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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106290
Ensembl Protein ID YDR477W
UniProt Accession P06782; D6VTA0; SNF1_YEAST
Genbank Protein ID AAA35058.1; AAB64904.1; DAA12310.1
Protein Name Carbon catabolite-derepressing protein kinase; Sucrose nonfermentating protein 1
Genbank Nucleotide ID M13971; U33050; BK006938
Gene Name SNF1; CAT1; CCR1; GLC2; PAS14; YDR477W; D8035.20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR477W YDR477W YDR477W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMPhospho.ELM
UniProtPHOSIDABioGRIDPhosphoBase
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 55.88 3.00e-104 376.00 IUUC-Ath-007014
UBD/Alpha-Helix/UBA 46.92 6.00e-145 509.00 IUUC-Spo-108202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Serine/threonine protein kinase essential for release from glucose repression (PubMed:3526554, PubMed:6366512, PubMed:3049551, PubMed:1944227, PubMed:8289797, PubMed:8628258, PubMed:25869125). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:8289797, PubMed:26667037). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (PubMed:15719021). The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR) (PubMed:25730376, PubMed:26394309). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway (PubMed:25428989). SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway (PubMed:26309257). Also phosphorylates and regulates the transcriptional activator CAT8 (PubMed:15121831).
 Serine/threonine protein kinase essential for release from glucose repression (PubMed:3526554, PubMed:6366512, PubMed:3049551, PubMed:1944227, PubMed:8289797, PubMed:8628258, PubMed:25869125). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:8289797, PubMed:26667037). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (PubMed:15719021). The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR) (PubMed:25730376, PubMed:26394309). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway (PubMed:25428989). SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway (PubMed:26309257). Also phosphorylates and regulates the transcriptional activator CAT8 (PubMed:15121831).
Protein Sequence
(Fasta)
MSSNNNTNTA PANANSSHHH HHHHHHHHHH GHGGSNSTLN NPKSSLADGA HIGNYQIVKT 60
LGEGSFGKVK LAYHTTTGQK VALKIINKKV LAKSDMQGRI EREISYLRLL RHPHIIKLYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106290|UBD,UBA|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAGCAGTA ACAACAACAC AAACACAGCA CCTGCCAATG CAAATTCTAG CCACCACCAC 60
CACCATCACC ACCATCACCA CCACCATCAC GGTCATGGCG GAAGCAACTC GACGCTAAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106290|UBD,UBA|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR013896--SNF1_UBA
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF16579--AdenylateSensor
PF00069--Pkinase
PF08587--UBA_2
SMART

SM00220--S_TKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000324--C:fungal-type vacuole
GO:0005641--C:nuclear envelope lumen
GO:0031965--C:nuclear membrane
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0005975--P:carbohydrate metabolic process
GO:0007155--P:cell adhesion
GO:0006995--P:cellular response to nitrogen starvation
GO:0071940--P:fungal-type cell wall assembly
GO:0035556--P:intracellular signal transduction
GO:0001403--P:invasive growth in response to glucose limitation
GO:0017148--P:negative regulation of translation
GO:1900436--P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0016239--P:positive regulation of macroautophagy
GO:0006468--P:protein phosphorylation
GO:0007124--P:pseudohyphal growth
GO:0001302--P:replicative cell aging
GO:0006986--P:response to unfolded protein
GO:0090606--P:single-species surface biofilm formation
KEGG sce:YDR477W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000713 Aegilops tauschii 40.97 4.00e-108 383.00
IUUC-Aml-001907 Ailuropoda melanoleuca 40.86 1.00e-104 371.00
IUUC-Atr-002770 Amborella trichopoda 53.78 9.00e-108 381.00
IUUC-Apl-003395 Anas platyrhynchos 42.34 4.00e-112 396.00
IUUC-Aca-004480 Anolis carolinensis 42.10 2.00e-117 414.00
IUUC-Aly-006289 Arabidopsis lyrata 41.73 5.00e-110 389.00
IUUC-Ath-007014 Arabidopsis thaliana 41.65 9.00e-111 391.00
IUUC-Ago-007957 Ashbya gossypii 76.01 0.00e+00 910.00
IUUC-Acl-008103 Aspergillus clavatus 45.60 8.00e-124 435.00
IUUC-Afl-008555 Aspergillus flavus 51.40 3.00e-123 434.00
IUUC-Afu-008949 Aspergillus fumigatus 52.44 2.00e-122 431.00
IUUC-Ani-009408 Aspergillus nidulans 56.23 2.00e-119 421.00
IUUC-Ang-009551 Aspergillus niger 51.88 5.00e-121 426.00
IUUC-Aor-010176 Aspergillus oryzae 51.40 3.00e-123 433.00
IUUC-Ate-010287 Aspergillus terreus 49.89 1.00e-118 419.00
IUUC-Ame-011019 Astyanax mexicanus 41.90 4.00e-115 406.00
IUUC-Bgr-012045 Blumeria graminis 50.48 2.00e-136 477.00
IUUC-Bta-012786 Bos taurus 40.86 8.00e-105 372.00
IUUC-Bci-013774 Botrytis cinerea 47.66 1.00e-136 478.00
IUUC-Bdi-014319 Brachypodium distachyon 41.83 2.00e-111 393.00
IUUC-Bol-016434 Brassica oleracea 40.79 3.00e-107 380.00
IUUC-Bra-016750 Brassica rapa 54.71 2.00e-106 377.00
IUUC-Cel-018518 Caenorhabditis elegans 41.90 1.00e-111 394.00
IUUC-Cja-019386 Callithrix jacchus 42.46 3.00e-117 413.00
IUUC-Cfa-020177 Canis familiaris 39.89 2.00e-104 370.00
IUUC-Cpo-021805 Cavia porcellus 42.46 8.00e-117 411.00
IUUC-Cre-022915 Chlamydomonas reinhardtii 50.15 2.00e-88 316.00
IUUC-Csa-024267 Chlorocebus sabaeus 42.46 3.00e-117 413.00
IUUC-Cho-024859 Choloepus hoffmanni 39.32 8.00e-101 358.00
IUUC-Cin-025550 Ciona intestinalis 43.84 4.00e-125 439.00
IUUC-Csv-026139 Ciona savignyi 45.25 1.00e-125 441.00
IUUC-Cgl-026480 Colletotrichum gloeosporioides 41.96 1.00e-64 239.00
IUUC-Cne-027044 Cryptococcus neoformans 51.92 7.00e-112 395.00
IUUC-Cme-027289 Cyanidioschyzon merolae 64.55 4.00e-103 366.00
IUUC-Dre-027749 Danio rerio 41.60 3.00e-111 393.00
IUUC-Dno-030006 Dasypus novemcinctus 41.23 4.00e-105 373.00
IUUC-Dor-030578 Dipodomys ordii 42.28 1.00e-116 411.00
IUUC-Dse-031507 Dothistroma septosporum 49.54 4.00e-142 496.00
IUUC-Dme-031704 Drosophila melanogaster 40.34 1.00e-113 401.00
IUUC-Ete-033055 Echinops telfairi 40.11 4.00e-104 369.00
IUUC-Eca-034016 Equus caballus 42.15 6.00e-110 389.00
IUUC-Eeu-034949 Erinaceus europaeus 44.32 2.00e-82 297.00
IUUC-Fca-035754 Felis catus 40.33 4.00e-102 363.00
IUUC-Fal-037363 Ficedula albicollis 40.67 7.00e-105 372.00
IUUC-Fox-038073 Fusarium oxysporum 43.15 4.00e-139 486.00
IUUC-Fso-038236 Fusarium solani 43.26 2.00e-135 474.00
IUUC-Gmo-039633 Gadus morhua 41.50 9.00e-114 401.00
IUUC-Ggr-039987 Gaeumannomyces graminis 41.99 3.00e-143 500.00
IUUC-Gga-040546 Gallus gallus 42.46 5.00e-118 416.00
IUUC-Gac-041822 Gasterosteus aculeatus 41.64 2.00e-113 400.00
IUUC-Gma-042824 Glycine max 40.39 4.00e-110 389.00
IUUC-Ggo-045303 Gorilla gorilla 42.46 2.00e-117 413.00
IUUC-Hsa-045746 Homo sapiens 42.46 2.00e-117 413.00
IUUC-Hvu-047406 Hordeum vulgare 42.37 3.00e-112 396.00
IUUC-Itr-048134 Ictidomys tridecemlineatus 42.65 1.00e-117 414.00
IUUC-Kpa-049190 Komagataella pastoris 64.57 0.00e+00 741.00
IUUC-Lch-049623 Latimeria chalumnae 40.49 1.00e-103 368.00
IUUC-Lpe-051392 Leersia perrieri 53.95 2.00e-109 387.00
IUUC-Loc-052928 Lepisosteus oculatus 42.62 4.00e-116 409.00
IUUC-Lma-053054 Leptosphaeria maculans 51.19 3.00e-145 507.00
IUUC-Laf-053459 Loxodonta africana 42.65 2.00e-118 417.00
IUUC-Mcc-055862 Macaca mulatta 42.46 2.00e-117 413.00
IUUC-Meu-056525 Macropus eugenii 44.67 1.00e-82 298.00
IUUC-Mor-057170 Magnaporthe oryzae 42.68 3.00e-145 507.00
IUUC-Mpo-057302 Magnaporthe poae 41.78 2.00e-144 503.00
IUUC-Mtr-058309 Medicago truncatula 41.32 1.00e-107 381.00
IUUC-Mla-059058 Melampsora laricipopulina 45.42 2.00e-129 453.00
IUUC-Mga-059206 Meleagris gallopavo 41.95 7.00e-111 392.00
IUUC-Mvi-060337 Microbotryum violaceum 46.56 7.00e-127 446.00
IUUC-Mmr-061619 Microcebus murinus 42.65 3.00e-117 413.00
IUUC-Mdo-062160 Monodelphis domestica 42.83 5.00e-118 416.00
IUUC-Mmu-063406 Mus musculus 42.28 1.00e-116 411.00
IUUC-Mac-064518 Musa acuminata 55.20 5.00e-105 372.00
IUUC-Mpu-066326 Mustela putorius furo 42.15 3.00e-110 389.00
IUUC-Mlu-067968 Myotis lucifugus 41.54 6.00e-109 385.00
IUUC-Nfi-068493 Neosartorya fischeri 52.54 6.00e-124 436.00
IUUC-Ncr-068665 Neurospora crassa 45.60 2.00e-149 521.00
IUUC-Nle-070158 Nomascus leucogenys 42.46 3.00e-117 413.00
IUUC-Opr-070272 Ochotona princeps 40.14 7.00e-101 359.00
IUUC-Ont-071395 Oreochromis niloticus 42.06 3.00e-115 406.00
IUUC-Oan-073322 Ornithorhynchus anatinus 39.29 3.00e-103 366.00
IUUC-Ocu-074188 Oryctolagus cuniculus 40.00 5.00e-101 359.00
IUUC-Oba-075436 Oryza barthii 53.64 1.00e-110 391.00
IUUC-Obr-076507 Oryza brachyantha 53.44 6.00e-109 385.00
IUUC-Ogl-077718 Oryza glaberrima 55.33 8.00e-106 375.00
IUUC-Ogu-078349 Oryza glumaepatula 53.64 1.00e-110 391.00
IUUC-Oin-079889 Oryza indica 55.04 5.00e-105 372.00
IUUC-Olo-080521 Oryza longistaminata 53.64 2.00e-110 390.00
IUUC-Ome-081630 Oryza meridionalis 53.37 4.00e-110 389.00
IUUC-Oni-082211 Oryza nivara 53.64 9.00e-111 392.00
IUUC-Opu-083617 Oryza punctata 56.60 5.00e-109 385.00
IUUC-Oru-084252 Oryza rufipogon 53.64 2.00e-110 390.00
IUUC-Osa-085548 Oryza sativa 53.64 2.00e-110 390.00
IUUC-Ola-086366 Oryzias latipes 42.43 4.00e-114 403.00
IUUC-Olu-087861 Ostreococcus lucimarinus 66.42 4.00e-106 376.00
IUUC-Oga-088003 Otolemur garnettii 41.08 8.00e-105 372.00
IUUC-Oar-089933 Ovis aries 40.86 8.00e-105 372.00
IUUC-Ptr-090741 Pan troglodytes 42.46 2.00e-117 413.00
IUUC-Pan-092526 Papio anubis 41.08 6.00e-105 372.00
IUUC-Psi-094034 Pelodiscus sinensis 40.67 7.00e-105 372.00
IUUC-Pma-094666 Petromyzon marinus 45.77 2.00e-83 301.00
IUUC-Pno-095030 Phaeosphaeria nodorum 62.75 8.00e-129 451.00
IUUC-Ppa-095615 Physcomitrella patens 41.81 2.00e-109 387.00
IUUC-Pfo-097050 Poecilia formosa 41.34 1.00e-111 394.00
IUUC-Pab-098023 Pongo abelii 42.46 2.00e-117 413.00
IUUC-Pop-100042 Populus trichocarpa 55.98 8.00e-108 382.00
IUUC-Pca-101104 Procavia capensis 57.24 6.00e-93 332.00
IUUC-Ppe-101642 Prunus persica 56.40 2.00e-107 380.00
IUUC-Pva-102470 Pteropus vampyrus 42.28 6.00e-115 405.00
IUUC-Pgr-103406 Puccinia graminis 41.75 1.00e-114 405.00
IUUC-Ptt-103713 Puccinia triticina 40.73 1.00e-93 335.00
IUUC-Pte-104259 Pyrenophora teres 50.64 2.00e-144 504.00
IUUC-Pyt-104752 Pyrenophora triticirepentis 51.20 2.00e-144 504.00
IUUC-Rno-104960 Rattus norvegicus 42.46 2.00e-116 410.00
IUUC-Sha-107603 Sarcophilus harrisii 41.04 8.00e-105 372.00
IUUC-Sja-107772 Schizosaccharomyces japonicus 47.29 2.00e-140 490.00
IUUC-Spo-108202 Schizosaccharomyces pombe 46.68 2.00e-149 520.00
IUUC-Ssl-108535 Sclerotinia sclerotiorum 43.30 2.00e-139 487.00
IUUC-Smo-109309 Selaginella moellendorffii 41.67 2.00e-112 397.00
IUUC-Sit-109745 Setaria italica 49.39 2.00e-109 387.00
IUUC-Sly-110890 Solanum lycopersicum 56.18 3.00e-106 376.00
IUUC-Stu-112144 Solanum tuberosum 58.77 4.00e-107 379.00
IUUC-Sar-113521 Sorex araneus 38.13 1.00e-79 288.00
IUUC-Sbi-114764 Sorghum bicolor 41.29 3.00e-111 393.00
IUUC-Sre-115141 Sporisorium reilianum 53.54 3.00e-128 450.00
IUUC-Ssc-115732 Sus scrofa 40.27 1.00e-103 367.00
IUUC-Tgu-117190 Taeniopygia guttata 40.67 1.00e-104 371.00
IUUC-Tru-118735 Takifugu rubripes 42.24 1.00e-116 411.00
IUUC-Tsy-119503 Tarsius syrichta 41.76 1.00e-106 378.00
IUUC-Tni-119833 Tetraodon nigroviridis 41.79 9.00e-113 398.00
IUUC-Tca-121386 Theobroma cacao 53.15 2.00e-107 380.00
IUUC-Tre-122070 Trichoderma reesei 42.82 2.00e-142 497.00
IUUC-Tvi-122305 Trichoderma virens 41.81 4.00e-138 483.00
IUUC-Tae-124621 Triticum aestivum 42.11 5.00e-112 395.00
IUUC-Tur-126416 Triticum urartu 42.11 8.00e-112 395.00
IUUC-Tme-127174 Tuber melanosporum 42.10 3.00e-108 383.00
IUUC-Tbe-127501 Tupaia belangeri 49.23 4.00e-75 274.00
IUUC-Ttr-129224 Tursiops truncatus 40.33 4.00e-102 363.00
IUUC-Uma-129372 Ustilago maydis 51.24 2.00e-127 447.00
IUUC-Vda-129819 Verticillium dahliae 40.15 5.00e-121 426.00
IUUC-Vpa-130220 Vicugna pacos 41.95 4.00e-110 389.00
IUUC-Vvi-131649 Vitis vinifera 55.72 2.00e-105 374.00
IUUC-Xtr-132954 Xenopus tropicalis 43.30 2.00e-118 417.00
IUUC-Xma-134119 Xiphophorus maculatus 41.87 4.00e-114 403.00
IUUC-Yli-134422 Yarrowia lipolytica 61.61 0.00e+00 730.00
IUUC-Zma-135621 Zea mays 50.38 1.00e-110 391.00
Created Date 25-Jun-2017

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