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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018518
Ensembl Protein ID T01C8.1b
UniProt Accession Q95ZQ4; Q22068; Q86FL6; AAPK2_CAEEL
Genbank Protein ID AAR06928.1; CCD68833.1; CCD68834.1; CCD68835.1
Protein Name 5'-AMP-activated protein kinase catalytic subunit alpha-2
Genbank Nucleotide ID AY347273; FO081053; FO081053; FO081053
Gene Name aak-2; T01C8.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00020142 T01C8.1a T01C8.1a
WBGene00020142 T01C8.1b T01C8.1b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 53.05 1.00e-122 437.00 IUUC-Ath-007014
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Role in motility and response to oxidative stress (PubMed:18408008, PubMed:24763318). Involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:15574588, PubMed:20110331). Plays a role in axon regrowth after axotomy in PLM neurons (PubMed:24431434). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621).
 Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Role in motility and response to oxidative stress (PubMed:18408008, PubMed:24763318). Involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:15574588, PubMed:20110331). Plays a role in axon regrowth after axotomy in PLM neurons (PubMed:24431434). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621).
Protein Sequence
(Fasta)
MFSHQDRDRD RKEDGGGDGT EMKSKSRSQP SGLNRVKNLS RKLSAKSRKE RKDRDSTDNS 60
SKMSSPGGET STKQQQELKA QIKIGHYILK ETLGVGTFGK VKVGIHETTQ YKVAVKILNR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018518|UBD,UBA|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAATGTTTTC TCATCAAGAT CGAGACCGCG ATAGGAAGGA GGACGGTGGT GGAGACGGTA 60
CTGAGATGAA ATCCAAGAGT CGGAGTCAGC CAAGTGGACT TAATCGCGTG AAAAATCTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018518|UBD,UBA|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase
Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF16579--AdenylateSensor
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0043025--C:neuronal cell body
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0008340--P:determination of adult lifespan
GO:0035262--P:gonad morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0032007--P:negative regulation of TOR signaling
GO:0018105--P:peptidyl-serine phosphorylation
GO:0061066--P:positive regulation of dauer larval development
KEGG cel:CELE_T01C8.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000713 Aegilops tauschii 47.61 2.00e-120 424.00
IUUC-Aml-001907 Ailuropoda melanoleuca 57.32 9.00e-165 572.00
IUUC-Atr-002770 Amborella trichopoda 47.84 6.00e-124 436.00
IUUC-Apl-003395 Anas platyrhynchos 57.88 6.00e-172 595.00
IUUC-Aca-004480 Anolis carolinensis 64.23 8.00e-179 618.00
IUUC-Aly-006289 Arabidopsis lyrata 48.97 5.00e-125 439.00
IUUC-Ath-007014 Arabidopsis thaliana 52.66 3.00e-125 441.00
IUUC-Ago-007957 Ashbya gossypii 42.51 1.00e-110 392.00
IUUC-Acl-008103 Aspergillus clavatus 57.48 5.00e-101 360.00
IUUC-Afl-008555 Aspergillus flavus 55.73 1.00e-103 369.00
IUUC-Afu-008949 Aspergillus fumigatus 60.43 1.00e-100 359.00
IUUC-Ani-009408 Aspergillus nidulans 53.94 2.00e-102 365.00
IUUC-Ang-009551 Aspergillus niger 58.16 2.00e-101 362.00
IUUC-Aor-010176 Aspergillus oryzae 55.73 1.00e-103 369.00
IUUC-Ate-010287 Aspergillus terreus 57.82 3.00e-101 361.00
IUUC-Ame-011019 Astyanax mexicanus 57.24 0.00e+00 627.00
IUUC-Bgr-012045 Blumeria graminis 58.04 8.00e-108 383.00
IUUC-Bta-012786 Bos taurus 57.77 1.00e-165 575.00
IUUC-Bci-013774 Botrytis cinerea 57.69 1.00e-106 379.00
IUUC-Bdi-014319 Brachypodium distachyon 46.41 6.00e-121 426.00
IUUC-Bol-016242 Brassica oleracea 49.16 8.00e-127 446.00
IUUC-Bra-016750 Brassica rapa 49.37 2.00e-127 447.00
IUUC-Cja-019386 Callithrix jacchus 57.62 0.00e+00 632.00
IUUC-Cfa-020177 Canis familiaris 57.12 1.00e-160 558.00
IUUC-Cpo-021805 Cavia porcellus 58.35 0.00e+00 639.00
IUUC-Cre-022915 Chlamydomonas reinhardtii 59.33 1.00e-87 314.00
IUUC-Csa-024267 Chlorocebus sabaeus 57.82 0.00e+00 628.00
IUUC-Cho-024859 Choloepus hoffmanni 55.98 1.00e-156 545.00
IUUC-Cin-025550 Ciona intestinalis 54.77 6.00e-172 595.00
IUUC-Csv-026139 Ciona savignyi 54.61 7.00e-175 605.00
IUUC-Cne-027044 Cryptococcus neoformans 46.95 2.00e-101 362.00
IUUC-Cme-027289 Cyanidioschyzon merolae 46.03 5.00e-112 397.00
IUUC-Dre-027749 Danio rerio 54.64 1.00e-167 581.00
IUUC-Dno-030006 Dasypus novemcinctus 57.42 6.00e-165 572.00
IUUC-Dor-030578 Dipodomys ordii 57.29 1.00e-180 625.00
IUUC-Dse-031507 Dothistroma septosporum 58.17 3.00e-106 378.00
IUUC-Dme-031704 Drosophila melanogaster 74.85 4.00e-147 513.00
IUUC-Ete-033055 Echinops telfairi 56.05 1.00e-167 582.00
IUUC-Eca-034016 Equus caballus 58.33 7.00e-173 598.00
IUUC-Fca-035754 Felis catus 56.51 9.00e-163 565.00
IUUC-Fal-037363 Ficedula albicollis 57.77 2.00e-165 574.00
IUUC-Fox-038073 Fusarium oxysporum 60.26 5.00e-108 384.00
IUUC-Fso-038236 Fusarium solani 61.89 3.00e-105 374.00
IUUC-Gmo-039633 Gadus morhua 54.31 3.00e-175 607.00
IUUC-Ggr-039987 Gaeumannomyces graminis 60.58 2.00e-103 368.00
IUUC-Gga-040546 Gallus gallus 58.30 0.00e+00 638.00
IUUC-Gac-041822 Gasterosteus aculeatus 57.32 3.00e-176 610.00
IUUC-Gma-042712 Glycine max 48.25 3.00e-124 437.00
IUUC-Ggo-045303 Gorilla gorilla 57.82 0.00e+00 633.00
IUUC-Hsa-045746 Homo sapiens 57.82 0.00e+00 633.00
IUUC-Hvu-047406 Hordeum vulgare 47.23 6.00e-124 436.00
IUUC-Itr-048134 Ictidomys tridecemlineatus 58.00 0.00e+00 635.00
IUUC-Kpa-049190 Komagataella pastoris 44.74 1.00e-115 408.00
IUUC-Lch-049623 Latimeria chalumnae 57.19 1.00e-164 571.00
IUUC-Lpe-051392 Leersia perrieri 46.54 5.00e-121 426.00
IUUC-Loc-052928 Lepisosteus oculatus 59.23 0.00e+00 640.00
IUUC-Lma-053054 Leptosphaeria maculans 57.06 2.00e-108 385.00
IUUC-Laf-053459 Loxodonta africana 58.00 0.00e+00 632.00
IUUC-Mcc-055862 Macaca mulatta 57.82 0.00e+00 633.00
IUUC-Mor-057170 Magnaporthe oryzae 49.34 2.00e-102 365.00
IUUC-Mpo-057302 Magnaporthe poae 59.30 4.00e-105 374.00
IUUC-Mtr-058309 Medicago truncatula 50.32 9.00e-123 432.00
IUUC-Mla-059058 Melampsora laricipopulina 56.99 2.00e-94 338.00
IUUC-Mga-059206 Meleagris gallopavo 58.85 2.00e-172 597.00
IUUC-Mvi-060337 Microbotryum violaceum 50.41 2.00e-101 361.00
IUUC-Mmr-061619 Microcebus murinus 58.17 0.00e+00 630.00
IUUC-Mdo-062160 Monodelphis domestica 57.65 2.00e-180 624.00
IUUC-Mmu-063406 Mus musculus 57.64 0.00e+00 629.00
IUUC-Mac-064518 Musa acuminata 44.96 1.00e-115 408.00
IUUC-Mpu-066326 Mustela putorius furo 57.96 2.00e-172 597.00
IUUC-Mlu-067968 Myotis lucifugus 57.14 2.00e-169 587.00
IUUC-Nfi-068493 Neosartorya fischeri 60.43 8.00e-101 360.00
IUUC-Ncr-068665 Neurospora crassa 49.75 2.00e-107 382.00
IUUC-Nle-070158 Nomascus leucogenys 57.82 0.00e+00 632.00
IUUC-Opr-070272 Ochotona princeps 56.16 1.00e-162 565.00
IUUC-Ont-071395 Oreochromis niloticus 57.82 0.00e+00 634.00
IUUC-Oan-073322 Ornithorhynchus anatinus 55.76 4.00e-158 550.00
IUUC-Ocu-074188 Oryctolagus cuniculus 56.92 4.00e-162 563.00
IUUC-Oba-075436 Oryza barthii 47.05 5.00e-123 433.00
IUUC-Obr-076507 Oryza brachyantha 47.36 2.00e-123 434.00
IUUC-Ogl-077718 Oryza glaberrima 49.77 2.00e-119 421.00
IUUC-Ogu-078349 Oryza glumaepatula 47.05 6.00e-123 433.00
IUUC-Oin-079889 Oryza indica 46.44 1.00e-119 422.00
IUUC-Olo-080521 Oryza longistaminata 47.05 8.00e-123 432.00
IUUC-Ome-081630 Oryza meridionalis 46.84 2.00e-122 431.00
IUUC-Oni-082211 Oryza nivara 47.05 2.00e-123 434.00
IUUC-Opu-083617 Oryza punctata 46.56 5.00e-122 429.00
IUUC-Oru-084252 Oryza rufipogon 47.05 5.00e-123 432.00
IUUC-Osa-085548 Oryza sativa 47.05 5.00e-123 432.00
IUUC-Ola-087169 Oryzias latipes 56.53 0.00e+00 631.00
IUUC-Olu-087861 Ostreococcus lucimarinus 49.65 4.00e-114 403.00
IUUC-Oga-088003 Otolemur garnettii 57.69 3.00e-165 573.00
IUUC-Oar-089933 Ovis aries 57.77 1.00e-165 575.00
IUUC-Ptr-090741 Pan troglodytes 57.82 0.00e+00 633.00
IUUC-Pan-092526 Papio anubis 57.87 2.00e-165 574.00
IUUC-Psi-094034 Pelodiscus sinensis 57.12 2.00e-163 567.00
IUUC-Pno-095030 Phaeosphaeria nodorum 57.70 1.00e-106 378.00
IUUC-Ppa-095615 Physcomitrella patens 51.26 3.00e-121 427.00
IUUC-Pfo-096295 Poecilia formosa 58.10 0.00e+00 630.00
IUUC-Pab-098023 Pongo abelii 57.82 0.00e+00 633.00
IUUC-Pop-100042 Populus trichocarpa 47.45 1.00e-124 438.00
IUUC-Pca-101104 Procavia capensis 63.01 4.00e-128 450.00
IUUC-Ppe-101642 Prunus persica 52.78 3.00e-122 430.00
IUUC-Pva-102470 Pteropus vampyrus 57.64 6.00e-180 622.00
IUUC-Pgr-103406 Puccinia graminis 56.51 1.00e-91 329.00
IUUC-Ptt-103713 Puccinia triticina 34.55 7.00e-78 283.00
IUUC-Pte-104259 Pyrenophora teres 55.84 5.00e-107 380.00
IUUC-Pyt-104752 Pyrenophora triticirepentis 56.47 4.00e-108 384.00
IUUC-Rno-104960 Rattus norvegicus 58.00 0.00e+00 634.00
IUUC-Sce-106290 Saccharomyces cerevisiae 40.93 1.00e-109 389.00
IUUC-Sha-107603 Sarcophilus harrisii 57.77 1.00e-164 571.00
IUUC-Sja-107772 Schizosaccharomyces japonicus 41.39 6.00e-109 386.00
IUUC-Spo-108202 Schizosaccharomyces pombe 42.47 5.00e-111 393.00
IUUC-Ssl-108535 Sclerotinia sclerotiorum 57.74 3.00e-109 388.00
IUUC-Smo-109309 Selaginella moellendorffii 48.78 1.00e-122 432.00
IUUC-Sit-109745 Setaria italica 47.30 1.00e-119 421.00
IUUC-Sly-110890 Solanum lycopersicum 48.87 6.00e-127 446.00
IUUC-Stu-112144 Solanum tuberosum 44.83 3.00e-114 404.00
IUUC-Sar-113521 Sorex araneus 48.98 3.00e-123 434.00
IUUC-Sbi-114764 Sorghum bicolor 47.10 3.00e-120 424.00
IUUC-Sre-115141 Sporisorium reilianum 62.76 5.00e-113 400.00
IUUC-Ssc-115732 Sus scrofa 57.22 6.00e-160 555.00
IUUC-Tgu-117190 Taeniopygia guttata 57.59 6.00e-165 572.00
IUUC-Tru-118735 Takifugu rubripes 57.42 0.00e+00 630.00
IUUC-Tsy-119503 Tarsius syrichta 56.40 5.00e-163 566.00
IUUC-Tni-119880 Tetraodon nigroviridis 58.27 0.00e+00 636.00
IUUC-Tca-121386 Theobroma cacao 49.18 1.00e-123 435.00
IUUC-Tre-122070 Trichoderma reesei 62.24 1.00e-107 382.00
IUUC-Tvi-122305 Trichoderma virens 61.32 4.00e-107 380.00
IUUC-Tae-123515 Triticum aestivum 47.00 3.00e-121 427.00
IUUC-Tur-126416 Triticum urartu 47.34 6.00e-122 429.00
IUUC-Tbe-127791 Tupaia belangeri 67.83 9.00e-92 328.00
IUUC-Ttr-129224 Tursiops truncatus 56.12 7.00e-164 569.00
IUUC-Uma-129372 Ustilago maydis 62.11 9.00e-112 396.00
IUUC-Vda-129819 Verticillium dahliae 54.90 9.00e-89 320.00
IUUC-Vpa-130220 Vicugna pacos 58.26 3.00e-172 596.00
IUUC-Vvi-131649 Vitis vinifera 48.06 1.00e-123 435.00
IUUC-Xtr-132954 Xenopus tropicalis 57.89 0.00e+00 631.00
IUUC-Xma-134119 Xiphophorus maculatus 58.10 0.00e+00 630.00
IUUC-Yli-134422 Yarrowia lipolytica 44.78 2.00e-112 398.00
IUUC-Zma-135621 Zea mays 58.77 1.00e-112 399.00
Created Date 25-Jun-2017

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