iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012270.1	ENSAMET00000013466.1	ENSAMEP00000012923.1
ENSAMEG00000012270.1	ENSAMET00000013471.1	ENSAMEP00000012928.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-92	308.7	218	561

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 218  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 302
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 303  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 375
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l +  k++c+ c+++qe++k+l++kk+P v ++hLkRf  +++ k r+k
   Q: 376  STPFWPlspgsegsvvngeshvagttTLTDCLRRFTRPEHLGSGAKIKCSGCHSYQESTKQLTMKKVPIVACFHLKRF--EHSAKLRRK 462
           *87777************************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + e+vl  
   Q: 463  ITTYVSFPLELDMTPFMASSKESRMNgqyqqltdslnnDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIEDVLD- 550
           *******************7766666888888888888**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 551  --SEGYLLFYHKQ 561
           ..********985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

AGAGTGRRPG LGEAPEPLQG XXXXLASSSS PSPPPARGRA LPPMVSRPEP ESEAMDAELT 60
PPGCSHLSSF KVDNWKQNLR AIYQCFVWSG TAEARKRKAK SCVCHVCGIH LNRLHSCLHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGGGCAG GGACGGGGCG CCGACCGGGG CTCGGGGAGG CCCCGGAGCC CCTGCAGGGC 60
TGCAGACTCA CCACTGTGCA GTGAAGTCCA CAAACTCAGG AGAGAAACGG TCGGCAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.57	5.00e-64	239.00
IUUC-Atr-002653	Amborella trichopoda	37.87	3.00e-98	352.00
IUUC-Apl-003433	Anas platyrhynchos	91.53	0.00e+00	939.00
IUUC-Aca-005347	Anolis carolinensis	87.41	0.00e+00	993.00
IUUC-Ago-007811	Ashbya gossypii	30.58	1.00e-52	200.00
IUUC-Acl-008124	Aspergillus clavatus	31.84	1.00e-58	220.00
IUUC-Afl-008464	Aspergillus flavus	32.77	5.00e-55	207.00
IUUC-Afu-008912	Aspergillus fumigatus	31.16	7.00e-57	214.00
IUUC-Ani-009168	Aspergillus nidulans	32.33	9.00e-58	217.00
IUUC-Aor-010035	Aspergillus oryzae	34.83	1.00e-38	153.00
IUUC-Ate-010382	Aspergillus terreus	32.05	5.00e-53	201.00
IUUC-Ame-011253	Astyanax mexicanus	84.50	0.00e+00	826.00
IUUC-Bgr-012150	Blumeria graminis	30.88	6.00e-49	188.00
IUUC-Bta-013303	Bos taurus	97.08	0.00e+00	1049.00
IUUC-Bci-013604	Botrytis cinerea	32.00	4.00e-57	215.00
IUUC-Bdi-014171	Brachypodium distachyon	34.95	7.00e-75	274.00
IUUC-Cja-019283	Callithrix jacchus	98.11	0.00e+00	879.00
IUUC-Cfa-021239	Canis familiaris	98.30	0.00e+00	975.00
IUUC-Cpo-022354	Cavia porcellus	95.43	0.00e+00	1055.00
IUUC-Csa-023145	Chlorocebus sabaeus	96.57	0.00e+00	1069.00
IUUC-Cho-024938	Choloepus hoffmanni	94.83	6.00e-65	241.00
IUUC-Cin-025109	Ciona intestinalis	57.03	4.00e-121	427.00
IUUC-Csv-026214	Ciona savignyi	55.09	8.00e-173	600.00
IUUC-Cne-027085	Cryptococcus neoformans	33.33	1.00e-63	237.00
IUUC-Dre-027433	Danio rerio	92.31	0.00e+00	918.00
IUUC-Dno-030095	Dasypus novemcinctus	95.95	0.00e+00	956.00
IUUC-Dor-030481	Dipodomys ordii	95.38	6.00e-99	354.00
IUUC-Dse-031415	Dothistroma septosporum	30.94	6.00e-61	228.00
IUUC-Dme-032074	Drosophila melanogaster	50.94	2.00e-138	485.00
IUUC-Ete-033175	Echinops telfairi	76.96	0.00e+00	712.00
IUUC-Eca-033736	Equus caballus	97.87	0.00e+00	966.00
IUUC-Eeu-034814	Erinaceus europaeus	95.22	2.00e-132	466.00
IUUC-Fca-035861	Felis catus	98.29	0.00e+00	972.00
IUUC-Fal-037645	Ficedula albicollis	91.81	0.00e+00	924.00
IUUC-Fox-038046	Fusarium oxysporum	31.63	6.00e-55	208.00
IUUC-Fso-038321	Fusarium solani	33.26	3.00e-55	209.00
IUUC-Gmo-038474	Gadus morhua	93.24	1.00e-170	592.00
IUUC-Gga-040624	Gallus gallus	90.29	0.00e+00	1005.00
IUUC-Gac-042197	Gasterosteus aculeatus	85.33	0.00e+00	924.00
IUUC-Gma-042897	Glycine max	32.31	1.00e-83	303.00
IUUC-Ggo-044409	Gorilla gorilla	96.76	0.00e+00	1071.00
IUUC-Hsa-046521	Homo sapiens	96.57	0.00e+00	1069.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	96.11	0.00e+00	1041.00
IUUC-Kpa-049135	Komagataella pastoris	35.41	4.00e-68	252.00
IUUC-Lch-050537	Latimeria chalumnae	92.32	0.00e+00	1009.00
IUUC-Lpe-050969	Leersia perrieri	37.89	1.00e-72	266.00
IUUC-Loc-052765	Lepisosteus oculatus	82.11	0.00e+00	895.00
IUUC-Lma-053105	Leptosphaeria maculans	33.67	4.00e-67	248.00
IUUC-Laf-053571	Loxodonta africana	96.80	0.00e+00	958.00
IUUC-Mcc-055166	Macaca mulatta	96.57	0.00e+00	1069.00
IUUC-Mor-057103	Magnaporthe oryzae	31.40	3.00e-56	212.00
IUUC-Mpo-057621	Magnaporthe poae	32.31	1.00e-55	210.00
IUUC-Mtr-057894	Medicago truncatula	37.07	5.00e-84	305.00
IUUC-Mga-059709	Meleagris gallopavo	91.53	0.00e+00	939.00
IUUC-Mvi-060530	Microbotryum violaceum	34.02	2.00e-58	219.00
IUUC-Mmr-060988	Microcebus murinus	96.37	0.00e+00	1063.00
IUUC-Mdo-063065	Monodelphis domestica	93.11	0.00e+00	1018.00
IUUC-Mmu-063829	Mus musculus	96.38	0.00e+00	1064.00
IUUC-Mpu-066687	Mustela putorius furo	96.37	0.00e+00	1051.00
IUUC-Nfi-068423	Neosartorya fischeri	31.16	1.00e-56	214.00
IUUC-Ncr-068809	Neurospora crassa	29.68	5.00e-58	218.00
IUUC-Nle-069261	Nomascus leucogenys	92.76	0.00e+00	1014.00
IUUC-Opr-070469	Ochotona princeps	79.91	0.00e+00	687.00
IUUC-Ont-071961	Oreochromis niloticus	88.78	0.00e+00	962.00
IUUC-Oan-073565	Ornithorhynchus anatinus	84.99	0.00e+00	907.00
IUUC-Ocu-074435	Oryctolagus cuniculus	96.68	0.00e+00	1038.00
IUUC-Obr-076652	Oryza brachyantha	41.42	3.00e-74	272.00
IUUC-Ogl-077910	Oryza glaberrima	36.48	1.00e-77	283.00
IUUC-Ogu-078479	Oryza glumaepatula	36.48	1.00e-77	283.00
IUUC-Oin-079697	Oryza indica	39.90	1.00e-75	277.00
IUUC-Olo-080811	Oryza longistaminata	41.03	1.00e-52	199.00
IUUC-Ome-081706	Oryza meridionalis	35.69	1.00e-76	281.00
IUUC-Oni-083070	Oryza nivara	36.48	2.00e-77	283.00
IUUC-Opu-083605	Oryza punctata	39.89	2.00e-67	248.00
IUUC-Oru-084522	Oryza rufipogon	36.48	1.00e-77	283.00
IUUC-Osa-085351	Oryza sativa	39.61	3.00e-76	279.00
IUUC-Ola-086743	Oryzias latipes	88.06	0.00e+00	754.00
IUUC-Olu-087695	Ostreococcus lucimarinus	32.08	2.00e-50	192.00
IUUC-Oga-089131	Otolemur garnettii	93.35	0.00e+00	1053.00
IUUC-Oar-089319	Ovis aries	97.86	0.00e+00	964.00
IUUC-Ptr-090783	Pan troglodytes	94.05	0.00e+00	965.00
IUUC-Pan-092927	Papio anubis	96.38	0.00e+00	1068.00
IUUC-Psi-093670	Pelodiscus sinensis	90.63	0.00e+00	939.00
IUUC-Pma-094323	Petromyzon marinus	69.71	0.00e+00	717.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.29	3.00e-56	213.00
IUUC-Pfo-096462	Poecilia formosa	88.34	0.00e+00	980.00
IUUC-Pab-097612	Pongo abelii	96.76	0.00e+00	1070.00
IUUC-Pva-102409	Pteropus vampyrus	80.00	0.00e+00	842.00
IUUC-Pte-104340	Pyrenophora teres	32.21	1.00e-60	227.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.81	1.00e-66	247.00
IUUC-Rno-105247	Rattus norvegicus	96.38	0.00e+00	1065.00
IUUC-Sce-106247	Saccharomyces cerevisiae	32.25	6.00e-52	198.00
IUUC-Sha-107538	Sarcophilus harrisii	94.47	1.00e-122	431.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.26	4.00e-65	242.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.14	8.00e-54	204.00
IUUC-Tgu-116938	Taeniopygia guttata	94.46	0.00e+00	948.00
IUUC-Tru-117622	Takifugu rubripes	87.57	0.00e+00	979.00
IUUC-Tsy-119431	Tarsius syrichta	85.47	0.00e+00	814.00
IUUC-Tni-120661	Tetraodon nigroviridis	90.55	0.00e+00	993.00
IUUC-Tre-122139	Trichoderma reesei	31.95	8.00e-55	207.00
IUUC-Tvi-122599	Trichoderma virens	29.37	1.00e-55	210.00
IUUC-Tae-125608	Triticum aestivum	35.15	3.00e-84	306.00
IUUC-Tme-127115	Tuber melanosporum	36.54	9.00e-80	290.00
IUUC-Uma-129455	Ustilago maydis	31.06	4.00e-33	136.00
IUUC-Xtr-132444	Xenopus tropicalis	89.48	0.00e+00	999.00
IUUC-Xma-133514	Xiphophorus maculatus	90.94	0.00e+00	995.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence