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Tag Content
iUUCD ID IUUC-Ssl-108475
Ensembl Protein ID EDO02982
UniProt Accession A7EJG6; ATG5_SCLS1
Genbank Protein ID EDO02982.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID CH476626
Gene Name atg5; SS1G_05459
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SS1G_05459 EDO02982 EDO02982
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 34.48 2.00e-03 37.70 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Sclerotinia sclerotiorum
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MQSLIWASAI PLYITHSSST IPYLINVPRV SYLALLFPRL TSFFGENVSS FSYEGILLKN 60
LPVGLLCDLY QPELPWRIEL GDGPLFDIHD TFINSVKEAD FMRNGNAKGI MSMSKEHSTQ 120
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Protein Fasta Sequence



>IUUC-Ssl-108475|E3,Cullin RING/Other|Sclerotinia sclerotiorum
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Nucleotide Sequence
(Fasta)
ATGCAATCTC TCATTTGGGC CTCTGCTATA CCATTGTATA TTACACATTC TTCCTCTACA 60
ATACCTTACT TGATAAATGT ACCTCGAGTC TCTTACTTGG CGCTTCTTTT CCCACGATTA 120
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Nucleotide Fasta Sequence



>IUUC-Ssl-108475|E3,Cullin RING/Other|Sclerotinia sclerotiorum
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG ssl:SS1G_05459
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 33.12 6.00e-13 67.40
IUUC-Aml-002403 Ailuropoda melanoleuca 28.18 9.00e-16 74.70
IUUC-Atr-002645 Amborella trichopoda 28.88 3.00e-16 77.00
IUUC-Apl-003611 Anas platyrhynchos 24.91 4.00e-17 79.70
IUUC-Aca-004411 Anolis carolinensis 26.12 3.00e-16 76.60
IUUC-Aly-005636 Arabidopsis lyrata 32.52 3.00e-12 63.50
IUUC-Ath-006959 Arabidopsis thaliana 32.52 3.00e-12 63.50
IUUC-Ago-007978 Ashbya gossypii 24.40 1.00e-05 41.60
IUUC-Acl-008328 Aspergillus clavatus 40.32 3.00e-41 159.00
IUUC-Afl-008638 Aspergillus flavus 37.93 9.00e-47 178.00
IUUC-Afu-009042 Aspergillus fumigatus 39.43 1.00e-49 187.00
IUUC-Ani-009364 Aspergillus nidulans 40.69 2.00e-33 134.00
IUUC-Aor-009889 Aspergillus oryzae 37.93 2.00e-46 176.00
IUUC-Ate-010511 Aspergillus terreus 43.84 6.00e-08 47.00
IUUC-Ame-011644 Astyanax mexicanus 29.41 1.10e-02 28.50
IUUC-Bgr-012153 Blumeria graminis 48.70 1.00e-68 250.00
IUUC-Bta-012360 Bos taurus 32.00 4.00e-09 52.00
IUUC-Bci-013723 Botrytis cinerea 88.35 9.00e-130 453.00
IUUC-Bdi-014520 Brachypodium distachyon 26.67 1.00e-09 55.50
IUUC-Bol-016053 Brassica oleracea 31.90 1.00e-13 68.60
IUUC-Bra-017072 Brassica rapa 33.13 1.00e-14 71.60
IUUC-Cel-018529 Caenorhabditis elegans 28.80 4.00e-13 66.20
IUUC-Cja-019569 Callithrix jacchus 27.34 2.00e-16 77.00
IUUC-Cfa-020473 Canis familiaris 27.68 7.00e-17 78.60
IUUC-Cpo-021421 Cavia porcellus 28.03 3.00e-17 80.10
IUUC-Csa-024197 Chlorocebus sabaeus 27.34 3.00e-16 76.60
IUUC-Cho-024521 Choloepus hoffmanni 27.20 7.00e-13 65.10
IUUC-Cin-025119 Ciona intestinalis 22.68 4.00e-11 59.70
IUUC-Csv-026192 Ciona savignyi 25.26 2.00e-15 73.60
IUUC-Cgl-026686 Colletotrichum gloeosporioides 52.79 6.00e-63 231.00
IUUC-Dre-028466 Danio rerio 26.74 3.00e-15 73.20
IUUC-Dse-031228 Dothistroma septosporum 35.80 7.00e-46 175.00
IUUC-Ete-032482 Echinops telfairi 27.20 2.00e-13 67.40
IUUC-Eca-034036 Equus caballus 27.34 1.00e-16 77.80
IUUC-Eeu-035235 Erinaceus europaeus 32.00 1.00e-08 51.60
IUUC-Fca-036263 Felis catus 27.68 1.00e-16 78.20
IUUC-Fal-037064 Ficedula albicollis 26.64 9.00e-18 81.60
IUUC-Fox-037813 Fusarium oxysporum 52.67 4.00e-75 271.00
IUUC-Fso-038139 Fusarium solani 53.82 1.00e-74 270.00
IUUC-Gmo-039509 Gadus morhua 30.94 3.00e-12 62.80
IUUC-Ggr-040111 Gaeumannomyces graminis 52.26 8.00e-68 248.00
IUUC-Gga-040517 Gallus gallus 25.61 1.00e-17 81.30
IUUC-Gac-042270 Gasterosteus aculeatus 26.72 5.00e-14 69.30
IUUC-Gma-044400 Glycine max 32.54 1.00e-14 71.20
IUUC-Ggo-045048 Gorilla gorilla 27.34 8.00e-17 78.60
IUUC-Hsa-046744 Homo sapiens 27.34 2.00e-16 77.00
IUUC-Kpa-049174 Komagataella pastoris 23.97 2.00e-14 70.50
IUUC-Lch-049475 Latimeria chalumnae 26.99 6.00e-19 85.50
IUUC-Lpe-051283 Leersia perrieri 28.63 1.00e-11 63.20
IUUC-Loc-052446 Lepisosteus oculatus 26.30 2.00e-18 84.30
IUUC-Lma-053278 Leptosphaeria maculans 36.71 4.00e-50 189.00
IUUC-Laf-054020 Loxodonta africana 27.84 3.00e-15 73.60
IUUC-Mcc-055176 Macaca mulatta 27.34 2.00e-16 77.00
IUUC-Mor-057164 Magnaporthe oryzae 49.81 9.00e-70 254.00
IUUC-Mpo-057428 Magnaporthe poae 50.37 5.00e-62 228.00
IUUC-Mtr-058424 Medicago truncatula 32.34 5.00e-14 68.90
IUUC-Mla-058872 Melampsora laricipopulina 24.60 2.00e-14 70.90
IUUC-Mga-059859 Meleagris gallopavo 25.61 1.00e-17 81.30
IUUC-Mmr-061482 Microcebus murinus 27.34 2.00e-16 77.00
IUUC-Mdo-062371 Monodelphis domestica 27.68 1.00e-18 84.30
IUUC-Mmu-063139 Mus musculus 26.99 1.00e-16 77.80
IUUC-Mac-065332 Musa acuminata 34.15 4.00e-15 73.20
IUUC-Mpu-066783 Mustela putorius furo 27.68 7.00e-17 78.60
IUUC-Mlu-068165 Myotis lucifugus 27.84 3.00e-15 73.60
IUUC-Nfi-068578 Neosartorya fischeri 39.62 9.00e-50 188.00
IUUC-Ncr-068636 Neurospora crassa 55.68 8.00e-75 271.00
IUUC-Nle-069740 Nomascus leucogenys 27.34 3.00e-16 76.60
IUUC-Opr-070802 Ochotona princeps 32.00 1.00e-08 51.20
IUUC-Ont-072222 Oreochromis niloticus 25.95 6.00e-17 79.00
IUUC-Oan-072760 Ornithorhynchus anatinus 32.04 2.00e-13 67.00
IUUC-Ocu-074844 Oryctolagus cuniculus 24.58 2.00e-09 53.10
IUUC-Oba-075834 Oryza barthii 26.59 9.00e-13 65.50
IUUC-Obr-076230 Oryza brachyantha 32.98 8.00e-08 48.50
IUUC-Ogl-077554 Oryza glaberrima 26.59 1.00e-12 65.50
IUUC-Ogu-078687 Oryza glumaepatula 30.49 2.00e-12 64.70
IUUC-Oin-079677 Oryza indica 26.69 5.00e-14 69.70
IUUC-Olo-081078 Oryza longistaminata 27.85 4.00e-13 67.00
IUUC-Ome-081548 Oryza meridionalis 31.10 6.00e-14 70.90
IUUC-Oni-082050 Oryza nivara 26.59 4.00e-13 67.00
IUUC-Opu-083609 Oryza punctata 26.59 1.00e-13 68.60
IUUC-Oru-085057 Oryza rufipogon 26.59 5.00e-13 66.60
IUUC-Osa-085917 Oryza sativa 26.97 2.00e-13 67.80
IUUC-Ola-087032 Oryzias latipes 24.91 8.00e-17 78.60
IUUC-Oga-088468 Otolemur garnettii 28.18 1.00e-16 77.80
IUUC-Oar-089751 Ovis aries 27.68 2.00e-17 80.50
IUUC-Ptr-091064 Pan troglodytes 27.34 2.00e-16 77.00
IUUC-Pan-092505 Papio anubis 27.84 3.00e-15 73.20
IUUC-Psi-093086 Pelodiscus sinensis 26.55 9.00e-17 78.20
IUUC-Pno-094825 Phaeosphaeria nodorum 38.28 2.00e-49 186.00
IUUC-Ppa-095419 Physcomitrella patens 28.92 7.00e-14 69.30
IUUC-Pfo-096224 Poecilia formosa 25.26 5.00e-16 75.90
IUUC-Pab-098501 Pongo abelii 27.34 2.00e-16 77.40
IUUC-Pop-099243 Populus trichocarpa 33.51 6.00e-15 72.80
IUUC-Ppe-101255 Prunus persica 33.13 2.00e-13 67.80
IUUC-Pva-102828 Pteropus vampyrus 27.68 1.00e-16 77.80
IUUC-Pgr-103672 Puccinia graminis 24.12 9.00e-11 58.90
IUUC-Ptt-104013 Puccinia triticina 22.85 2.00e-10 57.80
IUUC-Pyt-104615 Pyrenophora triticirepentis 36.02 1.00e-48 184.00
IUUC-Rno-106089 Rattus norvegicus 27.44 2.00e-16 76.60
IUUC-Sce-106216 Saccharomyces cerevisiae 23.35 4.00e-05 39.70
IUUC-Sha-106484 Sarcophilus harrisii 26.99 2.00e-17 80.90
IUUC-Sja-107699 Schizosaccharomyces japonicus 27.43 1.00e-27 114.00
IUUC-Spo-108177 Schizosaccharomyces pombe 29.72 2.00e-28 117.00
IUUC-Smo-109473 Selaginella moellendorffii 23.47 6.00e-09 52.80
IUUC-Sit-110736 Setaria italica 30.54 3.00e-14 70.10
IUUC-Sly-111657 Solanum lycopersicum 36.75 7.00e-19 85.90
IUUC-Sar-113050 Sorex araneus 33.99 5.00e-11 58.90
IUUC-Sbi-114258 Sorghum bicolor 33.58 2.00e-12 64.70
IUUC-Sre-114902 Sporisorium reilianum 23.08 2.00e-07 48.50
IUUC-Ssc-116166 Sus scrofa 25.61 2.00e-13 67.00
IUUC-Tgu-116814 Taeniopygia guttata 26.30 5.00e-18 82.40
IUUC-Tru-118172 Takifugu rubripes 24.65 4.00e-17 79.30
IUUC-Tsy-119010 Tarsius syrichta 32.60 2.00e-13 67.00
IUUC-Tni-120397 Tetraodon nigroviridis 28.73 4.00e-13 65.90
IUUC-Tca-121283 Theobroma cacao 33.53 1.00e-14 71.60
IUUC-Tre-122017 Trichoderma reesei 35.23 2.20e-02 33.50
IUUC-Tvi-122545 Trichoderma virens 50.19 7.00e-71 258.00
IUUC-Tae-122685 Triticum aestivum 31.48 1.00e-12 64.70
IUUC-Tur-126407 Triticum urartu 34.59 4.00e-12 63.20
IUUC-Tme-126913 Tuber melanosporum 31.07 3.00e-36 142.00
IUUC-Tbe-127738 Tupaia belangeri 25.23 1.00e-08 50.80
IUUC-Ttr-128528 Tursiops truncatus 27.68 2.00e-17 80.10
IUUC-Uma-129625 Ustilago maydis 22.73 7.00e-08 49.70
IUUC-Vda-129906 Verticillium dahliae 49.81 6.00e-64 234.00
IUUC-Vpa-130223 Vicugna pacos 26.13 7.00e-14 68.60
IUUC-Vvi-131617 Vitis vinifera 33.13 3.00e-14 70.50
IUUC-Xtr-132288 Xenopus tropicalis 26.64 3.00e-19 86.30
IUUC-Xma-134214 Xiphophorus maculatus 28.18 8.00e-12 61.20
IUUC-Yli-134377 Yarrowia lipolytica 31.32 2.00e-18 83.60
IUUC-Zma-135108 Zea mays 31.79 1.00e-12 65.50
Created Date 25-Jun-2017

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