iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108238

Ensembl Protein ID

SPAC521.02.1:pep

UniProt Accession

Q9P7B5; WSS1_SCHPO

Genbank Protein ID

CAB86466.1

Protein Name

DNA-dependent metalloprotease WSS1 homolog; DNA damage response protein WSS1 homolog

Genbank Nucleotide ID

CU329670

Gene Name

SPAC521.02

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC521.02	SPAC521.02.1	SPAC521.02.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/Other	38.46	4.00e-10	60.10	IUUC-Sce-106416

Active Site

Position(s)	Description	Evidence
118	N/A	{ECO:0000255\|PROSITE-ProRule:PRU10095}

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites (By similarity).

Protein Sequence
(Fasta)

MIAILYLYYI LTTSILLSVS FMLRINDDDH PNEKIGFISA IKGDFHDLSS DYLKRIAAMA 60
FPIMKEHGFG VTSLDEVAYN AKFWGRNWNK GECIELVLRD ASNRWLPFEF VMDVFLHELC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGACGGTACC ATAAAATATT AAAACGCAGT AACTCCATGA TCGCTATATT GTATTTATAT 60
TATATTCTGA CTACGAGTAT CCTTTTAAGT GTTAGCTTTA TGCTACGAAT AAACGACGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR013536--WLM_dom

PROSITE

PS51397--WLM
PS00142--ZINC_PROTEASE

Pfam

PF08325--WLM

Gene Ontology

GO:0005634--C:nucleus
GO:0004222--F:metalloendopeptidase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0019985--P:translesion synthesis

KEGG

spo:SPAC521.02

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008308	Aspergillus clavatus	40.00	1.00e-14	72.40
IUUC-Afl-008658	Aspergillus flavus	40.95	3.00e-15	74.30
IUUC-Afu-008913	Aspergillus fumigatus	40.00	1.00e-14	72.00
IUUC-Ani-009308	Aspergillus nidulans	40.00	1.00e-14	72.00
IUUC-Ang-009619	Aspergillus niger	39.05	3.00e-14	70.90
IUUC-Aor-009946	Aspergillus oryzae	40.95	3.00e-15	74.30
IUUC-Ate-010393	Aspergillus terreus	38.10	5.00e-14	70.10
IUUC-Bci-013702	Botrytis cinerea	38.10	1.00e-13	68.90
IUUC-Bdi-014770	Brachypodium distachyon	39.62	2.00e-14	71.60
IUUC-Cne-026853	Cryptococcus neoformans	28.81	5.00e-16	77.40
IUUC-Fox-037769	Fusarium oxysporum	40.00	9.00e-14	69.30
IUUC-Fso-038248	Fusarium solani	37.14	1.00e-11	62.00
IUUC-Ggr-040026	Gaeumannomyces graminis	40.95	7.00e-14	69.30
IUUC-Hvu-047699	Hordeum vulgare	38.68	6.00e-12	62.80
IUUC-Kpa-049326	Komagataella pastoris	31.43	8.00e-12	62.00
IUUC-Lpe-050735	Leersia perrieri	39.62	9.00e-15	72.40
IUUC-Lma-053304	Leptosphaeria maculans	37.14	2.00e-10	58.20
IUUC-Mor-057038	Magnaporthe oryzae	36.48	5.00e-32	130.00
IUUC-Mpo-057432	Magnaporthe poae	39.00	4.00e-31	127.00
IUUC-Nfi-068513	Neosartorya fischeri	40.95	4.00e-15	73.90
IUUC-Ncr-068633	Neurospora crassa	40.59	2.00e-12	65.50
IUUC-Oan-072850	Ornithorhynchus anatinus	50.00	4.90e-01	26.20
IUUC-Oba-075102	Oryza barthii	36.79	9.00e-10	55.80
IUUC-Obr-076781	Oryza brachyantha	32.08	2.00e-09	54.70
IUUC-Ogl-077291	Oryza glaberrima	37.74	3.00e-10	57.40
IUUC-Oin-079800	Oryza indica	37.74	6.00e-10	56.20
IUUC-Olo-080556	Oryza longistaminata	52.94	2.00e-07	45.10
IUUC-Ome-081262	Oryza meridionalis	37.74	3.00e-10	57.40
IUUC-Oni-082829	Oryza nivara	37.74	6.00e-10	56.20
IUUC-Opu-083275	Oryza punctata	37.74	4.00e-10	57.00
IUUC-Oru-084564	Oryza rufipogon	37.74	3.00e-10	57.40
IUUC-Osa-085600	Oryza sativa	37.74	3.00e-10	57.40
IUUC-Ola-087041	Oryzias latipes	47.83	1.40e-01	28.50
IUUC-Olu-087608	Ostreococcus lucimarinus	39.22	5.00e-06	42.00
IUUC-Pno-095010	Phaeosphaeria nodorum	37.14	1.00e-10	58.90
IUUC-Pfo-097358	Poecilia formosa	36.00	6.00e-03	33.90
IUUC-Pte-104280	Pyrenophora teres	37.14	2.00e-11	61.60
IUUC-Pyt-104755	Pyrenophora triticirepentis	37.37	3.00e-10	57.00
IUUC-Sce-106416	Saccharomyces cerevisiae	38.46	5.00e-11	59.30
IUUC-Ssl-108588	Sclerotinia sclerotiorum	34.29	1.00e-10	58.90
IUUC-Sbi-113896	Sorghum bicolor	38.14	7.00e-09	52.80
IUUC-Sre-114932	Sporisorium reilianum	29.23	5.00e-21	93.60
IUUC-Tre-121881	Trichoderma reesei	39.05	4.00e-14	70.90
IUUC-Tvi-122470	Trichoderma virens	40.00	4.00e-15	73.90
IUUC-Tae-125350	Triticum aestivum	37.74	5.00e-12	63.20
IUUC-Tur-126703	Triticum urartu	34.92	5.00e-12	62.80
IUUC-Tme-127206	Tuber melanosporum	33.33	8.00e-11	59.70
IUUC-Uma-129542	Ustilago maydis	31.02	2.00e-17	81.60
IUUC-Yli-134425	Yarrowia lipolytica	38.53	2.00e-15	74.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence