iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063563

UUCD1 version

UUC-MuM-01102

Ensembl Protein ID

ENSMUSP00000085581.6

UniProt Accession

Q9D1C1; Q3TUJ0; UBE2C_MOUSE

Genbank Protein ID

BAB22959.1; BAE35981.1

Protein Name

Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

Genbank Nucleotide ID

AK003722; AK160740

Gene Name

Ube2c; Ubch10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000001403.13	ENSMUST00000088248.12	ENSMUSP00000085581.6
ENSMUSG00000001403.13	ENSMUST00000001439.6	ENSMUSP00000001439.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.60e-44	152.1	34	166

Active Site

Position(s)	Description	Evidence
114	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++el+ l+++  +gisa p+++ +l++w  +i G ++t+Ye+  +kl++efp+ YP+++P+vkflt+++hPnv+++G++Cl+ilk  
   Q: 34   RLQQELMILMTSGDKGISAFPESD-NLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK-- 119
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           +kWs+ ++v+++llsiqsll epn++spln++aael+k+   ++kk +
   Q: 120  DKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT-AFKKYL 166
           ***********************************997655.488765 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MASQNRDPAA ASVAAVRKGA EPCGGAARGP VGKRLQQELM ILMTSGDKGI SAFPESDNLF 60
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTCAAACG CGGGCGGCGG CCCGCAGCCC CGCAGTTGCC CTTTCCTCTC CACACTCCTG 60
TCTCGGTGCC AGTACCTCTG GGATGGCCTC ACAAAACCGC GACCCAGCTG CTGCCAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:0031536--P:positive regulation of exit from mitosis
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:68612

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	95.58	1.00e-93	335.00
IUUC-Atr-002538	Amborella trichopoda	64.29	6.00e-52	196.00
IUUC-Aly-006086	Arabidopsis lyrata	58.18	2.00e-51	194.00
IUUC-Ath-006897	Arabidopsis thaliana	59.09	1.00e-50	192.00
IUUC-Acl-008223	Aspergillus clavatus	66.14	2.00e-38	151.00
IUUC-Afl-008675	Aspergillus flavus	54.82	9.00e-38	149.00
IUUC-Afu-008997	Aspergillus fumigatus	65.35	2.00e-37	147.00
IUUC-Ani-009470	Aspergillus nidulans	56.02	1.00e-38	152.00
IUUC-Ang-009648	Aspergillus niger	60.69	4.00e-38	150.00
IUUC-Aor-009977	Aspergillus oryzae	61.67	1.00e-31	128.00
IUUC-Ate-010318	Aspergillus terreus	52.60	4.00e-38	150.00
IUUC-Ame-011302	Astyanax mexicanus	75.88	1.00e-73	268.00
IUUC-Bta-013101	Bos taurus	97.21	9.00e-99	352.00
IUUC-Bci-013787	Botrytis cinerea	58.49	3.00e-45	174.00
IUUC-Bdi-014144	Brachypodium distachyon	68.57	3.00e-56	211.00
IUUC-Bol-015613	Brassica oleracea	57.40	6.00e-52	196.00
IUUC-Bra-017562	Brassica rapa	57.40	6.00e-52	196.00
IUUC-Cfa-020588	Canis familiaris	97.77	6.00e-96	342.00
IUUC-Cpo-021384	Cavia porcellus	96.65	4.00e-98	349.00
IUUC-Csa-023437	Chlorocebus sabaeus	95.53	2.00e-101	360.00
IUUC-Cho-024330	Choloepus hoffmanni	99.14	5.00e-67	245.00
IUUC-Cin-025365	Ciona intestinalis	55.96	1.00e-31	128.00
IUUC-Csv-025933	Ciona savignyi	59.77	2.00e-57	214.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	56.55	2.00e-45	174.00
IUUC-Cme-027266	Cyanidioschyzon merolae	52.59	2.00e-37	149.00
IUUC-Dre-027375	Danio rerio	75.88	9.00e-74	268.00
IUUC-Dno-029921	Dasypus novemcinctus	94.41	2.00e-92	330.00
IUUC-Dor-030209	Dipodomys ordii	93.30	2.00e-93	334.00
IUUC-Dse-031516	Dothistroma septosporum	54.67	4.00e-38	150.00
IUUC-Dme-031942	Drosophila melanogaster	66.43	2.00e-54	204.00
IUUC-Ete-032827	Echinops telfairi	82.65	1.00e-39	154.00
IUUC-Eca-034073	Equus caballus	97.21	2.00e-95	341.00
IUUC-Eeu-034854	Erinaceus europaeus	73.74	2.00e-67	248.00
IUUC-Fca-035666	Felis catus	97.21	2.00e-95	341.00
IUUC-Fal-037652	Ficedula albicollis	86.67	2.00e-53	199.00
IUUC-Fox-037793	Fusarium oxysporum	56.71	1.00e-44	172.00
IUUC-Fso-038151	Fusarium solani	56.71	2.00e-45	175.00
IUUC-Gmo-038894	Gadus morhua	77.22	5.00e-60	223.00
IUUC-Ggr-039730	Gaeumannomyces graminis	61.76	1.00e-35	142.00
IUUC-Gga-040537	Gallus gallus	86.03	1.00e-69	254.00
IUUC-Gac-041346	Gasterosteus aculeatus	72.16	2.00e-61	228.00
IUUC-Gma-043989	Glycine max	57.49	1.00e-53	201.00
IUUC-Ggo-045594	Gorilla gorilla	94.48	6.00e-100	356.00
IUUC-Hsa-046216	Homo sapiens	95.53	2.00e-101	360.00
IUUC-Hvu-047797	Hordeum vulgare	69.40	2.00e-53	201.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	97.21	2.00e-95	341.00
IUUC-Kpa-049294	Komagataella pastoris	61.97	9.00e-47	179.00
IUUC-Lch-049761	Latimeria chalumnae	68.72	1.00e-69	254.00
IUUC-Lpe-051089	Leersia perrieri	62.82	3.00e-54	204.00
IUUC-Loc-052297	Lepisosteus oculatus	75.88	1.00e-71	263.00
IUUC-Lma-053214	Leptosphaeria maculans	55.63	2.00e-43	167.00
IUUC-Laf-054468	Loxodonta africana	94.48	2.00e-99	354.00
IUUC-Mcc-055338	Macaca mulatta	95.53	2.00e-101	360.00
IUUC-Meu-056147	Macropus eugenii	91.06	6.00e-92	329.00
IUUC-Mor-057239	Magnaporthe oryzae	58.78	3.00e-42	164.00
IUUC-Mpo-057491	Magnaporthe poae	63.24	3.00e-44	171.00
IUUC-Mtr-057687	Medicago truncatula	59.64	2.00e-48	184.00
IUUC-Mla-058880	Melampsora laricipopulina	62.86	8.00e-49	186.00
IUUC-Mga-059929	Meleagris gallopavo	86.73	6.00e-49	184.00
IUUC-Mvi-060528	Microbotryum violaceum	58.11	2.00e-44	172.00
IUUC-Mmr-060747	Microcebus murinus	96.89	3.00e-84	303.00
IUUC-Mdo-062343	Monodelphis domestica	92.22	2.00e-92	331.00
IUUC-Mac-064823	Musa acuminata	63.12	4.00e-52	197.00
IUUC-Mpu-065746	Mustela putorius furo	96.69	2.00e-94	337.00
IUUC-Mlu-067388	Myotis lucifugus	95.58	9.00e-94	335.00
IUUC-Nfi-068577	Neosartorya fischeri	62.32	6.00e-38	149.00
IUUC-Ncr-068803	Neurospora crassa	55.83	1.00e-38	152.00
IUUC-Opr-070902	Ochotona princeps	93.33	2.00e-93	333.00
IUUC-Ont-071672	Oreochromis niloticus	69.14	3.00e-63	233.00
IUUC-Oan-073728	Ornithorhynchus anatinus	83.13	2.00e-38	150.00
IUUC-Ocu-074566	Oryctolagus cuniculus	93.33	6.00e-91	326.00
IUUC-Oba-075538	Oryza barthii	67.18	4.00e-51	192.00
IUUC-Obr-076757	Oryza brachyantha	70.65	2.00e-36	143.00
IUUC-Ogu-078467	Oryza glumaepatula	65.75	3.00e-55	207.00
IUUC-Oin-079533	Oryza indica	66.41	2.00e-50	191.00
IUUC-Olo-080673	Oryza longistaminata	67.94	1.00e-51	194.00
IUUC-Ome-081483	Oryza meridionalis	67.14	2.00e-54	204.00
IUUC-Oni-082321	Oryza nivara	65.75	3.00e-55	207.00
IUUC-Opu-083245	Oryza punctata	65.71	3.00e-53	201.00
IUUC-Oru-084641	Oryza rufipogon	62.99	2.00e-53	201.00
IUUC-Osa-085992	Oryza sativa	65.75	3.00e-55	207.00
IUUC-Ola-086807	Oryzias latipes	71.35	5.00e-70	256.00
IUUC-Olu-087834	Ostreococcus lucimarinus	70.80	2.00e-55	207.00
IUUC-Oga-088699	Otolemur garnettii	95.05	2.00e-100	357.00
IUUC-Oar-089542	Ovis aries	96.69	2.00e-94	337.00
IUUC-Ptr-091069	Pan troglodytes	95.53	2.00e-101	360.00
IUUC-Pan-092533	Papio anubis	94.48	7.00e-100	355.00
IUUC-Psi-093581	Pelodiscus sinensis	68.29	3.00e-58	217.00
IUUC-Pma-094607	Petromyzon marinus	71.18	6.00e-69	252.00
IUUC-Pno-094829	Phaeosphaeria nodorum	61.42	2.00e-42	164.00
IUUC-Ppa-095861	Physcomitrella patens	66.43	1.00e-54	205.00
IUUC-Pfo-096836	Poecilia formosa	69.54	1.00e-65	241.00
IUUC-Pab-098707	Pongo abelii	95.53	2.00e-101	360.00
IUUC-Pop-099870	Populus trichocarpa	66.43	2.00e-53	201.00
IUUC-Pca-100661	Procavia capensis	95.53	4.00e-97	346.00
IUUC-Ppe-101289	Prunus persica	56.57	1.00e-52	199.00
IUUC-Pva-103235	Pteropus vampyrus	92.18	7.00e-87	312.00
IUUC-Pte-104292	Pyrenophora teres	60.15	7.00e-44	169.00
IUUC-Rno-105501	Rattus norvegicus	97.21	2.00e-98	350.00
IUUC-Sce-106133	Saccharomyces cerevisiae	62.02	6.00e-37	146.00
IUUC-Sha-107205	Sarcophilus harrisii	91.03	8.00e-76	275.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	56.98	5.00e-50	190.00
IUUC-Spo-108136	Schizosaccharomyces pombe	55.81	2.00e-49	188.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	58.49	2.00e-45	174.00
IUUC-Smo-109459	Selaginella moellendorffii	66.18	5.00e-53	200.00
IUUC-Sit-110754	Setaria italica	66.43	1.00e-54	205.00
IUUC-Sly-111137	Solanum lycopersicum	65.49	7.00e-53	199.00
IUUC-Stu-112305	Solanum tuberosum	65.28	3.00e-53	200.00
IUUC-Sbi-114299	Sorghum bicolor	63.38	5.00e-51	193.00
IUUC-Ssc-115625	Sus scrofa	96.65	2.00e-95	341.00
IUUC-Tru-118289	Takifugu rubripes	76.74	8.00e-37	144.00
IUUC-Tni-120070	Tetraodon nigroviridis	70.99	5.00e-55	206.00
IUUC-Tca-121158	Theobroma cacao	66.43	2.00e-53	201.00
IUUC-Tre-121973	Trichoderma reesei	57.23	2.00e-44	171.00
IUUC-Tvi-122496	Trichoderma virens	57.83	6.00e-45	173.00
IUUC-Tae-123596	Triticum aestivum	65.75	1.00e-55	208.00
IUUC-Tur-126818	Triticum urartu	65.52	1.00e-42	164.00
IUUC-Tme-127044	Tuber melanosporum	65.69	1.00e-41	162.00
IUUC-Ttr-128548	Tursiops truncatus	76.54	9.00e-68	249.00
IUUC-Vda-129840	Verticillium dahliae	56.29	2.00e-44	171.00
IUUC-Vvi-131685	Vitis vinifera	60.84	7.00e-55	206.00
IUUC-Xtr-132953	Xenopus tropicalis	79.33	1.00e-81	295.00
IUUC-Xma-134093	Xiphophorus maculatus	69.54	1.00e-65	241.00
IUUC-Yli-134548	Yarrowia lipolytica	56.07	8.00e-50	189.00
IUUC-Zma-135182	Zea mays	65.71	6.00e-54	202.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence