iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000008620.2	ENSCJAT00000057560.1	ENSCJAP00000050326.1
ENSCJAG00000008620.2	ENSCJAT00000054248.1	ENSCJAP00000046779.1
ENSCJAG00000008620.2	ENSCJAT00000038596.2	ENSCJAP00000036540.2
ENSCJAG00000008620.2	ENSCJAT00000060550.1	ENSCJAP00000045846.1
ENSCJAG00000008620.2	ENSCJAT00000053540.1	ENSCJAP00000042473.1
ENSCJAG00000008620.2	ENSCJAT00000063484.1	ENSCJAP00000045506.1
ENSCJAG00000008620.2	ENSCJAT00000016804.2	ENSCJAP00000015905.2
ENSCJAG00000008620.2	ENSCJAT00000016836.2	ENSCJAP00000015934.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.60e-94	318.0	13	361

Active Site

Position(s)	Description	Evidence
100	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
176	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lF++++ +e +          +vv+++ ++tif
   Q: 13   MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFQWQPGEEPAG---------SVVQDSRLDTIF 90
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fak vi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ +++++++    +++af
   Q: 91   FAKRVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAK----EEDAF 175
           *****************************************************************************888....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvv...............................raflerikllesdeirf 236
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v                               +        ++++eirf
   Q: 176  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPViekriqkdrvlfccpgwstpptprlkgssplQ----P-PRYSEGEIRF 258
           **************************9.78899******************************9887654331....3.46999***** PP
   S: 237  nllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlareg 316
           nl+aiv+dr++i+++++  l+ +          +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la+++
   Q: 259  NLMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQ 347
           ****************976666677888888744569**************************************************** PP
   S: 317  ilrklveetisevrefg 333
           +l  lve+    + +++
   Q: 348  QLIPLVEKA---KEKQN 361
           ******993...33344 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

ARGGSGRCVA GAMTGNAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP 60
VHGLIFLFQW QPGEEPAGSV VQDSRLDTIF FAKRVINNAC ATQAIVSVLL NCTHQDVHLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGGAGT AACGCAGGCC CTCGCGACGC CGGCCTGTGG GGAGCGCGGT CCCACCCTCA 60
GGAACGGTCC GGCCGGGCCT AGCCAGGATG TCCCCACCCG ACGCTGGTTC CGTTACCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	43.33	3.00e-79	288.00
IUUC-Aml-001866	Ailuropoda melanoleuca	90.62	0.00e+00	629.00
IUUC-Atr-002966	Amborella trichopoda	42.01	2.00e-75	276.00
IUUC-Apl-003306	Anas platyrhynchos	85.87	4.00e-179	620.00
IUUC-Aca-004763	Anolis carolinensis	85.96	2.00e-172	597.00
IUUC-Aly-005581	Arabidopsis lyrata	44.38	1.00e-74	273.00
IUUC-Ath-007283	Arabidopsis thaliana	44.54	1.00e-77	283.00
IUUC-Ago-007999	Ashbya gossypii	39.32	3.00e-30	125.00
IUUC-Acl-008231	Aspergillus clavatus	37.83	4.00e-47	181.00
IUUC-Afl-008557	Aspergillus flavus	34.33	2.00e-49	189.00
IUUC-Afu-008988	Aspergillus fumigatus	39.78	6.00e-49	187.00
IUUC-Ani-009420	Aspergillus nidulans	34.58	2.00e-47	182.00
IUUC-Ang-009859	Aspergillus niger	36.26	2.00e-44	172.00
IUUC-Aor-010145	Aspergillus oryzae	34.33	2.00e-49	189.00
IUUC-Ate-010347	Aspergillus terreus	37.46	7.00e-48	184.00
IUUC-Ame-010791	Astyanax mexicanus	82.07	5.00e-175	606.00
IUUC-Bgr-012298	Blumeria graminis	34.34	3.00e-44	172.00
IUUC-Bta-013251	Bos taurus	89.74	7.00e-179	619.00
IUUC-Bci-013786	Botrytis cinerea	34.88	7.00e-53	200.00
IUUC-Bdi-014132	Brachypodium distachyon	45.30	1.00e-76	280.00
IUUC-Bol-015611	Brassica oleracea	45.51	5.00e-79	287.00
IUUC-Bra-017769	Brassica rapa	45.51	8.00e-79	286.00
IUUC-Cel-018604	Caenorhabditis elegans	42.69	7.00e-76	276.00
IUUC-Cfa-020207	Canis familiaris	90.62	0.00e+00	629.00
IUUC-Cpo-021925	Cavia porcellus	86.80	3.00e-173	600.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	41.44	1.00e-68	253.00
IUUC-Csa-023958	Chlorocebus sabaeus	91.04	0.00e+00	634.00
IUUC-Cho-024928	Choloepus hoffmanni	97.40	2.00e-41	162.00
IUUC-Cin-025771	Ciona intestinalis	49.57	2.00e-94	338.00
IUUC-Csv-026149	Ciona savignyi	53.04	2.00e-97	348.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	34.00	4.00e-46	178.00
IUUC-Cne-026955	Cryptococcus neoformans	34.15	4.00e-49	188.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.16	3.00e-44	172.00
IUUC-Dre-027409	Danio rerio	81.23	1.00e-171	595.00
IUUC-Dno-028921	Dasypus novemcinctus	90.03	2.00e-180	624.00
IUUC-Dse-031170	Dothistroma septosporum	36.36	1.00e-53	203.00
IUUC-Dme-031677	Drosophila melanogaster	54.85	2.00e-109	388.00
IUUC-Ete-032707	Echinops telfairi	63.46	1.00e-119	422.00
IUUC-Eca-033776	Equus caballus	89.56	5.00e-165	573.00
IUUC-Eeu-035305	Erinaceus europaeus	79.08	1.00e-87	316.00
IUUC-Fca-035846	Felis catus	90.93	0.00e+00	657.00
IUUC-Fal-037597	Ficedula albicollis	86.08	2.00e-152	531.00
IUUC-Fox-037670	Fusarium oxysporum	39.16	1.00e-50	193.00
IUUC-Fso-038243	Fusarium solani	39.46	5.00e-50	191.00
IUUC-Gmo-038499	Gadus morhua	76.25	6.00e-155	540.00
IUUC-Ggr-039975	Gaeumannomyces graminis	36.50	3.00e-43	168.00
IUUC-Gga-040904	Gallus gallus	85.75	4.00e-180	623.00
IUUC-Gac-042058	Gasterosteus aculeatus	80.65	4.00e-164	570.00
IUUC-Gma-043763	Glycine max	44.54	2.00e-79	288.00
IUUC-Ggo-044699	Gorilla gorilla	85.67	5.00e-166	576.00
IUUC-Hsa-046227	Homo sapiens	91.20	0.00e+00	632.00
IUUC-Hvu-047359	Hordeum vulgare	43.06	2.00e-77	282.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	90.81	0.00e+00	658.00
IUUC-Lch-049829	Latimeria chalumnae	83.87	4.00e-168	583.00
IUUC-Lpe-050899	Leersia perrieri	44.64	3.00e-73	268.00
IUUC-Loc-052264	Lepisosteus oculatus	82.16	3.00e-166	577.00
IUUC-Lma-053110	Leptosphaeria maculans	35.15	9.00e-44	170.00
IUUC-Laf-053639	Loxodonta africana	90.62	0.00e+00	629.00
IUUC-Mcc-055506	Macaca mulatta	91.04	0.00e+00	634.00
IUUC-Mor-057001	Magnaporthe oryzae	41.13	1.00e-49	189.00
IUUC-Mpo-057608	Magnaporthe poae	40.11	5.00e-32	130.00
IUUC-Mtr-057731	Medicago truncatula	45.18	1.00e-79	289.00
IUUC-Mla-059016	Melampsora laricipopulina	42.29	2.00e-42	164.00
IUUC-Mga-060178	Meleagris gallopavo	86.14	8.00e-167	579.00
IUUC-Mvi-060353	Microbotryum violaceum	35.26	7.00e-49	187.00
IUUC-Mmr-060738	Microcebus murinus	90.62	0.00e+00	629.00
IUUC-Mdo-062266	Monodelphis domestica	96.57	3.00e-118	417.00
IUUC-Mmu-063619	Mus musculus	88.27	7.00e-178	615.00
IUUC-Mac-065301	Musa acuminata	45.80	1.00e-82	299.00
IUUC-Mpu-066058	Mustela putorius furo	90.32	0.00e+00	626.00
IUUC-Mlu-067292	Myotis lucifugus	89.15	4.00e-177	613.00
IUUC-Nfi-068275	Neosartorya fischeri	34.12	5.00e-50	191.00
IUUC-Ncr-068713	Neurospora crassa	35.55	6.00e-53	201.00
IUUC-Nle-069013	Nomascus leucogenys	90.93	0.00e+00	648.00
IUUC-Opr-070628	Ochotona princeps	84.86	1.00e-171	595.00
IUUC-Ont-072688	Oreochromis niloticus	81.34	2.00e-164	571.00
IUUC-Oan-073004	Ornithorhynchus anatinus	85.98	5.00e-135	473.00
IUUC-Ocu-074303	Oryctolagus cuniculus	90.03	0.00e+00	644.00
IUUC-Oba-075002	Oryza barthii	44.72	4.00e-76	278.00
IUUC-Obr-076392	Oryza brachyantha	44.64	4.00e-74	271.00
IUUC-Ogl-077271	Oryza glaberrima	44.72	4.00e-76	278.00
IUUC-Ogu-078493	Oryza glumaepatula	44.72	6.00e-77	280.00
IUUC-Oin-080084	Oryza indica	44.72	6.00e-77	280.00
IUUC-Olo-080803	Oryza longistaminata	44.44	1.00e-76	279.00
IUUC-Ome-081146	Oryza meridionalis	43.89	2.00e-75	275.00
IUUC-Oni-082146	Oryza nivara	44.72	6.00e-77	280.00
IUUC-Opu-083633	Oryza punctata	44.35	6.00e-73	267.00
IUUC-Oru-084789	Oryza rufipogon	44.72	6.00e-77	280.00
IUUC-Osa-086196	Oryza sativa	44.72	6.00e-77	280.00
IUUC-Ola-087126	Oryzias latipes	81.52	2.00e-161	561.00
IUUC-Olu-087665	Ostreococcus lucimarinus	37.66	2.00e-63	236.00
IUUC-Oga-089140	Otolemur garnettii	91.79	0.00e+00	638.00
IUUC-Oar-090296	Ovis aries	89.44	5.00e-179	619.00
IUUC-Ptr-090566	Pan troglodytes	91.20	0.00e+00	632.00
IUUC-Pan-092052	Papio anubis	91.04	0.00e+00	634.00
IUUC-Psi-093723	Pelodiscus sinensis	85.76	1.00e-158	551.00
IUUC-Pma-094568	Petromyzon marinus	55.70	7.00e-101	360.00
IUUC-Pno-095120	Phaeosphaeria nodorum	35.45	6.00e-45	174.00
IUUC-Ppa-095761	Physcomitrella patens	43.24	9.00e-78	283.00
IUUC-Pfo-096210	Poecilia formosa	81.23	2.00e-165	574.00
IUUC-Pab-098463	Pongo abelii	91.50	0.00e+00	656.00
IUUC-Pop-099423	Populus trichocarpa	45.21	3.00e-79	288.00
IUUC-Pca-100108	Procavia capensis	87.59	3.00e-139	488.00
IUUC-Ppe-101176	Prunus persica	46.94	2.00e-80	292.00
IUUC-Pva-102629	Pteropus vampyrus	86.00	3.00e-148	517.00
IUUC-Pgr-103419	Puccinia graminis	36.07	6.00e-51	194.00
IUUC-Pte-104207	Pyrenophora teres	43.79	3.00e-32	130.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	36.04	1.00e-51	196.00
IUUC-Rno-105579	Rattus norvegicus	79.49	3.00e-157	547.00
IUUC-Sha-106894	Sarcophilus harrisii	84.21	9.00e-149	519.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	34.95	2.00e-53	202.00
IUUC-Spo-108371	Schizosaccharomyces pombe	37.76	1.00e-53	203.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	34.87	2.00e-42	165.00
IUUC-Smo-109396	Selaginella moellendorffii	46.74	1.00e-82	299.00
IUUC-Sit-110630	Setaria italica	45.45	4.00e-80	291.00
IUUC-Sly-110972	Solanum lycopersicum	46.04	2.00e-75	275.00
IUUC-Stu-112185	Solanum tuberosum	46.67	2.00e-83	301.00
IUUC-Sar-113294	Sorex araneus	80.55	2.00e-164	571.00
IUUC-Sbi-113951	Sorghum bicolor	45.74	1.00e-80	292.00
IUUC-Ssc-115501	Sus scrofa	88.62	6.00e-168	583.00
IUUC-Tgu-117152	Taeniopygia guttata	85.76	2.00e-152	531.00
IUUC-Tru-118388	Takifugu rubripes	80.35	3.00e-164	570.00
IUUC-Tsy-119109	Tarsius syrichta	90.91	0.00e+00	652.00
IUUC-Tni-120048	Tetraodon nigroviridis	80.35	1.00e-164	572.00
IUUC-Tca-121750	Theobroma cacao	45.08	7.00e-83	300.00
IUUC-Tre-122130	Trichoderma reesei	35.67	6.00e-50	191.00
IUUC-Tvi-122284	Trichoderma virens	35.87	2.00e-47	182.00
IUUC-Tae-124082	Triticum aestivum	43.33	2.00e-77	282.00
IUUC-Tur-126366	Triticum urartu	39.60	1.00e-60	226.00
IUUC-Tme-127187	Tuber melanosporum	37.16	4.00e-53	201.00
IUUC-Tbe-127619	Tupaia belangeri	81.59	3.00e-139	487.00
IUUC-Ttr-128867	Tursiops truncatus	86.59	7.00e-122	429.00
IUUC-Vda-129912	Verticillium dahliae	34.88	2.00e-47	182.00
IUUC-Vpa-130552	Vicugna pacos	98.56	3.00e-124	437.00
IUUC-Vvi-130881	Vitis vinifera	46.30	1.00e-78	286.00
IUUC-Xtr-131934	Xenopus tropicalis	78.15	2.00e-167	580.00
IUUC-Xma-133312	Xiphophorus maculatus	81.23	3.00e-165	573.00
IUUC-Zma-135462	Zea mays	39.66	5.00e-66	244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence