Xiphophorus maculatus	99.45	6.00e-86	309.00
IUUC-Yli-134339	Yarrowia lipolytica	57.42	2.00e-56	211.00
IUUC-Zma-135728	Zea mays	59.18	1.00e-49	189.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence