iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008952

Ensembl Protein ID

CADAFUAP00006596

UniProt Accession

Q4WVU5; PPIL2_ASPFU

Genbank Protein ID

EAL91281.2

Protein Name

Peptidyl-prolyl cis-trans isomerase-like 2; Cyclophilin-60; Cyclophilin-like protein Cyp-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase

Genbank Nucleotide ID

AAHF01000003

Gene Name

AFUA_5G13350; cyp8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00006596	CADAFUAT00006596	CADAFUAP00006596

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.90e-13	48.3	48	108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqaw 68
            C++sl+++++Pv++psG  +d +sI  w+++ g+ +Pv+++pl+++dl+  +  ++   ++
   Q: 48   FCSLSLQPFSHPVCTPSGTIFDLTSILPWIKKHGT-NPVDGSPLKSSDLIKLNIAKNESGEY 108
           6******************************9998.**************999988876666 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.

Protein Sequence
(Fasta)

MGKGTDKLYI THSEWASEDA YSASAGAGVG KARRGGENAG FRRLPFNFCS LSLQPFSHPV 60
CTPSGTIFDL TSILPWIKKH GTNPVDGSPL KSSDLIKLNI AKNESGEYVD PVTYKVLTDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCAAGG GTGAGTTTCT TTACCAAACT ATATTTCCAA CGCTTACAAC TGACTCCTGA 60
CTTGTTAGGA ACGGATAAGC TTTACGTATG ATGTTCCACA CTTTCTCTGC CTTCATGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX

Pfam

PF00160--Pro_isomerase

PRINTS

PR00153--CSAPPISMRASE

SMART

SM00504--Ubox

Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006457--P:protein folding

KEGG

afm:AFUA_5G13350

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000982	Aegilops tauschii	40.12	1.00e-80	292.00
IUUC-Aml-002351	Ailuropoda melanoleuca	43.56	5.00e-109	386.00
IUUC-Atr-002724	Amborella trichopoda	38.81	5.00e-96	343.00
IUUC-Apl-003515	Anas platyrhynchos	43.33	4.00e-100	356.00
IUUC-Aca-004802	Anolis carolinensis	42.86	1.00e-108	384.00
IUUC-Aly-005928	Arabidopsis lyrata	39.50	2.00e-91	328.00
IUUC-Ath-007574	Arabidopsis thaliana	38.93	7.00e-85	306.00
IUUC-Acl-008183	Aspergillus clavatus	90.04	0.00e+00	907.00
IUUC-Afl-008382	Aspergillus flavus	81.38	0.00e+00	819.00
IUUC-Ani-009146	Aspergillus nidulans	82.36	0.00e+00	882.00
IUUC-Ang-009743	Aspergillus niger	85.01	0.00e+00	850.00
IUUC-Aor-010027	Aspergillus oryzae	80.62	0.00e+00	812.00
IUUC-Ate-010569	Aspergillus terreus	84.00	0.00e+00	877.00
IUUC-Ame-010783	Astyanax mexicanus	41.98	2.00e-108	384.00
IUUC-Bgr-012172	Blumeria graminis	48.43	4.00e-114	403.00
IUUC-Bta-012459	Bos taurus	42.58	8.00e-103	365.00
IUUC-Bci-013693	Botrytis cinerea	57.91	2.00e-157	547.00
IUUC-Bdi-014623	Brachypodium distachyon	40.31	1.00e-99	355.00
IUUC-Bol-015781	Brassica oleracea	40.08	2.00e-94	338.00
IUUC-Bra-016624	Brassica rapa	40.08	6.00e-94	336.00
IUUC-Cel-018328	Caenorhabditis elegans	39.24	1.00e-91	328.00
IUUC-Cja-019427	Callithrix jacchus	45.53	6.00e-107	379.00
IUUC-Cfa-020829	Canis familiaris	43.01	3.00e-109	386.00
IUUC-Cpo-022189	Cavia porcellus	42.45	3.00e-108	383.00
IUUC-Cre-022723	Chlamydomonas reinhardtii	45.51	7.00e-46	176.00
IUUC-Csa-024212	Chlorocebus sabaeus	44.38	2.00e-107	380.00
IUUC-Cin-025720	Ciona intestinalis	41.74	4.00e-108	383.00
IUUC-Csv-026137	Ciona savignyi	42.28	1.00e-99	355.00
IUUC-Cgl-026532	Colletotrichum gloeosporioides	56.94	2.00e-155	540.00
IUUC-Cne-026830	Cryptococcus neoformans	41.98	9.00e-113	398.00
IUUC-Dre-028561	Danio rerio	44.91	3.00e-105	373.00
IUUC-Dno-029029	Dasypus novemcinctus	41.39	4.00e-95	340.00
IUUC-Dor-030683	Dipodomys ordii	49.67	1.00e-37	149.00
IUUC-Dse-031506	Dothistroma septosporum	63.14	4.00e-178	615.00
IUUC-Dme-032058	Drosophila melanogaster	41.56	3.00e-97	347.00
IUUC-Ete-033157	Echinops telfairi	35.35	9.00e-73	265.00
IUUC-Eeu-034470	Erinaceus europaeus	43.25	1.00e-67	248.00
IUUC-Fca-036571	Felis catus	44.99	5.00e-108	382.00
IUUC-Fal-037613	Ficedula albicollis	42.03	2.00e-107	380.00
IUUC-Fox-037795	Fusarium oxysporum	56.53	8.00e-165	571.00
IUUC-Fso-038213	Fusarium solani	51.56	1.00e-148	518.00
IUUC-Gmo-039609	Gadus morhua	44.77	2.00e-97	347.00
IUUC-Ggr-039825	Gaeumannomyces graminis	53.98	1.00e-150	524.00
IUUC-Gga-041191	Gallus gallus	42.51	6.00e-110	389.00
IUUC-Gac-041524	Gasterosteus aculeatus	45.00	1.00e-105	374.00
IUUC-Gma-042936	Glycine max	40.80	7.00e-96	342.00
IUUC-Ggo-045352	Gorilla gorilla	42.55	7.00e-108	382.00
IUUC-Hsa-045709	Homo sapiens	42.55	9.00e-108	382.00
IUUC-Hvu-047058	Hordeum vulgare	40.19	4.00e-94	337.00
IUUC-Itr-048483	Ictidomys tridecemlineatus	46.04	9.00e-107	378.00
IUUC-Lch-049681	Latimeria chalumnae	44.58	7.00e-100	355.00
IUUC-Lpe-050799	Leersia perrieri	39.16	1.00e-82	298.00
IUUC-Loc-052566	Lepisosteus oculatus	42.75	7.00e-95	339.00
IUUC-Lma-053028	Leptosphaeria maculans	61.26	2.00e-169	587.00
IUUC-Laf-054547	Loxodonta africana	43.68	9.00e-110	388.00
IUUC-Mcc-054753	Macaca mulatta	42.88	1.00e-107	382.00
IUUC-Meu-056855	Macropus eugenii	34.16	2.00e-35	140.00
IUUC-Mor-056941	Magnaporthe oryzae	54.10	7.00e-139	485.00
IUUC-Mpo-057306	Magnaporthe poae	53.81	9.00e-153	531.00
IUUC-Mtr-058349	Medicago truncatula	41.37	8.00e-94	335.00
IUUC-Mla-058842	Melampsora laricipopulina	43.92	2.00e-108	384.00
IUUC-Mga-060099	Meleagris gallopavo	42.52	9.00e-99	352.00
IUUC-Mvi-060413	Microbotryum violaceum	41.39	5.00e-101	359.00
IUUC-Mmr-061530	Microcebus murinus	43.01	7.00e-109	385.00
IUUC-Mdo-062668	Monodelphis domestica	45.27	2.00e-106	378.00
IUUC-Mmu-063871	Mus musculus	42.78	7.00e-109	385.00
IUUC-Mac-064559	Musa acuminata	51.12	2.00e-48	185.00
IUUC-Mpu-065919	Mustela putorius furo	43.73	5.00e-109	386.00
IUUC-Mlu-067846	Myotis lucifugus	44.10	4.00e-97	347.00
IUUC-Nfi-068507	Neosartorya fischeri	97.79	0.00e+00	906.00
IUUC-Ncr-068805	Neurospora crassa	54.29	1.00e-128	451.00
IUUC-Nle-070125	Nomascus leucogenys	39.20	2.00e-94	337.00
IUUC-Opr-070486	Ochotona princeps	42.24	7.00e-79	285.00
IUUC-Ont-071597	Oreochromis niloticus	46.67	4.00e-110	389.00
IUUC-Ocu-074411	Oryctolagus cuniculus	46.36	5.00e-108	382.00
IUUC-Oba-075040	Oryza barthii	43.18	1.00e-51	195.00
IUUC-Obr-076727	Oryza brachyantha	42.73	2.00e-50	192.00
IUUC-Ogl-077605	Oryza glaberrima	43.18	1.00e-51	195.00
IUUC-Ogu-078177	Oryza glumaepatula	43.18	1.00e-51	195.00
IUUC-Oin-079549	Oryza indica	43.18	3.00e-51	194.00
IUUC-Olo-081090	Oryza longistaminata	43.18	1.00e-51	195.00
IUUC-Ome-081979	Oryza meridionalis	43.18	2.00e-51	195.00
IUUC-Oni-082819	Oryza nivara	43.18	2.00e-51	194.00
IUUC-Opu-083212	Oryza punctata	43.18	1.00e-51	195.00
IUUC-Oru-084412	Oryza rufipogon	43.18	1.00e-51	195.00
IUUC-Osa-085431	Oryza sativa	46.04	5.00e-32	128.00
IUUC-Ola-086602	Oryzias latipes	47.96	3.00e-104	370.00
IUUC-Olu-087682	Ostreococcus lucimarinus	40.30	8.00e-85	305.00
IUUC-Oga-088999	Otolemur garnettii	41.68	1.00e-101	362.00
IUUC-Oar-089338	Ovis aries	38.64	2.00e-80	291.00
IUUC-Ptr-091185	Pan troglodytes	42.55	7.00e-108	382.00
IUUC-Pan-092321	Papio anubis	42.73	8.00e-109	385.00
IUUC-Psi-094018	Pelodiscus sinensis	45.34	4.00e-55	206.00
IUUC-Pma-094111	Petromyzon marinus	40.65	3.00e-79	286.00
IUUC-Pno-094782	Phaeosphaeria nodorum	59.79	5.00e-173	598.00
IUUC-Ppa-095335	Physcomitrella patens	36.67	5.00e-95	340.00
IUUC-Pfo-097393	Poecilia formosa	45.62	2.00e-108	384.00
IUUC-Pab-098263	Pongo abelii	38.91	8.00e-92	328.00
IUUC-Pop-099316	Populus trichocarpa	41.63	3.00e-86	310.00
IUUC-Pca-100387	Procavia capensis	57.94	2.00e-41	161.00
IUUC-Ppe-101275	Prunus persica	40.08	3.00e-94	337.00
IUUC-Pva-102150	Pteropus vampyrus	46.43	4.00e-94	336.00
IUUC-Pgr-103378	Puccinia graminis	48.34	3.00e-118	417.00
IUUC-Ptt-103908	Puccinia triticina	43.76	3.00e-103	367.00
IUUC-Pte-104248	Pyrenophora teres	59.22	3.00e-173	599.00
IUUC-Pyt-104645	Pyrenophora triticirepentis	59.22	1.00e-174	604.00
IUUC-Rno-105162	Rattus norvegicus	43.09	3.00e-110	390.00
IUUC-Sha-107123	Sarcophilus harrisii	54.44	2.00e-43	168.00
IUUC-Sja-107828	Schizosaccharomyces japonicus	46.68	7.00e-124	435.00
IUUC-Spo-108368	Schizosaccharomyces pombe	46.59	7.00e-130	455.00
IUUC-Smo-109102	Selaginella moellendorffii	40.00	4.00e-99	353.00
IUUC-Sit-110821	Setaria italica	41.30	5.00e-96	343.00
IUUC-Sly-111803	Solanum lycopersicum	38.89	1.00e-99	355.00
IUUC-Stu-112730	Solanum tuberosum	39.39	1.00e-98	352.00
IUUC-Sar-113618	Sorex araneus	44.38	3.00e-106	377.00
IUUC-Sbi-114487	Sorghum bicolor	41.87	8.00e-97	345.00
IUUC-Sre-115009	Sporisorium reilianum	41.43	6.00e-99	352.00
IUUC-Ssc-115984	Sus scrofa	43.07	6.00e-108	382.00
IUUC-Tgu-117410	Taeniopygia guttata	41.75	2.00e-108	384.00
IUUC-Tru-118537	Takifugu rubripes	41.94	4.00e-106	376.00
IUUC-Tsy-119318	Tarsius syrichta	33.33	1.00e-40	159.00
IUUC-Tni-120514	Tetraodon nigroviridis	44.09	1.00e-73	268.00
IUUC-Tca-121620	Theobroma cacao	40.45	2.00e-93	335.00
IUUC-Tre-121904	Trichoderma reesei	51.77	5.00e-128	449.00
IUUC-Tvi-122585	Trichoderma virens	56.79	3.00e-132	463.00
IUUC-Tae-125342	Triticum aestivum	40.00	8.00e-94	336.00
IUUC-Tme-126960	Tuber melanosporum	62.13	8.00e-168	581.00
IUUC-Tbe-127839	Tupaia belangeri	36.07	2.00e-34	137.00
IUUC-Ttr-129173	Tursiops truncatus	33.33	9.00e-72	262.00
IUUC-Uma-129595	Ustilago maydis	41.19	3.00e-92	330.00
IUUC-Vda-130012	Verticillium dahliae	56.26	2.00e-157	547.00
IUUC-Vvi-131156	Vitis vinifera	39.59	8.00e-101	359.00
IUUC-Xtr-132807	Xenopus tropicalis	43.75	5.00e-102	363.00
IUUC-Yli-134361	Yarrowia lipolytica	45.04	9.00e-37	145.00
IUUC-Zma-135759	Zea mays	50.97	5.00e-45	174.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence