iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125684

Ensembl Protein ID

TRIAE_CS42_5DL_TGACv1_435385_AA1449910.2

UniProt Accession

A0A1D5ZVN0; A0A1D5ZVN0_WHEAT

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_5DL_TGACv1_435385_AA1449910	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.1	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.1
TRIAE_CS42_5DL_TGACv1_435385_AA1449910	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.2	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.2
TRIAE_CS42_5DL_TGACv1_435385_AA1449910	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.3	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.3
TRIAE_CS42_5DL_TGACv1_435385_AA1449910	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.4	TRIAE_CS42_5DL_TGACv1_435385_AA1449910.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.00e-102	346.2	65	576

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedv 69
           YDRQ+r+wG+++q++l++a+++l+++g++G+E lKnLvl+G+gs+tvvD+++ve+s+l+++FL+++   
   Q: 65   YDRQLRIWGDQGQAALEKASICLLNCGPTGTEALKNLVLGGIGSVTVVDGSKVEQSDLGNNFLLDEGCL 133
           ********************************************************************* PP
   S: 70   gksKAevaaealkelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpl 137
           g+s+A++ + +l+eln+ v+++ +ees+ +  ++++ Ff++f+vV++++  +++ +k++++c++a++ l
   Q: 134  GQSRAKSICSFLQELNDAVKAKYVEESPATMIDTNPsFFSQFTVVLATQLLESSLLKLDSICRSANIVL 202
           **********************************99********************************* PP
   S: 138  iesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiewavlfn 194
           + ++++Gl G vrv+ik++ +++s++d   d++++ +P+++lk++           +++++++++v++ 
   Q: 203  VAARSYGLTGLVRVSIKEHCVIESKPDhslDDLRLHNPWPELKQFAKsidicdkdpVVHKHTPYIVILV 271
           *********************************************99999999999************* PP
   S: 195  klleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfec 262
            l+e++a +++++ +++++ek+e+kd++++ + + de+n++ea+e + k   +  i++ i+q++++ + 
   Q: 272  RLAEKWADAHDGQLPSTRQEKREFKDLIRAHMLNVDEDNYKEAVESSYKVSVTPGISDeIRQIIDD-SS 339
           ******************************************************************.55 PP
   S: 263  divtkskspfwv......................................................... 274
            +v+ s+s+fwv                                                         
   Q: 340  SEVNFSSSDFWVlvaslkefianegngelplegtipdmtslteyyvslqkiyqakaesdclaiehrvks 408
           599****************************************************************** PP
   S: 275  ..................sfcsnaealq..............vpekvekdeevvkasap.....lylll 306
                             +fc+n+++l+              v     + +++++++++     +y+ll
   Q: 409  ilrrigrdpdsisracikTFCKNTRKLKvcryrsmeeefsspV---LSEVKKYFADEDScfamnFYVLL 474
           ****************************666665555543221...223333333333367788***** PP
   S: 307  ralerfekkkgrkpgels...fekddds.avdlvtaaanlraeslgiep.kldddlikeiagniipaia 370
           ra++r++++++r pg ++   f  +  + +++l++aa +   +++g+++  l++dli+e+++++ ++i+
   Q: 475  RAVDRLAANYSRLPGIFDstgFTSEIGEdVPRLKEAAVSVL-SDMGLKGsSLSEDLIAEVCRFAGAEIH 542
           **************966511144554446777877777666.*************************** PP
   S: 371  ttnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +++a++gG+a+qEviK+v+++f+pl+ +f+f+++
   Q: 543  PVAAFIGGVASQEVIKLVTKQFVPLNGTFIFNGI 576
           *******************************986 PP

Organism

Triticum aestivum

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MHGRAGAKRL APTSASREQL HAREGGVAIP HLVPLPLLGR SHRRETTASA AMAAAAAAAE 60
PKTKYDRQLR IWGDQGQAAL EKASICLLNC GPTGTEALKN LVLGGIGSVT VVDGSKVEQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCATGTTT GCTTTGAGAC AGGCTGAGAG GATAGTACGC ATCATCCGGC CGTTCCTTGG 60
AATTGGATGC ACGGACGAGC CGGTGCAAAA CGCCTTGCAC CCACCTCCGC ATCGCGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	99.81	0.00e+00	1047.00
IUUC-Acl-008333	Aspergillus clavatus	33.33	9.00e-72	265.00
IUUC-Afl-008529	Aspergillus flavus	33.21	6.00e-77	282.00
IUUC-Afu-009071	Aspergillus fumigatus	32.69	6.00e-70	258.00
IUUC-Ani-009443	Aspergillus nidulans	32.42	6.00e-65	242.00
IUUC-Ang-009669	Aspergillus niger	32.79	1.00e-74	275.00
IUUC-Aor-009914	Aspergillus oryzae	32.91	4.00e-75	276.00
IUUC-Ate-010450	Aspergillus terreus	32.25	1.00e-70	261.00
IUUC-Bci-013892	Botrytis cinerea	31.32	1.00e-60	227.00
IUUC-Bra-017506	Brassica rapa	64.90	0.00e+00	726.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.90	2.00e-59	224.00
IUUC-Cne-026884	Cryptococcus neoformans	31.31	1.00e-68	254.00
IUUC-Lma-053112	Leptosphaeria maculans	32.68	4.00e-73	269.00
IUUC-Nfi-068245	Neosartorya fischeri	32.98	6.00e-70	258.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.04	4.00e-62	234.00
IUUC-Pte-104355	Pyrenophora teres	33.09	3.00e-71	263.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	32.97	2.00e-70	260.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.66	2.00e-33	137.00
IUUC-Tre-122103	Trichoderma reesei	32.84	3.00e-74	273.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence