iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000183751.14	ENST00000568546.5	ENSP00000454836.1
ENSG00000183751.14	ENST00000561907.5	ENSP00000454735.1
ENSG00000183751.14	ENST00000332704.5	ENSP00000331815.5
ENSG00000183751.14	ENST00000615855.4	ENSP00000481995.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-55	184.3	519	558
UBD/Beta-Prp	1.30e-97	328.3	413	640

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH  + +c++f +    l+++s Dgtik+W l ++ +lk+
   Q: 519  GHRRGLWCVQFsPMdQVLATASADGTIKLWALQDFSCLKT 558
           8999*******977789*******************9986 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls...........tgkcvhtlk....ghedsvlslsfspsgdklvsGshdrtir 119
           ++++ sgh+  v +v++s+ ++ +lvtgs+D t+k+w+l            +g+++   +     h++++ s+++ p+++ l++Gs+drt++
   Q: 413  CVAQGSGHTHSVGTVCCSRLKEsFLVTGSQDCTVKLWPLPkallskntapdNGPILLQAQttqrCHDKDINSVAIAPNDKLLATGSQDRTAK 504
           577789***********998778**************5555566666666688888877766668*************************** PP
   S: 120  vwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqt 211
           +w l++ q l  ++sgh++  +cv+++p +++l+++s+D+t++lW l+  ++l+t++g h+ sv +++f s g++l+s + dg vklw +++
   Q: 505  LWALPQCQLLG-VFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEG-HDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
           **********9.*********************************************9.********************************* PP
   S: 212  gecvrtlnghtdnvksvrfspnderlvsgssDgsiriW.dlrsgdl 256
           +ecvrtl +h+d v+ ++ s+ d++ ++g+sD  + +W d++  + 
   Q: 595  NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWkDVTEAEQ 640
           **************************************87766554 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAETAAGVGR FKTNYAVERK IEPFYKGGKA QLDQTGQHLF CVCGTRVNIL EVASGAVLRS 60
LEQEDQEDIT AFDLSPDNEV LVTASRALLL AQWAWQEGSV TRLWKAIHTA PVATMAFDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGTGAC GCCATCGCAG CGCGCCGGGA GTGTGGCGTT CTGTGAAGAG TTCGGTGCTA 60
ACCTCCCTCA CGCGGCGGTG GCTGCCGGGA CCCTAGCAGG TTTCAGCTGG AGCGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR013934--SSU_processome_Utp13
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08625--Utp13
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0030515--F:snoRNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364--P:rRNA processing

KEGG

hsa:10607

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000765	Aegilops tauschii	35.50	9.00e-145	507.00
IUUC-Aml-002376	Ailuropoda melanoleuca	88.93	0.00e+00	1397.00
IUUC-Atr-002486	Amborella trichopoda	38.04	5.00e-160	558.00
IUUC-Apl-003519	Anas platyrhynchos	61.23	0.00e+00	899.00
IUUC-Aca-004363	Anolis carolinensis	56.45	5.00e-149	520.00
IUUC-Aly-006152	Arabidopsis lyrata	35.09	3.00e-148	519.00
IUUC-Ath-006966	Arabidopsis thaliana	35.03	5.00e-148	518.00
IUUC-Ago-007746	Ashbya gossypii	30.58	3.00e-108	386.00
IUUC-Acl-008009	Aspergillus clavatus	30.21	1.00e-106	380.00
IUUC-Afl-008681	Aspergillus flavus	28.82	2.00e-95	344.00
IUUC-Afu-008798	Aspergillus fumigatus	29.67	5.00e-94	339.00
IUUC-Ani-009278	Aspergillus nidulans	27.88	4.00e-98	353.00
IUUC-Ang-009640	Aspergillus niger	29.37	3.00e-102	366.00
IUUC-Aor-010160	Aspergillus oryzae	28.82	3.00e-95	343.00
IUUC-Ate-010320	Aspergillus terreus	29.67	3.00e-105	376.00
IUUC-Ame-010930	Astyanax mexicanus	60.70	5.00e-75	273.00
IUUC-Bgr-012054	Blumeria graminis	28.57	4.00e-104	372.00
IUUC-Bta-012611	Bos taurus	90.11	0.00e+00	1406.00
IUUC-Bci-013797	Botrytis cinerea	30.54	9.00e-113	401.00
IUUC-Bdi-014384	Brachypodium distachyon	38.19	3.00e-162	566.00
IUUC-Bol-016483	Brassica oleracea	35.13	2.00e-148	520.00
IUUC-Bra-017798	Brassica rapa	35.86	5.00e-148	518.00
IUUC-Cel-018664	Caenorhabditis elegans	31.22	8.00e-119	421.00
IUUC-Cja-019092	Callithrix jacchus	94.67	0.00e+00	1531.00
IUUC-Cfa-021040	Canis familiaris	88.94	0.00e+00	1403.00
IUUC-Cpo-022529	Cavia porcellus	90.23	0.00e+00	1422.00
IUUC-Cre-022986	Chlamydomonas reinhardtii	59.54	3.00e-46	177.00
IUUC-Csa-024205	Chlorocebus sabaeus	96.66	0.00e+00	1565.00
IUUC-Cin-025560	Ciona intestinalis	45.26	0.00e+00	720.00
IUUC-Cgl-026481	Colletotrichum gloeosporioides	31.18	1.00e-115	410.00
IUUC-Cne-027082	Cryptococcus neoformans	30.51	7.00e-115	408.00
IUUC-Cme-027159	Cyanidioschyzon merolae	24.83	1.00e-30	129.00
IUUC-Dre-028138	Danio rerio	53.00	0.00e+00	884.00
IUUC-Dno-029914	Dasypus novemcinctus	66.34	0.00e+00	823.00
IUUC-Dor-030685	Dipodomys ordii	77.55	0.00e+00	933.00
IUUC-Dse-031429	Dothistroma septosporum	29.86	3.00e-101	363.00
IUUC-Dme-031995	Drosophila melanogaster	32.10	2.00e-118	420.00
IUUC-Ete-033086	Echinops telfairi	90.21	0.00e+00	796.00
IUUC-Eca-034354	Equus caballus	91.79	0.00e+00	1415.00
IUUC-Eeu-034832	Erinaceus europaeus	87.27	0.00e+00	824.00
IUUC-Fca-036136	Felis catus	83.83	0.00e+00	1320.00
IUUC-Fal-036859	Ficedula albicollis	65.40	0.00e+00	1044.00
IUUC-Fox-037863	Fusarium oxysporum	30.49	2.00e-101	363.00
IUUC-Fso-038389	Fusarium solani	30.71	3.00e-113	402.00
IUUC-Gmo-038711	Gadus morhua	57.93	0.00e+00	908.00
IUUC-Ggr-039820	Gaeumannomyces graminis	28.46	7.00e-103	369.00
IUUC-Gga-040263	Gallus gallus	65.42	0.00e+00	1085.00
IUUC-Gac-041291	Gasterosteus aculeatus	60.57	0.00e+00	1023.00
IUUC-Gma-044026	Glycine max	38.91	2.00e-167	582.00
IUUC-Ggo-044693	Gorilla gorilla	99.13	0.00e+00	1567.00
IUUC-Hvu-047608	Hordeum vulgare	37.24	8.00e-161	561.00
IUUC-Itr-048391	Ictidomys tridecemlineatus	90.71	0.00e+00	1486.00
IUUC-Kpa-049209	Komagataella pastoris	33.04	8.00e-122	431.00
IUUC-Lch-050085	Latimeria chalumnae	62.30	0.00e+00	999.00
IUUC-Lpe-050945	Leersia perrieri	38.46	2.00e-158	553.00
IUUC-Loc-052679	Lepisosteus oculatus	65.11	0.00e+00	1087.00
IUUC-Laf-053685	Loxodonta africana	88.59	0.00e+00	1354.00
IUUC-Mcc-055861	Macaca mulatta	96.78	0.00e+00	1533.00
IUUC-Meu-056820	Macropus eugenii	70.52	0.00e+00	964.00
IUUC-Mor-057234	Magnaporthe oryzae	28.14	1.00e-102	367.00
IUUC-Mpo-057456	Magnaporthe poae	29.67	9.00e-84	304.00
IUUC-Mtr-058122	Medicago truncatula	38.91	2.00e-167	582.00
IUUC-Mla-058980	Melampsora laricipopulina	28.32	7.00e-97	348.00
IUUC-Mga-060080	Meleagris gallopavo	63.13	0.00e+00	1076.00
IUUC-Mvi-060338	Microbotryum violaceum	34.99	7.00e-143	501.00
IUUC-Mmr-060762	Microcebus murinus	92.81	0.00e+00	1458.00
IUUC-Mdo-061975	Monodelphis domestica	73.91	0.00e+00	1160.00
IUUC-Mmu-064038	Mus musculus	89.75	0.00e+00	1412.00
IUUC-Mac-065189	Musa acuminata	36.46	2.00e-160	560.00
IUUC-Mpu-066526	Mustela putorius furo	89.73	0.00e+00	1399.00
IUUC-Mlu-067716	Myotis lucifugus	89.69	0.00e+00	1478.00
IUUC-Nfi-068474	Neosartorya fischeri	30.13	6.00e-97	348.00
IUUC-Ncr-068826	Neurospora crassa	28.42	2.00e-96	347.00
IUUC-Nle-069832	Nomascus leucogenys	97.40	0.00e+00	1575.00
IUUC-Opr-071183	Ochotona princeps	83.12	0.00e+00	1313.00
IUUC-Ont-072371	Oreochromis niloticus	61.51	0.00e+00	1021.00
IUUC-Oan-073491	Ornithorhynchus anatinus	66.54	0.00e+00	939.00
IUUC-Oba-075963	Oryza barthii	37.85	1.00e-160	560.00
IUUC-Obr-076173	Oryza brachyantha	38.62	2.00e-160	559.00
IUUC-Ogl-077692	Oryza glaberrima	37.85	2.00e-160	560.00
IUUC-Ogu-078965	Oryza glumaepatula	37.85	1.00e-160	560.00
IUUC-Oin-079708	Oryza indica	37.85	1.00e-160	560.00
IUUC-Olo-080679	Oryza longistaminata	37.53	5.00e-158	551.00
IUUC-Oni-082960	Oryza nivara	37.73	2.00e-160	559.00
IUUC-Opu-083282	Oryza punctata	37.42	2.00e-153	536.00
IUUC-Oru-085224	Oryza rufipogon	37.85	1.00e-160	560.00
IUUC-Osa-085320	Oryza sativa	37.85	1.00e-160	560.00
IUUC-Ola-086370	Oryzias latipes	58.53	3.00e-133	469.00
IUUC-Olu-087814	Ostreococcus lucimarinus	33.69	5.00e-102	365.00
IUUC-Oga-088458	Otolemur garnettii	88.53	0.00e+00	1487.00
IUUC-Oar-090032	Ovis aries	80.85	0.00e+00	988.00
IUUC-Ptr-090749	Pan troglodytes	98.51	0.00e+00	1551.00
IUUC-Pan-091691	Papio anubis	93.32	0.00e+00	1467.00
IUUC-Psi-093200	Pelodiscus sinensis	64.70	0.00e+00	1061.00
IUUC-Pma-094165	Petromyzon marinus	52.84	0.00e+00	650.00
IUUC-Pno-095048	Phaeosphaeria nodorum	32.22	1.00e-90	327.00
IUUC-Ppa-095336	Physcomitrella patens	39.53	1.00e-160	560.00
IUUC-Pfo-096132	Poecilia formosa	61.40	0.00e+00	990.00
IUUC-Pab-097855	Pongo abelii	97.52	0.00e+00	1575.00
IUUC-Pop-099434	Populus trichocarpa	36.42	3.00e-152	532.00
IUUC-Pca-100232	Procavia capensis	84.80	8.00e-165	574.00
IUUC-Ppe-101665	Prunus persica	36.69	2.00e-160	559.00
IUUC-Pva-102178	Pteropus vampyrus	89.89	0.00e+00	1429.00
IUUC-Pgr-103288	Puccinia graminis	29.17	4.00e-85	310.00
IUUC-Ptt-103808	Puccinia triticina	31.87	3.00e-86	313.00
IUUC-Pte-104205	Pyrenophora teres	30.48	3.00e-107	383.00
IUUC-Pyt-104658	Pyrenophora triticirepentis	29.36	2.00e-97	350.00
IUUC-Rno-105617	Rattus norvegicus	89.61	0.00e+00	1410.00
IUUC-Sce-106281	Saccharomyces cerevisiae	30.18	2.00e-108	386.00
IUUC-Sha-107378	Sarcophilus harrisii	73.95	0.00e+00	1145.00
IUUC-Sja-107718	Schizosaccharomyces japonicus	34.56	2.00e-123	437.00
IUUC-Spo-108361	Schizosaccharomyces pombe	33.67	1.00e-120	427.00
IUUC-Ssl-108592	Sclerotinia sclerotiorum	30.97	6.00e-115	408.00
IUUC-Smo-109257	Selaginella moellendorffii	39.07	1.00e-158	553.00
IUUC-Sit-110258	Setaria italica	36.61	2.00e-162	566.00
IUUC-Sly-111521	Solanum lycopersicum	36.51	9.00e-156	544.00
IUUC-Stu-112718	Solanum tuberosum	46.43	7.00e-34	135.00
IUUC-Sar-113586	Sorex araneus	77.40	1.00e-64	240.00
IUUC-Sbi-114768	Sorghum bicolor	38.07	1.00e-165	577.00
IUUC-Sre-115159	Sporisorium reilianum	33.70	1.00e-97	352.00
IUUC-Ssc-116342	Sus scrofa	68.23	0.00e+00	936.00
IUUC-Tgu-117320	Taeniopygia guttata	63.81	0.00e+00	1007.00
IUUC-Tru-118024	Takifugu rubripes	60.35	0.00e+00	978.00
IUUC-Tni-119971	Tetraodon nigroviridis	61.29	0.00e+00	992.00
IUUC-Tca-121248	Theobroma cacao	37.70	7.00e-159	554.00
IUUC-Tre-122079	Trichoderma reesei	30.79	3.00e-105	376.00
IUUC-Tvi-122554	Trichoderma virens	30.06	5.00e-104	372.00
IUUC-Tae-123552	Triticum aestivum	37.93	3.00e-163	569.00
IUUC-Tur-126436	Triticum urartu	36.68	7.00e-132	464.00
IUUC-Tme-126942	Tuber melanosporum	31.34	4.00e-111	395.00
IUUC-Tbe-128000	Tupaia belangeri	91.93	1.00e-86	314.00
IUUC-Ttr-128964	Tursiops truncatus	88.34	0.00e+00	1410.00
IUUC-Uma-129473	Ustilago maydis	32.49	1.00e-105	378.00
IUUC-Vda-129749	Verticillium dahliae	30.54	5.00e-98	352.00
IUUC-Vvi-131511	Vitis vinifera	39.13	4.00e-161	562.00
IUUC-Xtr-132816	Xenopus tropicalis	55.49	0.00e+00	892.00
IUUC-Xma-133672	Xiphophorus maculatus	61.78	0.00e+00	1025.00
IUUC-Yli-134602	Yarrowia lipolytica	34.77	7.00e-138	484.00
IUUC-Zma-135559	Zea mays	36.61	1.00e-155	544.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence