iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008078

Ensembl Protein ID

CADACLAP00007022

UniProt Accession

A1C7E4; SCONB_ASPCL

Genbank Protein ID

EAW14315.1

Protein Name

Probable E3 ubiquitin ligase complex SCF subunit sconB; Sulfur controller B; Sulfur metabolite repression control protein B

Genbank Nucleotide ID

DS027045

Gene Name

ACLA_073500; sconB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00007182	CADACLAT00007182	CADACLAP00007022

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-55	182.0	409	445
E3 adaptor/Cullin RING/SCF/F-box	7.20e-06	25.0	198	241
UBD/Beta-Prp	6.50e-76	254.2	367	699

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH+++++cl+f+dt l+sGs D ++kvW++rtg ++ 
   Q: 409  GHESGIRCLQFDDTKLISGSMDRSLKVWNWRTGECIS 445
           8**********66*********************975 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           l+ lp ei ++il +ld+++l++aa+v+rrw+ la+++ +w+++
   Q: 198  LTALPPEISFKILCYLDTTSLCKAAQVSRRWRALADDDVVWHRM 241
           6789********************************9****987 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
           ++ h++ i c++f  ++++latgs+d+tik+wd++tg  lr+l ghe+++++++f+++   l++gs Dr +kvw+ +tg+c++t++gh   v 
   Q: 367  FKGHTNGIMCLQF--EDNILATGSYDATIKIWDTETGEELRTLRGHESGIRCLQFDDT--KLISGSMDRSLKVWNWRTGECISTYTGHRGGVI 455
           3446667777***..*******************************************..6******************************** PP
   S: 99   slsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.... 187
            l+f++    l+s+s d+t+++w+ e ++    +l+gh+++vn v+v+ +++ ++s+s+D t+rlWdl t++++rt+ g h ++v+ ++    
   Q: 456  GLHFDA--TILASASVDKTVKIWNFEDKSTC--LLRGHTDWVNAVRVDTNSRTVFSASDDCTIRLWDLDTKTCIRTFHG-HVGQVQQVIplpr 543
           ******..*****************999988..59*******************************************9.*********9999 PP
   S: 188  ......fdsng..................................................kelvsgsldgtvklwdlqtgecvrtlnghtdn 224
                                                                        +++v+ +ld+t++lw+ +tg+c+rt+ gh + 
   Q: 544  efefedH---DaecendnvsvtsgdspaasprgipgldagtsetqsspfgpafdngrpappRYIVTSALDSTIRLWETSTGRCLRTFFGHLEG 633
           9885540...3556666666777777888888899999999999999999999999************************************* PP
   S: 225  vksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           v+ ++++  + r+vsg++D+ ++iWd r+g++ +t+++h     +v+++++gd+ +++gsed++v+++ ++
   Q: 634  VWALAAD--TLRIVSGAEDRMVKIWDPRTGKCERTFTGHS---GPVTCIGLGDSRFATGSEDCEVRMYGFQ 699
           **99999..*****************************88...55555666*****************886 PP

Organism

Aspergillus clavatus

Functional Description
(View)

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.

Protein Sequence
(Fasta)

MDTQRLSLRK ENGSAHSLLQ DQTGLKENTM NIPRDSSFNS IFGPSEVVDD AGTDRDFKHE 60
SHKFSITRAM PEKLAGKNIA PFLAKHIPEQ YAPLGSHAGE PVESSGANSR YCYRHRPDLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATACCC AGCGTCTGTC TTTGCGAAAA GAGAACGGCT CTGCACATTC GCTCTTGCAG 60
GATCAGACTG GTCTGAAGGA AAATACGATG AACATTCCGC GAGATTCGTC TTTTAATTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0071276--P:cellular response to cadmium ion
GO:0006270--P:DNA replication initiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0046685--P:response to arsenic-containing substance
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

act:ACLA_073500

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007794	Ashbya gossypii	42.52	3.00e-135	473.00
IUUC-Afl-008744	Aspergillus flavus	80.60	0.00e+00	1045.00
IUUC-Afu-008939	Aspergillus fumigatus	82.45	0.00e+00	1184.00
IUUC-Ani-009383	Aspergillus nidulans	78.21	0.00e+00	1055.00
IUUC-Ang-009570	Aspergillus niger	80.00	0.00e+00	1072.00
IUUC-Aor-010217	Aspergillus oryzae	82.43	0.00e+00	1035.00
IUUC-Ate-010336	Aspergillus terreus	82.02	0.00e+00	1076.00
IUUC-Bgr-012225	Blumeria graminis	58.06	0.00e+00	732.00
IUUC-Bci-013916	Botrytis cinerea	62.35	0.00e+00	833.00
IUUC-Cgl-026550	Colletotrichum gloeosporioides	53.11	0.00e+00	673.00
IUUC-Cne-026800	Cryptococcus neoformans	34.48	2.00e-96	345.00
IUUC-Dse-031413	Dothistroma septosporum	57.50	0.00e+00	719.00
IUUC-Fox-037683	Fusarium oxysporum	51.38	0.00e+00	656.00
IUUC-Fso-038092	Fusarium solani	57.12	0.00e+00	748.00
IUUC-Ggr-039842	Gaeumannomyces graminis	53.38	0.00e+00	700.00
IUUC-Kpa-049101	Komagataella pastoris	44.75	5.00e-161	559.00
IUUC-Lma-053200	Leptosphaeria maculans	56.13	0.00e+00	757.00
IUUC-Mor-057039	Magnaporthe oryzae	54.25	0.00e+00	696.00
IUUC-Mpo-057381	Magnaporthe poae	53.64	0.00e+00	689.00
IUUC-Mla-059099	Melampsora laricipopulina	39.39	2.00e-122	431.00
IUUC-Mvi-060426	Microbotryum violaceum	41.42	1.00e-54	206.00
IUUC-Nfi-068464	Neosartorya fischeri	82.31	0.00e+00	1186.00
IUUC-Ncr-068962	Neurospora crassa	51.76	0.00e+00	673.00
IUUC-Olu-087589	Ostreococcus lucimarinus	28.38	4.00e-31	127.00
IUUC-Pno-095133	Phaeosphaeria nodorum	53.10	1.00e-159	554.00
IUUC-Pgr-103527	Puccinia graminis	40.53	1.00e-65	242.00
IUUC-Ptt-103819	Puccinia triticina	31.27	2.00e-51	195.00
IUUC-Pte-104035	Pyrenophora teres	55.35	0.00e+00	694.00
IUUC-Pyt-104799	Pyrenophora triticirepentis	55.61	0.00e+00	701.00
IUUC-Sce-106343	Saccharomyces cerevisiae	41.63	3.00e-138	483.00
IUUC-Sja-107945	Schizosaccharomyces japonicus	39.93	1.00e-120	424.00
IUUC-Spo-108115	Schizosaccharomyces pombe	38.90	2.00e-111	394.00
IUUC-Sre-115173	Sporisorium reilianum	40.62	2.00e-101	362.00
IUUC-Tre-122126	Trichoderma reesei	55.37	0.00e+00	736.00
IUUC-Tvi-122482	Trichoderma virens	56.77	0.00e+00	743.00
IUUC-Tme-127212	Tuber melanosporum	57.75	0.00e+00	746.00
IUUC-Uma-129406	Ustilago maydis	39.77	3.00e-100	358.00
IUUC-Vda-129799	Verticillium dahliae	54.98	0.00e+00	706.00
IUUC-Yli-134408	Yarrowia lipolytica	46.09	8.00e-167	578.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence