iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-091974

Ensembl Protein ID

ENSPANP00000017784.1

UniProt Accession

A0A096NXI9; A0A096NXI9_PAPAN

Genbank Protein ID

ENSPANP00000017784

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHZZ01055158

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000006040.1	ENSPANT00000022831.1	ENSPANP00000017784.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-63	215.2	328	858
UBD/Alpha-Helix/UBA	1.10e-22	79.5	728	765

Active Site

Position(s)	Description	Evidence
337	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
821	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 328  TGIQNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 415
           7******************************.99999999********************67766666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 416  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 475
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaek 219
            ++v+ ++   + ++lpvp++   +k                              +++cLe++ ++e++++   ++++  ++k+ a+k
   Q: 476  TEKVKYTQRVDYIMQLPVPMDAALNKAeelleyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVK 561
           ********************998887799*****************************************97...************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts......................................... 267
           ++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                         
   Q: 562  TTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsph 649
           ********************997.*******************9888878888888888888888888888888888888877777777 PP
   S: 268  ..................................................................................peekqke 274
                                                                                             +     +
   Q: 650  fssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----T 733
           77777777777777777777777777777777777666666666666666666666666666666665555555555555550.....0 PP
   S: 275  ...................................................................kkkYeLiavvvHsG.slssGHY 295
                                                                              + kY+L+a ++H+G s+ +GHY
   Q: 734  ivsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHY 822
           5555555555555566666666667777777777777777777777777778888888888888888********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 823  VCHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 858
           ******.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 728  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 765
           889999******************************97 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRLK EEDPATGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAGTGAGGA GGCGCTGCTG TCAGTATTAC CGACGATCCG GGTCCCTAAG 60
GCTGGAGACC GGGTCCACAA AGACGAGTGC GCCTTCTCCT TCGACACGCC GGTAAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	43.96	0.00e+00	645.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.65	0.00e+00	1646.00
IUUC-Atr-002580	Amborella trichopoda	45.88	0.00e+00	737.00
IUUC-Apl-003774	Anas platyrhynchos	89.76	0.00e+00	1518.00
IUUC-Aca-005368	Anolis carolinensis	84.67	0.00e+00	1499.00
IUUC-Aly-005727	Arabidopsis lyrata	47.05	0.00e+00	731.00
IUUC-Ath-006974	Arabidopsis thaliana	47.15	0.00e+00	731.00
IUUC-Ago-007890	Ashbya gossypii	29.35	3.00e-82	299.00
IUUC-Acl-008057	Aspergillus clavatus	34.00	5.00e-124	438.00
IUUC-Afl-008547	Aspergillus flavus	36.39	6.00e-118	417.00
IUUC-Afu-008805	Aspergillus fumigatus	34.27	2.00e-114	406.00
IUUC-Ani-009441	Aspergillus nidulans	31.92	2.00e-97	349.00
IUUC-Ang-009720	Aspergillus niger	34.30	6.00e-118	418.00
IUUC-Aor-010111	Aspergillus oryzae	34.10	1.00e-126	447.00
IUUC-Ate-010531	Aspergillus terreus	32.06	2.00e-103	370.00
IUUC-Ame-011893	Astyanax mexicanus	64.22	0.00e+00	989.00
IUUC-Bgr-012183	Blumeria graminis	33.26	4.00e-121	429.00
IUUC-Bta-013179	Bos taurus	97.18	0.00e+00	1630.00
IUUC-Bci-013858	Botrytis cinerea	34.72	9.00e-131	461.00
IUUC-Bdi-014904	Brachypodium distachyon	46.63	0.00e+00	709.00
IUUC-Bol-015296	Brassica oleracea	47.67	0.00e+00	747.00
IUUC-Bra-017939	Brassica rapa	47.79	0.00e+00	751.00
IUUC-Cel-018625	Caenorhabditis elegans	34.81	3.00e-135	475.00
IUUC-Cja-019063	Callithrix jacchus	98.59	0.00e+00	1652.00
IUUC-Cfa-020976	Canis familiaris	94.82	0.00e+00	1577.00
IUUC-Cpo-022265	Cavia porcellus	94.83	0.00e+00	1571.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.68	5.00e-113	401.00
IUUC-Csa-024177	Chlorocebus sabaeus	95.95	0.00e+00	1466.00
IUUC-Cho-024702	Choloepus hoffmanni	88.44	0.00e+00	988.00
IUUC-Cin-025411	Ciona intestinalis	49.82	0.00e+00	835.00
IUUC-Csv-026347	Ciona savignyi	46.19	0.00e+00	796.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.48	8.00e-115	407.00
IUUC-Cne-026831	Cryptococcus neoformans	35.29	7.00e-128	451.00
IUUC-Dre-027982	Danio rerio	67.36	0.00e+00	1102.00
IUUC-Dno-029034	Dasypus novemcinctus	97.76	0.00e+00	1657.00
IUUC-Dor-030479	Dipodomys ordii	92.66	0.00e+00	709.00
IUUC-Dse-031467	Dothistroma septosporum	36.30	7.00e-132	464.00
IUUC-Dme-032075	Drosophila melanogaster	48.91	0.00e+00	796.00
IUUC-Ete-032865	Echinops telfairi	86.30	0.00e+00	1450.00
IUUC-Eca-034059	Equus caballus	97.79	0.00e+00	1649.00
IUUC-Eeu-035304	Erinaceus europaeus	91.65	0.00e+00	1486.00
IUUC-Fca-035515	Felis catus	97.53	0.00e+00	1637.00
IUUC-Fal-037271	Ficedula albicollis	86.01	0.00e+00	1414.00
IUUC-Fox-037745	Fusarium oxysporum	34.97	6.00e-130	457.00
IUUC-Fso-038158	Fusarium solani	35.53	7.00e-129	454.00
IUUC-Gmo-039071	Gadus morhua	64.84	0.00e+00	1076.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.45	3.00e-119	422.00
IUUC-Gga-040635	Gallus gallus	89.31	0.00e+00	1585.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.08	0.00e+00	1090.00
IUUC-Gma-043614	Glycine max	46.40	0.00e+00	705.00
IUUC-Ggo-044602	Gorilla gorilla	98.82	0.00e+00	1654.00
IUUC-Hsa-045959	Homo sapiens	98.82	0.00e+00	1654.00
IUUC-Hvu-047563	Hordeum vulgare	47.23	6.00e-170	590.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.24	0.00e+00	1640.00
IUUC-Kpa-049156	Komagataella pastoris	33.18	7.00e-115	408.00
IUUC-Lch-049648	Latimeria chalumnae	81.25	0.00e+00	1360.00
IUUC-Lpe-051523	Leersia perrieri	46.32	0.00e+00	713.00
IUUC-Loc-052520	Lepisosteus oculatus	61.56	0.00e+00	1024.00
IUUC-Lma-053216	Leptosphaeria maculans	34.60	3.00e-114	407.00
IUUC-Laf-054327	Loxodonta africana	96.47	0.00e+00	1620.00
IUUC-Mcc-055443	Macaca mulatta	99.18	0.00e+00	1661.00
IUUC-Meu-056298	Macropus eugenii	90.33	0.00e+00	1044.00
IUUC-Mor-057106	Magnaporthe oryzae	35.20	5.00e-131	461.00
IUUC-Mpo-057589	Magnaporthe poae	34.63	1.00e-123	437.00
IUUC-Mtr-058680	Medicago truncatula	48.08	0.00e+00	730.00
IUUC-Mla-058903	Melampsora laricipopulina	32.50	1.00e-120	427.00
IUUC-Mga-059669	Meleagris gallopavo	88.41	0.00e+00	1504.00
IUUC-Mvi-060476	Microbotryum violaceum	34.24	2.00e-119	423.00
IUUC-Mmr-060575	Microcebus murinus	97.53	0.00e+00	1636.00
IUUC-Mdo-062183	Monodelphis domestica	90.94	0.00e+00	1519.00
IUUC-Mmu-063592	Mus musculus	97.41	0.00e+00	1633.00
IUUC-Mac-065634	Musa acuminata	42.70	0.00e+00	686.00
IUUC-Mpu-066082	Mustela putorius furo	94.47	0.00e+00	1571.00
IUUC-Mlu-067345	Myotis lucifugus	97.18	0.00e+00	1632.00
IUUC-Nfi-068558	Neosartorya fischeri	35.17	4.00e-123	435.00
IUUC-Ncr-068960	Neurospora crassa	34.92	4.00e-117	415.00
IUUC-Nle-070173	Nomascus leucogenys	95.88	0.00e+00	1588.00
IUUC-Opr-070556	Ochotona princeps	96.94	0.00e+00	1632.00
IUUC-Ont-071502	Oreochromis niloticus	64.74	0.00e+00	1087.00
IUUC-Ocu-074861	Oryctolagus cuniculus	94.71	0.00e+00	1576.00
IUUC-Oba-075109	Oryza barthii	46.03	0.00e+00	714.00
IUUC-Obr-076292	Oryza brachyantha	47.32	0.00e+00	709.00
IUUC-Ogl-077065	Oryza glaberrima	47.32	0.00e+00	744.00
IUUC-Ogu-078776	Oryza glumaepatula	46.03	0.00e+00	726.00
IUUC-Oin-080048	Oryza indica	46.85	0.00e+00	738.00
IUUC-Olo-080711	Oryza longistaminata	44.19	0.00e+00	657.00
IUUC-Ome-081506	Oryza meridionalis	45.23	0.00e+00	669.00
IUUC-Oni-082320	Oryza nivara	45.49	0.00e+00	712.00
IUUC-Opu-083801	Oryza punctata	46.21	0.00e+00	708.00
IUUC-Oru-085139	Oryza rufipogon	45.49	0.00e+00	714.00
IUUC-Osa-085713	Oryza sativa	47.44	0.00e+00	747.00
IUUC-Ola-086951	Oryzias latipes	65.31	0.00e+00	1078.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.48	0.00e+00	638.00
IUUC-Oga-088625	Otolemur garnettii	98.12	0.00e+00	1634.00
IUUC-Oar-089995	Ovis aries	97.18	0.00e+00	1639.00
IUUC-Ptr-090640	Pan troglodytes	96.47	0.00e+00	1641.00
IUUC-Psi-093957	Pelodiscus sinensis	89.57	0.00e+00	1593.00
IUUC-Pma-094242	Petromyzon marinus	71.73	5.00e-166	577.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.14	9.00e-108	384.00
IUUC-Ppa-095901	Physcomitrella patens	48.91	0.00e+00	783.00
IUUC-Pfo-097148	Poecilia formosa	66.08	0.00e+00	1097.00
IUUC-Pab-098068	Pongo abelii	90.94	0.00e+00	1477.00
IUUC-Pop-098943	Populus trichocarpa	46.86	0.00e+00	719.00
IUUC-Pca-100738	Procavia capensis	97.67	0.00e+00	1138.00
IUUC-Ppe-101315	Prunus persica	47.22	0.00e+00	728.00
IUUC-Pva-102154	Pteropus vampyrus	95.53	0.00e+00	1601.00
IUUC-Pgr-103343	Puccinia graminis	33.38	2.00e-107	383.00
IUUC-Ptt-103928	Puccinia triticina	30.33	4.00e-104	372.00
IUUC-Pte-104306	Pyrenophora teres	31.80	5.00e-105	375.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.80	8.00e-108	384.00
IUUC-Rno-105801	Rattus norvegicus	97.06	0.00e+00	1628.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.12	5.00e-73	269.00
IUUC-Sha-107635	Sarcophilus harrisii	89.88	0.00e+00	1525.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.49	6.00e-108	385.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.95	5.00e-112	398.00
IUUC-Smo-108848	Selaginella moellendorffii	48.30	0.00e+00	737.00
IUUC-Sit-110728	Setaria italica	47.79	0.00e+00	768.00
IUUC-Sly-111523	Solanum lycopersicum	47.16	0.00e+00	761.00
IUUC-Sbi-114419	Sorghum bicolor	46.81	0.00e+00	748.00
IUUC-Sre-115225	Sporisorium reilianum	34.87	4.00e-125	442.00
IUUC-Ssc-115686	Sus scrofa	97.29	0.00e+00	1629.00
IUUC-Tgu-117346	Taeniopygia guttata	88.86	0.00e+00	1553.00
IUUC-Tru-118350	Takifugu rubripes	65.09	0.00e+00	1106.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.05	0.00e+00	1094.00
IUUC-Tca-121585	Theobroma cacao	47.51	0.00e+00	725.00
IUUC-Tre-122043	Trichoderma reesei	33.91	8.00e-120	424.00
IUUC-Tvi-122303	Trichoderma virens	34.22	2.00e-125	442.00
IUUC-Tae-123798	Triticum aestivum	46.51	0.00e+00	728.00
IUUC-Tur-126732	Triticum urartu	44.38	0.00e+00	682.00
IUUC-Tme-126909	Tuber melanosporum	34.98	1.00e-118	420.00
IUUC-Tbe-127261	Tupaia belangeri	90.53	0.00e+00	1035.00
IUUC-Uma-129599	Ustilago maydis	33.62	1.00e-126	447.00
IUUC-Vda-129688	Verticillium dahliae	33.26	7.00e-120	424.00
IUUC-Vvi-131116	Vitis vinifera	47.39	0.00e+00	706.00
IUUC-Xtr-131953	Xenopus tropicalis	78.65	0.00e+00	1348.00
IUUC-Xma-133837	Xiphophorus maculatus	66.20	0.00e+00	1099.00
IUUC-Yli-134510	Yarrowia lipolytica	35.49	6.00e-130	457.00
IUUC-Zma-135786	Zea mays	46.92	0.00e+00	716.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence