iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072530

Ensembl Protein ID

ENSONIP00000004927.1

UniProt Accession

I3J7T7; I3J7T7_ORENI

Genbank Protein ID

ENSONIP00000004927

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AERX01011681

Gene Name

urm1; URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003910.1	ENSONIT00000004930.1	ENSONIP00000004927.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	38.38	2.00e-15	75.50	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oreochromis niloticus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAASIAIHLE FGGGAELLFN GVKKHPVTLP SQSEPWDMKQ LLVWIQRNLL KERPELFVQG 60
DSVRPGILVL INDADWELMG ELDYQLQDQD NVVFISTLHG G 101

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Nucleotide Sequence
(Fasta)

ATGGCAGCGT CCATAGCGAT TCATCTGGAG TTTGGGTAAG CGACTATCGA GTGTGTGTGT 60
GTCTCTCTGA GTTACACAGA CAGAGCCTCG CTGTTAGCTT AAGACGTTTA TCGTGTGAAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	79.21	5.00e-46	175.00
IUUC-Atr-003089	Amborella trichopoda	57.58	1.00e-30	124.00
IUUC-Apl-003382	Anas platyrhynchos	84.62	1.00e-41	160.00
IUUC-Aca-004981	Anolis carolinensis	83.17	2.00e-47	179.00
IUUC-Aly-005517	Arabidopsis lyrata	57.61	3.00e-28	115.00
IUUC-Ath-006718	Arabidopsis thaliana	58.33	8.00e-25	104.00
IUUC-Ago-007917	Ashbya gossypii	39.39	3.00e-18	82.80
IUUC-Acl-008054	Aspergillus clavatus	68.00	6.00e-16	75.10
IUUC-Afl-008704	Aspergillus flavus	55.56	2.00e-21	93.20
IUUC-Aor-009890	Aspergillus oryzae	53.85	2.00e-25	107.00
IUUC-Bta-012448	Bos taurus	80.20	3.00e-46	176.00
IUUC-Bci-013865	Botrytis cinerea	46.08	8.00e-22	95.10
IUUC-Bdi-014980	Brachypodium distachyon	61.25	7.00e-25	105.00
IUUC-Bol-016055	Brassica oleracea	56.25	2.00e-24	103.00
IUUC-Bra-016845	Brassica rapa	56.25	2.00e-24	103.00
IUUC-Cel-018485	Caenorhabditis elegans	33.01	3.00e-11	59.70
IUUC-Cja-019587	Callithrix jacchus	81.19	3.00e-46	176.00
IUUC-Cfa-020653	Canis familiaris	79.21	4.00e-46	175.00
IUUC-Cpo-021622	Cavia porcellus	81.19	3.00e-46	176.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	53.06	2.00e-25	106.00
IUUC-Csa-023756	Chlorocebus sabaeus	77.22	2.00e-33	134.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	44.55	3.00e-21	93.20
IUUC-Cne-026953	Cryptococcus neoformans	54.81	1.00e-28	118.00
IUUC-Cme-027314	Cyanidioschyzon merolae	43.88	1.00e-19	87.40
IUUC-Dre-027884	Danio rerio	84.16	4.00e-47	178.00
IUUC-Dno-029262	Dasypus novemcinctus	76.25	1.00e-33	135.00
IUUC-Dor-030601	Dipodomys ordii	53.47	1.00e-22	97.80
IUUC-Dme-031893	Drosophila melanogaster	61.22	8.00e-31	124.00
IUUC-Ete-032773	Echinops telfairi	77.23	2.00e-42	163.00
IUUC-Eca-034187	Equus caballus	80.20	4.00e-46	175.00
IUUC-Eeu-034808	Erinaceus europaeus	76.24	1.00e-44	170.00
IUUC-Fca-036107	Felis catus	79.21	2.00e-46	176.00
IUUC-Fal-036607	Ficedula albicollis	82.42	5.00e-41	158.00
IUUC-Fox-037698	Fusarium oxysporum	46.15	2.00e-22	97.10
IUUC-Gmo-039492	Gadus morhua	86.14	2.00e-47	179.00
IUUC-Ggr-039965	Gaeumannomyces graminis	47.12	1.00e-20	92.00
IUUC-Gga-041268	Gallus gallus	81.19	7.00e-46	174.00
IUUC-Gac-042111	Gasterosteus aculeatus	95.05	6.00e-52	194.00
IUUC-Gma-043240	Glycine max	68.75	1.00e-23	101.00
IUUC-Ggo-045176	Gorilla gorilla	75.95	2.00e-26	111.00
IUUC-Hsa-046077	Homo sapiens	79.21	3.00e-39	152.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	84.27	8.00e-35	137.00
IUUC-Kpa-049157	Komagataella pastoris	47.47	4.00e-20	89.40
IUUC-Lch-049889	Latimeria chalumnae	80.20	5.00e-47	178.00
IUUC-Lpe-050783	Leersia perrieri	69.84	9.00e-23	98.20
IUUC-Loc-052400	Lepisosteus oculatus	85.15	8.00e-48	181.00
IUUC-Lma-053259	Leptosphaeria maculans	47.06	2.00e-21	94.00
IUUC-Laf-053596	Loxodonta africana	80.58	2.00e-45	173.00
IUUC-Mcc-054845	Macaca mulatta	84.09	3.00e-41	159.00
IUUC-Meu-055968	Macropus eugenii	81.19	5.00e-47	178.00
IUUC-Mor-057126	Magnaporthe oryzae	46.15	9.00e-19	85.50
IUUC-Mpo-057311	Magnaporthe poae	48.04	1.00e-21	95.50
IUUC-Mtr-058266	Medicago truncatula	59.15	2.00e-22	97.10
IUUC-Mla-058847	Melampsora laricipopulina	40.78	5.00e-12	63.20
IUUC-Mga-059468	Meleagris gallopavo	84.62	7.00e-42	161.00
IUUC-Mvi-060235	Microbotryum violaceum	36.42	8.00e-20	89.70
IUUC-Mdo-061948	Monodelphis domestica	80.20	2.00e-46	176.00
IUUC-Mmu-063946	Mus musculus	79.21	1.00e-45	173.00
IUUC-Mac-064812	Musa acuminata	71.88	2.00e-25	107.00
IUUC-Mpu-066763	Mustela putorius furo	79.21	4.00e-45	172.00
IUUC-Mlu-066970	Myotis lucifugus	78.48	5.00e-34	135.00
IUUC-Ncr-068824	Neurospora crassa	46.53	7.00e-20	88.60
IUUC-Nle-069849	Nomascus leucogenys	77.22	2.00e-33	134.00
IUUC-Opr-070227	Ochotona princeps	81.19	3.00e-46	176.00
IUUC-Oan-073191	Ornithorhynchus anatinus	85.39	2.00e-42	163.00
IUUC-Ocu-074460	Oryctolagus cuniculus	80.41	9.00e-45	171.00
IUUC-Oba-075499	Oryza barthii	70.31	3.00e-23	100.00
IUUC-Obr-076896	Oryza brachyantha	67.19	4.00e-22	98.20
IUUC-Ogl-077834	Oryza glaberrima	70.31	1.00e-23	100.00
IUUC-Ogu-078622	Oryza glumaepatula	70.31	1.00e-23	100.00
IUUC-Oin-079358	Oryza indica	70.31	4.00e-23	101.00
IUUC-Olo-081035	Oryza longistaminata	55.34	3.00e-24	104.00
IUUC-Oni-082425	Oryza nivara	70.31	1.00e-23	100.00
IUUC-Opu-083461	Oryza punctata	69.84	8.00e-23	99.80
IUUC-Oru-084875	Oryza rufipogon	63.38	1.00e-21	94.40
IUUC-Oga-089128	Otolemur garnettii	80.20	3.00e-46	176.00
IUUC-Oar-089896	Ovis aries	80.20	3.00e-46	176.00
IUUC-Ptr-091618	Pan troglodytes	75.95	2.00e-26	111.00
IUUC-Pan-092238	Papio anubis	77.22	2.00e-33	134.00
IUUC-Psi-093879	Pelodiscus sinensis	79.21	5.00e-45	172.00
IUUC-Pma-094484	Petromyzon marinus	76.24	5.00e-34	135.00
IUUC-Ppa-095801	Physcomitrella patens	59.26	8.00e-23	98.20
IUUC-Pfo-097192	Poecilia formosa	91.09	6.00e-51	191.00
IUUC-Pab-098203	Pongo abelii	79.21	4.00e-39	152.00
IUUC-Pop-099614	Populus trichocarpa	58.33	5.00e-24	102.00
IUUC-Pca-100507	Procavia capensis	77.22	7.00e-34	134.00
IUUC-Ppe-101174	Prunus persica	59.60	3.00e-30	122.00
IUUC-Pva-102735	Pteropus vampyrus	79.21	2.00e-42	163.00
IUUC-Pgr-103510	Puccinia graminis	37.86	7.00e-11	59.30
IUUC-Ptt-103918	Puccinia triticina	36.89	1.00e-10	58.50
IUUC-Pte-104173	Pyrenophora teres	50.49	7.00e-24	102.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	50.49	8.00e-24	101.00
IUUC-Rno-105820	Rattus norvegicus	80.20	8.00e-46	174.00
IUUC-Sce-106366	Saccharomyces cerevisiae	38.38	5.00e-16	75.50
IUUC-Sja-107727	Schizosaccharomyces japonicus	43.75	1.00e-17	81.30
IUUC-Spo-108074	Schizosaccharomyces pombe	41.84	1.00e-10	57.80
IUUC-Smo-108944	Selaginella moellendorffii	62.92	1.00e-26	110.00
IUUC-Sit-110277	Setaria italica	60.71	2.00e-24	103.00
IUUC-Sly-111505	Solanum lycopersicum	55.95	4.00e-24	102.00
IUUC-Stu-112076	Solanum tuberosum	57.14	1.00e-24	103.00
IUUC-Sbi-114274	Sorghum bicolor	63.16	2.00e-24	103.00
IUUC-Sre-114953	Sporisorium reilianum	58.25	6.00e-28	115.00
IUUC-Ssc-115418	Sus scrofa	80.20	4.00e-46	175.00
IUUC-Tgu-117311	Taeniopygia guttata	82.42	5.00e-41	158.00
IUUC-Tru-118598	Takifugu rubripes	92.13	8.00e-44	167.00
IUUC-Tni-120109	Tetraodon nigroviridis	88.24	3.00e-47	179.00
IUUC-Tca-120942	Theobroma cacao	56.63	1.00e-23	100.00
IUUC-Tre-122099	Trichoderma reesei	48.39	6.00e-16	75.10
IUUC-Tvi-122285	Trichoderma virens	49.04	2.00e-19	87.40
IUUC-Tae-125193	Triticum aestivum	70.31	2.00e-23	100.00
IUUC-Tur-126677	Triticum urartu	59.21	7.00e-21	92.00
IUUC-Tme-127120	Tuber melanosporum	45.19	4.00e-22	96.70
IUUC-Tbe-128050	Tupaia belangeri	59.41	2.00e-28	116.00
IUUC-Ttr-129019	Tursiops truncatus	77.23	8.00e-43	164.00
IUUC-Uma-129483	Ustilago maydis	57.28	4.00e-26	109.00
IUUC-Vda-129690	Verticillium dahliae	41.96	2.00e-17	80.50
IUUC-Vvi-131174	Vitis vinifera	59.04	2.00e-24	103.00
IUUC-Xma-133862	Xiphophorus maculatus	91.09	6.00e-51	191.00
IUUC-Yli-134398	Yarrowia lipolytica	45.45	4.00e-18	82.40
IUUC-Zma-134964	Zea mays	60.49	2.00e-23	99.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence