iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108032

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 4; E2 ubiquitin-conjugating enzyme 4; Ubiquitin carrier protein 4; Ubiquitin-protein ligase 4

Genbank Nucleotide ID

L37384

Gene Name

ubc4; SPBC119.02

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC119.02	SPBC119.02.1	SPBC119.02.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	12724408

Classification

Family	E-value	Score	Start	End
E2/UBC	5.70e-56	186.2	5	139
UBD/UBC-like/UBD_UBC	1.60e-77	256.4	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWs 93
           R+++el++l kdpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv+f+t+i+hPn+++nG++Cl+il+  ++Ws
   Q: 5    RINRELADLGKDPPSSCSAGPVGD-DLFHWQATIMGPADSPYAGGVFFLSIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILR--DQWS 94
           89**********************.9************************************************************9..**** PP
   S: 94   palsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           pal++++vllsi+sll++pnp++pl  e+a+ +k++r++y+  +r
   Q: 95   PALTISKVLLSICSLLTDPNPDDPLVPEIAHVYKTDRSRYELSAR 139
           ****************************************98776 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaal 93
           ri++el dl +d+++ +sa++v+ddlf+++ati+gp dspy ggvffl i++ptdypfkppkv+f+t+iyhpninsngsicldilr+qws+al
   Q: 5    RINRELADLGKDPPSSCSAGPVGDDLFHWQATIMGPADSPYAGGVFFLSIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPAL 97
           8******************************************************************************************** PP
   S: 94   tlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           t+skvlls+csll+d++pddplv+eia++yktd+ +y+  arewt
   Q: 98   TISKVLLSICSLLTDPNPDDPLVPEIAHVYKTDRSRYELSAREWT 142
           ********************************************8 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.

Protein Sequence
(Fasta)

MALKRINREL ADLGKDPPSS CSAGPVGDDL FHWQATIMGP ADSPYAGGVF FLSIHFPTDY 60
PFKPPKVNFT TRIYHPNINS NGSICLDILR DQWSPALTIS KVLLSICSLL TDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGATTTA GTGCATCCAT CGGTTATATG TTATTTCTAC CTCCGTCCAC GTTCTTCCAC 60
GAGCAAACTA CTGACTTTGT AAAATCGCAA AAGCAAACCA GTAACGATGG CTTTGAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0034067--P:protein localization to Golgi apparatus
GO:0000209--P:protein polyubiquitination
GO:0016485--P:protein processing
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060049--P:regulation of protein glycosylation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035103--P:sterol regulatory element binding protein cleavage

KEGG

spo:SPBC119.02

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000292	Aegilops tauschii	80.95	2.00e-72	262.00
IUUC-Aml-001563	Ailuropoda melanoleuca	79.59	2.00e-71	258.00
IUUC-Atr-002894	Amborella trichopoda	81.63	2.00e-73	265.00
IUUC-Apl-004043	Anas platyrhynchos	81.63	2.00e-71	259.00
IUUC-Aca-005236	Anolis carolinensis	84.35	8.00e-74	266.00
IUUC-Aly-006542	Arabidopsis lyrata	81.63	2.00e-72	262.00
IUUC-Ath-007224	Arabidopsis thaliana	81.63	2.00e-72	262.00
IUUC-Ago-007967	Ashbya gossypii	83.67	5.00e-76	274.00
IUUC-Acl-008266	Aspergillus clavatus	92.52	4.00e-81	290.00
IUUC-Afl-008709	Aspergillus flavus	88.03	3.00e-76	276.00
IUUC-Afu-008956	Aspergillus fumigatus	93.20	2.00e-81	291.00
IUUC-Ani-009401	Aspergillus nidulans	91.16	6.00e-80	287.00
IUUC-Ang-009725	Aspergillus niger	92.80	3.00e-68	248.00
IUUC-Aor-010157	Aspergillus oryzae	92.52	2.00e-81	291.00
IUUC-Ate-010438	Aspergillus terreus	93.20	6.00e-81	290.00
IUUC-Ame-011657	Astyanax mexicanus	85.62	9.00e-74	266.00
IUUC-Bgr-012238	Blumeria graminis	88.44	8.00e-77	276.00
IUUC-Bta-013158	Bos taurus	84.35	8.00e-74	266.00
IUUC-Bci-013661	Botrytis cinerea	91.84	5.00e-81	290.00
IUUC-Bdi-014561	Brachypodium distachyon	80.27	2.00e-72	262.00
IUUC-Bol-016512	Brassica oleracea	81.63	3.00e-73	264.00
IUUC-Bra-017985	Brassica rapa	81.63	3.00e-73	264.00
IUUC-Cel-018362	Caenorhabditis elegans	85.71	7.00e-75	270.00
IUUC-Cja-019886	Callithrix jacchus	84.35	8.00e-74	266.00
IUUC-Cfa-020436	Canis familiaris	84.35	8.00e-74	266.00
IUUC-Cpo-022334	Cavia porcellus	82.99	6.00e-73	263.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	83.67	3.00e-74	268.00
IUUC-Csa-023377	Chlorocebus sabaeus	83.92	3.00e-71	258.00
IUUC-Cho-024987	Choloepus hoffmanni	79.59	2.00e-71	258.00
IUUC-Cin-025379	Ciona intestinalis	83.56	7.00e-73	263.00
IUUC-Csv-026311	Ciona savignyi	76.71	1.00e-67	246.00
IUUC-Cgl-026490	Colletotrichum gloeosporioides	92.52	2.00e-81	291.00
IUUC-Cne-026957	Cryptococcus neoformans	86.99	2.00e-76	275.00
IUUC-Cme-027220	Cyanidioschyzon merolae	85.71	7.00e-76	273.00
IUUC-Dre-027758	Danio rerio	85.03	2.00e-74	268.00
IUUC-Dno-030067	Dasypus novemcinctus	79.59	2.00e-71	258.00
IUUC-Dor-030323	Dipodomys ordii	82.99	2.00e-73	265.00
IUUC-Dse-031397	Dothistroma septosporum	93.20	7.00e-82	293.00
IUUC-Dme-031594	Drosophila melanogaster	87.07	1.00e-75	272.00
IUUC-Ete-032540	Echinops telfairi	79.59	2.00e-71	258.00
IUUC-Eca-034167	Equus caballus	79.59	2.00e-71	258.00
IUUC-Eeu-034766	Erinaceus europaeus	84.29	1.00e-68	249.00
IUUC-Fca-035917	Felis catus	84.35	3.00e-74	268.00
IUUC-Fal-036904	Ficedula albicollis	83.57	5.00e-70	253.00
IUUC-Fox-038021	Fusarium oxysporum	92.52	4.00e-81	291.00
IUUC-Fso-038297	Fusarium solani	91.84	8.00e-81	290.00
IUUC-Gmo-038775	Gadus morhua	81.63	3.00e-73	264.00
IUUC-Ggr-039912	Gaeumannomyces graminis	85.53	6.00e-75	270.00
IUUC-Gga-041015	Gallus gallus	85.03	2.00e-74	268.00
IUUC-Gac-041509	Gasterosteus aculeatus	83.67	6.00e-74	267.00
IUUC-Gma-043766	Glycine max	81.63	1.00e-73	266.00
IUUC-Ggo-045361	Gorilla gorilla	83.67	1.00e-73	266.00
IUUC-Hsa-046157	Homo sapiens	84.35	3.00e-74	268.00
IUUC-Hvu-047546	Hordeum vulgare	78.23	5.00e-71	257.00
IUUC-Itr-048882	Ictidomys tridecemlineatus	82.43	3.00e-71	258.00
IUUC-Kpa-049290	Komagataella pastoris	82.31	5.00e-75	270.00
IUUC-Lch-050109	Latimeria chalumnae	81.63	2.00e-72	261.00
IUUC-Lpe-051289	Leersia perrieri	81.63	4.00e-73	264.00
IUUC-Loc-052838	Lepisosteus oculatus	83.67	1.00e-73	266.00
IUUC-Lma-053121	Leptosphaeria maculans	93.20	7.00e-82	293.00
IUUC-Laf-054244	Loxodonta africana	79.59	5.00e-63	231.00
IUUC-Mcc-055421	Macaca mulatta	83.67	1.00e-73	266.00
IUUC-Meu-056462	Macropus eugenii	83.45	3.00e-69	251.00
IUUC-Mor-057235	Magnaporthe oryzae	91.84	1.00e-80	289.00
IUUC-Mpo-057596	Magnaporthe poae	86.18	1.00e-75	272.00
IUUC-Mtr-058257	Medicago truncatula	81.63	8.00e-73	263.00
IUUC-Mla-059189	Melampsora laricipopulina	83.67	4.00e-73	264.00
IUUC-Mga-059237	Meleagris gallopavo	83.57	5.00e-70	253.00
IUUC-Mvi-060397	Microbotryum violaceum	83.67	9.00e-75	270.00
IUUC-Mmr-060889	Microcebus murinus	85.03	2.00e-74	268.00
IUUC-Mdo-062596	Monodelphis domestica	83.67	5.00e-74	267.00
IUUC-Mmu-063796	Mus musculus	85.03	2.00e-74	268.00
IUUC-Mac-065337	Musa acuminata	80.27	2.00e-72	261.00
IUUC-Mpu-066604	Mustela putorius furo	80.95	3.00e-71	258.00
IUUC-Mlu-067573	Myotis lucifugus	79.29	1.00e-67	246.00
IUUC-Nfi-068599	Neosartorya fischeri	93.20	2.00e-81	291.00
IUUC-Ncr-068677	Neurospora crassa	91.84	3.00e-80	288.00
IUUC-Nle-069715	Nomascus leucogenys	83.67	1.00e-73	266.00
IUUC-Opr-070191	Ochotona princeps	84.17	1.00e-69	253.00
IUUC-Ont-071403	Oreochromis niloticus	82.99	3.00e-73	265.00
IUUC-Oan-073026	Ornithorhynchus anatinus	82.98	5.00e-70	254.00
IUUC-Ocu-074315	Oryctolagus cuniculus	84.35	8.00e-74	266.00
IUUC-Oba-075344	Oryza barthii	82.31	3.00e-64	234.00
IUUC-Obr-076889	Oryza brachyantha	81.63	2.00e-63	232.00
IUUC-Ogl-077310	Oryza glaberrima	82.31	3.00e-64	234.00
IUUC-Ogu-078940	Oryza glumaepatula	82.31	3.00e-64	234.00
IUUC-Oin-079437	Oryza indica	82.31	3.00e-64	234.00
IUUC-Olo-080873	Oryza longistaminata	82.31	3.00e-64	234.00
IUUC-Ome-081233	Oryza meridionalis	82.31	3.00e-64	234.00
IUUC-Oni-082391	Oryza nivara	80.95	1.00e-72	264.00
IUUC-Opu-083694	Oryza punctata	81.63	2.00e-63	232.00
IUUC-Oru-085167	Oryza rufipogon	80.95	2.00e-72	264.00
IUUC-Osa-085757	Oryza sativa	82.31	3.00e-64	234.00
IUUC-Ola-087515	Oryzias latipes	82.99	1.00e-73	265.00
IUUC-Olu-087615	Ostreococcus lucimarinus	78.91	3.00e-68	248.00
IUUC-Oga-088477	Otolemur garnettii	82.88	3.00e-72	261.00
IUUC-Oar-090038	Ovis aries	84.35	3.00e-74	268.00
IUUC-Ptr-090707	Pan troglodytes	84.35	8.00e-74	266.00
IUUC-Pan-092143	Papio anubis	84.35	8.00e-74	266.00
IUUC-Psi-094076	Pelodiscus sinensis	84.35	3.00e-74	268.00
IUUC-Pma-094405	Petromyzon marinus	85.19	5.00e-67	244.00
IUUC-Pno-094765	Phaeosphaeria nodorum	93.20	7.00e-82	293.00
IUUC-Ppa-095177	Physcomitrella patens	80.27	1.00e-71	259.00
IUUC-Pfo-096867	Poecilia formosa	82.99	1.00e-73	265.00
IUUC-Pab-098760	Pongo abelii	84.35	5.00e-74	267.00
IUUC-Pop-099286	Populus trichocarpa	82.31	9.00e-74	266.00
IUUC-Pca-100678	Procavia capensis	79.59	2.00e-71	258.00
IUUC-Ppe-101431	Prunus persica	82.99	9.00e-74	266.00
IUUC-Pva-102770	Pteropus vampyrus	79.59	2.00e-71	258.00
IUUC-Pgr-103381	Puccinia graminis	84.35	4.00e-73	265.00
IUUC-Ptt-103723	Puccinia triticina	80.71	8.00e-65	237.00
IUUC-Pte-104015	Pyrenophora teres	93.20	1.00e-81	293.00
IUUC-Pyt-104701	Pyrenophora triticirepentis	93.20	1.00e-81	293.00
IUUC-Rno-105498	Rattus norvegicus	84.35	3.00e-74	268.00
IUUC-Sce-106463	Saccharomyces cerevisiae	84.03	1.00e-74	269.00
IUUC-Sha-106489	Sarcophilus harrisii	76.55	2.00e-68	248.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	98.64	2.00e-84	302.00
IUUC-Ssl-108443	Sclerotinia sclerotiorum	92.52	2.00e-81	291.00
IUUC-Smo-108941	Selaginella moellendorffii	80.95	1.00e-71	259.00
IUUC-Sit-109936	Setaria italica	80.95	5.00e-73	265.00
IUUC-Sly-111055	Solanum lycopersicum	80.95	4.00e-72	261.00
IUUC-Stu-112436	Solanum tuberosum	79.59	8.00e-73	263.00
IUUC-Sar-113302	Sorex araneus	84.89	6.00e-70	253.00
IUUC-Sbi-114883	Sorghum bicolor	81.63	4.00e-64	234.00
IUUC-Sre-115037	Sporisorium reilianum	86.81	2.00e-75	271.00
IUUC-Ssc-115391	Sus scrofa	83.67	1.00e-73	266.00
IUUC-Tgu-116727	Taeniopygia guttata	84.35	3.00e-74	268.00
IUUC-Tru-118628	Takifugu rubripes	86.39	9.00e-75	270.00
IUUC-Tsy-118832	Tarsius syrichta	82.31	2.00e-71	258.00
IUUC-Tni-120056	Tetraodon nigroviridis	83.67	6.00e-73	263.00
IUUC-Tca-121385	Theobroma cacao	81.63	1.00e-73	266.00
IUUC-Tre-122125	Trichoderma reesei	90.48	2.00e-79	285.00
IUUC-Tvi-122296	Trichoderma virens	90.48	2.00e-79	285.00
IUUC-Tae-125784	Triticum aestivum	80.95	3.00e-72	261.00
IUUC-Tur-126518	Triticum urartu	80.95	6.00e-73	264.00
IUUC-Tme-126912	Tuber melanosporum	91.16	3.00e-80	288.00
IUUC-Tbe-128122	Tupaia belangeri	85.48	3.00e-54	201.00
IUUC-Ttr-128363	Tursiops truncatus	79.59	2.00e-71	258.00
IUUC-Uma-129648	Ustilago maydis	86.39	2.00e-76	275.00
IUUC-Vda-129695	Verticillium dahliae	92.52	2.00e-81	291.00
IUUC-Vpa-130446	Vicugna pacos	82.98	1.00e-68	250.00
IUUC-Vvi-131016	Vitis vinifera	82.31	4.00e-74	267.00
IUUC-Xtr-132329	Xenopus tropicalis	84.35	8.00e-74	266.00
IUUC-Xma-133829	Xiphophorus maculatus	83.67	4.00e-73	264.00
IUUC-Yli-134353	Yarrowia lipolytica	83.67	4.00e-76	274.00
IUUC-Zma-135267	Zea mays	81.63	3.00e-64	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence