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Tag Content
iUUCD ID IUUC-Ani-009364
Ensembl Protein ID CADANIAP00003167
UniProt Accession Q5B2Q6; C8VF45; ATG5_EMENI
Genbank Protein ID EAA62355.1; CBF81013.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID AACD01000089; BN001305
Gene Name ANIA_05174; atg5; AN5174
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADANIAG00003167 CADANIAT00003167 CADANIAP00003167
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 25.85 6.00e-15 76.60 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus nidulans
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MEKATLNSIQ KSVWEGQIPL KIVLAPSESR TYDQTDPYLI SYPRISYLPS LLPRLKAFFS 60
SSLIDPTASQ PHDGWFSFEG VPLKWHYPVG LLYDLYAGAE PATKSSETEA LDDEQLPWRL 120
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Protein Fasta Sequence



>IUUC-Ani-009364|E3,Cullin RING/Other|Aspergillus nidulans
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Nucleotide Sequence
(Fasta)
ATGGAAAAAG CCACATTAAA CAGCATCCAG AAATCCGTCT GGGAGGGCCA GATCCCTCTA 60
AAGATTGTCC TTGCTCCATC TGAGAGCCGT ACATACGACC AGACAGACCC CTATCTTGTA 120
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Nucleotide Fasta Sequence



>IUUC-Ani-009364|E3,Cullin RING/Other|Aspergillus nidulans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG ani:AN5174.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 33.15 1.00e-22 100.00
IUUC-Aml-002403 Ailuropoda melanoleuca 27.95 2.00e-22 97.80
IUUC-Atr-002645 Amborella trichopoda 37.86 2.00e-27 114.00
IUUC-Apl-003611 Anas platyrhynchos 24.00 4.00e-26 109.00
IUUC-Aca-004411 Anolis carolinensis 25.15 1.00e-24 105.00
IUUC-Aly-005636 Arabidopsis lyrata 37.22 3.00e-24 103.00
IUUC-Ath-006959 Arabidopsis thaliana 37.22 9.00e-24 102.00
IUUC-Ago-007978 Ashbya gossypii 26.19 7.00e-15 72.40
IUUC-Acl-008328 Aspergillus clavatus 67.25 3.00e-101 359.00
IUUC-Afl-008638 Aspergillus flavus 68.14 4.00e-120 422.00
IUUC-Afu-009042 Aspergillus fumigatus 67.55 3.00e-126 442.00
IUUC-Aor-009889 Aspergillus oryzae 68.44 2.00e-122 429.00
IUUC-Ate-010511 Aspergillus terreus 79.80 9.00e-39 149.00
IUUC-Ame-011644 Astyanax mexicanus 32.47 4.00e-08 47.00
IUUC-Bgr-012153 Blumeria graminis 34.95 3.00e-38 150.00
IUUC-Bta-012360 Bos taurus 31.43 2.00e-20 90.10
IUUC-Bci-013723 Botrytis cinerea 38.14 1.00e-50 191.00
IUUC-Bdi-014520 Brachypodium distachyon 31.69 6.00e-18 83.20
IUUC-Bol-016053 Brassica oleracea 37.22 3.00e-26 110.00
IUUC-Bra-017072 Brassica rapa 36.67 1.00e-26 112.00
IUUC-Cel-018529 Caenorhabditis elegans 23.90 3.00e-13 67.00
IUUC-Cja-019569 Callithrix jacchus 23.08 2.00e-22 97.80
IUUC-Cfa-020473 Canis familiaris 23.38 6.00e-23 99.40
IUUC-Cpo-021421 Cavia porcellus 23.08 2.00e-23 100.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 31.43 2.00e-15 74.30
IUUC-Csa-024197 Chlorocebus sabaeus 23.08 2.00e-22 97.40
IUUC-Cho-024521 Choloepus hoffmanni 22.15 3.00e-16 76.60
IUUC-Cin-025119 Ciona intestinalis 27.67 6.00e-21 92.40
IUUC-Csv-026192 Ciona savignyi 23.78 2.00e-23 100.00
IUUC-Cgl-026686 Colletotrichum gloeosporioides 33.72 2.00e-35 140.00
IUUC-Dre-028466 Danio rerio 28.82 8.00e-27 112.00
IUUC-Dse-031228 Dothistroma septosporum 44.28 9.00e-83 298.00
IUUC-Dme-031703 Drosophila melanogaster 26.09 2.00e-21 94.00
IUUC-Ete-032482 Echinops telfairi 28.25 2.00e-16 77.80
IUUC-Eca-034036 Equus caballus 23.69 3.00e-23 100.00
IUUC-Eeu-035235 Erinaceus europaeus 31.43 3.00e-20 90.50
IUUC-Fca-036263 Felis catus 23.38 8.00e-23 99.00
IUUC-Fal-037064 Ficedula albicollis 24.31 1.00e-26 111.00
IUUC-Fox-037813 Fusarium oxysporum 35.76 3.00e-43 166.00
IUUC-Fso-038139 Fusarium solani 36.78 4.00e-42 162.00
IUUC-Gmo-039509 Gadus morhua 28.16 2.00e-24 103.00
IUUC-Ggr-040111 Gaeumannomyces graminis 36.36 2.00e-38 151.00
IUUC-Gga-040517 Gallus gallus 24.00 4.00e-26 109.00
IUUC-Gac-042270 Gasterosteus aculeatus 28.05 1.00e-24 105.00
IUUC-Gma-044400 Glycine max 36.70 9.00e-26 108.00
IUUC-Ggo-045048 Gorilla gorilla 23.08 8.00e-23 99.00
IUUC-Hsa-046744 Homo sapiens 23.08 1.00e-22 98.20
IUUC-Kpa-049174 Komagataella pastoris 25.97 3.00e-30 123.00
IUUC-Lch-049475 Latimeria chalumnae 25.91 2.00e-27 114.00
IUUC-Lpe-051283 Leersia perrieri 37.01 2.00e-22 99.80
IUUC-Loc-052446 Lepisosteus oculatus 23.38 4.00e-26 110.00
IUUC-Lma-053278 Leptosphaeria maculans 47.65 3.00e-79 286.00
IUUC-Laf-054020 Loxodonta africana 27.51 5.00e-22 96.30
IUUC-Mcc-055176 Macaca mulatta 23.08 1.00e-22 98.20
IUUC-Mor-057164 Magnaporthe oryzae 36.64 2.00e-42 164.00
IUUC-Mpo-057428 Magnaporthe poae 38.40 2.00e-35 140.00
IUUC-Mtr-058424 Medicago truncatula 37.23 3.00e-26 110.00
IUUC-Mla-058872 Melampsora laricipopulina 25.00 4.00e-23 100.00
IUUC-Mga-059859 Meleagris gallopavo 24.00 4.00e-26 109.00
IUUC-Mmr-061482 Microcebus murinus 23.38 7.00e-23 99.00
IUUC-Mdo-062371 Monodelphis domestica 24.31 2.00e-25 107.00
IUUC-Mmu-063139 Mus musculus 23.38 8.00e-23 99.00
IUUC-Mac-065332 Musa acuminata 38.33 9.00e-27 112.00
IUUC-Mpu-066783 Mustela putorius furo 23.38 2.00e-23 100.00
IUUC-Mlu-068165 Myotis lucifugus 27.95 6.00e-22 95.90
IUUC-Nfi-068578 Neosartorya fischeri 67.85 1.00e-127 447.00
IUUC-Ncr-068636 Neurospora crassa 36.01 2.00e-40 158.00
IUUC-Nle-069740 Nomascus leucogenys 23.08 2.00e-22 97.40
IUUC-Opr-070802 Ochotona princeps 30.29 7.00e-20 89.00
IUUC-Ont-072222 Oreochromis niloticus 28.14 5.00e-25 106.00
IUUC-Oan-072760 Ornithorhynchus anatinus 29.27 4.00e-23 99.80
IUUC-Oba-075834 Oryza barthii 35.52 1.00e-24 105.00
IUUC-Obr-076230 Oryza brachyantha 32.11 2.00e-12 64.70
IUUC-Ogl-077554 Oryza glaberrima 35.52 9.00e-25 105.00
IUUC-Ogu-078687 Oryza glumaepatula 34.97 1.00e-24 105.00
IUUC-Oin-079677 Oryza indica 34.11 3.00e-25 107.00
IUUC-Olo-081078 Oryza longistaminata 37.09 6.00e-23 100.00
IUUC-Ome-081548 Oryza meridionalis 34.76 1.00e-26 113.00
IUUC-Oni-082050 Oryza nivara 36.56 4.00e-25 107.00
IUUC-Opu-083609 Oryza punctata 35.29 4.00e-25 107.00
IUUC-Oru-085057 Oryza rufipogon 35.29 5.00e-25 106.00
IUUC-Osa-085917 Oryza sativa 35.52 3.00e-25 107.00
IUUC-Ola-087032 Oryzias latipes 28.51 2.00e-25 107.00
IUUC-Oga-088468 Otolemur garnettii 28.82 2.00e-25 107.00
IUUC-Oar-089751 Ovis aries 24.31 2.00e-23 101.00
IUUC-Ptr-091064 Pan troglodytes 23.08 1.00e-22 98.20
IUUC-Pan-092505 Papio anubis 27.51 4.00e-22 96.30
IUUC-Psi-093086 Pelodiscus sinensis 25.15 2.00e-24 103.00
IUUC-Pno-094825 Phaeosphaeria nodorum 43.89 8.00e-63 231.00
IUUC-Ppa-095419 Physcomitrella patens 32.62 1.00e-24 105.00
IUUC-Pfo-096224 Poecilia formosa 29.10 3.00e-27 113.00
IUUC-Pab-098501 Pongo abelii 23.08 8.00e-23 99.00
IUUC-Pop-099243 Populus trichocarpa 41.11 3.00e-25 107.00
IUUC-Ppe-101255 Prunus persica 38.04 5.00e-26 109.00
IUUC-Pva-102828 Pteropus vampyrus 23.69 2.00e-22 97.80
IUUC-Pgr-103672 Puccinia graminis 25.00 2.00e-21 94.70
IUUC-Ptt-104013 Puccinia triticina 25.00 1.00e-21 95.50
IUUC-Pyt-104615 Pyrenophora triticirepentis 44.25 4.00e-72 262.00
IUUC-Rno-106089 Rattus norvegicus 22.48 7.00e-18 82.40
IUUC-Sce-106216 Saccharomyces cerevisiae 25.85 7.00e-16 75.90
IUUC-Sha-106484 Sarcophilus harrisii 24.31 5.00e-26 109.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 27.73 2.00e-34 137.00
IUUC-Spo-108177 Schizosaccharomyces pombe 26.77 6.00e-28 115.00
IUUC-Ssl-108475 Sclerotinia sclerotiorum 36.17 2.00e-47 180.00
IUUC-Smo-109473 Selaginella moellendorffii 30.27 1.00e-22 98.60
IUUC-Sit-110736 Setaria italica 32.79 1.00e-25 108.00
IUUC-Sly-111657 Solanum lycopersicum 40.43 2.00e-31 127.00
IUUC-Sar-113050 Sorex araneus 30.00 1.00e-17 81.30
IUUC-Sbi-114258 Sorghum bicolor 32.02 1.00e-23 102.00
IUUC-Sre-114902 Sporisorium reilianum 28.57 2.00e-20 92.40
IUUC-Ssc-116166 Sus scrofa 23.38 1.00e-21 95.10
IUUC-Tgu-116814 Taeniopygia guttata 24.31 2.00e-26 110.00
IUUC-Tru-118172 Takifugu rubripes 23.08 6.00e-25 105.00
IUUC-Tsy-119010 Tarsius syrichta 29.61 1.00e-23 101.00
IUUC-Tni-120397 Tetraodon nigroviridis 28.78 3.00e-23 99.80
IUUC-Tca-121283 Theobroma cacao 38.30 2.00e-27 114.00
IUUC-Tvi-122545 Trichoderma virens 33.93 1.00e-37 147.00
IUUC-Tae-122685 Triticum aestivum 33.15 3.00e-22 97.10
IUUC-Tur-126407 Triticum urartu 34.36 4.00e-22 97.10
IUUC-Tme-126913 Tuber melanosporum 41.92 4.00e-73 265.00
IUUC-Tbe-127738 Tupaia belangeri 20.97 3.00e-12 63.20
IUUC-Ttr-128528 Tursiops truncatus 24.31 3.00e-23 100.00
IUUC-Uma-129625 Ustilago maydis 30.30 3.00e-20 91.30
IUUC-Vda-129906 Verticillium dahliae 36.31 9.00e-41 158.00
IUUC-Vpa-130223 Vicugna pacos 23.46 8.00e-22 95.50
IUUC-Vvi-131617 Vitis vinifera 37.77 6.00e-27 113.00
IUUC-Xtr-132288 Xenopus tropicalis 25.54 1.00e-26 111.00
IUUC-Xma-134214 Xiphophorus maculatus 29.76 2.00e-25 107.00
IUUC-Yli-134377 Yarrowia lipolytica 27.24 7.00e-17 79.00
IUUC-Zma-135108 Zea mays 33.77 5.00e-22 96.70
Created Date 25-Jun-2017

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