iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054327

UUCD1 version

UUC-LoA-01112

Ensembl Protein ID

ENSLAFP00000005516.3

UniProt Accession

G3SYE8; G3SYE8_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006569.3	ENSLAFT00000006571.3	ENSLAFP00000005516.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.30e-63	213.1	326	855
UBD/Alpha-Helix/UBA	1.10e-21	76.6	726	762

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k e++ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLERIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpalesgdgeqvpeQKEVQDGIA 413
           7******************************.899999999*******************66666666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeeklplpelvraqvPFNSCLEAYGAPEQVDD---FWSTALQAKSVAIKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 647
           *******************997.*******************98888788888888888888888888888888888888888888777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 648  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppddcvttivsmgf 736
           77777777777777777777777777777777777666666666666666666666666666666666555555555555555555555 PP
   S: 268  peekqke...........................................................kkkYeLiavvvHsG.slssGHYv 296
           +     +                                                             kY+L+a ++H+G s+ +GHYv
   Q: 737  S-----QdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgLGKYQLFAFISHMGtSTMCGHYV 820
           0.....055555566666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 821  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d +  +v+MGF++++al+aLra+nn+le+Av++++++
   Q: 726  DCVTTIVSMGFSQDQALKALRATNNSLERAVDWIFSH 762
           678889*****************************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HYNKTGQRVY LHLRRTRRPK EEDTTTGTGD PPRKKPTRLA IGMEGGFDLT EEKFEYDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAGTGAGGA GGCGCTGCTG TCAGTGTTAC CGACGATCCG GGTTCCTAAG 60
GCTGGAGACC GGGTCCACAA AGACGAGTGC GCCTTCTCCT TCGACACGCC GGTAAGGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100675377

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.19	0.00e+00	649.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.64	0.00e+00	1640.00
IUUC-Atr-002580	Amborella trichopoda	46.20	0.00e+00	739.00
IUUC-Apl-003774	Anas platyrhynchos	90.70	0.00e+00	1522.00
IUUC-Aca-005368	Anolis carolinensis	85.66	0.00e+00	1501.00
IUUC-Aly-005727	Arabidopsis lyrata	47.28	0.00e+00	731.00
IUUC-Ath-006974	Arabidopsis thaliana	47.38	0.00e+00	732.00
IUUC-Ago-007890	Ashbya gossypii	28.86	3.00e-83	303.00
IUUC-Acl-008057	Aspergillus clavatus	33.61	8.00e-124	437.00
IUUC-Afl-008547	Aspergillus flavus	36.45	2.00e-117	416.00
IUUC-Afu-008805	Aspergillus fumigatus	34.19	1.00e-114	407.00
IUUC-Ani-009441	Aspergillus nidulans	32.27	3.00e-97	349.00
IUUC-Ang-009720	Aspergillus niger	33.99	4.00e-118	419.00
IUUC-Aor-010111	Aspergillus oryzae	34.34	4.00e-127	449.00
IUUC-Ate-010531	Aspergillus terreus	31.81	4.00e-104	372.00
IUUC-Ame-011893	Astyanax mexicanus	64.72	0.00e+00	989.00
IUUC-Bgr-012183	Blumeria graminis	33.49	7.00e-122	431.00
IUUC-Bta-013179	Bos taurus	97.64	0.00e+00	1642.00
IUUC-Bci-013858	Botrytis cinerea	34.84	5.00e-130	458.00
IUUC-Bdi-014904	Brachypodium distachyon	46.85	0.00e+00	713.00
IUUC-Bol-015296	Brassica oleracea	47.79	0.00e+00	747.00
IUUC-Bra-017939	Brassica rapa	47.55	0.00e+00	748.00
IUUC-Cel-018625	Caenorhabditis elegans	34.81	6.00e-136	478.00
IUUC-Cja-019063	Callithrix jacchus	96.24	0.00e+00	1613.00
IUUC-Cfa-020976	Canis familiaris	95.51	0.00e+00	1592.00
IUUC-Cpo-022265	Cavia porcellus	94.93	0.00e+00	1579.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.36	5.00e-112	398.00
IUUC-Csa-024177	Chlorocebus sabaeus	94.16	0.00e+00	1444.00
IUUC-Cho-024702	Choloepus hoffmanni	88.77	0.00e+00	986.00
IUUC-Cin-025411	Ciona intestinalis	50.41	0.00e+00	834.00
IUUC-Csv-026347	Ciona savignyi	46.41	0.00e+00	793.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.02	1.00e-113	403.00
IUUC-Cne-026831	Cryptococcus neoformans	35.49	2.00e-128	453.00
IUUC-Dre-027982	Danio rerio	66.78	0.00e+00	1096.00
IUUC-Dno-029034	Dasypus novemcinctus	97.99	0.00e+00	1662.00
IUUC-Dor-030479	Dipodomys ordii	93.40	0.00e+00	715.00
IUUC-Dse-031467	Dothistroma septosporum	35.88	3.00e-131	462.00
IUUC-Dme-032075	Drosophila melanogaster	49.14	0.00e+00	802.00
IUUC-Ete-032865	Echinops telfairi	87.88	0.00e+00	1476.00
IUUC-Eca-034059	Equus caballus	97.90	0.00e+00	1659.00
IUUC-Eeu-035304	Erinaceus europaeus	91.74	0.00e+00	1493.00
IUUC-Fca-035515	Felis catus	97.99	0.00e+00	1649.00
IUUC-Fal-037271	Ficedula albicollis	87.56	0.00e+00	1425.00
IUUC-Fox-037745	Fusarium oxysporum	35.51	3.00e-129	455.00
IUUC-Fso-038158	Fusarium solani	35.84	7.00e-129	454.00
IUUC-Gmo-039071	Gadus morhua	64.48	0.00e+00	1070.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.13	3.00e-119	422.00
IUUC-Gga-040635	Gallus gallus	90.68	0.00e+00	1593.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.72	0.00e+00	1085.00
IUUC-Gma-043614	Glycine max	46.62	0.00e+00	707.00
IUUC-Ggo-044602	Gorilla gorilla	97.40	0.00e+00	1637.00
IUUC-Hsa-045959	Homo sapiens	97.40	0.00e+00	1637.00
IUUC-Hvu-047563	Hordeum vulgare	47.52	6.00e-169	587.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	97.52	0.00e+00	1642.00
IUUC-Kpa-049156	Komagataella pastoris	32.99	4.00e-116	412.00
IUUC-Lch-049648	Latimeria chalumnae	81.42	0.00e+00	1372.00
IUUC-Lpe-051523	Leersia perrieri	46.54	0.00e+00	716.00
IUUC-Loc-052520	Lepisosteus oculatus	62.70	0.00e+00	1012.00
IUUC-Lma-053216	Leptosphaeria maculans	34.44	1.00e-112	402.00
IUUC-Mcc-055443	Macaca mulatta	97.28	0.00e+00	1634.00
IUUC-Meu-056298	Macropus eugenii	93.92	0.00e+00	1070.00
IUUC-Mor-057106	Magnaporthe oryzae	35.05	1.00e-130	460.00
IUUC-Mpo-057589	Magnaporthe poae	34.79	1.00e-123	437.00
IUUC-Mtr-058680	Medicago truncatula	47.85	0.00e+00	734.00
IUUC-Mla-058903	Melampsora laricipopulina	32.09	8.00e-119	421.00
IUUC-Mga-059669	Meleagris gallopavo	89.82	0.00e+00	1511.00
IUUC-Mvi-060476	Microbotryum violaceum	34.54	3.00e-119	422.00
IUUC-Mmr-060575	Microcebus murinus	97.87	0.00e+00	1648.00
IUUC-Mdo-062183	Monodelphis domestica	91.38	0.00e+00	1530.00
IUUC-Mmu-063592	Mus musculus	97.76	0.00e+00	1646.00
IUUC-Mac-065634	Musa acuminata	43.01	0.00e+00	692.00
IUUC-Mpu-066082	Mustela putorius furo	94.69	0.00e+00	1578.00
IUUC-Mlu-067345	Myotis lucifugus	95.76	0.00e+00	1610.00
IUUC-Nfi-068558	Neosartorya fischeri	35.06	7.00e-123	434.00
IUUC-Ncr-068960	Neurospora crassa	34.95	8.00e-116	411.00
IUUC-Nle-070173	Nomascus leucogenys	94.69	0.00e+00	1576.00
IUUC-Opr-070556	Ochotona princeps	96.93	0.00e+00	1636.00
IUUC-Ont-071502	Oreochromis niloticus	64.27	0.00e+00	1082.00
IUUC-Ocu-074861	Oryctolagus cuniculus	94.81	0.00e+00	1583.00
IUUC-Oba-075109	Oryza barthii	46.67	0.00e+00	721.00
IUUC-Obr-076292	Oryza brachyantha	47.66	0.00e+00	714.00
IUUC-Ogl-077065	Oryza glaberrima	47.96	0.00e+00	751.00
IUUC-Ogu-078776	Oryza glumaepatula	46.67	0.00e+00	734.00
IUUC-Oin-080048	Oryza indica	47.49	0.00e+00	745.00
IUUC-Olo-080711	Oryza longistaminata	44.84	0.00e+00	664.00
IUUC-Ome-081506	Oryza meridionalis	45.90	0.00e+00	676.00
IUUC-Oni-082320	Oryza nivara	46.11	0.00e+00	720.00
IUUC-Opu-083801	Oryza punctata	46.43	0.00e+00	712.00
IUUC-Oru-085139	Oryza rufipogon	46.11	0.00e+00	721.00
IUUC-Osa-085713	Oryza sativa	48.07	0.00e+00	754.00
IUUC-Ola-086951	Oryzias latipes	65.19	0.00e+00	1081.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.89	7.00e-179	620.00
IUUC-Oga-088625	Otolemur garnettii	96.93	0.00e+00	1628.00
IUUC-Oar-089995	Ovis aries	94.82	0.00e+00	1610.00
IUUC-Ptr-090640	Pan troglodytes	94.81	0.00e+00	1615.00
IUUC-Pan-091974	Papio anubis	96.35	0.00e+00	1617.00
IUUC-Psi-093957	Pelodiscus sinensis	89.30	0.00e+00	1591.00
IUUC-Pma-094242	Petromyzon marinus	71.92	2.00e-165	575.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.53	6.00e-106	378.00
IUUC-Ppa-095901	Physcomitrella patens	49.25	0.00e+00	782.00
IUUC-Pfo-097148	Poecilia formosa	65.50	0.00e+00	1092.00
IUUC-Pab-098068	Pongo abelii	89.73	0.00e+00	1458.00
IUUC-Pop-098943	Populus trichocarpa	46.85	0.00e+00	714.00
IUUC-Pca-100738	Procavia capensis	91.50	0.00e+00	1490.00
IUUC-Ppe-101315	Prunus persica	47.09	0.00e+00	724.00
IUUC-Pva-102154	Pteropus vampyrus	96.10	0.00e+00	1614.00
IUUC-Pgr-103343	Puccinia graminis	33.38	1.00e-109	390.00
IUUC-Ptt-103928	Puccinia triticina	30.10	1.00e-105	377.00
IUUC-Pte-104306	Pyrenophora teres	32.50	5.00e-103	368.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.03	3.00e-105	375.00
IUUC-Rno-105801	Rattus norvegicus	97.40	0.00e+00	1644.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.36	2.00e-73	270.00
IUUC-Sha-107635	Sarcophilus harrisii	91.62	0.00e+00	1540.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.22	2.00e-109	389.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.15	5.00e-113	402.00
IUUC-Smo-108848	Selaginella moellendorffii	47.60	0.00e+00	733.00
IUUC-Sit-110728	Setaria italica	48.02	0.00e+00	770.00
IUUC-Sly-111523	Solanum lycopersicum	47.80	0.00e+00	767.00
IUUC-Sbi-114419	Sorghum bicolor	47.03	0.00e+00	754.00
IUUC-Sre-115225	Sporisorium reilianum	35.16	1.00e-125	444.00
IUUC-Ssc-115686	Sus scrofa	96.82	0.00e+00	1634.00
IUUC-Tgu-117346	Taeniopygia guttata	90.34	0.00e+00	1563.00
IUUC-Tru-118350	Takifugu rubripes	64.85	0.00e+00	1110.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.59	0.00e+00	1090.00
IUUC-Tca-121585	Theobroma cacao	47.50	0.00e+00	723.00
IUUC-Tre-122043	Trichoderma reesei	34.26	2.00e-119	423.00
IUUC-Tvi-122303	Trichoderma virens	34.73	2.00e-125	442.00
IUUC-Tae-125686	Triticum aestivum	47.07	0.00e+00	731.00
IUUC-Tur-126732	Triticum urartu	44.60	0.00e+00	686.00
IUUC-Tme-126909	Tuber melanosporum	34.02	4.00e-118	418.00
IUUC-Tbe-127261	Tupaia belangeri	90.18	0.00e+00	1028.00
IUUC-Uma-129599	Ustilago maydis	34.16	7.00e-130	457.00
IUUC-Vda-129688	Verticillium dahliae	33.84	6.00e-120	424.00
IUUC-Vvi-131116	Vitis vinifera	47.44	0.00e+00	704.00
IUUC-Xtr-131953	Xenopus tropicalis	79.51	0.00e+00	1362.00
IUUC-Xma-133837	Xiphophorus maculatus	65.73	0.00e+00	1096.00
IUUC-Yli-134510	Yarrowia lipolytica	34.91	9.00e-128	451.00
IUUC-Zma-135786	Zea mays	47.15	0.00e+00	720.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence