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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045982
UUCD1 version UUC-HoS-01175
Ensembl Protein ID ENSP00000366568.4
UniProt Accession P22314; Q5JRR8; Q96E13; UBA1_HUMAN
Genbank Protein ID CAA40296.1; AAA61246.1; CAI41708.1; EAW59290.1; AAH13041.1; CAA37078.1
Protein Name Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; Ubiquitin-activating enzyme E1
Genbank Nucleotide ID X56976; M58028; AL513366; CH471164; BC013041; X52897
Gene Name UBA1; A1S9T; UBE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130985.16 ENST00000377351.8 ENSP00000366568.4
ENSG00000130985.16 ENST00000442035.5 ENSP00000389583.1
ENSG00000130985.16 ENST00000451702.2 ENSP00000401101.1
ENSG00000130985.16 ENST00000377269.3 ENSP00000366481.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
DrugBankManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E1 E1_ThiF 16139798; 22456334
Classification
Family E-value Score Start End
E1 6.30e-240 798.0 451 931
Active Site
Position(s) Description Evidence
632 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpd 87
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+i v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++np+
   Q: 451  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgegGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPH 542
           ******************************************************************************************** PP
   S: 88   vnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctl 176
           ++v++h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+iP+ctl
   Q: 543  IRVTSHQNRVGPDTERIYdddFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTL 634
           ******************************************************************************************** PP
   S: 177  ketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikql 256
           k++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a+++++++++n+i+ql
   Q: 635  KNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQL 725
           *********************************.999999**************************************************** PP
   S: 257  lksfecdivtkskspfwv..........................................sfcsnaealqvp........ekvekdeevvka 298
           l++f++d++t+s++pfw+                                           + ++ +++qvp        + +++d+e ++a
   Q: 726  LHNFPPDQLTSSGAPFWSgpkrcphpltfdvnnplhldyvmaaanlfaqtygltgsqdraAVATFLQSVQVPeftpksgvKIHVSDQELQSA 817
           *********************************************************99977777777777755555555666666666666 PP
   S: 299  sap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqE 383
           +a+     l+ l+++l + +k +g k++ ++fekddds  ++d++ aa+nlrae+++i++ +d+++ k iag+iipaiatt+a+v Gl+++E
   Q: 818  NASvddsrLEELKATLPSPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDIPS-ADRHKSKLIAGKIIPAIATTTAAVVGLVCLE 908
           66688999****************************************************.******************************* PP
   S: 384  viKvvsg..kfeplknfflfdae 404
           ++Kvv+g  + + +kn fl++a+
   Q: 909  LYKVVQGhrQLDSYKNGFLNLAL 931
           *******999*********9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
 Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
Protein Sequence
(Fasta)
MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL SEVPSVPTNG MAKNGSEADI DEGLYSRQLY 60
VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTAQWA DLSSQFYLRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045982|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGTACGAC AGAGGTGGTT TGCTCTTCCG TTGCCCCGTG GCTTCAGCTC ATCTTTGGCA 60
GGAAGGCGAG GCTTCCGCCC GGCACAGGGG GTGAGCTGGA GCACCGTGCC CCCAAGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045982|E1,E1_ThiF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0436--Ligase
KW-0496--Mitochondrion
KW-0523--Neurodegeneration
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016567--P:protein ubiquitination
KEGG hsa:7317
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000367 Aegilops tauschii 46.51 0.00e+00 867.00
IUUC-Aml-001311 Ailuropoda melanoleuca 96.23 0.00e+00 2092.00
IUUC-Atr-002684 Amborella trichopoda 45.68 0.00e+00 897.00
IUUC-Aca-004620 Anolis carolinensis 80.46 0.00e+00 1785.00
IUUC-Aly-005515 Arabidopsis lyrata 45.74 0.00e+00 915.00
IUUC-Ath-006891 Arabidopsis thaliana 46.23 0.00e+00 923.00
IUUC-Ago-007873 Ashbya gossypii 54.48 0.00e+00 1061.00
IUUC-Acl-008181 Aspergillus clavatus 54.31 0.00e+00 1075.00
IUUC-Afl-008455 Aspergillus flavus 54.13 0.00e+00 1039.00
IUUC-Afu-009065 Aspergillus fumigatus 53.86 0.00e+00 1088.00
IUUC-Ani-009371 Aspergillus nidulans 53.68 0.00e+00 1055.00
IUUC-Ang-009737 Aspergillus niger 54.32 0.00e+00 1077.00
IUUC-Aor-010007 Aspergillus oryzae 54.13 0.00e+00 1038.00
IUUC-Ate-010466 Aspergillus terreus 54.07 0.00e+00 1105.00
IUUC-Ame-010933 Astyanax mexicanus 78.85 0.00e+00 1686.00
IUUC-Bgr-012281 Blumeria graminis 53.63 0.00e+00 1090.00
IUUC-Bta-012767 Bos taurus 96.60 0.00e+00 2104.00
IUUC-Bci-013721 Botrytis cinerea 54.61 0.00e+00 1038.00
IUUC-Bdi-014843 Brachypodium distachyon 45.83 0.00e+00 874.00
IUUC-Bol-015665 Brassica oleracea 44.51 0.00e+00 904.00
IUUC-Bra-017252 Brassica rapa 44.52 0.00e+00 909.00
IUUC-Cel-018260 Caenorhabditis elegans 49.57 0.00e+00 951.00
IUUC-Cja-019152 Callithrix jacchus 98.39 0.00e+00 2133.00
IUUC-Cfa-020622 Canis familiaris 95.27 0.00e+00 2019.00
IUUC-Cpo-022526 Cavia porcellus 96.88 0.00e+00 2081.00
IUUC-Cre-022702 Chlamydomonas reinhardtii 45.50 0.00e+00 847.00
IUUC-Csa-023780 Chlorocebus sabaeus 98.39 0.00e+00 2130.00
IUUC-Cho-024896 Choloepus hoffmanni 87.87 1.00e-119 424.00
IUUC-Cin-025790 Ciona intestinalis 63.66 0.00e+00 1368.00
IUUC-Csv-026084 Ciona savignyi 60.69 0.00e+00 1345.00
IUUC-Cgl-026512 Colletotrichum gloeosporioides 53.85 0.00e+00 1104.00
IUUC-Cne-026960 Cryptococcus neoformans 56.05 0.00e+00 1125.00
IUUC-Cme-027290 Cyanidioschyzon merolae 44.68 0.00e+00 841.00
IUUC-Dre-028149 Danio rerio 78.75 0.00e+00 1712.00
IUUC-Dno-028884 Dasypus novemcinctus 96.60 0.00e+00 2107.00
IUUC-Dor-030229 Dipodomys ordii 92.34 0.00e+00 1993.00
IUUC-Dse-031524 Dothistroma septosporum 52.64 0.00e+00 1078.00
IUUC-Dme-032045 Drosophila melanogaster 60.33 0.00e+00 1273.00
IUUC-Ete-032544 Echinops telfairi 84.95 0.00e+00 877.00
IUUC-Eca-033330 Equus caballus 97.64 0.00e+00 2126.00
IUUC-Fca-036255 Felis catus 97.64 0.00e+00 2097.00
IUUC-Fal-037445 Ficedula albicollis 49.39 0.00e+00 892.00
IUUC-Fox-038007 Fusarium oxysporum 54.02 9.00e-168 583.00
IUUC-Fso-038339 Fusarium solani 54.34 0.00e+00 1068.00
IUUC-Gmo-039338 Gadus morhua 75.62 0.00e+00 1613.00
IUUC-Ggr-039823 Gaeumannomyces graminis 54.24 0.00e+00 1122.00
IUUC-Gga-040365 Gallus gallus 47.51 0.00e+00 818.00
IUUC-Gac-041773 Gasterosteus aculeatus 75.91 0.00e+00 1616.00
IUUC-Gma-043198 Glycine max 44.42 0.00e+00 882.00
IUUC-Ggo-045336 Gorilla gorilla 99.62 0.00e+00 2132.00
IUUC-Hvu-047418 Hordeum vulgare 46.18 0.00e+00 886.00
IUUC-Itr-048460 Ictidomys tridecemlineatus 97.64 0.00e+00 2122.00
IUUC-Kpa-049112 Komagataella pastoris 51.67 0.00e+00 1022.00
IUUC-Lch-050371 Latimeria chalumnae 80.26 0.00e+00 1779.00
IUUC-Lpe-051299 Leersia perrieri 44.85 0.00e+00 897.00
IUUC-Loc-052936 Lepisosteus oculatus 80.55 0.00e+00 1759.00
IUUC-Lma-053315 Leptosphaeria maculans 52.45 0.00e+00 1103.00
IUUC-Laf-053948 Loxodonta africana 94.23 0.00e+00 2046.00
IUUC-Mcc-055843 Macaca mulatta 98.68 0.00e+00 2143.00
IUUC-Meu-056258 Macropus eugenii 87.71 0.00e+00 1918.00
IUUC-Mor-057269 Magnaporthe oryzae 54.29 0.00e+00 1098.00
IUUC-Mpo-057435 Magnaporthe poae 54.30 0.00e+00 1085.00
IUUC-Mtr-058572 Medicago truncatula 44.58 0.00e+00 867.00
IUUC-Mla-059176 Melampsora laricipopulina 56.05 0.00e+00 1107.00
IUUC-Mvi-060437 Microbotryum violaceum 53.83 0.00e+00 1073.00
IUUC-Mmr-061405 Microcebus murinus 95.75 0.00e+00 2066.00
IUUC-Mdo-062032 Monodelphis domestica 86.32 0.00e+00 1892.00
IUUC-Mmu-063280 Mus musculus 95.56 0.00e+00 2063.00
IUUC-Mac-065505 Musa acuminata 46.07 0.00e+00 892.00
IUUC-Mpu-066409 Mustela putorius furo 97.45 0.00e+00 2118.00
IUUC-Mlu-067217 Myotis lucifugus 95.75 0.00e+00 2086.00
IUUC-Nfi-068407 Neosartorya fischeri 54.15 0.00e+00 1068.00
IUUC-Ncr-068698 Neurospora crassa 55.06 0.00e+00 1113.00
IUUC-Nle-070072 Nomascus leucogenys 93.69 0.00e+00 1996.00
IUUC-Ont-071671 Oreochromis niloticus 78.30 0.00e+00 1691.00
IUUC-Oan-073306 Ornithorhynchus anatinus 49.50 0.00e+00 728.00
IUUC-Ocu-074544 Oryctolagus cuniculus 96.88 0.00e+00 2109.00
IUUC-Oba-075120 Oryza barthii 45.93 0.00e+00 885.00
IUUC-Obr-076557 Oryza brachyantha 46.36 0.00e+00 877.00
IUUC-Ogl-077887 Oryza glaberrima 45.93 0.00e+00 889.00
IUUC-Ogu-078305 Oryza glumaepatula 44.52 0.00e+00 892.00
IUUC-Oin-080154 Oryza indica 44.52 0.00e+00 890.00
IUUC-Olo-081089 Oryza longistaminata 44.62 0.00e+00 891.00
IUUC-Ome-081942 Oryza meridionalis 45.93 0.00e+00 885.00
IUUC-Oni-082365 Oryza nivara 45.83 0.00e+00 887.00
IUUC-Opu-083977 Oryza punctata 46.21 0.00e+00 890.00
IUUC-Oru-084469 Oryza rufipogon 44.62 0.00e+00 895.00
IUUC-Osa-085949 Oryza sativa 46.13 0.00e+00 895.00
IUUC-Ola-087002 Oryzias latipes 77.72 0.00e+00 1681.00
IUUC-Olu-087687 Ostreococcus lucimarinus 44.21 0.00e+00 818.00
IUUC-Oga-088594 Otolemur garnettii 97.45 0.00e+00 2086.00
IUUC-Oar-090068 Ovis aries 96.32 0.00e+00 2098.00
IUUC-Pan-092114 Papio anubis 98.68 0.00e+00 2143.00
IUUC-Pma-094214 Petromyzon marinus 57.56 2.00e-52 198.00
IUUC-Pno-095154 Phaeosphaeria nodorum 52.81 0.00e+00 1106.00
IUUC-Ppa-095416 Physcomitrella patens 46.24 0.00e+00 905.00
IUUC-Pfo-097184 Poecilia formosa 77.53 0.00e+00 1675.00
IUUC-Pab-097861 Pongo abelii 99.15 0.00e+00 2109.00
IUUC-Pop-098934 Populus trichocarpa 45.18 0.00e+00 925.00
IUUC-Pca-100347 Procavia capensis 91.31 0.00e+00 1644.00
IUUC-Ppe-102012 Prunus persica 44.64 0.00e+00 907.00
IUUC-Pva-102584 Pteropus vampyrus 97.26 0.00e+00 2135.00
IUUC-Pgr-103336 Puccinia graminis 54.46 0.00e+00 1061.00
IUUC-Ptt-103939 Puccinia triticina 53.89 0.00e+00 1065.00
IUUC-Pte-104200 Pyrenophora teres 53.74 0.00e+00 1102.00
IUUC-Pyt-104441 Pyrenophora triticirepentis 52.63 0.00e+00 1091.00
IUUC-Rno-105462 Rattus norvegicus 96.41 0.00e+00 2057.00
IUUC-Sce-106245 Saccharomyces cerevisiae 52.28 0.00e+00 1085.00
IUUC-Sha-107142 Sarcophilus harrisii 87.71 0.00e+00 1935.00
IUUC-Sja-107841 Schizosaccharomyces japonicus 55.61 0.00e+00 1144.00
IUUC-Spo-108034 Schizosaccharomyces pombe 54.01 0.00e+00 1081.00
IUUC-Ssl-108497 Sclerotinia sclerotiorum 54.69 0.00e+00 1060.00
IUUC-Smo-109211 Selaginella moellendorffii 46.41 0.00e+00 897.00
IUUC-Sit-110281 Setaria italica 46.04 0.00e+00 899.00
IUUC-Sly-111237 Solanum lycopersicum 46.09 0.00e+00 868.00
IUUC-Stu-112109 Solanum tuberosum 45.09 0.00e+00 914.00
IUUC-Sar-113737 Sorex araneus 95.94 0.00e+00 2081.00
IUUC-Sbi-114089 Sorghum bicolor 45.74 0.00e+00 896.00
IUUC-Sre-115148 Sporisorium reilianum 55.03 0.00e+00 1091.00
IUUC-Ssc-115777 Sus scrofa 97.54 0.00e+00 2117.00
IUUC-Tru-118742 Takifugu rubripes 77.34 0.00e+00 1627.00
IUUC-Tsy-119485 Tarsius syrichta 98.02 2.00e-175 608.00
IUUC-Tni-120401 Tetraodon nigroviridis 77.63 0.00e+00 1630.00
IUUC-Tca-121672 Theobroma cacao 44.80 0.00e+00 910.00
IUUC-Tre-122009 Trichoderma reesei 53.63 0.00e+00 1046.00
IUUC-Tvi-122259 Trichoderma virens 53.92 0.00e+00 1037.00
IUUC-Tae-125113 Triticum aestivum 46.56 0.00e+00 868.00
IUUC-Tur-126189 Triticum urartu 46.12 0.00e+00 864.00
IUUC-Tme-127055 Tuber melanosporum 53.91 0.00e+00 1025.00
IUUC-Tbe-127487 Tupaia belangeri 97.01 0.00e+00 1051.00
IUUC-Ttr-128331 Tursiops truncatus 96.60 0.00e+00 2090.00
IUUC-Uma-129387 Ustilago maydis 55.06 0.00e+00 1089.00
IUUC-Vda-129977 Verticillium dahliae 53.81 0.00e+00 1019.00
IUUC-Vvi-130857 Vitis vinifera 45.42 0.00e+00 910.00
IUUC-Xtr-132026 Xenopus tropicalis 64.08 0.00e+00 1280.00
IUUC-Xma-133805 Xiphophorus maculatus 77.34 0.00e+00 1652.00
IUUC-Yli-134547 Yarrowia lipolytica 54.15 0.00e+00 1111.00
IUUC-Zma-135052 Zea mays 45.89 0.00e+00 903.00
Created Date 25-Jun-2017

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