• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045934
UUCD1 version UUC-HoS-01194
Ensembl Protein ID ENSP00000222402.2
UniProt Accession Q9Y2X8; A4D1V0; UB2D4_HUMAN
Genbank Protein ID AAD31180.1; BAA91697.1; EAL24010.1; EAW94182.1; AAH04104.1
Protein Name Ubiquitin-conjugating enzyme E2 D4; E2 ubiquitin-conjugating enzyme D4; HBUCE1; Ubiquitin carrier protein D4; Ubiquitin-protein ligase D4
Genbank Nucleotide ID AF125044; AK001446; CH236951; CH471073; BC004104
Gene Name UBE2D4; UBCH5D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000078967.12 ENST00000450743.5 ENSP00000391678.1
ENSG00000078967.12 ENST00000454350.5 ENSP00000401824.1
ENSG00000078967.12 ENST00000222402.7 ENSP00000222402.2
ENSG00000078967.12 ENST00000415051.5 ENSP00000414331.1
ENSG00000078967.12 ENST00000446008.5 ENSP00000397406.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 19690564
Classification
Family E-value Score Start End
E2/UBC 8.20e-57 192.5 5 139
UBD/UBC-like/UBD_UBC 3.10e-83 278.4 5 142
Active Site
Position(s) Description Evidence
85 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388,
ECO:0000255|PROSITE-ProRule:PRU10133}
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+tki+hPn+++nG++Cl+il+  ++W
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGD-DLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILR--SQW 93
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           spal+v++vllsi+sll++pnp++pl  e+a+++k++re+y++ +r
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAR 139
           ******************************************9987 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaa 92
           ri+kel dl+rd++aq+sa++v+ddlf+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+tkiyhpninsngsicldilrsqws+a
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPA 96
           8******************************************************************************************* PP
   S: 93   ltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           lt+skvlls+csll+d++pddplv+eia+ yk+d+eky+r arewt
   Q: 97   LTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWT 142
           *********************************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.
 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.
Protein Sequence
(Fasta)
MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045934|E2,E2/UBC;UBD,UBD_UBC|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTCCCGGC GTGCAGCTTG GTGGCGGCTG AGCCGGCAGC GGGCCGCCTC AGGCAGCCCC 60
GGCCGGGCCG CCCGGGTCCC CGGCAGCGGG GTAGGATGGC GCTAAAGCGG ATCCAGAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045934|E2,E2/UBC;UBD,UBD_UBC|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
KEGG hsa:51619
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000292 Aegilops tauschii 79.59 7.00e-70 255.00
IUUC-Atr-002861 Amborella trichopoda 80.95 1.00e-70 258.00
IUUC-Aly-006221 Arabidopsis lyrata 81.63 2.00e-71 260.00
IUUC-Ath-007700 Arabidopsis thaliana 81.63 2.00e-70 257.00
IUUC-Acl-008266 Aspergillus clavatus 85.03 3.00e-74 270.00
IUUC-Afl-008709 Aspergillus flavus 79.58 3.00e-69 256.00
IUUC-Afu-008956 Aspergillus fumigatus 85.71 1.00e-74 271.00
IUUC-Ani-009401 Aspergillus nidulans 83.67 4.00e-73 266.00
IUUC-Ate-010438 Aspergillus terreus 84.35 2.00e-73 267.00
IUUC-Ame-011566 Astyanax mexicanus 95.92 4.00e-83 299.00
IUUC-Bci-013661 Botrytis cinerea 83.67 3.00e-74 270.00
IUUC-Bdi-014561 Brachypodium distachyon 80.95 1.00e-71 261.00
IUUC-Bol-015722 Brassica oleracea 82.31 3.00e-72 263.00
IUUC-Bra-017985 Brassica rapa 82.31 1.00e-71 261.00
IUUC-Cja-019014 Callithrix jacchus 97.18 1.00e-81 295.00
IUUC-Cpo-021897 Cavia porcellus 97.90 3.00e-82 296.00
IUUC-Cre-022765 Chlamydomonas reinhardtii 80.27 2.00e-70 257.00
IUUC-Csa-023377 Chlorocebus sabaeus 97.20 2.00e-81 294.00
IUUC-Cgl-026490 Colletotrichum gloeosporioides 84.35 6.00e-74 269.00
IUUC-Cne-026957 Cryptococcus neoformans 80.82 4.00e-70 256.00
IUUC-Cme-027220 Cyanidioschyzon merolae 83.67 2.00e-72 263.00
IUUC-Dre-028686 Danio rerio 99.32 1.00e-85 308.00
IUUC-Dor-030323 Dipodomys ordii 99.32 1.00e-85 308.00
IUUC-Dse-031397 Dothistroma septosporum 84.35 4.00e-74 270.00
IUUC-Eca-033231 Equus caballus 100.00 3.00e-81 293.00
IUUC-Gmo-038775 Gadus morhua 91.84 2.00e-80 290.00
IUUC-Gma-043733 Glycine max 81.63 2.00e-71 261.00
IUUC-Ggo-045361 Gorilla gorilla 100.00 5.00e-86 309.00
IUUC-Hvu-047546 Hordeum vulgare 78.23 2.00e-69 254.00
IUUC-Kpa-049290 Komagataella pastoris 78.91 2.00e-69 254.00
IUUC-Lch-050109 Latimeria chalumnae 87.76 1.00e-77 281.00
IUUC-Lpe-051289 Leersia perrieri 81.63 5.00e-71 259.00
IUUC-Loc-052838 Lepisosteus oculatus 100.00 5.00e-86 309.00
IUUC-Mcc-055421 Macaca mulatta 100.00 5.00e-86 309.00
IUUC-Mtr-058257 Medicago truncatula 80.27 2.00e-70 257.00
IUUC-Mac-064668 Musa acuminata 80.27 2.00e-70 258.00
IUUC-Nfi-068599 Neosartorya fischeri 85.71 1.00e-74 271.00
IUUC-Nle-069715 Nomascus leucogenys 100.00 5.00e-86 309.00
IUUC-Ont-072562 Oreochromis niloticus 96.60 8.00e-84 301.00
IUUC-Oan-073026 Ornithorhynchus anatinus 99.29 2.00e-81 294.00
IUUC-Oba-075411 Oryza barthii 81.63 6.00e-71 259.00
IUUC-Obr-076691 Oryza brachyantha 80.95 2.00e-70 258.00
IUUC-Ogl-076968 Oryza glaberrima 81.63 8.00e-72 262.00
IUUC-Ogu-078091 Oryza glumaepatula 80.69 1.00e-70 260.00
IUUC-Oin-079659 Oryza indica 81.63 8.00e-72 262.00
IUUC-Olo-080786 Oryza longistaminata 81.63 6.00e-71 259.00
IUUC-Ome-081920 Oryza meridionalis 80.95 4.00e-70 256.00
IUUC-Oni-082391 Oryza nivara 81.63 6.00e-72 264.00
IUUC-Opu-083833 Oryza punctata 80.27 8.00e-71 258.00
IUUC-Oru-085167 Oryza rufipogon 81.63 5.00e-72 264.00
IUUC-Osa-086003 Oryza sativa 81.63 8.00e-72 262.00
IUUC-Ola-087515 Oryzias latipes 97.28 4.00e-84 303.00
IUUC-Olu-087615 Ostreococcus lucimarinus 77.55 8.00e-67 245.00
IUUC-Pan-092614 Papio anubis 97.24 2.00e-82 297.00
IUUC-Ppa-095177 Physcomitrella patens 80.95 1.00e-70 258.00
IUUC-Pfo-096867 Poecilia formosa 97.28 4.00e-84 303.00
IUUC-Pab-098760 Pongo abelii 99.32 2.00e-85 307.00
IUUC-Pop-098799 Populus trichocarpa 80.95 1.00e-70 258.00
IUUC-Ppe-101431 Prunus persica 81.63 3.00e-71 259.00
IUUC-Pte-104015 Pyrenophora teres 84.35 3.00e-74 270.00
IUUC-Pyt-104701 Pyrenophora triticirepentis 84.35 3.00e-74 270.00
IUUC-Sce-106463 Saccharomyces cerevisiae 81.25 2.00e-70 257.00
IUUC-Ssl-108443 Sclerotinia sclerotiorum 84.35 1.00e-74 271.00
IUUC-Smo-108911 Selaginella moellendorffii 80.95 4.00e-70 256.00
IUUC-Sit-109936 Setaria italica 81.63 9.00e-72 263.00
IUUC-Sly-110857 Solanum lycopersicum 81.63 2.00e-71 261.00
IUUC-Stu-112436 Solanum tuberosum 81.63 3.00e-72 263.00
IUUC-Sbi-114840 Sorghum bicolor 81.63 5.00e-72 262.00
IUUC-Ssc-115391 Sus scrofa 100.00 5.00e-86 309.00
IUUC-Tsy-118832 Tarsius syrichta 97.28 4.00e-83 299.00
IUUC-Tca-121542 Theobroma cacao 81.63 2.00e-72 265.00
IUUC-Tae-123340 Triticum aestivum 82.31 7.00e-73 265.00
IUUC-Tur-126518 Triticum urartu 79.59 3.00e-70 258.00
IUUC-Tbe-128122 Tupaia belangeri 96.77 4.00e-61 226.00
IUUC-Vda-129695 Verticillium dahliae 84.35 6.00e-74 269.00
IUUC-Vvi-131016 Vitis vinifera 80.27 5.00e-71 259.00
IUUC-Xtr-132238 Xenopus tropicalis 97.96 1.00e-84 305.00
IUUC-Zma-135267 Zea mays 80.27 3.00e-62 230.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved