iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048289

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01003879

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000001338.2	ENSSTOT00000001336.2	ENSSTOP00000001196.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-108	361.9	490	816

Active Site

Position(s)	Description	Evidence
785	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 490  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 573
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 574  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 660
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 661  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 749
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 750  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 816
           *****************...8888866666**************************************97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

RKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM DNNAAAIKAL ELYKINAKLC 60
DPHPSKKGAS SAYLENSKGA PNNSEIKMNK KEGKGARIDF KDVTYLTEEI VYEILELCRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAAGCGAG CAGCTGCAAA GCATCTAATA GAACGCTACT ACCACCAGTT AACTGAGGGC 60
TGTGGAAATG AGGCCTGCAC GAATGAGTTT TGTGCTTCCT GTCCAACTTT TCTCCGTATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	94.39	0.00e+00	1528.00
IUUC-Atr-003144	Amborella trichopoda	47.03	3.00e-94	338.00
IUUC-Apl-003742	Anas platyrhynchos	90.91	0.00e+00	1474.00
IUUC-Aca-004873	Anolis carolinensis	90.14	0.00e+00	1489.00
IUUC-Ago-007908	Ashbya gossypii	34.38	4.00e-66	246.00
IUUC-Acl-008288	Aspergillus clavatus	37.01	4.00e-77	283.00
IUUC-Afl-008402	Aspergillus flavus	31.90	4.00e-72	265.00
IUUC-Afu-008762	Aspergillus fumigatus	31.46	2.00e-78	287.00
IUUC-Ani-009176	Aspergillus nidulans	32.94	8.00e-78	285.00
IUUC-Ang-009791	Aspergillus niger	36.50	7.00e-74	272.00
IUUC-Aor-009921	Aspergillus oryzae	32.07	8.00e-73	268.00
IUUC-Ame-011166	Astyanax mexicanus	82.73	0.00e+00	1361.00
IUUC-Bgr-011981	Blumeria graminis	38.86	4.00e-80	293.00
IUUC-Bta-013286	Bos taurus	93.55	0.00e+00	1471.00
IUUC-Bci-013697	Botrytis cinerea	34.68	8.00e-69	255.00
IUUC-Cja-019707	Callithrix jacchus	94.15	0.00e+00	1516.00
IUUC-Cfa-020154	Canis familiaris	94.03	0.00e+00	1504.00
IUUC-Cpo-021292	Cavia porcellus	94.14	0.00e+00	1536.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	94.26	0.00e+00	1518.00
IUUC-Cho-025059	Choloepus hoffmanni	89.94	0.00e+00	1429.00
IUUC-Cin-025643	Ciona intestinalis	44.63	0.00e+00	685.00
IUUC-Csv-026282	Ciona savignyi	44.30	0.00e+00	647.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	38.31	2.00e-79	290.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.61	1.00e-99	357.00
IUUC-Dre-027901	Danio rerio	81.89	0.00e+00	1343.00
IUUC-Dno-029320	Dasypus novemcinctus	93.91	0.00e+00	1513.00
IUUC-Dor-030756	Dipodomys ordii	91.95	0.00e+00	708.00
IUUC-Dse-031239	Dothistroma septosporum	35.14	3.00e-71	263.00
IUUC-Dme-032035	Drosophila melanogaster	48.36	2.00e-162	566.00
IUUC-Eca-033843	Equus caballus	93.79	0.00e+00	1482.00
IUUC-Eeu-035109	Erinaceus europaeus	91.79	0.00e+00	1459.00
IUUC-Fca-036344	Felis catus	92.63	0.00e+00	1502.00
IUUC-Fal-036747	Ficedula albicollis	90.91	0.00e+00	1475.00
IUUC-Fox-037941	Fusarium oxysporum	32.93	5.00e-88	319.00
IUUC-Fso-038388	Fusarium solani	40.76	9.00e-87	315.00
IUUC-Gmo-038840	Gadus morhua	62.15	0.00e+00	1036.00
IUUC-Ggr-040110	Gaeumannomyces graminis	38.53	2.00e-78	287.00
IUUC-Gga-040399	Gallus gallus	90.79	0.00e+00	1473.00
IUUC-Gac-041933	Gasterosteus aculeatus	81.40	0.00e+00	1292.00
IUUC-Ggo-044804	Gorilla gorilla	94.50	0.00e+00	1520.00
IUUC-Hsa-045727	Homo sapiens	94.50	0.00e+00	1520.00
IUUC-Kpa-049152	Komagataella pastoris	36.74	9.00e-61	228.00
IUUC-Lch-050197	Latimeria chalumnae	87.25	0.00e+00	1436.00
IUUC-Loc-052743	Lepisosteus oculatus	85.78	0.00e+00	1417.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	5.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	92.87	0.00e+00	1505.00
IUUC-Mcc-054934	Macaca mulatta	94.26	0.00e+00	1517.00
IUUC-Meu-056061	Macropus eugenii	86.28	0.00e+00	1335.00
IUUC-Mor-057045	Magnaporthe oryzae	37.47	2.00e-78	287.00
IUUC-Mga-059271	Meleagris gallopavo	90.80	0.00e+00	1471.00
IUUC-Mmr-061288	Microcebus murinus	94.03	0.00e+00	1518.00
IUUC-Mdo-062975	Monodelphis domestica	92.17	0.00e+00	1484.00
IUUC-Mmu-063674	Mus musculus	92.61	0.00e+00	1477.00
IUUC-Mpu-066568	Mustela putorius furo	94.50	0.00e+00	1530.00
IUUC-Mlu-067522	Myotis lucifugus	85.45	0.00e+00	1390.00
IUUC-Nfi-068439	Neosartorya fischeri	38.24	1.00e-77	285.00
IUUC-Ncr-068903	Neurospora crassa	38.30	3.00e-76	280.00
IUUC-Nle-069505	Nomascus leucogenys	94.50	0.00e+00	1520.00
IUUC-Opr-070570	Ochotona princeps	86.46	0.00e+00	1388.00
IUUC-Ont-071527	Oreochromis niloticus	82.22	0.00e+00	1367.00
IUUC-Oan-073446	Ornithorhynchus anatinus	85.79	0.00e+00	942.00
IUUC-Ocu-074922	Oryctolagus cuniculus	92.78	0.00e+00	1524.00
IUUC-Ola-086996	Oryzias latipes	81.92	0.00e+00	1382.00
IUUC-Oga-088261	Otolemur garnettii	93.91	0.00e+00	1519.00
IUUC-Oar-090024	Ovis aries	93.55	0.00e+00	1471.00
IUUC-Ptr-090455	Pan troglodytes	94.50	0.00e+00	1520.00
IUUC-Pan-092509	Papio anubis	93.62	0.00e+00	1361.00
IUUC-Psi-092974	Pelodiscus sinensis	90.67	0.00e+00	1445.00
IUUC-Pma-094643	Petromyzon marinus	68.23	0.00e+00	1187.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.34	1.00e-57	218.00
IUUC-Pfo-096905	Poecilia formosa	81.62	0.00e+00	1357.00
IUUC-Pab-097840	Pongo abelii	92.15	0.00e+00	1475.00
IUUC-Pca-100869	Procavia capensis	92.41	0.00e+00	1492.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	666.00
IUUC-Ptt-103736	Puccinia triticina	38.62	7.00e-75	275.00
IUUC-Rno-105453	Rattus norvegicus	92.37	0.00e+00	1478.00
IUUC-Sce-106306	Saccharomyces cerevisiae	35.66	3.00e-61	229.00
IUUC-Sha-107651	Sarcophilus harrisii	92.17	0.00e+00	1486.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	32.78	5.00e-74	273.00
IUUC-Smo-108858	Selaginella moellendorffii	48.85	2.00e-114	406.00
IUUC-Sar-113293	Sorex araneus	93.32	0.00e+00	1507.00
IUUC-Ssc-115979	Sus scrofa	93.67	0.00e+00	1514.00
IUUC-Tgu-116901	Taeniopygia guttata	90.91	0.00e+00	1474.00
IUUC-Tru-118368	Takifugu rubripes	82.28	0.00e+00	1358.00
IUUC-Tsy-119516	Tarsius syrichta	90.16	0.00e+00	1410.00
IUUC-Tni-120143	Tetraodon nigroviridis	81.59	0.00e+00	1351.00
IUUC-Tre-122108	Trichoderma reesei	39.76	7.00e-76	279.00
IUUC-Tvi-122644	Trichoderma virens	39.43	1.00e-75	278.00
IUUC-Tbe-127484	Tupaia belangeri	87.24	0.00e+00	1018.00
IUUC-Ttr-129078	Tursiops truncatus	93.43	0.00e+00	1485.00
IUUC-Vda-129969	Verticillium dahliae	37.50	5.00e-81	296.00
IUUC-Vpa-130312	Vicugna pacos	85.61	0.00e+00	1266.00
IUUC-Xtr-132881	Xenopus tropicalis	88.19	0.00e+00	1441.00
IUUC-Xma-133122	Xiphophorus maculatus	81.38	0.00e+00	1350.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence