iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115243

Ensembl Protein ID

ENSSSCP00000011271.2

UniProt Accession

F1S861; F1S861_PIG

Genbank Protein ID

ENSSSCP00000011271

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU498828

Gene Name

NFKB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000010580.3	ENSSSCT00000011573.2	ENSSSCP00000011271.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.50e-06	26.9	555	596

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 3    etaleqLkeiFPnldysviqvvLeantgsleaavnnLLegse 44
            + ++ L e+FP++++++ q+vL   +g+le+av++L eg+e
   Q: 555  LPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKE 596
           56778899*******************************975 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MDSCYDPSLP GIIEYDDFKF NPSIVEPKEP APETADGPYL VIVEQPKQRG FRFRYGCEGP 60
SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD PPRAHAHSLV GKQCSELGVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCTGGGTC AGCGGATCCC GCAGCAGGCT GGTCCCTAGG ACAAAACTCA CACCTGATTG 60
AGGGCCATCC TCACTCTCGC TTCGCGCGCT GAGCAAATAT TTCCCCTCTA AGGGGCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003892--CUE
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR033926--IPT_NFkappaB
IPR000451--NFkB/Dor
IPR008967--p53-like_TF_DNA-bd
IPR030492--RHD_CS
IPR032397--RHD_dimer
IPR011539--RHD_DNA_bind_dom

PROSITE

PS51140--CUE
PS01204--REL_1
PS50254--REL_2

Pfam

PF00531--Death
PF16179--RHD_dimer
PF00554--RHD_DNA_bind

PRINTS

PR00057--NFKBTNSCPFCT

SMART

SM00005--DEATH
SM00429--IPT

Gene Ontology

GO:0033257--C:Bcl3/NF-kappaB2 complex
GO:0005829--C:cytosol
GO:0033256--C:I-kappaB/NF-kappaB complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0030198--P:extracellular matrix organization
GO:0002268--P:follicular dendritic cell differentiation
GO:0002467--P:germinal center formation
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0038061--P:NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0034097--P:response to cytokine
GO:0048536--P:spleen development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001790	Ailuropoda melanoleuca	72.73	6.00e-72	263.00
IUUC-Apl-003944	Anas platyrhynchos	38.86	6.00e-25	107.00
IUUC-Ago-007785	Ashbya gossypii	35.85	3.20e-01	29.30
IUUC-Acl-008346	Aspergillus clavatus	28.57	9.80e-01	28.90
IUUC-Afu-008947	Aspergillus fumigatus	38.89	1.30e+00	28.50
IUUC-Ate-010403	Aspergillus terreus	36.36	2.10e+00	27.70
IUUC-Ame-011202	Astyanax mexicanus	46.24	7.00e-17	80.90
IUUC-Bta-012549	Bos taurus	61.24	8.00e-57	213.00
IUUC-Cja-019719	Callithrix jacchus	69.38	7.00e-69	253.00
IUUC-Cfa-021223	Canis familiaris	71.29	5.00e-74	270.00
IUUC-Cpo-021485	Cavia porcellus	64.11	7.00e-61	226.00
IUUC-Csa-023808	Chlorocebus sabaeus	69.86	5.00e-64	237.00
IUUC-Cne-026987	Cryptococcus neoformans	32.43	1.30e+00	28.50
IUUC-Dre-027377	Danio rerio	46.67	5.00e-16	77.80
IUUC-Dno-029148	Dasypus novemcinctus	67.14	1.00e-71	262.00
IUUC-Dor-030884	Dipodomys ordii	67.46	5.00e-63	233.00
IUUC-Dme-031833	Drosophila melanogaster	26.60	2.00e-07	49.30
IUUC-Eca-033224	Equus caballus	74.16	8.00e-79	286.00
IUUC-Fca-036557	Felis catus	71.29	3.00e-72	265.00
IUUC-Fal-036631	Ficedula albicollis	40.28	9.00e-27	113.00
IUUC-Gmo-038930	Gadus morhua	30.99	1.00e-14	73.20
IUUC-Gga-041066	Gallus gallus	40.76	7.00e-27	114.00
IUUC-Gac-041736	Gasterosteus aculeatus	28.44	3.00e-15	75.10
IUUC-Ggo-045551	Gorilla gorilla	70.48	1.00e-62	232.00
IUUC-Hsa-046256	Homo sapiens	70.81	4.00e-64	237.00
IUUC-Itr-047925	Ictidomys tridecemlineatus	70.81	3.00e-74	271.00
IUUC-Lch-049728	Latimeria chalumnae	46.24	1.00e-18	85.50
IUUC-Loc-052375	Lepisosteus oculatus	32.56	6.00e-17	80.90
IUUC-Laf-054367	Loxodonta africana	65.55	7.00e-66	243.00
IUUC-Mcc-055535	Macaca mulatta	68.90	7.00e-64	236.00
IUUC-Meu-056716	Macropus eugenii	62.24	5.00e-26	110.00
IUUC-Mla-059087	Melampsora laricipopulina	41.30	9.00e-03	32.70
IUUC-Mga-059259	Meleagris gallopavo	41.51	2.00e-27	115.00
IUUC-Mdo-062874	Monodelphis domestica	47.20	2.00e-27	115.00
IUUC-Mmu-063091	Mus musculus	64.11	2.00e-63	235.00
IUUC-Mpu-066538	Mustela putorius furo	72.25	5.00e-73	267.00
IUUC-Mlu-068118	Myotis lucifugus	70.33	4.00e-66	244.00
IUUC-Nle-069262	Nomascus leucogenys	70.81	4.00e-64	237.00
IUUC-Opr-070887	Ochotona princeps	66.99	3.00e-63	234.00
IUUC-Ont-072566	Oreochromis niloticus	30.14	1.00e-15	76.60
IUUC-Oan-073555	Ornithorhynchus anatinus	58.70	2.00e-23	102.00
IUUC-Ocu-073954	Oryctolagus cuniculus	70.00	5.00e-70	257.00
IUUC-Ola-087131	Oryzias latipes	30.88	2.00e-16	79.30
IUUC-Oga-088232	Otolemur garnettii	59.33	1.00e-47	182.00
IUUC-Oar-090288	Ovis aries	64.59	8.00e-60	223.00
IUUC-Ptr-091641	Pan troglodytes	70.81	4.00e-64	237.00
IUUC-Pan-092307	Papio anubis	68.90	7.00e-72	263.00
IUUC-Psi-093174	Pelodiscus sinensis	50.00	4.00e-11	61.60
IUUC-Pfo-096255	Poecilia formosa	32.24	3.00e-17	82.00
IUUC-Pab-098066	Pongo abelii	70.33	1.00e-72	265.00
IUUC-Pca-101113	Procavia capensis	63.16	4.00e-58	217.00
IUUC-Pva-102662	Pteropus vampyrus	69.86	5.00e-72	263.00
IUUC-Rno-105183	Rattus norvegicus	57.42	3.00e-46	178.00
IUUC-Sha-107507	Sarcophilus harrisii	41.20	3.00e-31	128.00
IUUC-Spo-108061	Schizosaccharomyces pombe	32.43	1.10e+00	28.90
IUUC-Sre-115033	Sporisorium reilianum	37.84	1.20e-01	32.00
IUUC-Tgu-117106	Taeniopygia guttata	40.28	4.00e-27	114.00
IUUC-Tru-117992	Takifugu rubripes	43.18	4.00e-16	78.20
IUUC-Tni-120145	Tetraodon nigroviridis	31.10	2.00e-15	75.90
IUUC-Tbe-127268	Tupaia belangeri	72.73	3.00e-69	254.00
IUUC-Uma-129410	Ustilago maydis	37.84	1.40e-01	32.00
IUUC-Xtr-132299	Xenopus tropicalis	51.09	9.00e-21	93.60
IUUC-Xma-133702	Xiphophorus maculatus	32.54	2.00e-17	82.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence