iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021607

Ensembl Protein ID

ENSCPOP00000001339.2

UniProt Accession

O35507; PPARA_CAVPO

Genbank Protein ID

CAA03951.1

Protein Name

Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1

Genbank Nucleotide ID

AJ000222

Gene Name

Ppara; PPARA; NR1C1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000001483.3	ENSCPOT00000001502.2	ENSCPOP00000001339.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	88.89	0.00e+00	835.00	IUUC-Hsa-046893

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Functional Description
(View)

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).

Protein Sequence
(Fasta)

MVDMESPLCP LSPLEAEDLE SPLSEYFLQE MGTIQDISRS LGEDSSGSFG FPEYQYLGSG 60
PGSDGSVITD TLSPASSPSS VSYPEVPCGV DEPPSSALNI ECRICGDKAS GYHYGVHACE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGCCGGG TCACCCTGAC GTGCCTCTCC CAGGACGGTG GAGAACTGAG GAGATCCAGA 60
GGCCAAATCG TCTCCCCCTT TTGCACCTCC CACGGCCAAG GCTGGAGTTA CAGGCCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0032099--P:negative regulation of appetite
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0042060--P:wound healing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002222	Ailuropoda melanoleuca	86.60	0.00e+00	827.00
IUUC-Apl-003330	Anas platyrhynchos	81.57	0.00e+00	761.00
IUUC-Aca-004598	Anolis carolinensis	80.34	0.00e+00	763.00
IUUC-Acl-008339	Aspergillus clavatus	45.45	3.10e-01	28.50
IUUC-Ame-011508	Astyanax mexicanus	71.00	0.00e+00	658.00
IUUC-Bta-012621	Bos taurus	88.03	0.00e+00	825.00
IUUC-Cja-019688	Callithrix jacchus	88.68	0.00e+00	831.00
IUUC-Cfa-020859	Canis familiaris	87.61	0.00e+00	838.00
IUUC-Csa-023313	Chlorocebus sabaeus	88.68	0.00e+00	828.00
IUUC-Cho-024741	Choloepus hoffmanni	77.56	0.00e+00	695.00
IUUC-Dre-027446	Danio rerio	70.36	0.00e+00	646.00
IUUC-Dno-029173	Dasypus novemcinctus	85.26	0.00e+00	777.00
IUUC-Dor-030581	Dipodomys ordii	86.51	0.00e+00	775.00
IUUC-Dme-031794	Drosophila melanogaster	36.46	8.00e-57	216.00
IUUC-Ete-032330	Echinops telfairi	84.62	0.00e+00	798.00
IUUC-Eca-033712	Equus caballus	88.03	0.00e+00	821.00
IUUC-Fca-036555	Felis catus	87.87	0.00e+00	832.00
IUUC-Fal-036677	Ficedula albicollis	82.05	0.00e+00	759.00
IUUC-Gmo-039240	Gadus morhua	78.88	7.00e-179	619.00
IUUC-Gga-040473	Gallus gallus	81.84	0.00e+00	763.00
IUUC-Gac-041872	Gasterosteus aculeatus	70.97	0.00e+00	669.00
IUUC-Ggo-045226	Gorilla gorilla	88.89	0.00e+00	830.00
IUUC-Hsa-046893	Homo sapiens	88.89	0.00e+00	830.00
IUUC-Itr-048952	Ictidomys tridecemlineatus	88.03	0.00e+00	822.00
IUUC-Lch-050116	Latimeria chalumnae	75.00	0.00e+00	695.00
IUUC-Loc-052131	Lepisosteus oculatus	80.79	0.00e+00	648.00
IUUC-Laf-054323	Loxodonta africana	87.82	0.00e+00	830.00
IUUC-Mcc-054841	Macaca mulatta	88.87	0.00e+00	834.00
IUUC-Meu-056833	Macropus eugenii	77.14	0.00e+00	694.00
IUUC-Mga-059995	Meleagris gallopavo	73.94	0.00e+00	674.00
IUUC-Mdo-061954	Monodelphis domestica	81.25	0.00e+00	703.00
IUUC-Mmu-064295	Mus musculus	87.61	0.00e+00	787.00
IUUC-Mpu-066216	Mustela putorius furo	87.61	0.00e+00	830.00
IUUC-Nle-069970	Nomascus leucogenys	88.68	0.00e+00	828.00
IUUC-Ont-071594	Oreochromis niloticus	71.82	0.00e+00	663.00
IUUC-Oan-073501	Ornithorhynchus anatinus	84.60	0.00e+00	682.00
IUUC-Ocu-074634	Oryctolagus cuniculus	81.31	0.00e+00	793.00
IUUC-Oni-082926	Oryza nivara	29.41	1.30e-02	30.80
IUUC-Ola-086585	Oryzias latipes	77.60	1.00e-178	619.00
IUUC-Oga-088738	Otolemur garnettii	87.61	0.00e+00	816.00
IUUC-Oar-090453	Ovis aries	88.03	0.00e+00	826.00
IUUC-Ptr-091518	Pan troglodytes	88.87	0.00e+00	833.00
IUUC-Pan-092006	Papio anubis	89.08	0.00e+00	835.00
IUUC-Psi-093352	Pelodiscus sinensis	79.87	0.00e+00	759.00
IUUC-Pfo-096060	Poecilia formosa	69.73	0.00e+00	653.00
IUUC-Pab-098602	Pongo abelii	83.33	0.00e+00	738.00
IUUC-Pva-102175	Pteropus vampyrus	82.91	0.00e+00	770.00
IUUC-Rno-105283	Rattus norvegicus	87.39	0.00e+00	784.00
IUUC-Sce-106436	Saccharomyces cerevisiae	29.03	8.00e-03	32.00
IUUC-Sha-106560	Sarcophilus harrisii	85.47	0.00e+00	782.00
IUUC-Ssc-115266	Sus scrofa	88.68	0.00e+00	844.00
IUUC-Tgu-116778	Taeniopygia guttata	82.05	0.00e+00	759.00
IUUC-Tru-118436	Takifugu rubripes	71.04	0.00e+00	655.00
IUUC-Tsy-119642	Tarsius syrichta	90.00	3.00e-121	428.00
IUUC-Tni-119859	Tetraodon nigroviridis	70.61	0.00e+00	651.00
IUUC-Tbe-127464	Tupaia belangeri	86.32	0.00e+00	827.00
IUUC-Ttr-129307	Tursiops truncatus	84.01	0.00e+00	773.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence