iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	38.28	6.00e-94	340.00	IUUC-Sce-106399

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity). Probable chromatin remodeling factor. Probable helicase-like transcription factor involved in transcriptional gene silencing. Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci. May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed:25420628).

Protein Sequence
(Fasta)

MKRDFDEISE EEWSQHSFNA SRVLKRPRTP KKTRAATNPT PSIESFAFRR PSTAMTIESN 60
SSDGDCVEIE DLGDSDSDVK IVNGEDLLLE DEEEVEETKV VMRAARVGRR FVIEDEEASD 120

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Nucleotide Sequence
(Fasta)

GCGCGCATAG CTTTTGGAGG ATGCCGCTCT TTTGTAAGAA GCAACACGTT GTTGAGTCTC 60
TAACCTTTCT TTGAAATCTT GACCTTTCCC TTCCTTCTCC GCTAAATTCG TTTTAATTTC 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0943--RNA-mediated gene silencing
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER

Pfam

PF00271--Helicase_C
PF00176--SNF2_N

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071494--P:cellular response to UV-C
GO:0016569--P:covalent chromatin modification
GO:0006281--P:DNA repair
GO:0031047--P:gene silencing by RNA
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT2G02090

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000567	Aegilops tauschii	73.86	0.00e+00	960.00
IUUC-Aml-002063	Ailuropoda melanoleuca	37.62	1.00e-104	374.00
IUUC-Atr-003078	Amborella trichopoda	76.09	0.00e+00	1003.00
IUUC-Apl-003860	Anas platyrhynchos	40.39	1.00e-107	383.00
IUUC-Aca-004485	Anolis carolinensis	38.49	2.00e-108	386.00
IUUC-Aly-006561	Arabidopsis lyrata	96.61	0.00e+00	1395.00
IUUC-Ago-007758	Ashbya gossypii	38.08	8.00e-93	334.00
IUUC-Acl-008226	Aspergillus clavatus	39.41	4.00e-94	338.00
IUUC-Afl-008556	Aspergillus flavus	39.41	1.00e-92	333.00
IUUC-Afu-008799	Aspergillus fumigatus	38.89	2.00e-94	340.00
IUUC-Ani-009127	Aspergillus nidulans	38.22	2.00e-88	320.00
IUUC-Ang-009676	Aspergillus niger	39.22	6.00e-92	332.00
IUUC-Aor-010184	Aspergillus oryzae	38.34	8.00e-93	334.00
IUUC-Ate-010559	Aspergillus terreus	39.78	5.00e-92	332.00
IUUC-Ame-011933	Astyanax mexicanus	39.29	3.00e-95	342.00
IUUC-Bgr-012028	Blumeria graminis	38.86	9.00e-57	213.00
IUUC-Bta-012963	Bos taurus	37.78	3.00e-105	376.00
IUUC-Bci-013670	Botrytis cinerea	37.55	1.00e-90	327.00
IUUC-Bdi-014286	Brachypodium distachyon	74.96	0.00e+00	965.00
IUUC-Bol-016519	Brassica oleracea	95.08	0.00e+00	1185.00
IUUC-Bra-017239	Brassica rapa	95.42	0.00e+00	1192.00
IUUC-Cel-018253	Caenorhabditis elegans	40.12	1.00e-95	344.00
IUUC-Cja-019465	Callithrix jacchus	37.62	9.00e-105	374.00
IUUC-Cfa-020637	Canis familiaris	37.78	3.00e-105	375.00
IUUC-Cpo-021822	Cavia porcellus	37.94	2.00e-105	376.00
IUUC-Csa-023315	Chlorocebus sabaeus	37.78	3.00e-105	375.00
IUUC-Cin-025444	Ciona intestinalis	36.57	5.00e-98	351.00
IUUC-Cgl-026383	Colletotrichum gloeosporioides	33.46	7.00e-71	261.00
IUUC-Cne-027090	Cryptococcus neoformans	37.61	1.00e-83	303.00
IUUC-Dre-028385	Danio rerio	41.15	1.00e-96	347.00
IUUC-Dno-028932	Dasypus novemcinctus	37.62	2.00e-104	373.00
IUUC-Dse-031394	Dothistroma septosporum	33.91	4.00e-75	276.00
IUUC-Dme-031640	Drosophila melanogaster	40.34	5.00e-99	355.00
IUUC-Eca-033276	Equus caballus	37.46	1.00e-104	373.00
IUUC-Fca-035936	Felis catus	36.98	4.00e-101	362.00
IUUC-Fal-037636	Ficedula albicollis	40.29	4.00e-107	382.00
IUUC-Fso-038229	Fusarium solani	34.38	2.00e-82	300.00
IUUC-Gmo-039654	Gadus morhua	39.89	4.00e-94	338.00
IUUC-Ggr-039922	Gaeumannomyces graminis	34.22	2.00e-69	257.00
IUUC-Gga-040646	Gallus gallus	37.83	5.00e-106	378.00
IUUC-Gac-042320	Gasterosteus aculeatus	41.04	6.00e-92	331.00
IUUC-Gma-042832	Glycine max	70.82	0.00e+00	1074.00
IUUC-Ggo-044875	Gorilla gorilla	34.22	2.00e-86	313.00
IUUC-Hsa-046992	Homo sapiens	37.62	8.00e-105	374.00
IUUC-Hvu-047408	Hordeum vulgare	73.69	0.00e+00	957.00
IUUC-Itr-047881	Ictidomys tridecemlineatus	40.04	3.00e-104	371.00
IUUC-Kpa-049212	Komagataella pastoris	39.41	3.00e-93	335.00
IUUC-Lpe-050987	Leersia perrieri	75.45	0.00e+00	980.00
IUUC-Loc-052272	Lepisosteus oculatus	39.82	7.00e-104	371.00
IUUC-Lma-053118	Leptosphaeria maculans	37.29	1.00e-90	327.00
IUUC-Laf-053436	Loxodonta africana	37.26	3.00e-98	352.00
IUUC-Mcc-055209	Macaca mulatta	37.78	5.00e-105	375.00
IUUC-Mor-056994	Magnaporthe oryzae	33.89	6.00e-69	255.00
IUUC-Mpo-057305	Magnaporthe poae	33.99	1.00e-70	261.00
IUUC-Mtr-058432	Medicago truncatula	81.51	0.00e+00	1065.00
IUUC-Mla-058972	Melampsora laricipopulina	39.31	7.00e-96	343.00
IUUC-Mga-059572	Meleagris gallopavo	38.90	2.00e-105	376.00
IUUC-Mvi-060209	Microbotryum violaceum	40.14	8.00e-99	355.00
IUUC-Mmr-061416	Microcebus murinus	36.35	1.00e-96	346.00
IUUC-Mdo-062869	Monodelphis domestica	40.36	6.00e-106	378.00
IUUC-Mmu-064272	Mus musculus	37.54	3.00e-99	355.00
IUUC-Mac-064963	Musa acuminata	69.59	0.00e+00	962.00
IUUC-Mpu-065755	Mustela putorius furo	37.62	8.00e-105	374.00
IUUC-Mlu-067604	Myotis lucifugus	37.46	8.00e-108	384.00
IUUC-Nfi-068310	Neosartorya fischeri	39.07	9.00e-95	341.00
IUUC-Ncr-068841	Neurospora crassa	33.82	1.00e-79	290.00
IUUC-Nle-069227	Nomascus leucogenys	37.62	9.00e-105	374.00
IUUC-Opr-071088	Ochotona princeps	37.90	3.00e-95	342.00
IUUC-Ont-072291	Oreochromis niloticus	39.17	7.00e-95	341.00
IUUC-Oan-073460	Ornithorhynchus anatinus	38.24	8.00e-110	390.00
IUUC-Ocu-074811	Oryctolagus cuniculus	37.78	2.00e-105	376.00
IUUC-Oba-075463	Oryza barthii	76.94	0.00e+00	940.00
IUUC-Obr-076342	Oryza brachyantha	76.06	0.00e+00	1001.00
IUUC-Ogu-078837	Oryza glumaepatula	75.99	0.00e+00	990.00
IUUC-Oin-079623	Oryza indica	76.03	0.00e+00	985.00
IUUC-Ome-081105	Oryza meridionalis	75.93	0.00e+00	1001.00
IUUC-Oni-082598	Oryza nivara	74.52	0.00e+00	980.00
IUUC-Opu-084040	Oryza punctata	75.86	0.00e+00	994.00
IUUC-Oru-084219	Oryza rufipogon	74.55	0.00e+00	976.00
IUUC-Osa-085461	Oryza sativa	75.99	0.00e+00	991.00
IUUC-Ola-087307	Oryzias latipes	40.85	1.00e-90	327.00
IUUC-Olu-087812	Ostreococcus lucimarinus	43.95	4.00e-135	474.00
IUUC-Oga-089064	Otolemur garnettii	37.70	4.00e-105	375.00
IUUC-Oar-090054	Ovis aries	37.78	4.00e-105	375.00
IUUC-Ptr-091228	Pan troglodytes	37.78	2.00e-105	376.00
IUUC-Pan-092769	Papio anubis	37.32	2.00e-90	327.00
IUUC-Psi-093202	Pelodiscus sinensis	40.07	9.00e-108	384.00
IUUC-Pma-094725	Petromyzon marinus	38.97	3.00e-112	399.00
IUUC-Pno-095130	Phaeosphaeria nodorum	36.65	4.00e-85	309.00
IUUC-Ppa-095559	Physcomitrella patens	61.61	0.00e+00	783.00
IUUC-Pfo-096546	Poecilia formosa	38.89	2.00e-97	350.00
IUUC-Pab-097698	Pongo abelii	37.42	5.00e-104	372.00
IUUC-Pop-099986	Populus trichocarpa	81.83	0.00e+00	1063.00
IUUC-Ppe-101649	Prunus persica	72.79	0.00e+00	1112.00
IUUC-Pva-102138	Pteropus vampyrus	40.04	3.00e-102	366.00
IUUC-Pgr-103272	Puccinia graminis	38.54	3.00e-92	332.00
IUUC-Ptt-103880	Puccinia triticina	37.54	2.00e-97	349.00
IUUC-Pte-104260	Pyrenophora teres	37.50	3.00e-88	319.00
IUUC-Rno-105903	Rattus norvegicus	37.38	9.00e-99	354.00
IUUC-Sce-106399	Saccharomyces cerevisiae	38.28	6.00e-95	341.00
IUUC-Sha-106783	Sarcophilus harrisii	40.33	1.00e-102	367.00
IUUC-Sja-107887	Schizosaccharomyces japonicus	40.33	6.00e-102	365.00
IUUC-Spo-108154	Schizosaccharomyces pombe	40.04	2.00e-103	370.00
IUUC-Smo-108759	Selaginella moellendorffii	57.12	0.00e+00	689.00
IUUC-Sit-110023	Setaria italica	74.18	0.00e+00	975.00
IUUC-Sly-111423	Solanum lycopersicum	68.76	0.00e+00	1011.00
IUUC-Sbi-114688	Sorghum bicolor	75.00	0.00e+00	979.00
IUUC-Sre-114983	Sporisorium reilianum	36.79	9.00e-79	288.00
IUUC-Ssc-116030	Sus scrofa	37.62	9.00e-105	374.00
IUUC-Tgu-117451	Taeniopygia guttata	40.11	7.00e-106	377.00
IUUC-Tru-118600	Takifugu rubripes	41.04	4.00e-89	322.00
IUUC-Tni-119758	Tetraodon nigroviridis	40.67	6.00e-91	328.00
IUUC-Tca-121797	Theobroma cacao	83.09	0.00e+00	1077.00
IUUC-Tre-121883	Trichoderma reesei	33.70	1.00e-71	264.00
IUUC-Tvi-122333	Trichoderma virens	33.04	1.00e-78	287.00
IUUC-Tae-122848	Triticum aestivum	73.86	0.00e+00	960.00
IUUC-Tur-126594	Triticum urartu	73.53	0.00e+00	956.00
IUUC-Tme-127106	Tuber melanosporum	37.17	1.00e-89	324.00
IUUC-Tbe-127911	Tupaia belangeri	38.65	1.00e-94	340.00
IUUC-Ttr-128597	Tursiops truncatus	37.62	2.00e-104	373.00
IUUC-Uma-129321	Ustilago maydis	38.25	2.00e-77	283.00
IUUC-Vpa-130686	Vicugna pacos	33.57	2.00e-74	273.00
IUUC-Vvi-131046	Vitis vinifera	72.21	0.00e+00	1090.00
IUUC-Xtr-132740	Xenopus tropicalis	34.97	1.00e-95	343.00
IUUC-Xma-134260	Xiphophorus maculatus	40.14	4.00e-98	352.00
IUUC-Yli-134634	Yarrowia lipolytica	37.27	2.00e-98	353.00
IUUC-Zma-135493	Zea mays	74.84	0.00e+00	976.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence