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Tag Content
iUUCD ID IUUC-Ago-007976
Ensembl Protein ID AAS52960
UniProt Accession Q756I2; CUE1_ASHGO
Genbank Protein ID AAS52960.1
Protein Name Coupling of ubiquitin conjugation to ER degradation protein 1
Genbank Nucleotide ID AE016818
Gene Name CUE1; AER279W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_AER279W AAS52960 AAS52960
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/CUE 8.90e-10 36.4 66 106
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +++++e ++ ++P+l++++i+ +L ++ gs+ea+v++ L+g 
   Q: 66   NDDMIEVVQALAPHLHSEQIRYDL-ERSGSVEATVERYLRGE 106
           679*********************.**************985 PP
   
Organism Ashbya gossypii
Functional Description
(View)

Functional Description


     Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
 Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).
Protein Sequence
(Fasta)
MDQSSALFLA LLLVLFVLVK WFIKTESHPS AQHATVDTGL SSQSTGAAGG RAQGTGAVRR 60
RRRPVNDDMI EVVQALAPHL HSEQIRYDLE RSGSVEATVE RYLRGEDFPF PPGYTAPIPP 120
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Protein Fasta Sequence


>IUUC-Ago-007976|UBD,CUE|Ashbya gossypii
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Nucleotide Sequence
(Fasta)
ATGGATCAAT CCTCTGCACT CTTCCTAGCT TTGCTGCTGG TGCTGTTCGT TTTGGTGAAG 60
TGGTTTATTA AAACCGAGTC CCACCCCTCA GCGCAGCACG CCACGGTAGA CACGGGACTC 120
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Nucleotide Fasta Sequence


>IUUC-Ago-007976|UBD,CUE|Ashbya gossypii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
Interpro

IPR003892--CUE
PROSITE

PS51140--CUE
Pfam

PF02845--CUE
SMART

SM00546--CUE
Gene Ontology

GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0097051--P:establishment of protein localization to endoplasmic reticulum membrane
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG ago:AGOS_AER279W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002330 Ailuropoda melanoleuca 36.36 3.10e-01 27.70
IUUC-Apl-003946 Anas platyrhynchos 34.09 1.20e-01 28.50
IUUC-Aca-004676 Anolis carolinensis 30.23 4.50e-01 24.60
IUUC-Afl-008749 Aspergillus flavus 38.64 4.00e-04 35.40
IUUC-Afu-008970 Aspergillus fumigatus 34.92 5.00e-05 38.90
IUUC-Ani-009377 Aspergillus nidulans 29.27 2.00e-04 37.00
IUUC-Ang-009733 Aspergillus niger 35.58 5.00e-09 52.00
IUUC-Aor-010075 Aspergillus oryzae 38.64 4.00e-04 35.40
IUUC-Ate-010445 Aspergillus terreus 28.67 5.00e-06 42.00
IUUC-Bgr-012130 Blumeria graminis 45.00 2.00e-03 33.10
IUUC-Bta-012397 Bos taurus 36.36 3.10e-01 27.30
IUUC-Bci-013678 Botrytis cinerea 37.50 4.70e-02 28.90
IUUC-Cfa-020710 Canis familiaris 36.36 2.50e-01 27.70
IUUC-Cpo-022111 Cavia porcellus 36.36 3.00e-01 27.30
IUUC-Cgl-026735 Colletotrichum gloeosporioides 37.84 2.60e-02 29.60
IUUC-Dno-028873 Dasypus novemcinctus 36.36 2.70e-01 27.70
IUUC-Dor-030537 Dipodomys ordii 36.36 1.80e-01 28.50
IUUC-Dse-031559 Dothistroma septosporum 39.34 9.00e-06 41.20
IUUC-Ete-032422 Echinops telfairi 31.43 9.80e-02 29.30
IUUC-Eca-033757 Equus caballus 36.36 3.20e-01 27.30
IUUC-Eeu-034556 Erinaceus europaeus 36.36 2.00e-01 28.10
IUUC-Fca-035438 Felis catus 36.36 3.50e-01 27.30
IUUC-Fal-036911 Ficedula albicollis 36.36 6.10e-02 29.60
IUUC-Fox-037893 Fusarium oxysporum 35.14 4.40e-02 28.90
IUUC-Fso-038207 Fusarium solani 35.14 5.60e-02 28.50
IUUC-Ggr-039795 Gaeumannomyces graminis 32.43 3.60e-01 25.80
IUUC-Gga-041239 Gallus gallus 36.36 5.70e-02 30.00
IUUC-Itr-048661 Ictidomys tridecemlineatus 36.36 3.10e-01 27.30
IUUC-Kpa-049306 Komagataella pastoris 35.71 7.00e-03 30.80
IUUC-Lma-053215 Leptosphaeria maculans 26.87 2.00e-04 37.00
IUUC-Laf-053886 Loxodonta africana 33.87 9.80e-02 29.30
IUUC-Mcc-055313 Macaca mulatta 32.56 6.80e-02 27.70
IUUC-Meu-056355 Macropus eugenii 37.50 6.60e-02 29.60
IUUC-Mor-057019 Magnaporthe oryzae 35.14 1.10e-01 27.70
IUUC-Mga-060065 Meleagris gallopavo 36.36 3.80e-02 30.00
IUUC-Mvi-060273 Microbotryum violaceum 42.59 1.00e-04 37.70
IUUC-Mmu-064080 Mus musculus 36.36 1.80e-01 28.10
IUUC-Mpu-066233 Mustela putorius furo 36.36 3.20e-01 27.30
IUUC-Mlu-067489 Myotis lucifugus 36.36 3.30e-01 27.30
IUUC-Nfi-068461 Neosartorya fischeri 29.79 3.00e-05 39.70
IUUC-Ogu-078481 Oryza glumaepatula 38.10 4.00e-03 34.30
IUUC-Ome-081941 Oryza meridionalis 38.10 4.00e-03 33.90
IUUC-Oni-082488 Oryza nivara 38.10 4.00e-03 34.30
IUUC-Opu-083500 Oryza punctata 39.22 1.50e-02 32.30
IUUC-Oga-089100 Otolemur garnettii 36.36 3.40e-01 27.30
IUUC-Oar-089813 Ovis aries 36.36 3.10e-01 27.30
IUUC-Pca-100900 Procavia capensis 34.88 2.30e-01 28.10
IUUC-Pva-103248 Pteropus vampyrus 37.04 3.90e+00 23.90
IUUC-Rno-105755 Rattus norvegicus 36.36 1.50e-01 28.50
IUUC-Sce-106256 Saccharomyces cerevisiae 45.86 1.00e-37 146.00
IUUC-Sha-107434 Sarcophilus harrisii 36.36 1.40e-01 28.10
IUUC-Spo-108323 Schizosaccharomyces pombe 44.90 4.00e-10 55.80
IUUC-Sre-115215 Sporisorium reilianum 46.88 1.00e-10 57.40
IUUC-Ssc-116047 Sus scrofa 30.12 3.80e-02 30.00
IUUC-Tgu-117436 Taeniopygia guttata 34.09 1.20e-01 28.50
IUUC-Tre-122164 Trichoderma reesei 32.43 5.20e-02 28.50
IUUC-Tvi-122291 Trichoderma virens 32.43 4.80e-02 28.90
IUUC-Ttr-128895 Tursiops truncatus 36.36 2.90e-01 27.70
IUUC-Uma-129431 Ustilago maydis 46.48 6.00e-11 58.50
IUUC-Vda-129964 Verticillium dahliae 37.84 2.30e-02 29.60
Created Date 25-Jun-2017

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