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Tag Content
UUCD2 ID IUUC-Mcc-055823
UUCD1 version UUC-MaM-01094
Ensembl Protein ID ENSMMUP00000061062.1
UniProt Accession A0A1D5RL67; A0A1D5RL67_MACMU
Genbank Protein ID AFJ70185.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 8
Genbank Nucleotide ID JSUE03038246
Gene Name USP8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000014884.3 ENSMMUT00000057711.1 ENSMMUP00000061062.1
ENSMMUG00000014884.3 ENSMMUT00000020884.3 ENSMMUP00000019540.3
ENSMMUG00000014884.3 ENSMMUT00000053259.1 ENSMMUP00000053299.1
ENSMMUG00000014884.3 ENSMMUT00000040587.2 ENSMMUP00000033637.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.80e-109 364.9 777 1107
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 777  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 863
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 864  YSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNehlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
           *********************8833333333222201144556666***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 951  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1032
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1033 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1107
           ***********9988...69*************************88888*******************...********8 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSVL GPANIKKAVE EAERLSESLK LRYEEAEVRK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055823|DUB,USP|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAGAACTA CTTTTAAGGA AATATAGCAT CCATTGTGAA AGGGGAAAAG TAAAGATAAT 60
TCATCATGCC TGCTGTGGCT TCAGTTCCTA AAGAACTCTA CCTCAGTTCT TCACTAAAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055823|DUB,USP|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome
Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer
SMART

SM00450--RHOD
Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mcc:715523
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001661 Ailuropoda melanoleuca 91.44 0.00e+00 1889.00
IUUC-Apl-003226 Anas platyrhynchos 67.60 0.00e+00 1441.00
IUUC-Aca-004936 Anolis carolinensis 65.54 0.00e+00 1302.00
IUUC-Ago-007959 Ashbya gossypii 35.89 4.00e-55 209.00
IUUC-Acl-008102 Aspergillus clavatus 31.59 4.00e-51 196.00
IUUC-Afl-008604 Aspergillus flavus 32.34 6.00e-50 192.00
IUUC-Afu-009001 Aspergillus fumigatus 31.39 3.00e-50 194.00
IUUC-Ani-009291 Aspergillus nidulans 31.45 4.00e-50 193.00
IUUC-Ang-009844 Aspergillus niger 32.73 3.00e-49 190.00
IUUC-Aor-010098 Aspergillus oryzae 32.34 2.00e-49 191.00
IUUC-Ate-010585 Aspergillus terreus 31.94 2.00e-49 191.00
IUUC-Ame-011029 Astyanax mexicanus 58.89 8.00e-70 256.00
IUUC-Bta-013008 Bos taurus 87.75 0.00e+00 1803.00
IUUC-Bol-015281 Brassica oleracea 38.21 1.00e-46 181.00
IUUC-Bra-017228 Brassica rapa 39.10 1.00e-48 187.00
IUUC-Cel-018482 Caenorhabditis elegans 33.82 6.00e-52 199.00
IUUC-Cja-019173 Callithrix jacchus 96.60 0.00e+00 2017.00
IUUC-Cfa-021243 Canis familiaris 91.41 0.00e+00 1895.00
IUUC-Cpo-021522 Cavia porcellus 85.69 0.00e+00 1736.00
IUUC-Cre-022582 Chlamydomonas reinhardtii 44.35 2.00e-82 298.00
IUUC-Csa-023616 Chlorocebus sabaeus 99.26 0.00e+00 1739.00
IUUC-Cho-024381 Choloepus hoffmanni 77.56 0.00e+00 1548.00
IUUC-Cin-025287 Ciona intestinalis 49.87 3.00e-98 353.00
IUUC-Csv-026253 Ciona savignyi 47.78 6.00e-87 315.00
IUUC-Cne-026821 Cryptococcus neoformans 39.61 2.00e-74 275.00
IUUC-Dre-028440 Danio rerio 69.00 0.00e+00 734.00
IUUC-Dno-029039 Dasypus novemcinctus 90.16 0.00e+00 1916.00
IUUC-Dor-031043 Dipodomys ordii 96.12 6.00e-133 468.00
IUUC-Dse-031463 Dothistroma septosporum 28.65 5.00e-42 166.00
IUUC-Dme-032089 Drosophila melanogaster 45.43 2.00e-84 307.00
IUUC-Ete-033040 Echinops telfairi 80.43 0.00e+00 1517.00
IUUC-Eca-033449 Equus caballus 92.04 0.00e+00 1907.00
IUUC-Eeu-034693 Erinaceus europaeus 95.69 3.00e-131 462.00
IUUC-Fca-035794 Felis catus 98.74 0.00e+00 930.00
IUUC-Fal-037322 Ficedula albicollis 80.34 0.00e+00 914.00
IUUC-Gmo-038584 Gadus morhua 66.73 0.00e+00 662.00
IUUC-Gga-041188 Gallus gallus 83.19 0.00e+00 933.00
IUUC-Gac-041850 Gasterosteus aculeatus 73.05 0.00e+00 744.00
IUUC-Ggo-045565 Gorilla gorilla 98.48 0.00e+00 2077.00
IUUC-Hsa-046438 Homo sapiens 98.39 0.00e+00 2075.00
IUUC-Itr-048883 Ictidomys tridecemlineatus 89.09 0.00e+00 1817.00
IUUC-Kpa-049321 Komagataella pastoris 33.51 4.00e-49 189.00
IUUC-Lch-050485 Latimeria chalumnae 84.31 0.00e+00 865.00
IUUC-Loc-052769 Lepisosteus oculatus 74.75 0.00e+00 769.00
IUUC-Lma-053021 Leptosphaeria maculans 33.33 1.00e-53 205.00
IUUC-Laf-053432 Loxodonta africana 85.92 0.00e+00 1036.00
IUUC-Meu-056099 Macropus eugenii 96.65 2.00e-163 570.00
IUUC-Mla-059089 Melampsora laricipopulina 40.18 8.00e-72 265.00
IUUC-Mga-059739 Meleagris gallopavo 83.01 0.00e+00 929.00
IUUC-Mvi-060559 Microbotryum violaceum 40.84 2.00e-76 280.00
IUUC-Mmr-061158 Microcebus murinus 91.50 0.00e+00 1878.00
IUUC-Mdo-061801 Monodelphis domestica 90.71 0.00e+00 1020.00
IUUC-Mmu-063665 Mus musculus 81.66 0.00e+00 1669.00
IUUC-Mpu-066738 Mustela putorius furo 91.50 0.00e+00 1876.00
IUUC-Mlu-067307 Myotis lucifugus 88.12 0.00e+00 1818.00
IUUC-Nfi-068410 Neosartorya fischeri 31.67 1.00e-50 195.00
IUUC-Nle-069314 Nomascus leucogenys 98.21 0.00e+00 2069.00
IUUC-Opr-070378 Ochotona princeps 81.04 0.00e+00 1222.00
IUUC-Ont-071545 Oreochromis niloticus 76.47 0.00e+00 764.00
IUUC-Oan-073537 Ornithorhynchus anatinus 75.95 0.00e+00 1524.00
IUUC-Ocu-074193 Oryctolagus cuniculus 89.00 0.00e+00 1826.00
IUUC-Ola-086622 Oryzias latipes 57.09 0.00e+00 1080.00
IUUC-Oga-088271 Otolemur garnettii 89.20 0.00e+00 1836.00
IUUC-Oar-090431 Ovis aries 88.05 0.00e+00 1815.00
IUUC-Ptr-091339 Pan troglodytes 98.12 0.00e+00 2103.00
IUUC-Pan-091783 Papio anubis 99.53 0.00e+00 1160.00
IUUC-Psi-093187 Pelodiscus sinensis 63.83 1.00e-161 563.00
IUUC-Pma-094626 Petromyzon marinus 58.67 4.00e-142 497.00
IUUC-Pfo-096463 Poecilia formosa 75.46 0.00e+00 753.00
IUUC-Pab-097645 Pongo abelii 98.39 0.00e+00 2075.00
IUUC-Pva-103222 Pteropus vampyrus 83.17 0.00e+00 931.00
IUUC-Pgr-103408 Puccinia graminis 35.92 5.00e-54 206.00
IUUC-Ptt-103699 Puccinia triticina 46.15 5.00e-68 253.00
IUUC-Pte-104348 Pyrenophora teres 29.13 6.00e-40 159.00
IUUC-Pyt-104711 Pyrenophora triticirepentis 31.39 3.00e-51 197.00
IUUC-Rno-105510 Rattus norvegicus 81.48 0.00e+00 1706.00
IUUC-Sce-106166 Saccharomyces cerevisiae 35.81 1.00e-51 198.00
IUUC-Sha-106879 Sarcophilus harrisii 89.07 0.00e+00 1007.00
IUUC-Sja-107836 Schizosaccharomyces japonicus 36.86 2.00e-48 187.00
IUUC-Sar-113019 Sorex araneus 83.18 0.00e+00 1753.00
IUUC-Sre-115031 Sporisorium reilianum 36.77 7.00e-69 256.00
IUUC-Ssc-116334 Sus scrofa 88.75 0.00e+00 1842.00
IUUC-Tgu-117062 Taeniopygia guttata 80.52 0.00e+00 914.00
IUUC-Tru-117908 Takifugu rubripes 57.67 0.00e+00 1154.00
IUUC-Tsy-118867 Tarsius syrichta 88.48 0.00e+00 1099.00
IUUC-Tni-120206 Tetraodon nigroviridis 74.65 0.00e+00 730.00
IUUC-Tme-127144 Tuber melanosporum 40.00 1.00e-78 288.00
IUUC-Tbe-127877 Tupaia belangeri 88.89 3.00e-101 363.00
IUUC-Ttr-128580 Tursiops truncatus 86.67 0.00e+00 1746.00
IUUC-Uma-129340 Ustilago maydis 36.23 1.00e-71 265.00
IUUC-Vpa-130541 Vicugna pacos 90.52 0.00e+00 1881.00
IUUC-Xtr-132161 Xenopus tropicalis 58.94 0.00e+00 1203.00
IUUC-Xma-134271 Xiphophorus maculatus 75.46 0.00e+00 751.00
IUUC-Yli-134561 Yarrowia lipolytica 36.10 4.00e-60 226.00
Created Date 25-Jun-2017

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