iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108271

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable E3 ubiquitin-protein ligase mug30; HECT-type E3 ubiquitin transferase mug30; Meiotically up-regulated gene 30 protein

Genbank Nucleotide ID

CU329671

Gene Name

mug30; SPBP8B7.27

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBP8B7.27	SPBP8B7.27.1	SPBP8B7.27.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-80	266.6	454	805

Active Site

Position(s)	Description	Evidence
775	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++d++k l+vef+gEeg+d+gG++re+l ll++++++p+ glf  ++e++++ ++  +++     ++++++++ G+l+g+a+ ++  ld++++
   Q: 454  NKDFRKALKVEFLGEEGIDAGGLKREWLLLLTRKVFSPEFGLFvNCEESSNYLWFNYSHRS----KEIDYYHMSGILMGIAIHNSINLDVQMP 542
           6899***************************************556666777777666554....89************************** PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           ++fyk+ll+ +ls++dl +++p ly+ lke++   e d++++   l+f+++ + ++  +++eLk+gG++ +V neN++eYv ++v+y l++ +
   Q: 543  RAFYKKLLQLPLSFNDLDDFQPSLYRGLKELLLF-EGDVKNT-YGLNFTINLKAVEGFRTVELKEGGSELSVDNENRKEYVLRYVDYLLNTTV 633
           ********************************77.7899887.9999999999**************************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGe.eeidvedlkketky.........................kggytedspaiqwFwevl 253
           k+q+ af +Gf +v+  + +slF+ +e++ li G+ e id+e lk+ + y                          + + ++ + i wFw+ +
   Q: 634  KKQFSAFFDGFMKVCGGNAISLFQDNEISKLIRGSeEVIDWELLKNVCVYdfydqnaisnsisesepsmtaskylCHSFVSKRKIILWFWDLI 726
           ***********************************8999*********99999*****9999999999999888878899999999******* PP
   S: 254  eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +  s + +k fL FvTgs+r+P+ G  +++ r+ v+    + d+lP s+TCfn L+++eYss e+lk+kL +A  et+gF+
   Q: 727  SHYSLKMQKLFLIFVTGSDRIPATGAHNFQLRISVLGP--DSDQLPISHTCFNHLCIWEYSSREKLKKKLDTALLETNGFN 805
           ******************************66555544..77*************************************97 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probable E3 ubiquitin-protein ligase. Has a role in meiosis.

Protein Sequence
(Fasta)

MSRPIEIANV SSGNRRTLPA LHGSSFSSRS ELDNNTNSKI SRRLRELVCQ RMGENPLRLR 60
QSFHETISND SYGNSEKLVI RPCICCNSVL RYPAQAMCFR CSLCMTVNDV YFCLSGSQIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGACGAAA GAATGTTAGA ATGACTACGC CATGAGAACC TGTTGAATAT CGTAATATTT 60
AAGAAATAAC TATACCAATA TATGTATAGT GTAGTATGGC CTAGATATGT ACCATACTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0469--Meiosis
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001607--Znf_UBP

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00290--ZnF_UBP

Gene Ontology

GO:0032153--C:cell division site
GO:0051286--C:cell tip
GO:0005737--C:cytoplasm
GO:0044732--C:mitotic spindle pole body
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051321--P:meiotic cell cycle

KEGG

spo:SPBP8B7.27

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	33.48	3.00e-91	327.00
IUUC-Atr-003144	Amborella trichopoda	33.20	1.00e-72	265.00
IUUC-Apl-003589	Anas platyrhynchos	33.45	3.00e-81	294.00
IUUC-Aca-004350	Anolis carolinensis	32.74	6.00e-82	296.00
IUUC-Ago-007908	Ashbya gossypii	35.94	2.00e-88	318.00
IUUC-Acl-008288	Aspergillus clavatus	34.95	2.00e-110	392.00
IUUC-Afl-008402	Aspergillus flavus	35.14	1.00e-105	375.00
IUUC-Afu-008762	Aspergillus fumigatus	35.97	1.00e-112	399.00
IUUC-Ani-009176	Aspergillus nidulans	37.26	4.00e-111	394.00
IUUC-Ang-009791	Aspergillus niger	36.83	1.00e-113	402.00
IUUC-Aor-009921	Aspergillus oryzae	34.82	3.00e-105	374.00
IUUC-Ate-010295	Aspergillus terreus	37.04	5.00e-116	410.00
IUUC-Ame-010768	Astyanax mexicanus	32.78	9.00e-74	270.00
IUUC-Bgr-011981	Blumeria graminis	35.20	4.00e-109	387.00
IUUC-Bta-012945	Bos taurus	33.13	4.00e-86	310.00
IUUC-Bci-013697	Botrytis cinerea	35.28	7.00e-100	357.00
IUUC-Cel-018150	Caenorhabditis elegans	30.37	1.00e-49	189.00
IUUC-Cja-019263	Callithrix jacchus	33.48	1.00e-85	309.00
IUUC-Cfa-020486	Canis familiaris	33.54	3.00e-91	327.00
IUUC-Cpo-021755	Cavia porcellus	33.54	2.00e-91	328.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	35.16	5.00e-52	196.00
IUUC-Csa-023814	Chlorocebus sabaeus	33.33	3.00e-76	277.00
IUUC-Cho-024325	Choloepus hoffmanni	31.33	8.00e-64	236.00
IUUC-Cin-025232	Ciona intestinalis	31.93	4.00e-69	254.00
IUUC-Csv-026282	Ciona savignyi	34.93	1.00e-54	206.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	32.95	1.00e-103	369.00
IUUC-Cme-027151	Cyanidioschyzon merolae	32.45	1.00e-69	256.00
IUUC-Dre-028551	Danio rerio	32.70	3.00e-88	317.00
IUUC-Dno-029497	Dasypus novemcinctus	33.51	2.00e-85	308.00
IUUC-Dor-030158	Dipodomys ordii	33.80	4.00e-63	234.00
IUUC-Dse-031239	Dothistroma septosporum	33.03	1.00e-100	359.00
IUUC-Dme-032103	Drosophila melanogaster	32.89	1.00e-61	229.00
IUUC-Ete-032902	Echinops telfairi	32.62	1.00e-79	288.00
IUUC-Eca-033678	Equus caballus	33.54	3.00e-91	327.00
IUUC-Eeu-035109	Erinaceus europaeus	33.41	4.00e-59	221.00
IUUC-Fca-035590	Felis catus	33.54	1.00e-91	329.00
IUUC-Fal-037123	Ficedula albicollis	31.98	3.00e-73	267.00
IUUC-Fox-037941	Fusarium oxysporum	34.00	1.00e-110	392.00
IUUC-Fso-038388	Fusarium solani	33.81	3.00e-109	388.00
IUUC-Gmo-039553	Gadus morhua	31.48	2.00e-77	281.00
IUUC-Ggr-040110	Gaeumannomyces graminis	35.02	1.00e-110	392.00
IUUC-Gga-040406	Gallus gallus	33.10	1.00e-84	305.00
IUUC-Gac-042141	Gasterosteus aculeatus	31.92	2.00e-86	311.00
IUUC-Ggo-045504	Gorilla gorilla	33.33	3.00e-86	311.00
IUUC-Hsa-045786	Homo sapiens	33.38	8.00e-87	312.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	31.89	2.00e-64	238.00
IUUC-Kpa-049152	Komagataella pastoris	30.79	4.00e-89	320.00
IUUC-Lch-050197	Latimeria chalumnae	36.98	1.00e-73	269.00
IUUC-Loc-052173	Lepisosteus oculatus	33.49	8.00e-94	336.00
IUUC-Laf-054017	Loxodonta africana	33.08	7.00e-87	313.00
IUUC-Mcc-055713	Macaca mulatta	33.74	3.00e-87	314.00
IUUC-Meu-056061	Macropus eugenii	34.30	5.00e-65	240.00
IUUC-Mor-057045	Magnaporthe oryzae	35.54	2.00e-113	402.00
IUUC-Mla-059187	Melampsora laricipopulina	36.82	1.00e-72	264.00
IUUC-Mga-059884	Meleagris gallopavo	34.92	1.00e-76	278.00
IUUC-Mmr-061344	Microcebus murinus	33.38	2.00e-90	324.00
IUUC-Mdo-062653	Monodelphis domestica	32.18	2.00e-86	311.00
IUUC-Mmu-063775	Mus musculus	35.02	7.00e-82	296.00
IUUC-Mpu-066069	Mustela putorius furo	33.38	3.00e-91	327.00
IUUC-Mlu-067925	Myotis lucifugus	32.04	2.00e-87	314.00
IUUC-Nfi-068439	Neosartorya fischeri	35.66	1.00e-111	396.00
IUUC-Ncr-068903	Neurospora crassa	36.64	1.00e-110	392.00
IUUC-Nle-070046	Nomascus leucogenys	33.59	5.00e-91	327.00
IUUC-Opr-070891	Ochotona princeps	30.39	7.00e-59	220.00
IUUC-Ont-072126	Oreochromis niloticus	32.86	9.00e-92	329.00
IUUC-Oan-072933	Ornithorhynchus anatinus	32.62	5.00e-84	303.00
IUUC-Ocu-073800	Oryctolagus cuniculus	33.23	6.00e-87	313.00
IUUC-Ola-086988	Oryzias latipes	32.18	7.00e-88	316.00
IUUC-Oga-088117	Otolemur garnettii	34.10	2.00e-83	301.00
IUUC-Oar-089371	Ovis aries	33.23	1.00e-85	309.00
IUUC-Ptr-090551	Pan troglodytes	33.59	3.00e-87	314.00
IUUC-Pan-092067	Papio anubis	33.54	9.00e-87	312.00
IUUC-Psi-092963	Pelodiscus sinensis	31.50	5.00e-81	293.00
IUUC-Pma-094113	Petromyzon marinus	32.60	3.00e-70	257.00
IUUC-Ppa-095354	Physcomitrella patens	33.83	1.00e-79	289.00
IUUC-Pfo-096562	Poecilia formosa	32.23	1.00e-88	318.00
IUUC-Pab-098680	Pongo abelii	31.99	3.00e-87	314.00
IUUC-Pca-100869	Procavia capensis	34.08	3.00e-66	244.00
IUUC-Pva-103040	Pteropus vampyrus	35.88	4.00e-56	211.00
IUUC-Pgr-103315	Puccinia graminis	33.90	7.00e-89	320.00
IUUC-Ptt-103736	Puccinia triticina	35.28	3.00e-90	324.00
IUUC-Rno-105270	Rattus norvegicus	35.17	9.00e-82	296.00
IUUC-Sce-106306	Saccharomyces cerevisiae	30.60	6.00e-96	343.00
IUUC-Sha-106819	Sarcophilus harrisii	33.23	2.00e-90	324.00
IUUC-Sja-107974	Schizosaccharomyces japonicus	42.52	1.00e-96	345.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	36.04	3.00e-108	384.00
IUUC-Smo-108858	Selaginella moellendorffii	35.78	2.00e-88	318.00
IUUC-Sar-113134	Sorex araneus	31.46	3.00e-74	270.00
IUUC-Ssc-115441	Sus scrofa	33.03	5.00e-87	313.00
IUUC-Tgu-117166	Taeniopygia guttata	33.63	4.00e-81	293.00
IUUC-Tru-118368	Takifugu rubripes	35.58	4.00e-70	257.00
IUUC-Tsy-118898	Tarsius syrichta	30.68	2.00e-62	231.00
IUUC-Tni-120143	Tetraodon nigroviridis	35.81	2.00e-70	258.00
IUUC-Tre-122108	Trichoderma reesei	35.81	7.00e-99	353.00
IUUC-Tvi-122644	Trichoderma virens	34.38	2.00e-101	362.00
IUUC-Tme-127004	Tuber melanosporum	39.87	8.00e-125	440.00
IUUC-Tbe-127640	Tupaia belangeri	31.89	1.00e-64	239.00
IUUC-Ttr-128352	Tursiops truncatus	32.17	1.00e-79	288.00
IUUC-Vda-129969	Verticillium dahliae	35.67	2.00e-104	372.00
IUUC-Vpa-130448	Vicugna pacos	34.73	4.00e-63	234.00
IUUC-Xtr-132594	Xenopus tropicalis	32.21	1.00e-72	266.00
IUUC-Xma-134157	Xiphophorus maculatus	31.68	7.00e-77	279.00
IUUC-Yli-134470	Yarrowia lipolytica	38.29	5.00e-95	340.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence