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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063470
Ensembl Protein ID ENSMUSP00000080081.4
UniProt Accession O35943; FRDA_MOUSE
Genbank Protein ID AAB67778.1
Protein Name Frataxin, mitochondrial; Frataxin intermediate form; Frataxin mature form
Genbank Nucleotide ID U95736
Gene Name Fxn; Frda
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000059363.10 ENSMUST00000081333.10 ENSMUSP00000080081.4
ENSMUSG00000059363.10 ENSMUST00000123684.1 ENSMUSP00000117047.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 73.08 4.00e-78 288.00 IUUC-Hsa-046921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity).
 Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity).
Protein Sequence
(Fasta)
MWAFGGRAAV GLLPRTASRA SAWVGNPRWR EPIVTCGRRG LHVTVNAGAT RHAHLNLHYL 60
QILNIKKQSV CVVHLRNLGT LDNPSSLDET AYERLAEETL DSLAEFFEDL ADKPYTLEDY 120
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Protein Fasta Sequence


>IUUC-Mmu-063470|UBD,UBD/Other/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GTCCTCGCGC GGGGCGGAGC GGCCGCGGAG CTGGAGTAGC ATGTGGGCGT TCGGAGGTCG 60
CGCAGCCGTG GGCTTGCTGC CCCGGACGGC GTCCCGGGCC TCCGCCTGGG TCGGGAACCC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063470|UBD,UBD/Other/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport
Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS
PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2
Pfam

PF01491--Frataxin_Cyay
PRINTS

PR00904--FRATAXIN
SMART

SM01219--Frataxin_Cyay
Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0051536--F:iron-sulfur cluster binding
GO:0007628--P:adult walking behavior
GO:0009060--P:aerobic respiration
GO:0006879--P:cellular iron ion homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0034599--P:cellular response to oxidative stress
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0016226--P:iron-sulfur cluster assembly
GO:0007005--P:mitochondrion organization
GO:0043066--P:negative regulation of apoptotic process
GO:0040015--P:negative regulation of multicellular organism growth
GO:0046621--P:negative regulation of organ growth
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0006119--P:oxidative phosphorylation
GO:1904234--P:positive regulation of aconitate hydratase activity
GO:0043085--P:positive regulation of catalytic activity
GO:0030307--P:positive regulation of cell growth
GO:0008284--P:positive regulation of cell proliferation
GO:0051349--P:positive regulation of lyase activity
GO:1904231--P:positive regulation of succinate dehydrogenase activity
GO:0019230--P:proprioception
GO:0016540--P:protein autoprocessing
GO:0010722--P:regulation of ferrochelatase activity
GO:0010039--P:response to iron ion
KEGG mmu:14297
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002122 Ailuropoda melanoleuca 73.91 1.00e-78 285.00
IUUC-Apl-003853 Anas platyrhynchos 81.82 2.00e-56 210.00
IUUC-Aca-005026 Anolis carolinensis 71.53 1.00e-58 218.00
IUUC-Aly-006200 Arabidopsis lyrata 46.88 7.00e-20 90.10
IUUC-Ath-007033 Arabidopsis thaliana 46.88 5.00e-20 90.50
IUUC-Ago-007707 Ashbya gossypii 47.27 2.00e-20 90.50
IUUC-Acl-008146 Aspergillus clavatus 41.13 1.00e-17 83.20
IUUC-Afl-008501 Aspergillus flavus 46.51 2.00e-14 72.40
IUUC-Afu-008851 Aspergillus fumigatus 38.64 2.00e-17 82.40
IUUC-Ani-009129 Aspergillus nidulans 40.21 8.00e-12 63.50
IUUC-Ang-009557 Aspergillus niger 39.52 5.00e-17 80.90
IUUC-Ate-010486 Aspergillus terreus 40.32 2.00e-17 82.00
IUUC-Bgr-012108 Blumeria graminis 42.74 1.00e-15 76.30
IUUC-Bta-013437 Bos taurus 68.25 1.00e-71 261.00
IUUC-Bci-013810 Botrytis cinerea 53.25 2.00e-15 75.10
IUUC-Bdi-014226 Brachypodium distachyon 45.00 2.00e-25 108.00
IUUC-Bol-015092 Brassica oleracea 47.87 5.00e-20 90.50
IUUC-Bra-017945 Brassica rapa 48.89 2.00e-19 87.80
IUUC-Cel-018466 Caenorhabditis elegans 51.38 2.00e-26 110.00
IUUC-Cja-019306 Callithrix jacchus 71.09 4.00e-69 253.00
IUUC-Cfa-020063 Canis familiaris 72.04 5.00e-78 283.00
IUUC-Cpo-021325 Cavia porcellus 75.00 9.00e-84 302.00
IUUC-Cre-022889 Chlamydomonas reinhardtii 53.85 1.00e-21 96.30
IUUC-Csa-023739 Chlorocebus sabaeus 72.12 3.00e-79 287.00
IUUC-Cho-024324 Choloepus hoffmanni 70.14 2.00e-66 244.00
IUUC-Cgl-026402 Colletotrichum gloeosporioides 43.86 1.00e-18 86.30
IUUC-Cne-027094 Cryptococcus neoformans 38.27 1.00e-12 66.20
IUUC-Cme-027112 Cyanidioschyzon merolae 42.34 1.00e-13 68.60
IUUC-Dre-028813 Danio rerio 65.81 1.00e-43 169.00
IUUC-Dno-029949 Dasypus novemcinctus 83.82 4.00e-53 199.00
IUUC-Dse-031482 Dothistroma septosporum 40.68 9.00e-19 86.70
IUUC-Dme-031608 Drosophila melanogaster 51.18 3.00e-34 137.00
IUUC-Ete-032937 Echinops telfairi 96.88 6.00e-13 66.60
IUUC-Eca-033899 Equus caballus 89.54 2.00e-65 240.00
IUUC-Fca-036579 Felis catus 76.74 7.00e-63 233.00
IUUC-Fox-037940 Fusarium oxysporum 48.28 1.00e-22 99.00
IUUC-Fso-038465 Fusarium solani 50.00 7.00e-23 100.00
IUUC-Ggr-040089 Gaeumannomyces graminis 44.83 1.00e-20 92.40
IUUC-Gga-040910 Gallus gallus 68.94 4.00e-62 230.00
IUUC-Gma-044349 Glycine max 47.11 3.00e-25 107.00
IUUC-Ggo-044854 Gorilla gorilla 74.04 5.00e-69 253.00
IUUC-Hsa-046921 Homo sapiens 73.08 2.00e-67 248.00
IUUC-Hvu-047142 Hordeum vulgare 43.51 3.00e-25 108.00
IUUC-Kpa-049187 Komagataella pastoris 41.23 6.00e-16 76.60
IUUC-Lch-050614 Latimeria chalumnae 73.28 5.00e-55 206.00
IUUC-Lpe-051184 Leersia perrieri 42.50 2.00e-24 105.00
IUUC-Loc-052083 Lepisosteus oculatus 68.07 5.00e-47 179.00
IUUC-Lma-053209 Leptosphaeria maculans 41.07 3.00e-15 74.30
IUUC-Laf-054090 Loxodonta africana 72.12 6.00e-78 283.00
IUUC-Meu-056814 Macropus eugenii 74.15 2.00e-63 234.00
IUUC-Mor-057169 Magnaporthe oryzae 47.86 3.00e-22 98.20
IUUC-Mpo-057483 Magnaporthe poae 46.55 6.00e-22 97.40
IUUC-Mtr-058166 Medicago truncatula 47.75 5.00e-20 90.50
IUUC-Mla-059015 Melampsora laricipopulina 43.52 3.00e-18 84.30
IUUC-Mvi-060356 Microbotryum violaceum 52.27 6.00e-20 90.50
IUUC-Mdo-062658 Monodelphis domestica 76.87 4.00e-63 233.00
IUUC-Mac-065327 Musa acuminata 48.76 2.00e-26 111.00
IUUC-Mpu-065761 Mustela putorius furo 82.35 6.00e-66 242.00
IUUC-Mlu-067175 Myotis lucifugus 69.41 2.00e-76 278.00
IUUC-Nfi-068535 Neosartorya fischeri 38.64 2.00e-17 82.00
IUUC-Ncr-068966 Neurospora crassa 42.52 2.00e-21 95.50
IUUC-Opr-070533 Ochotona princeps 52.38 6.00e-30 123.00
IUUC-Oan-073024 Ornithorhynchus anatinus 80.67 9.00e-59 219.00
IUUC-Ocu-074451 Oryctolagus cuniculus 72.87 1.00e-64 239.00
IUUC-Oba-075540 Oryza barthii 45.69 3.00e-24 105.00
IUUC-Obr-076285 Oryza brachyantha 42.98 1.00e-24 107.00
IUUC-Ogl-077827 Oryza glaberrima 45.69 3.00e-24 105.00
IUUC-Ogu-078491 Oryza glumaepatula 45.69 2.00e-24 105.00
IUUC-Oin-080149 Oryza indica 45.69 3.00e-24 104.00
IUUC-Olo-080318 Oryza longistaminata 43.44 2.00e-22 98.20
IUUC-Oni-083037 Oryza nivara 45.69 3.00e-24 105.00
IUUC-Opu-083448 Oryza punctata 45.69 2.00e-24 105.00
IUUC-Oru-084793 Oryza rufipogon 46.55 9.00e-25 106.00
IUUC-Osa-086032 Oryza sativa 45.69 3.00e-24 105.00
IUUC-Ola-086956 Oryzias latipes 62.50 2.00e-42 165.00
IUUC-Olu-087806 Ostreococcus lucimarinus 44.00 7.00e-16 76.60
IUUC-Oga-089029 Otolemur garnettii 75.71 4.00e-76 276.00
IUUC-Oar-089471 Ovis aries 66.82 1.00e-69 255.00
IUUC-Pan-092091 Papio anubis 72.60 1.00e-79 288.00
IUUC-Psi-093193 Pelodiscus sinensis 78.91 2.00e-66 244.00
IUUC-Pma-094540 Petromyzon marinus 63.03 8.00e-43 165.00
IUUC-Pno-094873 Phaeosphaeria nodorum 32.83 4.00e-17 81.30
IUUC-Ppa-095343 Physcomitrella patens 46.59 1.00e-18 86.70
IUUC-Pfo-097093 Poecilia formosa 56.25 1.00e-44 172.00
IUUC-Pab-098781 Pongo abelii 95.00 1.00e-28 118.00
IUUC-Pop-098983 Populus trichocarpa 41.80 6.00e-22 97.10
IUUC-Pca-100872 Procavia capensis 64.93 1.00e-56 212.00
IUUC-Ppe-101711 Prunus persica 44.83 7.00e-21 93.60
IUUC-Pva-102256 Pteropus vampyrus 72.51 2.00e-76 278.00
IUUC-Pgr-103607 Puccinia graminis 43.55 1.00e-20 92.80
IUUC-Pte-104220 Pyrenophora teres 36.97 7.00e-15 72.80
IUUC-Pyt-104562 Pyrenophora triticirepentis 36.97 2.00e-15 75.50
IUUC-Rno-105021 Rattus norvegicus 87.02 2.00e-101 360.00
IUUC-Sce-106182 Saccharomyces cerevisiae 48.61 1.00e-15 75.50
IUUC-Sha-107279 Sarcophilus harrisii 77.55 6.00e-64 236.00
IUUC-Sja-107819 Schizosaccharomyces japonicus 40.65 3.00e-20 90.90
IUUC-Spo-108197 Schizosaccharomyces pombe 42.11 1.00e-19 89.00
IUUC-Smo-108810 Selaginella moellendorffii 53.57 2.00e-21 94.00
IUUC-Sit-110256 Setaria italica 41.22 6.00e-24 103.00
IUUC-Sly-111448 Solanum lycopersicum 44.26 4.00e-23 100.00
IUUC-Stu-112702 Solanum tuberosum 44.26 3.00e-23 101.00
IUUC-Sbi-113956 Sorghum bicolor 45.83 7.00e-26 110.00
IUUC-Sre-115024 Sporisorium reilianum 31.87 2.00e-17 82.40
IUUC-Ssc-116034 Sus scrofa 72.04 1.00e-78 285.00
IUUC-Tgu-117503 Taeniopygia guttata 74.65 8.00e-56 208.00
IUUC-Tsy-119166 Tarsius syrichta 63.64 2.00e-40 158.00
IUUC-Tni-120703 Tetraodon nigroviridis 38.76 1.00e-25 109.00
IUUC-Tca-121473 Theobroma cacao 48.96 4.00e-20 90.90
IUUC-Tre-122241 Trichoderma reesei 43.97 1.00e-19 89.00
IUUC-Tvi-122347 Trichoderma virens 41.38 5.00e-18 84.00
IUUC-Tae-124560 Triticum aestivum 43.33 1.00e-23 102.00
IUUC-Tur-126452 Triticum urartu 45.61 9.00e-25 106.00
IUUC-Tme-127205 Tuber melanosporum 47.92 1.00e-18 84.70
IUUC-Ttr-128186 Tursiops truncatus 72.87 3.00e-69 254.00
IUUC-Uma-129523 Ustilago maydis 33.82 5.00e-15 74.30
IUUC-Vda-129793 Verticillium dahliae 44.83 2.00e-20 92.00
IUUC-Vpa-130040 Vicugna pacos 87.07 4.00e-72 263.00
IUUC-Vvi-131588 Vitis vinifera 41.41 4.00e-21 94.40
IUUC-Yli-134631 Yarrowia lipolytica 35.33 4.00e-19 87.40
IUUC-Zma-135478 Zea mays 46.22 3.00e-26 111.00
Created Date 25-Jun-2017

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