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Tag Content
iUUCD ID IUUC-Nfi-068578
Ensembl Protein ID CADNFIAP00004303
UniProt Accession A1DMA1; ATG5_NEOFI
Genbank Protein ID EAW15922.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID DS027698
Gene Name NFIA_052680; atg5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADNFIAG00004431 CADNFIAT00004431 CADNFIAP00004303
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 22.77 1.00e-08 55.80 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Neosartorya fischeri
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MRTSSRMENQ ASLSSIQRAV WDGKLPLQIT LASSESRTYD QTDPYLIACP RISYLPSLLP 60
RLRAFFSSSL IEPNSQPHEG WFSFEGVPLK WHLPVGLLYD LYAGADPASK GTRIDETDHP 120
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Protein Fasta Sequence



>IUUC-Nfi-068578|E3,Cullin RING/Other|Neosartorya fischeri
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Nucleotide Sequence
(Fasta)
ATGAGAACAT CCTCAAGGAT GGAAAATCAA GCCTCTCTTA GCAGCATCCA GAGAGCTGTA 60
TGGGATGGAA AACTGCCGTT GCAGATAACG CTTGCTTCAT CGGAGAGTCG AACATATGAC 120
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Nucleotide Fasta Sequence



>IUUC-Nfi-068578|E3,Cullin RING/Other|Neosartorya fischeri
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG nfi:NFIA_052680
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 31.12 2.00e-25 109.00
IUUC-Aml-002403 Ailuropoda melanoleuca 26.10 5.00e-25 105.00
IUUC-Atr-002645 Amborella trichopoda 35.06 4.00e-28 117.00
IUUC-Apl-003611 Anas platyrhynchos 27.01 4.00e-31 126.00
IUUC-Aca-004411 Anolis carolinensis 27.44 2.00e-28 117.00
IUUC-Aly-005636 Arabidopsis lyrata 35.11 2.00e-23 101.00
IUUC-Ath-006959 Arabidopsis thaliana 35.11 3.00e-23 100.00
IUUC-Ago-007978 Ashbya gossypii 27.00 3.00e-12 63.90
IUUC-Acl-008328 Aspergillus clavatus 78.82 4.00e-130 455.00
IUUC-Afl-008638 Aspergillus flavus 78.12 6.00e-133 464.00
IUUC-Afu-009042 Aspergillus fumigatus 96.01 9.00e-178 613.00
IUUC-Ani-009364 Aspergillus nidulans 68.73 3.00e-123 432.00
IUUC-Aor-009889 Aspergillus oryzae 77.81 8.00e-135 471.00
IUUC-Ate-010511 Aspergillus terreus 60.71 8.00e-41 156.00
IUUC-Ame-011644 Astyanax mexicanus 32.89 2.00e-08 48.10
IUUC-Bgr-012153 Blumeria graminis 38.15 4.00e-43 166.00
IUUC-Bta-012360 Bos taurus 31.11 3.00e-21 92.40
IUUC-Bci-013723 Botrytis cinerea 39.02 8.00e-51 191.00
IUUC-Bdi-014520 Brachypodium distachyon 30.39 2.00e-20 91.70
IUUC-Bol-016053 Brassica oleracea 35.11 1.00e-25 108.00
IUUC-Bra-017072 Brassica rapa 34.57 3.00e-26 110.00
IUUC-Cel-018529 Caenorhabditis elegans 25.71 8.00e-15 72.40
IUUC-Cja-019569 Callithrix jacchus 25.96 1.00e-25 108.00
IUUC-Cfa-020473 Canis familiaris 26.28 3.00e-26 110.00
IUUC-Cpo-021421 Cavia porcellus 26.28 8.00e-26 108.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 30.86 4.00e-15 72.80
IUUC-Csa-024197 Chlorocebus sabaeus 25.96 1.00e-25 108.00
IUUC-Cho-024521 Choloepus hoffmanni 24.64 5.00e-18 82.80
IUUC-Cin-025119 Ciona intestinalis 25.56 2.00e-25 107.00
IUUC-Csv-026192 Ciona savignyi 27.16 1.00e-27 115.00
IUUC-Cgl-026686 Colletotrichum gloeosporioides 35.00 3.00e-38 150.00
IUUC-Dre-028466 Danio rerio 27.22 6.00e-29 119.00
IUUC-Dse-031228 Dothistroma septosporum 46.56 5.00e-87 312.00
IUUC-Dme-031703 Drosophila melanogaster 28.57 5.00e-23 99.40
IUUC-Ete-032482 Echinops telfairi 25.00 8.00e-20 88.60
IUUC-Eca-034036 Equus caballus 26.28 3.00e-26 110.00
IUUC-Eeu-035235 Erinaceus europaeus 31.49 4.00e-21 93.20
IUUC-Fca-036263 Felis catus 26.28 4.00e-26 109.00
IUUC-Fal-037064 Ficedula albicollis 26.69 7.00e-30 122.00
IUUC-Fox-037813 Fusarium oxysporum 37.93 9.00e-46 174.00
IUUC-Fso-038139 Fusarium solani 39.20 3.00e-45 173.00
IUUC-Gmo-039509 Gadus morhua 29.36 3.00e-26 109.00
IUUC-Ggr-040111 Gaeumannomyces graminis 39.62 1.00e-40 158.00
IUUC-Gga-040517 Gallus gallus 26.69 1.00e-30 124.00
IUUC-Gac-042270 Gasterosteus aculeatus 27.27 2.00e-26 111.00
IUUC-Gma-044400 Glycine max 35.05 6.00e-25 105.00
IUUC-Ggo-045048 Gorilla gorilla 25.96 6.00e-26 109.00
IUUC-Hsa-046744 Homo sapiens 25.96 8.00e-26 108.00
IUUC-Kpa-049174 Komagataella pastoris 24.38 3.00e-27 113.00
IUUC-Lch-049475 Latimeria chalumnae 27.01 1.00e-28 118.00
IUUC-Lpe-051283 Leersia perrieri 33.21 3.00e-25 108.00
IUUC-Loc-052446 Lepisosteus oculatus 25.48 7.00e-30 122.00
IUUC-Lma-053278 Leptosphaeria maculans 47.68 7.00e-82 295.00
IUUC-Laf-054020 Loxodonta africana 25.79 2.00e-24 103.00
IUUC-Mcc-055176 Macaca mulatta 25.96 8.00e-26 108.00
IUUC-Mor-057164 Magnaporthe oryzae 39.05 2.00e-44 170.00
IUUC-Mpo-057428 Magnaporthe poae 38.67 1.00e-38 151.00
IUUC-Mtr-058424 Medicago truncatula 36.32 4.00e-25 106.00
IUUC-Mla-058872 Melampsora laricipopulina 26.76 2.00e-25 108.00
IUUC-Mga-059859 Meleagris gallopavo 26.69 1.00e-30 124.00
IUUC-Mmr-061482 Microcebus murinus 25.72 8.00e-26 108.00
IUUC-Mdo-062371 Monodelphis domestica 27.24 1.00e-28 118.00
IUUC-Mmu-063139 Mus musculus 26.28 8.00e-27 112.00
IUUC-Mac-065332 Musa acuminata 36.13 1.00e-27 115.00
IUUC-Mpu-066783 Mustela putorius furo 25.96 1.00e-25 108.00
IUUC-Mlu-068165 Myotis lucifugus 27.04 1.00e-24 105.00
IUUC-Ncr-068636 Neurospora crassa 40.19 8.00e-43 166.00
IUUC-Nle-069740 Nomascus leucogenys 25.96 1.00e-25 108.00
IUUC-Opr-070802 Ochotona princeps 30.94 8.00e-21 92.40
IUUC-Ont-072222 Oreochromis niloticus 25.80 1.00e-28 118.00
IUUC-Oan-072760 Ornithorhynchus anatinus 31.13 3.00e-26 110.00
IUUC-Ocu-074844 Oryctolagus cuniculus 21.29 9.00e-07 45.10
IUUC-Oba-075834 Oryza barthii 32.04 4.00e-28 117.00
IUUC-Obr-076230 Oryza brachyantha 26.34 4.00e-14 70.10
IUUC-Ogl-077554 Oryza glaberrima 32.04 4.00e-28 117.00
IUUC-Ogu-078687 Oryza glumaepatula 31.21 3.00e-27 114.00
IUUC-Oin-079677 Oryza indica 30.67 2.00e-28 118.00
IUUC-Olo-081078 Oryza longistaminata 32.82 2.00e-25 108.00
IUUC-Ome-081548 Oryza meridionalis 32.33 7.00e-30 124.00
IUUC-Oni-082050 Oryza nivara 32.04 3.00e-28 117.00
IUUC-Opu-083609 Oryza punctata 32.69 2.00e-29 120.00
IUUC-Oru-085057 Oryza rufipogon 32.04 2.00e-28 117.00
IUUC-Osa-085917 Oryza sativa 32.04 1.00e-28 118.00
IUUC-Ola-087032 Oryzias latipes 26.25 1.00e-27 114.00
IUUC-Oga-088468 Otolemur garnettii 26.18 2.00e-27 114.00
IUUC-Oar-089751 Ovis aries 26.37 2.00e-26 110.00
IUUC-Ptr-091064 Pan troglodytes 25.96 8.00e-26 108.00
IUUC-Pan-092505 Papio anubis 25.79 2.00e-24 104.00
IUUC-Psi-093086 Pelodiscus sinensis 28.21 1.00e-29 121.00
IUUC-Pno-094825 Phaeosphaeria nodorum 46.15 2.00e-66 243.00
IUUC-Ppa-095419 Physcomitrella patens 32.29 1.00e-25 108.00
IUUC-Pfo-096224 Poecilia formosa 26.11 2.00e-30 124.00
IUUC-Pab-098501 Pongo abelii 25.96 6.00e-26 109.00
IUUC-Pop-099243 Populus trichocarpa 39.47 2.00e-25 108.00
IUUC-Ppe-101255 Prunus persica 37.89 7.00e-27 112.00
IUUC-Pva-102828 Pteropus vampyrus 26.92 6.00e-26 109.00
IUUC-Pgr-103672 Puccinia graminis 25.14 4.00e-20 90.50
IUUC-Ptt-104013 Puccinia triticina 24.93 7.00e-20 89.70
IUUC-Pyt-104615 Pyrenophora triticirepentis 44.61 5.00e-74 269.00
IUUC-Rno-106089 Rattus norvegicus 24.56 9.00e-21 91.70
IUUC-Sce-106216 Saccharomyces cerevisiae 23.15 9.00e-10 55.80
IUUC-Sha-106484 Sarcophilus harrisii 26.37 9.00e-29 118.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 30.77 1.00e-38 150.00
IUUC-Spo-108177 Schizosaccharomyces pombe 27.18 2.00e-28 117.00
IUUC-Ssl-108475 Sclerotinia sclerotiorum 38.05 4.00e-48 182.00
IUUC-Smo-109473 Selaginella moellendorffii 32.14 8.00e-22 95.90
IUUC-Sit-110736 Setaria italica 35.45 3.00e-27 114.00
IUUC-Sly-111657 Solanum lycopersicum 38.00 6.00e-32 129.00
IUUC-Sar-113050 Sorex araneus 30.73 7.00e-19 85.50
IUUC-Sbi-114258 Sorghum bicolor 28.07 5.00e-25 106.00
IUUC-Sre-114902 Sporisorium reilianum 28.51 1.00e-20 92.80
IUUC-Ssc-116166 Sus scrofa 25.71 1.00e-22 98.60
IUUC-Tgu-116814 Taeniopygia guttata 27.01 4.00e-31 126.00
IUUC-Tru-118172 Takifugu rubripes 26.11 2.00e-28 117.00
IUUC-Tsy-119010 Tarsius syrichta 30.66 5.00e-25 106.00
IUUC-Tni-120397 Tetraodon nigroviridis 29.91 1.00e-25 107.00
IUUC-Tca-121283 Theobroma cacao 36.84 1.00e-26 112.00
IUUC-Tvi-122545 Trichoderma virens 37.35 1.00e-39 154.00
IUUC-Tae-122685 Triticum aestivum 31.27 2.00e-25 107.00
IUUC-Tur-126407 Triticum urartu 29.97 7.00e-24 102.00
IUUC-Tme-126913 Tuber melanosporum 42.36 6.00e-70 255.00
IUUC-Tbe-127738 Tupaia belangeri 23.93 3.00e-13 66.20
IUUC-Ttr-128528 Tursiops truncatus 27.01 2.00e-26 110.00
IUUC-Uma-129625 Ustilago maydis 29.39 2.00e-21 95.50
IUUC-Vda-129906 Verticillium dahliae 36.77 1.00e-42 164.00
IUUC-Vpa-130223 Vicugna pacos 25.81 1.00e-24 105.00
IUUC-Vvi-131617 Vitis vinifera 36.00 1.00e-26 112.00
IUUC-Xtr-132288 Xenopus tropicalis 27.80 3.00e-30 123.00
IUUC-Xma-134214 Xiphophorus maculatus 30.37 4.00e-27 112.00
IUUC-Yli-134377 Yarrowia lipolytica 28.39 2.00e-16 77.40
IUUC-Zma-135108 Zea mays 36.31 2.00e-22 98.20
Created Date 25-Jun-2017

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