iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040129

Ensembl Protein ID

ENSGALP00000013729.4

UniProt Accession

Q8QGH2; SUMO1_CHICK

Genbank Protein ID

AAL85281.1; CAG31129.1

Protein Name

Small ubiquitin-related modifier 1

Genbank Nucleotide ID

AF461015; AJ719470

Gene Name

SUMO1; RCJMB04_2j18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000008435.4	ENSGALT00000013744.4	ENSGALP00000013729.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	5.40e-31	107.5	20	97
ULD/UDP/UBQ/UBQ_Other	8.50e-07	29.1	28	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 7    apvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           ++++lkv gqd+se++fk+k++++lkkl+e+ Y++r+++ +ns+rf+f+gq+i +++tp+el++e+ed+ie++++++GG
   Q: 20   EYIKLKVIGQDSSEIHFKVKMTTHLKKLKES-YCQRQGVPMNSLRFLFEGQRITDNHTPKELGMEEEDVIEVYQEQTGG 97
           79*****************************.**********************************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 7    sldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
             d+se  +kv+ ++  ++LKe   +++g+p+++ r +++G+ + d++t +++g+ ++++i +++++ 
   Q: 28   GQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRITDNHTPKELGMEEEDVIEVYQEQT 95
           445557778899999*************************************************9875 PP

Organism

Gallus gallus

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

Protein Sequence
(Fasta)

MSDQEAKPSA EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN 60
SLRFLFEGQR ITDNHTPKEL GMEEEDVIEV YQEQTGGHST V 101

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTTGCGC TGCGGGCAGA GAAAGGAGCC GAGCCCCGCA GCGGCCCAAC CGAGCCCGTC 60
GCCCGCCCCG CGCCCAGCCA TGTCGGACCA GGTACGCGGG GAGCCCCGGC AGCGGGGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0097165--C:nuclear stress granule
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0008076--C:voltage-gated potassium channel complex
GO:0015459--F:potassium channel regulator activity
GO:0031386--F:protein tag
GO:0003723--F:RNA binding
GO:0008134--F:transcription factor binding
GO:0071276--P:cellular response to cadmium ion
GO:0034605--P:cellular response to heat
GO:0045759--P:negative regulation of action potential
GO:1902260--P:negative regulation of delayed rectifier potassium channel activity
GO:0043392--P:negative regulation of DNA binding
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0060021--P:palate development
GO:0030578--P:PML body organization
GO:1901896--P:positive regulation of calcium-transporting ATPase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031334--P:positive regulation of protein complex assembly
GO:0090204--P:protein localization to nuclear pore
GO:0050821--P:protein stabilization
GO:0016925--P:protein sumoylation
GO:0086004--P:regulation of cardiac muscle cell contraction

KEGG

gga:373930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001056	Aegilops tauschii	39.64	2.00e-17	80.10
IUUC-Aml-001606	Ailuropoda melanoleuca	96.94	4.00e-53	198.00
IUUC-Apl-003638	Anas platyrhynchos	100.00	3.00e-54	202.00
IUUC-Aca-004710	Anolis carolinensis	96.04	4.00e-54	201.00
IUUC-Ago-007749	Ashbya gossypii	48.98	1.00e-18	84.00
IUUC-Ani-009300	Aspergillus nidulans	42.27	1.00e-16	77.00
IUUC-Ame-011662	Astyanax mexicanus	86.73	1.00e-45	173.00
IUUC-Bta-013491	Bos taurus	98.02	3.00e-55	205.00
IUUC-Cel-018251	Caenorhabditis elegans	65.82	8.00e-29	117.00
IUUC-Cja-019109	Callithrix jacchus	95.05	2.00e-53	199.00
IUUC-Cfa-020657	Canis familiaris	97.03	5.00e-55	204.00
IUUC-Cpo-022508	Cavia porcellus	97.94	8.00e-53	197.00
IUUC-Cre-022970	Chlamydomonas reinhardtii	46.00	1.00e-20	90.10
IUUC-Csa-023026	Chlorocebus sabaeus	97.03	7.00e-45	171.00
IUUC-Cho-024767	Choloepus hoffmanni	98.61	1.00e-38	151.00
IUUC-Cne-027072	Cryptococcus neoformans	48.48	2.00e-14	70.50
IUUC-Dre-028383	Danio rerio	87.63	1.00e-44	170.00
IUUC-Dno-029820	Dasypus novemcinctus	98.02	3.00e-55	205.00
IUUC-Ete-032782	Echinops telfairi	74.23	2.00e-34	136.00
IUUC-Eca-033958	Equus caballus	97.03	5.00e-55	204.00
IUUC-Eeu-034822	Erinaceus europaeus	97.98	4.00e-54	201.00
IUUC-Fca-035601	Felis catus	96.94	5.00e-53	198.00
IUUC-Fal-036740	Ficedula albicollis	100.00	5.00e-54	202.00
IUUC-Gmo-038847	Gadus morhua	92.65	8.00e-34	134.00
IUUC-Gac-042112	Gasterosteus aculeatus	86.60	3.00e-46	175.00
IUUC-Ggo-045413	Gorilla gorilla	98.02	3.00e-55	205.00
IUUC-Hsa-046108	Homo sapiens	98.02	3.00e-55	205.00
IUUC-Itr-047968	Ictidomys tridecemlineatus	98.00	1.00e-54	203.00
IUUC-Lch-049881	Latimeria chalumnae	83.51	7.00e-39	151.00
IUUC-Loc-052189	Lepisosteus oculatus	89.58	2.00e-47	179.00
IUUC-Laf-053478	Loxodonta africana	96.94	1.00e-52	197.00
IUUC-Mcc-055059	Macaca mulatta	64.19	3.00e-46	176.00
IUUC-Meu-056112	Macropus eugenii	97.03	1.00e-54	204.00
IUUC-Mla-059030	Melampsora laricipopulina	40.51	1.00e-07	48.50
IUUC-Mga-060035	Meleagris gallopavo	100.00	2.00e-54	202.00
IUUC-Mmr-060903	Microcebus murinus	98.02	3.00e-55	205.00
IUUC-Mdo-062633	Monodelphis domestica	97.03	8.00e-55	204.00
IUUC-Mmu-063272	Mus musculus	98.02	3.00e-55	205.00
IUUC-Mpu-066505	Mustela putorius furo	95.92	2.00e-52	196.00
IUUC-Mlu-067991	Myotis lucifugus	95.05	9.00e-49	184.00
IUUC-Nle-069344	Nomascus leucogenys	98.63	2.00e-39	152.00
IUUC-Opr-070351	Ochotona princeps	48.51	2.00e-17	81.30
IUUC-Ont-071436	Oreochromis niloticus	86.60	3.00e-46	175.00
IUUC-Oan-072986	Ornithorhynchus anatinus	98.15	2.00e-26	109.00
IUUC-Ocu-073781	Oryctolagus cuniculus	95.05	7.00e-53	197.00
IUUC-Ola-086373	Oryzias latipes	85.57	1.00e-44	170.00
IUUC-Olu-087670	Ostreococcus lucimarinus	44.29	1.00e-16	77.00
IUUC-Oga-088024	Otolemur garnettii	87.13	3.00e-49	185.00
IUUC-Oar-089991	Ovis aries	96.04	2.00e-53	199.00
IUUC-Ptr-090688	Pan troglodytes	96.04	6.00e-54	201.00
IUUC-Pan-092204	Papio anubis	98.02	3.00e-55	205.00
IUUC-Psi-093396	Pelodiscus sinensis	100.00	3.00e-54	202.00
IUUC-Pfo-096306	Poecilia formosa	85.00	8.00e-46	174.00
IUUC-Pab-098393	Pongo abelii	98.02	3.00e-55	207.00
IUUC-Pop-099042	Populus trichocarpa	45.36	7.00e-21	91.70
IUUC-Pca-100237	Procavia capensis	97.03	5.00e-53	199.00
IUUC-Pva-102353	Pteropus vampyrus	97.47	3.00e-42	162.00
IUUC-Pgr-103683	Puccinia graminis	40.74	4.00e-15	72.40
IUUC-Rno-105286	Rattus norvegicus	98.02	3.00e-55	205.00
IUUC-Sce-106231	Saccharomyces cerevisiae	47.42	3.00e-19	85.90
IUUC-Sha-106712	Sarcophilus harrisii	97.22	2.00e-38	149.00
IUUC-Sja-107710	Schizosaccharomyces japonicus	51.04	2.00e-22	97.10
IUUC-Spo-108261	Schizosaccharomyces pombe	51.04	8.00e-22	95.10
IUUC-Sit-110664	Setaria italica	32.58	5.00e-08	49.70
IUUC-Sar-113550	Sorex araneus	96.91	5.00e-52	194.00
IUUC-Sre-115172	Sporisorium reilianum	53.16	1.00e-19	87.40
IUUC-Ssc-115837	Sus scrofa	94.06	1.00e-53	200.00
IUUC-Tgu-117064	Taeniopygia guttata	100.00	8.00e-54	200.00
IUUC-Tru-117752	Takifugu rubripes	86.60	2.00e-46	176.00
IUUC-Tsy-119358	Tarsius syrichta	97.33	2.00e-39	153.00
IUUC-Tni-120621	Tetraodon nigroviridis	86.60	9.00e-46	174.00
IUUC-Tae-124177	Triticum aestivum	45.83	2.00e-20	90.10
IUUC-Tme-126902	Tuber melanosporum	45.68	8.00e-18	80.90
IUUC-Tbe-127355	Tupaia belangeri	74.23	2.00e-34	136.00
IUUC-Ttr-128166	Tursiops truncatus	96.04	5.00e-54	202.00
IUUC-Uma-129444	Ustilago maydis	53.16	3.00e-20	89.00
IUUC-Vpa-130172	Vicugna pacos	98.02	4.00e-55	206.00
IUUC-Xtr-132473	Xenopus tropicalis	93.14	8.00e-52	194.00
IUUC-Xma-133814	Xiphophorus maculatus	85.00	3.00e-46	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence