iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026831

Ensembl Protein ID

AAW44054

UniProt Accession

Q5KF83; Q5KF83_CRYNJ

Genbank Protein ID

AAW44054.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AE017346

Gene Name

CNF02660

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNF02660	AAW44054	AAW44054

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-58	194.8	307	795
UBD/Alpha-Helix/UBA	1.20e-18	65.1	666	697

Active Site

Position(s)	Description	Evidence
316	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
743	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp...kepkgellkslqklfeel......................wkskkkavsprellka 76
           tGl+NlgN+CYm SvLQ+L+++p +r+ + +  +e++n+ +      p  ++ +++ kl   l                        + ++ ++p+++++ 
   Q: 307  TGLRNLGNSCYMASVLQTLFSLPAFRSRYTT--PEAFNHFQTcpnLLPASCIECQMLKLGDGLlsgryshvarlppptthfeeqeAPKFQQGIKPTQFKAL 405
           7******************************..4444444332235566677777777777775555555555555554443332366666********** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           +++ +eefs+++qqD++Efl++ll +l++e                         +++ + +    ++++++ ++++++c +c++v  + e     slpv+
   Q: 406  IGRGHEEFSTMRQQDSEEFLQHLLTRLRDEA------------------------KRQGRDEAAEPTEILKFAMEQRLQCGKCKRVGLQVEGVDLASLPVE 482
           *******************************........................456777788899********************************** PP
   S: 178  gkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.. 267
             e    e         +l+ cLe+  +ee + +   y+c++ck+k++a k++k+k++P+ L+lh+k+f  +  ++ ++k++  v++p++L+l++ +++  
   Q: 483  AVEAGVSEdgkklyegvELETCLEQLCAEEAVAE---YQCDHCKEKTTAYKSTKFKTFPDLLVLHMKKF--QLVNWLPTKLDIPVSVPDMLTLDHLVAHgl 578
           88877666888888999***************96...********************************..7788*******************9888888 PP
   S: 268  ................................................................................peekqke.............. 274
                                                                                           p     +              
   Q: 579  qpgeeeltvsssspslpefnatamaqleamgfptvrcqkallatgnsdaeiamgwlfehmedpdidapielggskaasneP-----Sqeqigmiadmgfsh 674
           888888888888888888888777777777777777777777777777777777777777766666666666666665550.....044556666666666 PP
   S: 275  ................................................kkkYeLiavvvHsG.slssGHYvayvkn..........ekgkWllfdDskVte 316
                                                           + kY+L a ++H+G s++sGHYva +++          e+g+W+l++D+kV  
   Q: 675  nqarkalresdgnperaiewlfsnpgdpgedaapagsaepsiggssslPAKYRLKAFISHKGpSVHSGHYVATIRQpqagiegereEEGEWVLYNDEKVVR 775
           666666777777777778888888888888888888888889999999****************************99999998888888**********9 PP
   S: 317  vkeeevleetgstaYvlfYkr 337
                 +e++   aY+++Y+r
   Q: 776  AASGGGEEMR-GLAYLYVYER 795
           9988888755.799***9997 PP

UBD/Alpha-Helix/UBA

   S: 10   lve.MGFdreealqaLraannnleaAveyLld 40
           +++ MGF+ ++a++aLr++++n+e+A+e+L++
   Q: 666  MIAdMGFSHNQARKALRESDGNPERAIEWLFS 697
           5566***************************8 PP

Organism

Cryptococcus neoformans

Protein Sequence
(Fasta)

MSCTHLQPSL HSLKPPSPSQ QVHREECTLC FDGQDDPRGV VVCLSCFNGA CLSPDRQHAH 60
LHYQRTGHPL GMVIKRSRKE IRKRDSSEPP MKKLAISAPK DEEIWDYHTA FVCLACSSAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCTGCA CGCACCTCCA GCCATCCCTC CATTCCCTCA AACCACCCTC CCCCTCCCAG 60
CAAGTACACC GGTGAGTGTA CTCCATCCCC ACGCAGCCAT CCCCTGACAA CCGCCAAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cne:CNF02660

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.92	2.00e-100	358.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.47	2.00e-132	464.00
IUUC-Atr-002580	Amborella trichopoda	33.71	9.00e-116	409.00
IUUC-Apl-003774	Anas platyrhynchos	34.95	5.00e-131	459.00
IUUC-Aca-005368	Anolis carolinensis	35.52	1.00e-140	492.00
IUUC-Aly-005727	Arabidopsis lyrata	35.73	2.00e-127	448.00
IUUC-Ath-006974	Arabidopsis thaliana	35.74	4.00e-127	446.00
IUUC-Ago-007890	Ashbya gossypii	31.31	7.00e-100	356.00
IUUC-Acl-008057	Aspergillus clavatus	45.32	0.00e+00	643.00
IUUC-Afl-008547	Aspergillus flavus	45.79	1.00e-161	561.00
IUUC-Afu-008805	Aspergillus fumigatus	41.20	2.00e-155	540.00
IUUC-Ani-009441	Aspergillus nidulans	43.28	2.00e-153	534.00
IUUC-Ang-009720	Aspergillus niger	43.23	2.00e-180	624.00
IUUC-Aor-010111	Aspergillus oryzae	46.00	0.00e+00	672.00
IUUC-Ate-010531	Aspergillus terreus	41.84	3.00e-165	573.00
IUUC-Ame-011470	Astyanax mexicanus	32.58	1.00e-120	425.00
IUUC-Bgr-012183	Blumeria graminis	42.94	0.00e+00	630.00
IUUC-Bta-013179	Bos taurus	34.66	8.00e-133	466.00
IUUC-Bci-013858	Botrytis cinerea	46.79	0.00e+00	702.00
IUUC-Bdi-014904	Brachypodium distachyon	34.77	9.00e-113	399.00
IUUC-Bol-015296	Brassica oleracea	35.77	6.00e-128	449.00
IUUC-Bra-017619	Brassica rapa	34.82	3.00e-124	437.00
IUUC-Cel-018625	Caenorhabditis elegans	31.73	6.00e-90	323.00
IUUC-Cja-019063	Callithrix jacchus	34.89	6.00e-131	459.00
IUUC-Cfa-020976	Canis familiaris	35.60	1.00e-136	478.00
IUUC-Cpo-022265	Cavia porcellus	35.56	5.00e-138	483.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	32.75	9.00e-69	252.00
IUUC-Csa-024177	Chlorocebus sabaeus	35.17	6.00e-123	433.00
IUUC-Cho-024702	Choloepus hoffmanni	33.04	2.00e-80	291.00
IUUC-Cin-025411	Ciona intestinalis	34.68	5.00e-112	396.00
IUUC-Csv-026347	Ciona savignyi	32.87	2.00e-106	378.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	45.47	0.00e+00	629.00
IUUC-Cme-027335	Cyanidioschyzon merolae	34.72	6.00e-64	237.00
IUUC-Dre-027651	Danio rerio	33.26	2.00e-122	431.00
IUUC-Dno-029034	Dasypus novemcinctus	34.66	3.00e-134	471.00
IUUC-Dor-030479	Dipodomys ordii	36.34	6.00e-62	230.00
IUUC-Dse-031467	Dothistroma septosporum	44.93	0.00e+00	665.00
IUUC-Dme-032075	Drosophila melanogaster	34.80	6.00e-112	396.00
IUUC-Ete-032865	Echinops telfairi	31.96	7.00e-113	399.00
IUUC-Eca-034059	Equus caballus	34.51	1.00e-131	462.00
IUUC-Eeu-035304	Erinaceus europaeus	37.15	2.00e-122	431.00
IUUC-Fca-035515	Felis catus	34.55	8.00e-133	466.00
IUUC-Fal-037271	Ficedula albicollis	35.32	4.00e-128	450.00
IUUC-Fox-037745	Fusarium oxysporum	47.90	0.00e+00	706.00
IUUC-Fso-038158	Fusarium solani	47.52	0.00e+00	691.00
IUUC-Gmo-039071	Gadus morhua	35.25	2.00e-119	421.00
IUUC-Ggr-040098	Gaeumannomyces graminis	44.36	7.00e-177	612.00
IUUC-Gga-040635	Gallus gallus	35.05	2.00e-137	481.00
IUUC-Gac-042528	Gasterosteus aculeatus	34.30	1.00e-118	419.00
IUUC-Gma-043614	Glycine max	34.13	2.00e-115	408.00
IUUC-Ggo-044602	Gorilla gorilla	34.78	2.00e-132	464.00
IUUC-Hsa-045959	Homo sapiens	34.78	2.00e-132	464.00
IUUC-Hvu-047563	Hordeum vulgare	38.23	6.00e-110	389.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.85	3.00e-133	467.00
IUUC-Kpa-049156	Komagataella pastoris	40.95	1.00e-161	561.00
IUUC-Lch-049648	Latimeria chalumnae	35.15	2.00e-129	454.00
IUUC-Lpe-051523	Leersia perrieri	34.36	3.00e-112	397.00
IUUC-Loc-052072	Lepisosteus oculatus	32.91	2.00e-122	431.00
IUUC-Lma-053216	Leptosphaeria maculans	45.34	2.00e-177	615.00
IUUC-Laf-054327	Loxodonta africana	34.55	2.00e-132	464.00
IUUC-Mcc-055443	Macaca mulatta	34.62	4.00e-132	463.00
IUUC-Meu-056361	Macropus eugenii	34.49	7.00e-90	323.00
IUUC-Mor-057106	Magnaporthe oryzae	48.18	0.00e+00	697.00
IUUC-Mpo-057589	Magnaporthe poae	44.59	6.00e-179	619.00
IUUC-Mtr-058680	Medicago truncatula	35.22	9.00e-124	436.00
IUUC-Mla-058903	Melampsora laricipopulina	45.01	0.00e+00	678.00
IUUC-Mga-059669	Meleagris gallopavo	34.81	1.00e-128	451.00
IUUC-Mvi-060476	Microbotryum violaceum	47.07	0.00e+00	677.00
IUUC-Mmr-060575	Microcebus murinus	34.32	2.00e-132	464.00
IUUC-Mdo-062183	Monodelphis domestica	34.84	3.00e-132	464.00
IUUC-Mmu-063592	Mus musculus	34.82	3.00e-133	467.00
IUUC-Mac-065634	Musa acuminata	35.14	1.00e-64	239.00
IUUC-Mpu-066082	Mustela putorius furo	35.67	7.00e-136	476.00
IUUC-Mlu-067345	Myotis lucifugus	34.92	1.00e-133	468.00
IUUC-Nfi-068558	Neosartorya fischeri	43.95	8.00e-168	582.00
IUUC-Ncr-068960	Neurospora crassa	45.73	0.00e+00	625.00
IUUC-Nle-070173	Nomascus leucogenys	35.60	3.00e-135	474.00
IUUC-Opr-070556	Ochotona princeps	34.55	1.00e-132	465.00
IUUC-Ont-071502	Oreochromis niloticus	35.17	2.00e-120	424.00
IUUC-Oan-072959	Ornithorhynchus anatinus	41.80	9.00e-48	181.00
IUUC-Ocu-074861	Oryctolagus cuniculus	35.67	3.00e-136	477.00
IUUC-Oba-075109	Oryza barthii	34.65	2.00e-112	398.00
IUUC-Obr-076292	Oryza brachyantha	34.85	5.00e-114	403.00
IUUC-Ogl-077065	Oryza glaberrima	35.53	2.00e-120	424.00
IUUC-Ogu-078776	Oryza glumaepatula	34.37	9.00e-115	405.00
IUUC-Oin-080048	Oryza indica	35.49	4.00e-119	420.00
IUUC-Olo-080711	Oryza longistaminata	33.92	1.00e-101	362.00
IUUC-Ome-081506	Oryza meridionalis	34.78	8.00e-105	372.00
IUUC-Oni-082320	Oryza nivara	33.29	4.00e-111	393.00
IUUC-Opu-083801	Oryza punctata	33.88	7.00e-106	376.00
IUUC-Oru-085139	Oryza rufipogon	33.53	3.00e-111	394.00
IUUC-Osa-085713	Oryza sativa	35.77	9.00e-122	429.00
IUUC-Ola-086951	Oryzias latipes	32.88	3.00e-111	394.00
IUUC-Olu-087822	Ostreococcus lucimarinus	30.92	2.00e-92	331.00
IUUC-Oga-088625	Otolemur garnettii	34.55	1.00e-132	465.00
IUUC-Oar-089995	Ovis aries	34.66	2.00e-132	464.00
IUUC-Ptr-090640	Pan troglodytes	35.97	2.00e-137	481.00
IUUC-Pan-091974	Papio anubis	34.62	3.00e-131	461.00
IUUC-Psi-093957	Pelodiscus sinensis	35.04	5.00e-138	483.00
IUUC-Pma-094242	Petromyzon marinus	39.90	7.00e-75	272.00
IUUC-Pno-094835	Phaeosphaeria nodorum	43.79	2.00e-155	541.00
IUUC-Ppa-095901	Physcomitrella patens	34.76	1.00e-126	445.00
IUUC-Pfo-097148	Poecilia formosa	35.51	2.00e-120	424.00
IUUC-Pab-098068	Pongo abelii	32.80	2.00e-110	391.00
IUUC-Pop-098943	Populus trichocarpa	34.41	2.00e-116	411.00
IUUC-Pca-100738	Procavia capensis	35.79	2.00e-97	348.00
IUUC-Ppe-101315	Prunus persica	34.26	1.00e-116	412.00
IUUC-Pva-102154	Pteropus vampyrus	34.55	1.00e-132	464.00
IUUC-Pgr-103343	Puccinia graminis	44.04	7.00e-158	548.00
IUUC-Ptt-103928	Puccinia triticina	39.20	2.00e-157	547.00
IUUC-Pte-104306	Pyrenophora teres	44.99	1.00e-166	578.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	45.25	3.00e-172	596.00
IUUC-Rno-105801	Rattus norvegicus	34.93	5.00e-134	469.00
IUUC-Sce-106304	Saccharomyces cerevisiae	32.73	5.00e-102	363.00
IUUC-Sha-107635	Sarcophilus harrisii	34.70	9.00e-135	472.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	39.53	2.00e-155	540.00
IUUC-Spo-108144	Schizosaccharomyces pombe	40.47	9.00e-163	565.00
IUUC-Smo-108703	Selaginella moellendorffii	36.61	3.00e-119	421.00
IUUC-Sit-110728	Setaria italica	35.09	5.00e-126	443.00
IUUC-Sly-111523	Solanum lycopersicum	34.21	1.00e-124	439.00
IUUC-Sar-113733	Sorex araneus	34.38	2.00e-58	218.00
IUUC-Sbi-114419	Sorghum bicolor	35.21	5.00e-122	429.00
IUUC-Sre-115225	Sporisorium reilianum	47.90	0.00e+00	713.00
IUUC-Ssc-115686	Sus scrofa	34.85	1.00e-132	465.00
IUUC-Tgu-117346	Taeniopygia guttata	34.44	2.00e-132	464.00
IUUC-Tru-118350	Takifugu rubripes	33.26	3.00e-115	407.00
IUUC-Tsy-119278	Tarsius syrichta	31.15	3.00e-105	374.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.83	2.00e-113	401.00
IUUC-Tca-121585	Theobroma cacao	35.50	3.00e-119	421.00
IUUC-Tre-122043	Trichoderma reesei	46.08	0.00e+00	625.00
IUUC-Tvi-122303	Trichoderma virens	45.65	0.00e+00	642.00
IUUC-Tae-123798	Triticum aestivum	35.09	1.00e-119	422.00
IUUC-Tur-126732	Triticum urartu	32.33	5.00e-106	376.00
IUUC-Tme-126909	Tuber melanosporum	46.29	0.00e+00	665.00
IUUC-Tbe-127261	Tupaia belangeri	32.58	5.00e-79	287.00
IUUC-Ttr-128295	Tursiops truncatus	29.81	4.00e-102	363.00
IUUC-Uma-129599	Ustilago maydis	47.89	0.00e+00	730.00
IUUC-Vda-129688	Verticillium dahliae	46.90	0.00e+00	646.00
IUUC-Vpa-130170	Vicugna pacos	28.94	1.00e-90	325.00
IUUC-Vvi-131116	Vitis vinifera	34.69	2.00e-114	404.00
IUUC-Xtr-131953	Xenopus tropicalis	34.36	1.00e-121	429.00
IUUC-Xma-133837	Xiphophorus maculatus	35.51	1.00e-120	425.00
IUUC-Yli-134510	Yarrowia lipolytica	42.93	3.00e-162	563.00
IUUC-Zma-135786	Zea mays	34.64	1.00e-113	402.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence