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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106216
UUCD1 version UUC-SaC-00075
Ensembl Protein ID YPL149W
UniProt Accession Q12380; D6W3M0; ATG5_YEAST
Genbank Protein ID BAA11937.1; CAA65572.1; CAA97854.1; DAA11286.1
Protein Name Autophagy protein 5
Genbank Nucleotide ID D83519; X96770; Z73505; BK006949
Gene Name ATG5; APG5; YPL149W; P2601
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPL149W YPL149W YPL149W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Other E3 adaptor/Cullin RING/Other 17986448
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity. Plays a role in the regulation of filamentous growth and chronological longevity.
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity. Plays a role in the regulation of filamentous growth and chronological longevity.
Protein Sequence
(Fasta)
MNDIKQLLWN GELNVLVSID PSFLMKGSPR EIAVLRIRVP RETYLVNYMP LIWNKIKSFL 60
SFDPLTDSEK YFWFEHNKTP IPWNYPVGVL FDCLAGKSAT FTTSFENQVK DVLTFLRIHL 120
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Protein Fasta Sequence



>IUUC-Sce-106216|E3,Cullin RING/Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAATGACA TTAAACAATT ACTTTGGAAT GGTGAGCTTA ATGTGCTGGT ATCGATCGAT 60
CCTTCATTTT TGATGAAAGG AAGTCCAAGA GAAATTGCGG TGCTACGAAT AAGGGTACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Sce-106216|E3,Cullin RING/Other|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0008047--F:enzyme activator activity
GO:0016787--F:hydrolase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus

KEGG sce:YPL149W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 25.33 7.00e-09 54.30
IUUC-Aml-002403 Ailuropoda melanoleuca 24.50 6.00e-10 55.80
IUUC-Atr-002645 Amborella trichopoda 24.36 2.00e-07 47.80
IUUC-Apl-003611 Anas platyrhynchos 22.30 2.00e-11 61.20
IUUC-Aca-004411 Anolis carolinensis 22.90 5.00e-10 56.20
IUUC-Aly-005636 Arabidopsis lyrata 24.06 2.00e-07 47.80
IUUC-Ath-006959 Arabidopsis thaliana 23.85 3.00e-07 47.00
IUUC-Ago-007978 Ashbya gossypii 31.72 4.00e-40 156.00
IUUC-Acl-008328 Aspergillus clavatus 24.19 1.00e-08 52.00
IUUC-Afl-008638 Aspergillus flavus 24.63 8.00e-12 62.40
IUUC-Afu-009042 Aspergillus fumigatus 23.15 1.00e-09 54.70
IUUC-Ani-009364 Aspergillus nidulans 25.85 4.00e-16 76.60
IUUC-Aor-009889 Aspergillus oryzae 24.63 8.00e-12 62.40
IUUC-Ate-010511 Aspergillus terreus 32.26 3.00e-04 35.00
IUUC-Ame-011644 Astyanax mexicanus 24.69 3.00e-03 30.80
IUUC-Bgr-012153 Blumeria graminis 23.39 1.00e-04 38.10
IUUC-Bta-012360 Bos taurus 26.37 2.00e-06 42.70
IUUC-Bci-013723 Botrytis cinerea 34.48 1.00e-04 38.10
IUUC-Bdi-014520 Brachypodium distachyon 21.46 1.00e-07 48.90
IUUC-Bol-016053 Brassica oleracea 26.00 2.00e-10 57.40
IUUC-Bra-017072 Brassica rapa 26.00 2.00e-10 57.80
IUUC-Cel-018529 Caenorhabditis elegans 20.61 2.00e-05 40.80
IUUC-Cja-019569 Callithrix jacchus 23.05 1.00e-09 54.70
IUUC-Cfa-020473 Canis familiaris 23.05 2.00e-09 54.30
IUUC-Cpo-021421 Cavia porcellus 23.55 3.00e-09 53.10
IUUC-Cre-022862 Chlamydomonas reinhardtii 20.73 3.00e-05 40.00
IUUC-Csa-024197 Chlorocebus sabaeus 23.05 6.00e-10 55.80
IUUC-Cho-024521 Choloepus hoffmanni 24.21 2.00e-09 53.90
IUUC-Cin-025119 Ciona intestinalis 21.60 1.00e-05 41.20
IUUC-Csv-026192 Ciona savignyi 23.37 2.00e-08 50.40
IUUC-Cgl-026686 Colletotrichum gloeosporioides 23.46 1.00e-03 35.00
IUUC-Dre-028466 Danio rerio 23.55 2.00e-12 64.30
IUUC-Dse-031228 Dothistroma septosporum 22.65 5.00e-11 59.70
IUUC-Dme-031703 Drosophila melanogaster 20.25 2.00e-08 50.80
IUUC-Ete-032482 Echinops telfairi 23.51 3.00e-07 46.60
IUUC-Eca-034036 Equus caballus 23.99 8.00e-10 55.50
IUUC-Eeu-035235 Erinaceus europaeus 26.37 6.00e-06 42.70
IUUC-Fca-036263 Felis catus 23.39 6.00e-10 55.80
IUUC-Fal-037064 Ficedula albicollis 21.69 4.00e-11 59.70
IUUC-Fox-037813 Fusarium oxysporum 20.39 2.00e-03 34.30
IUUC-Fso-038139 Fusarium solani 25.49 8.00e-06 42.00
IUUC-Gmo-039509 Gadus morhua 23.05 9.00e-08 48.10
IUUC-Ggr-040111 Gaeumannomyces graminis 23.08 5.00e-06 43.10
IUUC-Gga-040517 Gallus gallus 22.97 3.00e-12 63.50
IUUC-Gac-042270 Gasterosteus aculeatus 21.58 3.00e-07 47.00
IUUC-Gma-044400 Glycine max 25.49 1.00e-10 58.20
IUUC-Ggo-045048 Gorilla gorilla 24.72 1.00e-10 57.80
IUUC-Hsa-046744 Homo sapiens 23.39 1.00e-10 58.20
IUUC-Hvu-047083 Hordeum vulgare 25.43 9.30e-02 31.20
IUUC-Kpa-049174 Komagataella pastoris 28.34 4.00e-25 106.00
IUUC-Lch-049475 Latimeria chalumnae 22.92 1.00e-08 51.60
IUUC-Lpe-051283 Leersia perrieri 23.67 2.00e-11 63.20
IUUC-Loc-052446 Lepisosteus oculatus 20.95 2.00e-09 53.90
IUUC-Lma-053278 Leptosphaeria maculans 20.74 2.00e-08 51.20
IUUC-Laf-054020 Loxodonta africana 24.50 5.00e-10 55.80
IUUC-Mcc-055176 Macaca mulatta 23.39 1.00e-10 58.20
IUUC-Mor-057164 Magnaporthe oryzae 25.49 5.00e-06 42.70
IUUC-Mpo-057428 Magnaporthe poae 24.84 6.00e-07 45.80
IUUC-Mtr-058424 Medicago truncatula 23.68 3.00e-09 53.50
IUUC-Mla-058872 Melampsora laricipopulina 24.27 1.00e-11 62.00
IUUC-Mga-059859 Meleagris gallopavo 22.97 3.00e-12 63.50
IUUC-Mmr-061482 Microcebus murinus 23.05 2.00e-09 54.30
IUUC-Mdo-062371 Monodelphis domestica 22.37 1.00e-12 64.70
IUUC-Mmu-063139 Mus musculus 23.99 4.00e-10 56.20
IUUC-Mac-065332 Musa acuminata 27.33 3.00e-12 63.90
IUUC-Mpu-066783 Mustela putorius furo 23.29 1.00e-09 54.70
IUUC-Mlu-068165 Myotis lucifugus 25.42 5.00e-11 59.30
IUUC-Nfi-068578 Neosartorya fischeri 22.77 8.00e-10 55.80
IUUC-Ncr-068636 Neurospora crassa 34.09 1.00e-03 35.40
IUUC-Nle-069740 Nomascus leucogenys 23.39 2.00e-10 57.80
IUUC-Opr-070802 Ochotona princeps 32.31 6.00e-06 42.70
IUUC-Ont-072222 Oreochromis niloticus 23.39 8.00e-11 58.50
IUUC-Oan-072760 Ornithorhynchus anatinus 23.12 2.00e-08 50.10
IUUC-Ocu-074844 Oryctolagus cuniculus 23.74 1.00e-03 33.90
IUUC-Oba-075834 Oryza barthii 21.77 2.00e-10 58.20
IUUC-Obr-076230 Oryza brachyantha 23.64 3.00e-05 40.00
IUUC-Ogl-077554 Oryza glaberrima 22.18 8.00e-11 59.30
IUUC-Ogu-078687 Oryza glumaepatula 21.74 2.00e-10 58.20
IUUC-Oin-079677 Oryza indica 22.31 7.00e-10 56.20
IUUC-Olo-081078 Oryza longistaminata 22.18 7.00e-11 60.10
IUUC-Ome-081548 Oryza meridionalis 22.18 2.00e-10 59.30
IUUC-Oni-082050 Oryza nivara 22.18 5.00e-11 60.10
IUUC-Opu-083609 Oryza punctata 22.58 2.00e-11 60.80
IUUC-Oru-085057 Oryza rufipogon 22.18 4.00e-11 60.10
IUUC-Osa-085917 Oryza sativa 22.18 1.00e-11 61.60
IUUC-Ola-087032 Oryzias latipes 23.55 3.00e-13 66.60
IUUC-Olu-087877 Ostreococcus lucimarinus 23.58 4.00e-03 32.00
IUUC-Oga-088468 Otolemur garnettii 24.16 6.00e-12 62.40
IUUC-Oar-089751 Ovis aries 23.99 2.00e-09 53.90
IUUC-Ptr-091064 Pan troglodytes 23.39 1.00e-10 58.20
IUUC-Pan-092505 Papio anubis 24.50 5.00e-10 56.20
IUUC-Psi-093086 Pelodiscus sinensis 22.15 3.00e-10 56.60
IUUC-Pno-094825 Phaeosphaeria nodorum 20.58 2.00e-12 63.90
IUUC-Ppa-095419 Physcomitrella patens 20.00 2.00e-06 44.70
IUUC-Pfo-096224 Poecilia formosa 23.31 3.00e-12 63.50
IUUC-Pab-098501 Pongo abelii 24.72 2.00e-10 57.40
IUUC-Pop-099243 Populus trichocarpa 25.33 8.00e-08 48.90
IUUC-Ppe-101255 Prunus persica 25.00 3.00e-09 53.90
IUUC-Pva-102828 Pteropus vampyrus 23.31 3.00e-09 53.50
IUUC-Pgr-103672 Puccinia graminis 23.12 5.00e-12 63.20
IUUC-Ptt-104013 Puccinia triticina 24.19 7.00e-13 65.90
IUUC-Pyt-104615 Pyrenophora triticirepentis 19.05 9.00e-08 48.90
IUUC-Rno-106089 Rattus norvegicus 25.20 3.00e-09 53.10
IUUC-Sha-106484 Sarcophilus harrisii 22.71 5.00e-14 69.30
IUUC-Sja-107699 Schizosaccharomyces japonicus 20.98 9.00e-10 55.10
IUUC-Spo-108177 Schizosaccharomyces pombe 26.83 2.00e-19 87.40
IUUC-Ssl-108475 Sclerotinia sclerotiorum 34.48 1.00e-04 37.70
IUUC-Smo-109473 Selaginella moellendorffii 22.70 1.00e-07 48.50
IUUC-Sit-110736 Setaria italica 23.38 1.00e-09 55.50
IUUC-Sly-111657 Solanum lycopersicum 23.71 3.00e-12 64.30
IUUC-Sar-113050 Sorex araneus 36.17 2.00e-05 40.40
IUUC-Sbi-114258 Sorghum bicolor 23.81 6.00e-09 53.10
IUUC-Sre-114902 Sporisorium reilianum 25.00 3.00e-13 67.80
IUUC-Ssc-116166 Sus scrofa 23.05 2.00e-08 51.20
IUUC-Tgu-116814 Taeniopygia guttata 22.97 2.00e-12 64.30
IUUC-Tru-118172 Takifugu rubripes 22.30 9.00e-10 55.50
IUUC-Tsy-119010 Tarsius syrichta 28.57 9.00e-08 48.50
IUUC-Tni-120397 Tetraodon nigroviridis 29.36 2.00e-07 47.00
IUUC-Tca-121283 Theobroma cacao 26.32 1.00e-09 55.10
IUUC-Tvi-122545 Trichoderma virens 23.81 2.00e-02 30.80
IUUC-Tae-122685 Triticum aestivum 25.66 1.00e-09 55.10
IUUC-Tur-126407 Triticum urartu 25.00 4.00e-09 53.50
IUUC-Tme-126913 Tuber melanosporum 25.00 3.00e-18 83.60
IUUC-Tbe-127738 Tupaia belangeri 22.90 7.00e-03 31.60
IUUC-Ttr-128528 Tursiops truncatus 23.05 4.00e-09 53.10
IUUC-Uma-129625 Ustilago maydis 22.97 1.00e-11 62.80
IUUC-Vda-129906 Verticillium dahliae 24.83 7.00e-08 48.90
IUUC-Vpa-130223 Vicugna pacos 23.21 3.00e-09 53.10
IUUC-Vvi-131617 Vitis vinifera 24.19 7.00e-08 49.30
IUUC-Xtr-132288 Xenopus tropicalis 22.37 8.00e-10 55.50
IUUC-Xma-134214 Xiphophorus maculatus 31.19 6.00e-10 55.10
IUUC-Yli-134377 Yarrowia lipolytica 22.22 5.00e-07 46.20
IUUC-Zma-135108 Zea mays 23.81 3.00e-09 53.90
Created Date 25-Jun-2017

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