iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-009007

Ensembl Protein ID

CADAFUAP00007496

UniProt Accession

E9R1Z4; E9R1Z4_ASPFU

Genbank Protein ID

EAL90628.1

Protein Name

SCF ubiquitin ligase complex subunit CulA, putative

Genbank Nucleotide ID

AAHF01000004

Gene Name

AFUA_1G12960

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00007496	CADAFUAT00007496	CADAFUAP00007496

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	5.20e-186	618.9	26	670

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 24   tavynlclsk..........................................vgaklYkklkevleefikqvkkkveesedeqlLktynreWe 74
            av+n+c+s+                                          +g++lYk l e+l  ++++v ++  ++++e+lL +y+reW 
   Q: 26   LAVHNFCTSQkavsngqglqahrggssfrplcewyvglcwpcsddfssvahlLGEELYKLLGEYLSRHLEAVYRESLSHTEEALLGFYIREWV 118
           5677777777777777777777777777777777777777778888888888***************************************** PP
   S: 75   kfreqlkvlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk.. 160
           ++++++k+++++f+yl+r++vk+     +k+v++v++L l +w+++++ +++++++e++l+lie++R+ge+++++ ++++v s+v+L+l++  
   Q: 119  RYTTAAKYVNHLFRYLNRHWVKReidegKKNVYDVYTLHLVKWKDDFFMKVHEKVMEAVLNLIEKQRNGETIEQSQIKNIVDSFVSLGLDEnd 211
           **************************9999************************************************************99* PP
   S: 161  .....laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallr 248
                l++y+  FE++f  at+ +y++es +f++en+v eY+kk+earl ee+ r+  yl++   + L+ ++  +l++ h e l +e++ ll+
   Q: 212  ntkstLEVYRVYFEKPFIAATRVYYENESRQFVAENSVVEYMKKAEARLDEEKARVGLYLHPDIMKRLTDTCLDVLVTAHSELLRDEFQVLLD 304
           ********************************************************************************************* PP
   S: 249  dkktedlsrmykLlsrvlngleellkeleshikeqgkaalt...aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvn 338
           +++++dl+rmy+Llsr+++gl++l+ ++e+h++++g+aa++   ae ++ +pk+yV  ll+++ ++q+lv+eaFn + +F+ +ld+a+++fvn
   Q: 305  NERQDDLARMYRLLSRIKDGLDPLRAKFETHVRKAGLAAVEkvaAEGEAFEPKMYVDALLQVHTRYQNLVNEAFNGESEFVRSLDNACREFVN 397
           *****************************************887788888******************************************* PP
   S: 339  knsvlka..akspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgae 429
           +n+v k   +kspEllAry D+lL+k+sk ++e ele++l ++++vfkyi++kdvF+k+Y k+LakRL++  s+s++aE s+i+kLke+cg+e
   Q: 398  RNKVCKSssTKSPELLARYTDSLLKKGSKAAEESELEEMLVQIMTVFKYIEDKDVFQKFYSKMLAKRLVHVSSVSDDAETSMISKLKEACGFE 490
           ******9889*********************************************************************************** PP
   S: 430  ftskLerMfqdlkvSedlnrqFk....eekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlg 518
           +t+kL+rMfqd+++S+dln ++k    +  +++  +++v+   ++L +g+Wp  + t  +s P+e+ kt+e+f++fY +kh+gRkL+W+++l+
   Q: 491  YTNKLQRMFQDIQISKDLNSNYKdwqeKVLDEDDRKKQVDAHFQILGTGFWPLNPPTTGFSAPPEIVKTYERFQSFYYDKHNGRKLTWLWQLC 583
           ***********************88554445566678899999***********99999********************************** PP
   S: 519  raelkaelkkg...kyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           ++e+ka++ k+   +y++qVstfQm +LL+fn+++++++ +++kat l +e L   l  L++ k  vl  +pe+++ e +++fs+N +f
   Q: 584  KGEVKANYIKNtkvPYTFQVSTFQMGILLLFNENDTLTYSDIQKATSLAPEILDPNLAILLKAK--VLLPSPEGAKPEPGTSFSLNYNF 670
           ******99777778************************************************98..********************998 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MTLTKREFAY TDLASSTALR IHFIWLAVHN FCTSQKAVSN GQGLQAHRGG SSFRPLCEWY 60
VGLCWPCSDD FSSVAHLLGE ELYKLLGEYL SRHLEAVYRE SLSHTEEALL GFYIREWVRY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCTTGA CGAAACGTGA GTTCGCCTAC ACCGACCTCG CGAGCTCCAC CGCCCTTCGG 60
ATACACTTCA TATGGCTGTG GCTCGGAATC TGGGCTAATT TAAGTAGATG GACATTCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:1903467--P:negative regulation of mitotic DNA replication initiation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

afm:AFUA_1G12960

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002277	Ailuropoda melanoleuca	48.61	0.00e+00	669.00
IUUC-Apl-003503	Anas platyrhynchos	48.48	5.00e-155	539.00
IUUC-Aca-005030	Anolis carolinensis	43.24	1.00e-142	498.00
IUUC-Ago-007977	Ashbya gossypii	33.08	6.00e-125	439.00
IUUC-Acl-008190	Aspergillus clavatus	92.76	0.00e+00	1356.00
IUUC-Afl-008542	Aspergillus flavus	87.35	0.00e+00	1097.00
IUUC-Ani-009290	Aspergillus nidulans	83.80	0.00e+00	1279.00
IUUC-Ang-009600	Aspergillus niger	88.83	0.00e+00	1331.00
IUUC-Aor-009978	Aspergillus oryzae	87.48	0.00e+00	1211.00
IUUC-Ate-010584	Aspergillus terreus	88.61	0.00e+00	1296.00
IUUC-Ame-011861	Astyanax mexicanus	50.50	0.00e+00	652.00
IUUC-Bgr-012209	Blumeria graminis	66.44	0.00e+00	986.00
IUUC-Bta-012878	Bos taurus	48.75	0.00e+00	668.00
IUUC-Bci-013941	Botrytis cinerea	67.29	0.00e+00	1029.00
IUUC-Cel-018294	Caenorhabditis elegans	39.63	1.00e-153	535.00
IUUC-Cja-018965	Callithrix jacchus	52.01	0.00e+00	651.00
IUUC-Cfa-020671	Canis familiaris	48.75	0.00e+00	668.00
IUUC-Cpo-021762	Cavia porcellus	48.88	0.00e+00	670.00
IUUC-Cre-022585	Chlamydomonas reinhardtii	31.77	2.00e-91	328.00
IUUC-Csa-023873	Chlorocebus sabaeus	48.88	0.00e+00	670.00
IUUC-Cin-025547	Ciona intestinalis	45.41	1.00e-174	605.00
IUUC-Csv-026083	Ciona savignyi	46.07	0.00e+00	639.00
IUUC-Cgl-026452	Colletotrichum gloeosporioides	64.66	0.00e+00	973.00
IUUC-Cne-026919	Cryptococcus neoformans	46.36	0.00e+00	644.00
IUUC-Dre-027875	Danio rerio	50.92	0.00e+00	656.00
IUUC-Dno-028931	Dasypus novemcinctus	48.88	0.00e+00	667.00
IUUC-Dor-030846	Dipodomys ordii	53.17	1.00e-143	502.00
IUUC-Dse-031472	Dothistroma septosporum	64.08	0.00e+00	977.00
IUUC-Dme-031793	Drosophila melanogaster	43.65	5.00e-170	589.00
IUUC-Ete-033112	Echinops telfairi	45.14	1.00e-72	266.00
IUUC-Eca-034309	Equus caballus	48.75	0.00e+00	668.00
IUUC-Fca-036330	Felis catus	47.83	0.00e+00	642.00
IUUC-Fal-036899	Ficedula albicollis	48.31	7.00e-161	558.00
IUUC-Fox-037705	Fusarium oxysporum	66.71	0.00e+00	942.00
IUUC-Fso-038367	Fusarium solani	68.29	0.00e+00	981.00
IUUC-Gmo-038708	Gadus morhua	50.42	0.00e+00	652.00
IUUC-Ggr-039917	Gaeumannomyces graminis	66.09	0.00e+00	981.00
IUUC-Gga-041038	Gallus gallus	48.88	0.00e+00	670.00
IUUC-Gac-041820	Gasterosteus aculeatus	47.86	0.00e+00	674.00
IUUC-Ggo-045154	Gorilla gorilla	42.42	3.00e-129	454.00
IUUC-Hsa-046034	Homo sapiens	48.88	0.00e+00	670.00
IUUC-Itr-048285	Ictidomys tridecemlineatus	48.88	0.00e+00	671.00
IUUC-Kpa-049231	Komagataella pastoris	40.29	5.00e-146	509.00
IUUC-Lch-049673	Latimeria chalumnae	48.75	0.00e+00	664.00
IUUC-Loc-052490	Lepisosteus oculatus	48.81	0.00e+00	653.00
IUUC-Lma-053191	Leptosphaeria maculans	66.54	0.00e+00	1004.00
IUUC-Laf-054582	Loxodonta africana	48.88	0.00e+00	670.00
IUUC-Mcc-055162	Macaca mulatta	48.35	0.00e+00	657.00
IUUC-Meu-055904	Macropus eugenii	46.84	7.00e-73	266.00
IUUC-Mor-057035	Magnaporthe oryzae	65.33	0.00e+00	938.00
IUUC-Mpo-057555	Magnaporthe poae	66.36	0.00e+00	986.00
IUUC-Mla-059021	Melampsora laricipopulina	54.00	0.00e+00	717.00
IUUC-Mga-060078	Meleagris gallopavo	48.88	0.00e+00	670.00
IUUC-Mvi-060519	Microbotryum violaceum	51.34	0.00e+00	723.00
IUUC-Mmr-061312	Microcebus murinus	48.88	0.00e+00	670.00
IUUC-Mdo-062867	Monodelphis domestica	48.61	0.00e+00	667.00
IUUC-Mmu-063336	Mus musculus	48.88	0.00e+00	670.00
IUUC-Mpu-066400	Mustela putorius furo	48.15	2.00e-160	557.00
IUUC-Mlu-067800	Myotis lucifugus	48.61	0.00e+00	669.00
IUUC-Nfi-068384	Neosartorya fischeri	99.56	0.00e+00	1358.00
IUUC-Ncr-068965	Neurospora crassa	64.26	0.00e+00	929.00
IUUC-Nle-069729	Nomascus leucogenys	48.88	0.00e+00	670.00
IUUC-Opr-071197	Ochotona princeps	33.58	9.00e-104	369.00
IUUC-Ont-071729	Oreochromis niloticus	48.09	0.00e+00	654.00
IUUC-Oan-073309	Ornithorhynchus anatinus	48.88	0.00e+00	670.00
IUUC-Ocu-074661	Oryctolagus cuniculus	51.13	0.00e+00	664.00
IUUC-Ola-087422	Oryzias latipes	48.95	0.00e+00	664.00
IUUC-Oga-088130	Otolemur garnettii	48.88	0.00e+00	670.00
IUUC-Oar-089510	Ovis aries	48.05	0.00e+00	632.00
IUUC-Ptr-090665	Pan troglodytes	48.88	0.00e+00	670.00
IUUC-Pan-092218	Papio anubis	48.88	0.00e+00	670.00
IUUC-Psi-093175	Pelodiscus sinensis	48.88	0.00e+00	670.00
IUUC-Pma-094502	Petromyzon marinus	49.37	0.00e+00	639.00
IUUC-Pno-095067	Phaeosphaeria nodorum	67.45	0.00e+00	1044.00
IUUC-Pfo-096705	Poecilia formosa	48.36	0.00e+00	675.00
IUUC-Pab-097578	Pongo abelii	48.88	0.00e+00	670.00
IUUC-Pca-100242	Procavia capensis	52.68	3.00e-146	510.00
IUUC-Pva-102155	Pteropus vampyrus	42.73	9.00e-157	545.00
IUUC-Pgr-103297	Puccinia graminis	50.53	0.00e+00	731.00
IUUC-Ptt-103706	Puccinia triticina	49.00	8.00e-111	393.00
IUUC-Pte-104257	Pyrenophora teres	66.27	0.00e+00	1021.00
IUUC-Pyt-104795	Pyrenophora triticirepentis	66.27	0.00e+00	1020.00
IUUC-Rno-105939	Rattus norvegicus	48.88	0.00e+00	670.00
IUUC-Sce-106293	Saccharomyces cerevisiae	32.25	3.00e-120	424.00
IUUC-Sha-106949	Sarcophilus harrisii	48.88	0.00e+00	670.00
IUUC-Sja-107737	Schizosaccharomyces japonicus	46.84	0.00e+00	629.00
IUUC-Spo-108280	Schizosaccharomyces pombe	48.74	0.00e+00	648.00
IUUC-Sar-113138	Sorex araneus	36.79	2.00e-127	448.00
IUUC-Sre-114984	Sporisorium reilianum	53.38	0.00e+00	699.00
IUUC-Ssc-115829	Sus scrofa	48.54	0.00e+00	660.00
IUUC-Tgu-116950	Taeniopygia guttata	48.88	0.00e+00	670.00
IUUC-Tru-118558	Takifugu rubripes	50.35	0.00e+00	668.00
IUUC-Tsy-119621	Tarsius syrichta	39.04	4.00e-103	367.00
IUUC-Tni-120460	Tetraodon nigroviridis	50.28	0.00e+00	671.00
IUUC-Tre-122223	Trichoderma reesei	67.86	0.00e+00	927.00
IUUC-Tvi-122539	Trichoderma virens	60.79	0.00e+00	868.00
IUUC-Tme-126926	Tuber melanosporum	66.36	0.00e+00	1004.00
IUUC-Tbe-127369	Tupaia belangeri	52.57	2.00e-90	325.00
IUUC-Ttr-129022	Tursiops truncatus	49.44	1.00e-154	538.00
IUUC-Uma-129341	Ustilago maydis	52.97	0.00e+00	674.00
IUUC-Vda-129857	Verticillium dahliae	67.24	0.00e+00	924.00
IUUC-Vpa-130166	Vicugna pacos	44.46	4.00e-141	493.00
IUUC-Xtr-131818	Xenopus tropicalis	48.75	0.00e+00	662.00
IUUC-Xma-134206	Xiphophorus maculatus	50.42	0.00e+00	655.00
IUUC-Yli-134486	Yarrowia lipolytica	42.05	2.00e-160	558.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence