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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063859
UUCD1 version UUC-MuM-00534
Ensembl Protein ID ENSMUSP00000051809.6
UniProt Accession Q6QI06; E9QPE0; Q0VAV4; Q69Z40; Q6PDL2; Q6RI74; Q8BPH9; Q8CBF2; RICTR_MOUSE
Genbank Protein ID AAR89074.1; AAS46920.1; AAH58643.1; AAI20904.1; BAC29321.2; BAC35882.1; BAD32604.1
Protein Name Rapamycin-insensitive companion of mTOR; AVO3 homolog; Protein pianissimo
Genbank Nucleotide ID AY497009; AY540053; AC102825; BC120903; AK036149; AK075662; AK173326
Gene Name Rictor; Kiaa1999
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000050310.8 ENSMUST00000061656.6 ENSMUSP00000051809.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 95.38 0.00e+00 3077.00 IUUC-Hsa-046897
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
 Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Protein Sequence
(Fasta)
MAAIGRGRSL KNLRIRGRND SGEENVPLDL TREPSDNLRE ILQNVAKLQG VSNMRKLGHL 60
NNFTKLLCDI GHSEEKLGFN YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063859|E3,Cullin RING/Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGTGACTG AAACCCGTCA ATATGGCGGC GATCGGCCGC GGCCGCTCTC TGAAGAACCT 60
CCGAATACGA GGTAAGCCCG CTCGCCGCCC TCGCTCGCCT CACCCGGTGC GGGTCACGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063859|E3,Cullin RING/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR028268--Pianissimo_fam
IPR028267--Pianissimo_N
IPR029453--Rictor_IV
IPR029451--RICTOR_M
IPR029259--RICTOR_phospho
IPR029452--RICTOR_V
Pfam

PF14663--RasGEF_N_2
PF14666--RICTOR_M
PF14664--RICTOR_N
PF14665--RICTOR_phospho
PF14668--RICTOR_V
SMART

SM01307--RICTOR_M
SM01308--RICTOR_N
SM01309--RICTOR_phospho
SM01310--RICTOR_V
Gene Ontology

GO:0031932--C:TORC2 complex
GO:0008047--F:enzyme activator activity
GO:0019901--F:protein kinase binding
GO:0043022--F:ribosome binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0009790--P:embryo development
GO:0030950--P:establishment or maintenance of actin cytoskeleton polarity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0032008--P:positive regulation of TOR signaling
GO:0032956--P:regulation of actin cytoskeleton organization
GO:2000114--P:regulation of establishment of cell polarity
GO:0010468--P:regulation of gene expression
GO:0043087--P:regulation of GTPase activity
GO:0050727--P:regulation of inflammatory response
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:0051896--P:regulation of protein kinase B signaling
GO:0001932--P:regulation of protein phosphorylation
GO:0031929--P:TOR signaling
KEGG mmu:78757
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004111 Anas platyrhynchos 74.22 0.00e+00 2279.00
IUUC-Aca-004885 Anolis carolinensis 82.60 0.00e+00 2733.00
IUUC-Ago-007975 Ashbya gossypii 27.65 7.00e-42 166.00
IUUC-Afu-008889 Aspergillus fumigatus 29.41 2.00e-102 367.00
IUUC-Ang-009838 Aspergillus niger 28.35 7.00e-101 362.00
IUUC-Ate-010586 Aspergillus terreus 28.47 5.00e-100 359.00
IUUC-Bgr-012287 Blumeria graminis 29.06 1.00e-101 365.00
IUUC-Bta-013347 Bos taurus 95.79 0.00e+00 3060.00
IUUC-Bci-013718 Botrytis cinerea 30.25 2.00e-111 397.00
IUUC-Cja-019360 Callithrix jacchus 95.38 0.00e+00 3103.00
IUUC-Cpo-022258 Cavia porcellus 98.88 1.00e-155 541.00
IUUC-Cho-024748 Choloepus hoffmanni 85.79 0.00e+00 1346.00
IUUC-Cin-025491 Ciona intestinalis 40.37 2.00e-105 377.00
IUUC-Csv-025990 Ciona savignyi 39.50 1.00e-154 540.00
IUUC-Cgl-026666 Colletotrichum gloeosporioides 29.20 2.00e-99 358.00
IUUC-Cne-026882 Cryptococcus neoformans 30.61 5.00e-80 293.00
IUUC-Dre-027391 Danio rerio 84.34 0.00e+00 1770.00
IUUC-Dno-029612 Dasypus novemcinctus 91.98 0.00e+00 2881.00
IUUC-Dor-030974 Dipodomys ordii 93.28 0.00e+00 1327.00
IUUC-Ete-032905 Echinops telfairi 88.19 0.00e+00 2800.00
IUUC-Eca-033490 Equus caballus 92.43 0.00e+00 2904.00
IUUC-Eeu-035218 Erinaceus europaeus 83.83 0.00e+00 1346.00
IUUC-Fca-035568 Felis catus 94.41 0.00e+00 2954.00
IUUC-Fal-037265 Ficedula albicollis 85.79 0.00e+00 2746.00
IUUC-Fox-037847 Fusarium oxysporum 29.65 2.00e-96 347.00
IUUC-Fso-038392 Fusarium solani 28.78 4.00e-102 367.00
IUUC-Gmo-039569 Gadus morhua 73.43 0.00e+00 1709.00
IUUC-Ggr-039786 Gaeumannomyces graminis 28.97 3.00e-98 354.00
IUUC-Gga-040814 Gallus gallus 85.71 0.00e+00 2779.00
IUUC-Gac-042152 Gasterosteus aculeatus 66.51 0.00e+00 2071.00
IUUC-Hsa-046897 Homo sapiens 95.38 0.00e+00 3101.00
IUUC-Itr-047870 Ictidomys tridecemlineatus 93.74 0.00e+00 2920.00
IUUC-Kpa-049264 Komagataella pastoris 29.67 9.00e-51 196.00
IUUC-Lch-049566 Latimeria chalumnae 79.20 0.00e+00 2477.00
IUUC-Loc-052514 Lepisosteus oculatus 77.49 0.00e+00 2475.00
IUUC-Lma-053045 Leptosphaeria maculans 30.18 3.00e-87 317.00
IUUC-Laf-053388 Loxodonta africana 95.44 0.00e+00 3093.00
IUUC-Mcc-055195 Macaca mulatta 93.83 0.00e+00 3039.00
IUUC-Meu-056687 Macropus eugenii 85.19 3.00e-89 324.00
IUUC-Mor-056999 Magnaporthe oryzae 28.49 2.00e-101 364.00
IUUC-Mpo-057301 Magnaporthe poae 29.12 1.00e-102 368.00
IUUC-Mla-058853 Melampsora laricipopulina 27.20 4.00e-74 273.00
IUUC-Mga-059725 Meleagris gallopavo 75.25 0.00e+00 2105.00
IUUC-Mmr-060679 Microcebus murinus 95.87 0.00e+00 2961.00
IUUC-Mlu-067734 Myotis lucifugus 94.71 0.00e+00 3011.00
IUUC-Nfi-068380 Neosartorya fischeri 29.21 3.00e-101 363.00
IUUC-Ncr-068779 Neurospora crassa 28.70 2.00e-99 358.00
IUUC-Opr-071025 Ochotona princeps 84.78 0.00e+00 1877.00
IUUC-Ont-072104 Oreochromis niloticus 76.03 0.00e+00 1779.00
IUUC-Ocu-074388 Oryctolagus cuniculus 95.90 0.00e+00 3102.00
IUUC-Oru-084208 Oryza rufipogon 22.48 3.90e-02 32.30
IUUC-Ola-087503 Oryzias latipes 69.57 0.00e+00 2256.00
IUUC-Oar-089642 Ovis aries 96.02 0.00e+00 3073.00
IUUC-Ptr-090779 Pan troglodytes 95.27 0.00e+00 3120.00
IUUC-Pan-092099 Papio anubis 95.55 0.00e+00 3112.00
IUUC-Psi-093606 Pelodiscus sinensis 85.97 0.00e+00 2792.00
IUUC-Pno-094990 Phaeosphaeria nodorum 28.86 3.00e-87 317.00
IUUC-Pab-098429 Pongo abelii 94.32 0.00e+00 3055.00
IUUC-Pca-101045 Procavia capensis 90.58 0.00e+00 2981.00
IUUC-Pva-102675 Pteropus vampyrus 90.64 0.00e+00 1399.00
IUUC-Pgr-103341 Puccinia graminis 28.12 5.00e-42 167.00
IUUC-Ptt-103999 Puccinia triticina 28.63 1.00e-42 169.00
IUUC-Rno-104957 Rattus norvegicus 97.21 0.00e+00 3008.00
IUUC-Sce-106173 Saccharomyces cerevisiae 28.69 2.00e-41 165.00
IUUC-Sha-107121 Sarcophilus harrisii 88.92 0.00e+00 2860.00
IUUC-Sja-107806 Schizosaccharomyces japonicus 27.35 3.00e-77 283.00
IUUC-Spo-108187 Schizosaccharomyces pombe 27.89 2.00e-90 327.00
IUUC-Ssl-108665 Sclerotinia sclerotiorum 36.59 1.00e-64 242.00
IUUC-Sar-113499 Sorex araneus 85.92 0.00e+00 2549.00
IUUC-Sre-114992 Sporisorium reilianum 28.57 2.00e-96 348.00
IUUC-Ssc-115246 Sus scrofa 96.08 0.00e+00 3075.00
IUUC-Tgu-116455 Taeniopygia guttata 85.29 0.00e+00 2734.00
IUUC-Tru-118605 Takifugu rubripes 69.37 0.00e+00 2206.00
IUUC-Tsy-119061 Tarsius syrichta 89.64 0.00e+00 2849.00
IUUC-Tni-119726 Tetraodon nigroviridis 76.38 0.00e+00 1618.00
IUUC-Tre-121918 Trichoderma reesei 29.21 5.00e-100 360.00
IUUC-Tvi-122587 Trichoderma virens 28.96 1.00e-94 342.00
IUUC-Tbe-127960 Tupaia belangeri 91.44 0.00e+00 2350.00
IUUC-Ttr-128848 Tursiops truncatus 94.16 0.00e+00 2635.00
IUUC-Uma-129394 Ustilago maydis 29.07 5.00e-101 363.00
IUUC-Vda-129772 Verticillium dahliae 28.78 5.00e-95 343.00
IUUC-Vpa-130325 Vicugna pacos 92.74 0.00e+00 2822.00
IUUC-Xtr-132777 Xenopus tropicalis 78.51 0.00e+00 2472.00
IUUC-Xma-133798 Xiphophorus maculatus 69.24 0.00e+00 2252.00
IUUC-Yli-134450 Yarrowia lipolytica 28.03 2.00e-74 274.00
Created Date 25-Jun-2017

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