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Tag Content
iUUCD ID IUUC-Afu-009042
Ensembl Protein ID CADAFUAP00001990
UniProt Accession Q4WNA5; ATG5_ASPFU
Genbank Protein ID EAL88559.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID AAHF01000006
Gene Name AFUA_6G07040; atg5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADAFUAG00001990 CADAFUAT00001990 CADAFUAP00001990
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 23.15 2.00e-08 54.70 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus fumigatus
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MRTSSMMENQ VSLSSIQRAV WDGKLPLQIT LASSESRTYD QTDPYLIACP RISYLPSLLP 60
RLRAFFSPSL IEPNSQPHEG WFSFEGVPLK WHLPVGLLYD LYAGADPASK GTRVDETDHP 120
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Protein Fasta Sequence



>IUUC-Afu-009042|E3,Cullin RING/Other|Aspergillus fumigatus
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Nucleotide Sequence
(Fasta)
ATGAGAACAT CCTCAATGAT GGAAAATCAA GTTTCTCTTA GCAGCATCCA GAGAGCTGTA 60
TGGGATGGAA AACTGCCATT GCAGATAACG CTTGCTTCAT CAGAGAGTCG AACATATGAC 120
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Nucleotide Fasta Sequence



>IUUC-Afu-009042|E3,Cullin RING/Other|Aspergillus fumigatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG afm:AFUA_6G07040
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 28.32 8.00e-25 107.00
IUUC-Aml-002403 Ailuropoda melanoleuca 25.80 1.00e-24 104.00
IUUC-Atr-002645 Amborella trichopoda 34.46 5.00e-27 113.00
IUUC-Apl-003611 Anas platyrhynchos 27.01 2.00e-31 127.00
IUUC-Aca-004411 Anolis carolinensis 27.44 1.00e-28 118.00
IUUC-Aly-005636 Arabidopsis lyrata 35.11 6.00e-23 99.80
IUUC-Ath-006959 Arabidopsis thaliana 35.11 1.00e-22 98.60
IUUC-Ago-007978 Ashbya gossypii 26.63 3.00e-12 63.50
IUUC-Acl-008328 Aspergillus clavatus 78.50 9.00e-129 451.00
IUUC-Afl-008638 Aspergillus flavus 76.90 1.00e-131 460.00
IUUC-Ani-009364 Aspergillus nidulans 68.44 2.00e-121 427.00
IUUC-Aor-009889 Aspergillus oryzae 76.60 2.00e-133 466.00
IUUC-Ate-010511 Aspergillus terreus 59.29 8.00e-40 153.00
IUUC-Ame-011644 Astyanax mexicanus 32.89 3.00e-08 47.80
IUUC-Bgr-012153 Blumeria graminis 38.54 2.00e-43 167.00
IUUC-Bta-012360 Bos taurus 30.56 4.00e-21 92.00
IUUC-Bci-013723 Botrytis cinerea 37.84 2.00e-50 191.00
IUUC-Bdi-014520 Brachypodium distachyon 29.68 6.00e-20 89.70
IUUC-Bol-016053 Brassica oleracea 35.11 3.00e-25 107.00
IUUC-Bra-017072 Brassica rapa 34.57 1.00e-25 108.00
IUUC-Cel-018529 Caenorhabditis elegans 21.90 2.00e-14 70.90
IUUC-Cja-019569 Callithrix jacchus 25.32 2.00e-25 107.00
IUUC-Cfa-020473 Canis familiaris 25.64 6.00e-26 108.00
IUUC-Cpo-021421 Cavia porcellus 25.00 2.00e-25 107.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 31.43 7.00e-15 72.00
IUUC-Csa-024197 Chlorocebus sabaeus 25.32 3.00e-25 107.00
IUUC-Cho-024521 Choloepus hoffmanni 23.91 8.00e-18 82.00
IUUC-Cin-025119 Ciona intestinalis 24.92 1.00e-24 105.00
IUUC-Csv-026192 Ciona savignyi 27.48 4.00e-27 113.00
IUUC-Cgl-026686 Colletotrichum gloeosporioides 34.82 6.00e-38 149.00
IUUC-Dre-028466 Danio rerio 26.69 3.00e-29 120.00
IUUC-Dse-031228 Dothistroma septosporum 46.08 3.00e-86 309.00
IUUC-Dme-031703 Drosophila melanogaster 28.10 2.00e-22 97.40
IUUC-Ete-032482 Echinops telfairi 24.28 1.00e-19 87.80
IUUC-Eca-034036 Equus caballus 25.64 6.00e-26 109.00
IUUC-Eeu-035235 Erinaceus europaeus 30.94 6.00e-21 92.40
IUUC-Fca-036263 Felis catus 25.64 9.00e-26 108.00
IUUC-Fal-037064 Ficedula albicollis 26.69 3.00e-30 123.00
IUUC-Fox-037813 Fusarium oxysporum 37.93 6.00e-46 175.00
IUUC-Fso-038139 Fusarium solani 38.20 2.00e-44 170.00
IUUC-Gmo-039509 Gadus morhua 29.30 4.00e-26 109.00
IUUC-Ggr-040111 Gaeumannomyces graminis 39.62 4.00e-41 160.00
IUUC-Gga-040517 Gallus gallus 26.69 5.00e-31 126.00
IUUC-Gac-042270 Gasterosteus aculeatus 27.04 2.00e-25 107.00
IUUC-Gma-044400 Glycine max 35.05 3.00e-24 103.00
IUUC-Ggo-045048 Gorilla gorilla 25.32 1.00e-25 108.00
IUUC-Hsa-046744 Homo sapiens 25.32 2.00e-25 107.00
IUUC-Kpa-049174 Komagataella pastoris 26.85 4.00e-28 116.00
IUUC-Lch-049475 Latimeria chalumnae 27.01 4.00e-29 119.00
IUUC-Lpe-051283 Leersia perrieri 31.43 3.00e-24 105.00
IUUC-Loc-052446 Lepisosteus oculatus 25.40 5.00e-30 122.00
IUUC-Lma-053278 Leptosphaeria maculans 47.99 3.00e-82 296.00
IUUC-Laf-054020 Loxodonta africana 25.48 4.00e-24 103.00
IUUC-Mcc-055176 Macaca mulatta 25.32 2.00e-25 107.00
IUUC-Mor-057164 Magnaporthe oryzae 39.81 1.00e-44 171.00
IUUC-Mpo-057428 Magnaporthe poae 41.27 3.00e-38 149.00
IUUC-Mtr-058424 Medicago truncatula 31.47 2.00e-25 107.00
IUUC-Mla-058872 Melampsora laricipopulina 27.04 7.00e-25 106.00
IUUC-Mga-059859 Meleagris gallopavo 26.69 5.00e-31 126.00
IUUC-Mmr-061482 Microcebus murinus 25.08 1.00e-25 108.00
IUUC-Mdo-062371 Monodelphis domestica 27.39 2.00e-28 117.00
IUUC-Mmu-063139 Mus musculus 25.64 1.00e-26 111.00
IUUC-Mac-065332 Musa acuminata 35.60 1.00e-26 112.00
IUUC-Mpu-066783 Mustela putorius furo 25.32 3.00e-25 107.00
IUUC-Mlu-068165 Myotis lucifugus 25.47 9.00e-24 102.00
IUUC-Nfi-068578 Neosartorya fischeri 96.01 1.00e-177 613.00
IUUC-Ncr-068636 Neurospora crassa 38.77 7.00e-43 166.00
IUUC-Nle-069740 Nomascus leucogenys 25.32 2.00e-25 107.00
IUUC-Opr-070802 Ochotona princeps 30.39 1.00e-20 91.70
IUUC-Ont-072222 Oreochromis niloticus 25.72 9.00e-29 118.00
IUUC-Oan-072760 Ornithorhynchus anatinus 31.13 3.00e-26 109.00
IUUC-Ocu-074844 Oryctolagus cuniculus 20.79 8.00e-07 45.10
IUUC-Oba-075834 Oryza barthii 31.51 4.00e-27 113.00
IUUC-Obr-076230 Oryza brachyantha 25.91 1.00e-13 68.90
IUUC-Ogl-077554 Oryza glaberrima 31.16 7.00e-27 112.00
IUUC-Ogu-078687 Oryza glumaepatula 29.90 2.00e-26 111.00
IUUC-Oin-079677 Oryza indica 31.32 4.00e-28 117.00
IUUC-Olo-081078 Oryza longistaminata 31.15 2.00e-24 105.00
IUUC-Ome-081548 Oryza meridionalis 31.58 1.00e-28 120.00
IUUC-Oni-082050 Oryza nivara 31.51 3.00e-27 114.00
IUUC-Opu-083609 Oryza punctata 32.09 1.00e-27 115.00
IUUC-Oru-085057 Oryza rufipogon 31.51 2.00e-27 114.00
IUUC-Osa-085917 Oryza sativa 31.51 1.00e-27 115.00
IUUC-Ola-087032 Oryzias latipes 25.72 1.00e-27 114.00
IUUC-Oga-088468 Otolemur garnettii 26.20 4.00e-27 113.00
IUUC-Oar-089751 Ovis aries 25.72 5.00e-26 109.00
IUUC-Ptr-091064 Pan troglodytes 25.32 2.00e-25 107.00
IUUC-Pan-092505 Papio anubis 25.48 3.00e-24 103.00
IUUC-Psi-093086 Pelodiscus sinensis 27.56 4.00e-30 123.00
IUUC-Pno-094825 Phaeosphaeria nodorum 46.50 3.00e-67 246.00
IUUC-Ppa-095419 Physcomitrella patens 32.32 2.00e-25 108.00
IUUC-Pfo-096224 Poecilia formosa 26.05 2.00e-30 124.00
IUUC-Pab-098501 Pongo abelii 25.32 1.00e-25 108.00
IUUC-Pop-099243 Populus trichocarpa 38.95 1.00e-24 105.00
IUUC-Ppe-101255 Prunus persica 37.37 5.00e-26 109.00
IUUC-Pva-102828 Pteropus vampyrus 25.32 4.00e-25 106.00
IUUC-Pgr-103672 Puccinia graminis 24.71 3.00e-20 90.90
IUUC-Ptt-104013 Puccinia triticina 25.63 5.00e-21 93.20
IUUC-Pyt-104615 Pyrenophora triticirepentis 43.43 4.00e-74 269.00
IUUC-Rno-106089 Rattus norvegicus 23.86 2.00e-20 90.90
IUUC-Sce-106216 Saccharomyces cerevisiae 23.15 2.00e-09 54.70
IUUC-Sha-106484 Sarcophilus harrisii 26.37 5.00e-29 119.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 31.09 2.00e-38 150.00
IUUC-Spo-108177 Schizosaccharomyces pombe 27.83 4.00e-29 119.00
IUUC-Ssl-108475 Sclerotinia sclerotiorum 38.36 3.00e-48 183.00
IUUC-Smo-109473 Selaginella moellendorffii 32.22 2.00e-21 94.70
IUUC-Sit-110736 Setaria italica 35.45 2.00e-26 111.00
IUUC-Sly-111657 Solanum lycopersicum 38.00 6.00e-31 126.00
IUUC-Sar-113050 Sorex araneus 30.11 3.00e-18 83.60
IUUC-Sbi-114258 Sorghum bicolor 27.72 1.00e-24 105.00
IUUC-Sre-114902 Sporisorium reilianum 28.70 5.00e-20 90.50
IUUC-Ssc-116166 Sus scrofa 25.40 1.00e-22 97.80
IUUC-Tgu-116814 Taeniopygia guttata 27.01 3.00e-31 127.00
IUUC-Tru-118172 Takifugu rubripes 26.05 1.00e-28 118.00
IUUC-Tsy-119010 Tarsius syrichta 30.66 4.00e-25 106.00
IUUC-Tni-120397 Tetraodon nigroviridis 29.86 2.00e-25 106.00
IUUC-Tca-121283 Theobroma cacao 36.32 1.00e-25 108.00
IUUC-Tvi-122545 Trichoderma virens 36.11 2.00e-39 154.00
IUUC-Tae-122685 Triticum aestivum 28.52 1.00e-24 105.00
IUUC-Tur-126407 Triticum urartu 29.27 7.00e-23 99.40
IUUC-Tme-126913 Tuber melanosporum 42.36 6.00e-71 258.00
IUUC-Tbe-127738 Tupaia belangeri 23.93 1.00e-13 67.80
IUUC-Ttr-128528 Tursiops truncatus 25.40 1.00e-25 108.00
IUUC-Uma-129625 Ustilago maydis 29.18 9.00e-21 93.20
IUUC-Vda-129906 Verticillium dahliae 37.10 2.00e-43 166.00
IUUC-Vpa-130223 Vicugna pacos 25.16 2.00e-24 103.00
IUUC-Vvi-131617 Vitis vinifera 36.32 2.00e-25 108.00
IUUC-Xtr-132288 Xenopus tropicalis 27.33 1.00e-30 124.00
IUUC-Xma-134214 Xiphophorus maculatus 30.33 4.00e-27 112.00
IUUC-Yli-134377 Yarrowia lipolytica 28.81 1.00e-16 77.80
IUUC-Zma-135108 Zea mays 36.31 9.00e-22 95.90
Created Date 25-Jun-2017

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