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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046635
UUCD1 version UUC-HoS-00410
Ensembl Protein ID ENSP00000220509.5
UniProt Accession Q9P253; Q8TCG0; Q96DI3; Q9H268; VPS18_HUMAN
Genbank Protein ID AAG34679.1; BAA95999.1; CAD28515.1; AAH01513.1
Protein Name Vacuolar protein sorting-associated protein 18 homolog
Genbank Nucleotide ID AF308802; AB040908; AL713725; BC001513
Gene Name VPS18; KIAA1475
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000104142.10 ENST00000220509.9 ENSP00000220509.5
ENSG00000104142.10 ENST00000558855.5 ENSP00000453265.1
ENSG00000104142.10 ENST00000558474.1 ENSP00000453555.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16996030; 18772139; 16203730
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.30e-05 26.5 853 947
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp......CgHvfhadCl.qkw.pglknssskefr........................................... 41
           Ca+C  df   pl+++      CgH+fhadCl q++ pgl+  ++k++r                                           
   Q: 853  CATC--DF---PLLNRpfylflCGHMFHADCLlQAVrPGLP--AYKQARleelqrklgaapppakgsarakeaeggaatagpsreqlkadld 937
           9***..99...66555666668*********9788887777..8888877777777777777777777788888888888888888888888 PP
   S: 42   ......CPlC 45
                 C++C
   Q: 938  elvaaeCVYC 947
           8888888887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).
 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).
Protein Sequence
(Fasta)
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID FTPSERITSL 60
VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV HKMFLDHTGS HLLIALSSTE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046635|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCCCGCGTCA CGGGGGCGGG AGTCAGCTGA GCTGCCGGGG CGAGGTTGGG ATCACCTGGC 60
ACCGGCTGAA GGGAGCCTGT GATTTTTTTG TAGCGGGGGC GGGGAGTAAG GTGCAAGACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046635|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50236--CHCR
Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18
Gene Ontology

GO:0005884--C:actin filament
GO:0030123--C:AP-3 adaptor complex
GO:0005776--C:autophagosome
GO:0030136--C:clathrin-coated vesicle
GO:0033263--C:CORVET complex
GO:0005769--C:early endosome
GO:0030897--C:HOPS complex
GO:0005770--C:late endosome
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0046872--F:metal ion binding
GO:0030674--F:protein binding, bridging
GO:0019905--F:syntaxin binding
GO:0006914--P:autophagy
GO:0007032--P:endosome organization
GO:0008333--P:endosome to lysosome transport
GO:0006886--P:intracellular protein transport
GO:0007040--P:lysosome organization
GO:0035542--P:regulation of SNARE complex assembly
GO:0006904--P:vesicle docking involved in exocytosis
GO:0046718--P:viral entry into host cell
KEGG hsa:57617
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000419 Aegilops tauschii 32.24 1.00e-108 387.00
IUUC-Aml-001240 Ailuropoda melanoleuca 97.64 0.00e+00 1880.00
IUUC-Atr-003125 Amborella trichopoda 32.62 5.00e-121 429.00
IUUC-Apl-004181 Anas platyrhynchos 72.69 0.00e+00 1487.00
IUUC-Aca-004437 Anolis carolinensis 72.59 0.00e+00 1467.00
IUUC-Aly-006046 Arabidopsis lyrata 33.23 2.00e-134 473.00
IUUC-Ath-006932 Arabidopsis thaliana 33.47 7.00e-134 471.00
IUUC-Ago-007800 Ashbya gossypii 24.01 1.00e-56 214.00
IUUC-Acl-008035 Aspergillus clavatus 31.31 5.00e-111 395.00
IUUC-Afl-008714 Aspergillus flavus 31.06 2.00e-110 394.00
IUUC-Afu-009063 Aspergillus fumigatus 32.32 1.00e-112 401.00
IUUC-Ani-009384 Aspergillus nidulans 32.70 5.00e-115 409.00
IUUC-Ang-009507 Aspergillus niger 32.17 7.00e-111 395.00
IUUC-Aor-010094 Aspergillus oryzae 31.06 2.00e-110 393.00
IUUC-Ate-010421 Aspergillus terreus 31.42 2.00e-96 347.00
IUUC-Ame-011797 Astyanax mexicanus 65.75 0.00e+00 1309.00
IUUC-Bgr-012107 Blumeria graminis 31.46 3.00e-109 389.00
IUUC-Bta-012339 Bos taurus 97.12 0.00e+00 1886.00
IUUC-Bci-013895 Botrytis cinerea 33.81 4.00e-119 422.00
IUUC-Bdi-014554 Brachypodium distachyon 34.09 1.00e-126 447.00
IUUC-Bol-015270 Brassica oleracea 33.68 2.00e-135 477.00
IUUC-Bra-017424 Brassica rapa 33.40 3.00e-131 462.00
IUUC-Cel-018455 Caenorhabditis elegans 26.11 2.00e-87 317.00
IUUC-Cja-019629 Callithrix jacchus 98.36 0.00e+00 1925.00
IUUC-Cfa-020425 Canis familiaris 97.53 0.00e+00 1876.00
IUUC-Cpo-021349 Cavia porcellus 95.89 0.00e+00 1845.00
IUUC-Cre-022799 Chlamydomonas reinhardtii 29.52 2.00e-26 114.00
IUUC-Csa-023559 Chlorocebus sabaeus 99.59 0.00e+00 1937.00
IUUC-Cho-024862 Choloepus hoffmanni 89.11 0.00e+00 1390.00
IUUC-Cin-025599 Ciona intestinalis 41.33 3.00e-176 612.00
IUUC-Csv-026152 Ciona savignyi 42.94 0.00e+00 765.00
IUUC-Cgl-026551 Colletotrichum gloeosporioides 31.00 5.00e-112 399.00
IUUC-Cne-026907 Cryptococcus neoformans 31.22 2.00e-111 397.00
IUUC-Dre-027747 Danio rerio 65.91 0.00e+00 1353.00
IUUC-Dno-029668 Dasypus novemcinctus 96.92 0.00e+00 1870.00
IUUC-Dor-030404 Dipodomys ordii 91.06 0.00e+00 1772.00
IUUC-Dse-031345 Dothistroma septosporum 33.70 1.00e-121 431.00
IUUC-Dme-031711 Drosophila melanogaster 34.12 4.00e-147 516.00
IUUC-Ete-032308 Echinops telfairi 90.35 0.00e+00 915.00
IUUC-Eca-033637 Equus caballus 97.53 0.00e+00 1896.00
IUUC-Eeu-035151 Erinaceus europaeus 95.82 0.00e+00 1387.00
IUUC-Fca-035585 Felis catus 97.23 0.00e+00 1870.00
IUUC-Fal-037122 Ficedula albicollis 72.40 0.00e+00 1485.00
IUUC-Fox-038030 Fusarium oxysporum 33.33 2.00e-121 430.00
IUUC-Fso-038426 Fusarium solani 33.47 7.00e-126 445.00
IUUC-Gmo-038784 Gadus morhua 66.33 0.00e+00 1315.00
IUUC-Ggr-039973 Gaeumannomyces graminis 33.91 4.00e-122 432.00
IUUC-Gga-040692 Gallus gallus 74.02 0.00e+00 1511.00
IUUC-Gac-041868 Gasterosteus aculeatus 66.02 0.00e+00 1315.00
IUUC-Gma-044274 Glycine max 33.84 1.00e-135 477.00
IUUC-Ggo-045053 Gorilla gorilla 99.79 0.00e+00 1922.00
IUUC-Hvu-047361 Hordeum vulgare 33.71 7.00e-126 445.00
IUUC-Itr-048868 Ictidomys tridecemlineatus 97.33 0.00e+00 1868.00
IUUC-Kpa-049270 Komagataella pastoris 24.48 5.00e-78 286.00
IUUC-Lch-050188 Latimeria chalumnae 68.65 0.00e+00 1228.00
IUUC-Lpe-051026 Leersia perrieri 34.66 8.00e-132 464.00
IUUC-Loc-051821 Lepisosteus oculatus 67.01 0.00e+00 1339.00
IUUC-Lma-053178 Leptosphaeria maculans 36.20 7.00e-100 358.00
IUUC-Laf-053552 Loxodonta africana 97.02 0.00e+00 1874.00
IUUC-Mcc-054667 Macaca mulatta 99.69 0.00e+00 1919.00
IUUC-Meu-056422 Macropus eugenii 92.37 0.00e+00 865.00
IUUC-Mor-056981 Magnaporthe oryzae 33.09 2.00e-120 427.00
IUUC-Mtr-058703 Medicago truncatula 33.57 1.00e-131 464.00
IUUC-Mla-059088 Melampsora laricipopulina 34.72 3.00e-92 333.00
IUUC-Mga-059798 Meleagris gallopavo 73.72 0.00e+00 1504.00
IUUC-Mvi-060404 Microbotryum violaceum 33.57 1.00e-119 425.00
IUUC-Mmr-061630 Microcebus murinus 98.46 0.00e+00 1895.00
IUUC-Mdo-062354 Monodelphis domestica 92.91 0.00e+00 1831.00
IUUC-Mmu-063199 Mus musculus 95.79 0.00e+00 1870.00
IUUC-Mac-065595 Musa acuminata 35.70 7.00e-113 401.00
IUUC-Mpu-066596 Mustela putorius furo 96.92 0.00e+00 1890.00
IUUC-Mlu-067455 Myotis lucifugus 97.02 0.00e+00 1867.00
IUUC-Nfi-068565 Neosartorya fischeri 32.48 2.00e-114 406.00
IUUC-Ncr-068748 Neurospora crassa 33.50 4.00e-125 442.00
IUUC-Nle-068979 Nomascus leucogenys 99.53 0.00e+00 1725.00
IUUC-Opr-070711 Ochotona princeps 95.68 0.00e+00 1863.00
IUUC-Ont-072603 Oreochromis niloticus 66.02 0.00e+00 1337.00
IUUC-Oan-073136 Ornithorhynchus anatinus 84.93 0.00e+00 820.00
IUUC-Ocu-074496 Oryctolagus cuniculus 97.02 0.00e+00 1879.00
IUUC-Oba-075933 Oryza barthii 32.86 4.00e-110 392.00
IUUC-Obr-076290 Oryza brachyantha 33.78 1.00e-131 464.00
IUUC-Ogu-078728 Oryza glumaepatula 32.86 1.00e-110 394.00
IUUC-Oin-079954 Oryza indica 33.23 1.00e-122 434.00
IUUC-Olo-081033 Oryza longistaminata 31.89 6.00e-105 375.00
IUUC-Ome-081797 Oryza meridionalis 32.64 4.00e-117 416.00
IUUC-Oni-082802 Oryza nivara 32.86 1.00e-110 394.00
IUUC-Opu-083595 Oryza punctata 34.70 9.00e-131 461.00
IUUC-Oru-084199 Oryza rufipogon 32.86 1.00e-110 394.00
IUUC-Osa-085349 Oryza sativa 33.74 7.00e-131 461.00
IUUC-Ola-087482 Oryzias latipes 65.82 0.00e+00 1320.00
IUUC-Olu-087797 Ostreococcus lucimarinus 25.08 7.00e-63 236.00
IUUC-Oga-088817 Otolemur garnettii 97.64 0.00e+00 1918.00
IUUC-Oar-090350 Ovis aries 94.63 0.00e+00 1445.00
IUUC-Ptr-090999 Pan troglodytes 99.69 0.00e+00 1920.00
IUUC-Pan-092704 Papio anubis 99.69 0.00e+00 1919.00
IUUC-Psi-093529 Pelodiscus sinensis 73.61 0.00e+00 1476.00
IUUC-Pma-094400 Petromyzon marinus 56.42 0.00e+00 1094.00
IUUC-Pno-094875 Phaeosphaeria nodorum 33.09 1.00e-118 421.00
IUUC-Ppa-095231 Physcomitrella patens 33.11 1.00e-130 461.00
IUUC-Pfo-096967 Poecilia formosa 65.21 0.00e+00 1322.00
IUUC-Pab-098300 Pongo abelii 99.69 0.00e+00 1918.00
IUUC-Pop-098966 Populus trichocarpa 34.17 5.00e-140 492.00
IUUC-Pca-100643 Procavia capensis 95.33 0.00e+00 1775.00
IUUC-Ppe-101589 Prunus persica 33.64 2.00e-135 477.00
IUUC-Pva-102766 Pteropus vampyrus 96.92 0.00e+00 1829.00
IUUC-Pgr-103330 Puccinia graminis 30.35 2.00e-106 380.00
IUUC-Ptt-103809 Puccinia triticina 31.58 5.00e-90 326.00
IUUC-Pte-104319 Pyrenophora teres 32.64 1.00e-117 418.00
IUUC-Pyt-104798 Pyrenophora triticirepentis 31.50 3.00e-105 376.00
IUUC-Rno-105817 Rattus norvegicus 95.17 0.00e+00 1862.00
IUUC-Sce-106255 Saccharomyces cerevisiae 23.18 4.00e-44 173.00
IUUC-Sha-107479 Sarcophilus harrisii 93.06 0.00e+00 1823.00
IUUC-Sja-107976 Schizosaccharomyces japonicus 24.83 4.00e-69 256.00
IUUC-Spo-108146 Schizosaccharomyces pombe 26.68 5.00e-73 269.00
IUUC-Ssl-108663 Sclerotinia sclerotiorum 33.60 2.00e-110 393.00
IUUC-Smo-109585 Selaginella moellendorffii 34.54 8.00e-124 438.00
IUUC-Sit-110275 Setaria italica 34.60 3.00e-130 459.00
IUUC-Sly-111073 Solanum lycopersicum 34.47 1.00e-134 474.00
IUUC-Stu-112392 Solanum tuberosum 27.62 4.00e-14 71.20
IUUC-Sar-113718 Sorex araneus 93.02 0.00e+00 1783.00
IUUC-Sbi-114080 Sorghum bicolor 34.70 9.00e-136 478.00
IUUC-Sre-115160 Sporisorium reilianum 31.87 2.00e-123 437.00
IUUC-Ssc-115997 Sus scrofa 96.40 0.00e+00 1872.00
IUUC-Tgu-116904 Taeniopygia guttata 73.44 0.00e+00 1342.00
IUUC-Tru-117946 Takifugu rubripes 64.80 0.00e+00 1318.00
IUUC-Tni-119692 Tetraodon nigroviridis 65.11 0.00e+00 1318.00
IUUC-Tca-121455 Theobroma cacao 34.15 2.00e-137 483.00
IUUC-Tre-122128 Trichoderma reesei 32.38 1.00e-122 434.00
IUUC-Tvi-122657 Trichoderma virens 33.30 4.00e-124 439.00
IUUC-Tae-125953 Triticum aestivum 34.26 2.00e-127 450.00
IUUC-Tur-126110 Triticum urartu 30.64 6.00e-94 338.00
IUUC-Tme-127173 Tuber melanosporum 30.38 5.00e-103 369.00
IUUC-Ttr-128420 Tursiops truncatus 97.02 0.00e+00 1868.00
IUUC-Uma-129580 Ustilago maydis 31.54 2.00e-122 434.00
IUUC-Vda-129790 Verticillium dahliae 31.10 8.00e-111 395.00
IUUC-Vvi-131095 Vitis vinifera 33.09 1.00e-131 464.00
IUUC-Xtr-131906 Xenopus tropicalis 68.96 0.00e+00 1373.00
IUUC-Xma-134197 Xiphophorus maculatus 65.62 0.00e+00 1323.00
IUUC-Yli-134617 Yarrowia lipolytica 28.62 2.00e-97 350.00
IUUC-Zma-134979 Zea mays 32.37 4.00e-103 369.00
Created Date 25-Jun-2017

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