iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118686

UUCD1 version

UUC-TaR-01077

Ensembl Protein ID

ENSTRUP00000044180.1

UniProt Accession

H2V4P6; H2V4P6_TAKRU

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Gene Name

nae1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017245.1	ENSTRUT00000044328.1	ENSTRUP00000044180.1
ENSTRUG00000017245.1	ENSTRUT00000044329.1	ENSTRUP00000044181.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.40e-115	386.8	12	524

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l++++v+l++a+++G+E+lKnLvl G+g +t+vD++ v+ ++++++F+++ +++gk++A++a e l+eln+dv+
   Q: 12   YDRQLRLWGDHGQESLENSHVCLINATATGTEILKNLVLPGIGAFTIVDGHVVTGEDVGNNFFLSNSSIGKNRAQAATELLQELNSDVS 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ees+++l ++++ Ff +f++V+  + ++++ +++ +++++a+vp+++++t+Gl+G++r +++++t+++s++d   +++++++Pf 
   Q: 101  GNFVEESPDKLLDNDPeFFHRFSIVIGVQLPESTFLRLGTVLWSASVPFLICKTYGLIGYMRLVVQEHTVIESHPDnalEDLRLDQPFA 189
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +lk+++          +++++++w+ +++k+le++ +e++++++++++eke++++ +++++++      edeenfeeai+ +++a+ +t
   Q: 190  ELKDHVKsydldnmdkKDHSHTPWIIIVAKYLEKWLSEHNCQPPKNYKEKEAFRQFIREGIRKnengvpEDEENFEEAIKSVNTALTPT 278
           *****88888889998************************************************************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i+s +k+l++s +c++vt+++++fw+                                                              
   Q: 279  KIPSvVKDLFNSEQCNNVTSQTPSFWLmlqavkefvlnegngslpvrgtipdmiadsqkfiklqnvyrtkamqdaaavskyverllqsv 367
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavd 334
                         fc+n++ l+v            ++v+ de+++ +++p     +yl+lr+++rf ++++  pg+ ++++++d +++
   Q: 368  gkppesipeqdikLFCKNSSFLRVVhcrsladeysvDTVNRDEITSCMDNPdsemvFYLMLRSIDRFYQQHSHFPGVYNYQVEED-IIK 455
           ***********************666666666666677777777777777777778*****************************.999 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           l+  + +l  ++++ + +++dd+i+e++++++++ + +++++gG aaqE+iK++s++f+p+ n+f++ a+
   Q: 456  LKLCVNSLL-QEYNFNVNIKDDYIHEFCRYGAAEPHMVASFLGGSAAQEAIKIISHQFVPFSNTFIYSAM 524
           999888888.********************************************************9876 PP

Organism

Takifugu rubripes

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAATKASKEQ KYDRQLRLWG DHGQESLENS HVCLINATAT GTEILKNLVL PGIGAFTIVD 60
GHVVTGEDVG NNFFLSNSSI GKNRAQAATE LLQELNSDVS GNFVEESPDK LLDNDPEFFH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGGCAGCC ACCAAAGCGT CCAAAGAACA AAAATACGAC AGACAACTGA GGTAAATTTA 60
AACTATACTG CAAACGTCAC AAAACACTGT GTTTTTCCTA CATGCATTTC TGCATAGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

tru:101063444

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	39.55	1.00e-120	426.00
IUUC-Aml-002333	Ailuropoda melanoleuca	71.75	0.00e+00	835.00
IUUC-Atr-002644	Amborella trichopoda	37.83	2.00e-108	385.00
IUUC-Apl-003446	Anas platyrhynchos	70.91	0.00e+00	800.00
IUUC-Aca-004450	Anolis carolinensis	70.34	0.00e+00	816.00
IUUC-Aly-006187	Arabidopsis lyrata	39.51	8.00e-124	437.00
IUUC-Ath-006692	Arabidopsis thaliana	39.47	8.00e-124	437.00
IUUC-Ago-007900	Ashbya gossypii	27.04	1.00e-40	160.00
IUUC-Acl-008333	Aspergillus clavatus	34.48	5.00e-84	305.00
IUUC-Afl-008529	Aspergillus flavus	34.77	3.00e-86	312.00
IUUC-Afu-009071	Aspergillus fumigatus	34.71	9.00e-87	314.00
IUUC-Ani-009443	Aspergillus nidulans	34.77	3.00e-82	299.00
IUUC-Ang-009669	Aspergillus niger	33.45	1.00e-84	307.00
IUUC-Aor-009914	Aspergillus oryzae	34.64	8.00e-85	307.00
IUUC-Ate-010450	Aspergillus terreus	33.69	5.00e-86	311.00
IUUC-Ame-011183	Astyanax mexicanus	80.49	0.00e+00	937.00
IUUC-Bgr-012111	Blumeria graminis	29.71	2.00e-58	219.00
IUUC-Bta-012583	Bos taurus	72.02	0.00e+00	837.00
IUUC-Bci-013892	Botrytis cinerea	32.66	7.00e-63	234.00
IUUC-Bdi-014592	Brachypodium distachyon	40.49	2.00e-124	439.00
IUUC-Bol-016399	Brassica oleracea	39.89	5.00e-124	437.00
IUUC-Bra-017506	Brassica rapa	39.09	2.00e-120	425.00
IUUC-Cel-018456	Caenorhabditis elegans	36.28	5.00e-94	338.00
IUUC-Cja-020007	Callithrix jacchus	71.24	0.00e+00	830.00
IUUC-Cfa-020324	Canis familiaris	71.83	0.00e+00	837.00
IUUC-Cpo-022248	Cavia porcellus	61.47	2.00e-129	456.00
IUUC-Csa-023149	Chlorocebus sabaeus	67.52	0.00e+00	697.00
IUUC-Cho-024537	Choloepus hoffmanni	61.17	6.00e-174	603.00
IUUC-Cin-025763	Ciona intestinalis	47.38	2.00e-153	536.00
IUUC-Csv-026113	Ciona savignyi	44.65	6.00e-143	500.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.34	1.00e-68	253.00
IUUC-Cne-026884	Cryptococcus neoformans	29.47	2.00e-72	266.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.23	6.00e-18	85.90
IUUC-Dre-028140	Danio rerio	83.11	0.00e+00	948.00
IUUC-Dno-030033	Dasypus novemcinctus	70.88	0.00e+00	728.00
IUUC-Dor-030513	Dipodomys ordii	48.88	4.00e-81	295.00
IUUC-Dse-031536	Dothistroma septosporum	31.32	3.00e-79	289.00
IUUC-Dme-031683	Drosophila melanogaster	41.68	2.00e-123	435.00
IUUC-Ete-032420	Echinops telfairi	61.82	0.00e+00	679.00
IUUC-Eca-033992	Equus caballus	69.59	0.00e+00	684.00
IUUC-Eeu-034713	Erinaceus europaeus	57.48	2.00e-86	313.00
IUUC-Fca-036548	Felis catus	71.08	0.00e+00	824.00
IUUC-Fal-037600	Ficedula albicollis	69.92	0.00e+00	780.00
IUUC-Fox-038037	Fusarium oxysporum	36.36	4.00e-67	248.00
IUUC-Fso-038387	Fusarium solani	34.00	1.00e-75	277.00
IUUC-Gmo-038562	Gadus morhua	81.50	0.00e+00	941.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.77	7.00e-70	258.00
IUUC-Gga-041129	Gallus gallus	71.48	0.00e+00	811.00
IUUC-Gac-042558	Gasterosteus aculeatus	85.98	0.00e+00	974.00
IUUC-Gma-043610	Glycine max	38.61	2.00e-116	412.00
IUUC-Ggo-045611	Gorilla gorilla	71.24	0.00e+00	831.00
IUUC-Hsa-046563	Homo sapiens	71.46	0.00e+00	834.00
IUUC-Hvu-047790	Hordeum vulgare	36.02	3.00e-76	278.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	71.46	0.00e+00	829.00
IUUC-Kpa-049309	Komagataella pastoris	34.22	7.00e-79	288.00
IUUC-Lch-050038	Latimeria chalumnae	71.72	0.00e+00	828.00
IUUC-Lpe-051535	Leersia perrieri	39.80	3.00e-108	385.00
IUUC-Loc-051917	Lepisosteus oculatus	75.42	0.00e+00	847.00
IUUC-Lma-053112	Leptosphaeria maculans	33.51	8.00e-84	304.00
IUUC-Laf-053690	Loxodonta africana	71.83	0.00e+00	841.00
IUUC-Mcc-055117	Macaca mulatta	69.79	0.00e+00	815.00
IUUC-Meu-056761	Macropus eugenii	58.80	0.00e+00	656.00
IUUC-Mor-057230	Magnaporthe oryzae	33.15	3.00e-76	278.00
IUUC-Mpo-057514	Magnaporthe poae	32.66	3.00e-69	256.00
IUUC-Mtr-058551	Medicago truncatula	37.84	2.00e-115	409.00
IUUC-Mla-059183	Melampsora laricipopulina	35.21	9.00e-97	347.00
IUUC-Mga-060144	Meleagris gallopavo	70.42	0.00e+00	793.00
IUUC-Mvi-060221	Microbotryum violaceum	33.77	4.00e-81	295.00
IUUC-Mmr-061325	Microcebus murinus	69.55	0.00e+00	811.00
IUUC-Mdo-062532	Monodelphis domestica	72.59	0.00e+00	847.00
IUUC-Mmu-063956	Mus musculus	71.83	0.00e+00	837.00
IUUC-Mac-064521	Musa acuminata	38.18	7.00e-118	417.00
IUUC-Mpu-066716	Mustela putorius furo	70.62	0.00e+00	781.00
IUUC-Mlu-067459	Myotis lucifugus	71.46	0.00e+00	832.00
IUUC-Nfi-068245	Neosartorya fischeri	35.28	2.00e-86	313.00
IUUC-Ncr-068910	Neurospora crassa	32.97	3.00e-76	279.00
IUUC-Nle-070034	Nomascus leucogenys	69.14	0.00e+00	801.00
IUUC-Opr-070552	Ochotona princeps	65.93	0.00e+00	684.00
IUUC-Ont-071426	Oreochromis niloticus	88.56	0.00e+00	1006.00
IUUC-Oan-073389	Ornithorhynchus anatinus	69.37	0.00e+00	654.00
IUUC-Ocu-074911	Oryctolagus cuniculus	71.83	0.00e+00	834.00
IUUC-Oba-075437	Oryza barthii	40.49	6.00e-114	404.00
IUUC-Obr-076684	Oryza brachyantha	40.38	4.00e-109	388.00
IUUC-Ogl-077170	Oryza glaberrima	40.49	6.00e-114	404.00
IUUC-Ogu-078844	Oryza glumaepatula	40.64	2.00e-106	379.00
IUUC-Oin-079105	Oryza indica	40.30	5.00e-113	401.00
IUUC-Olo-080943	Oryza longistaminata	37.88	6.00e-101	361.00
IUUC-Oni-082891	Oryza nivara	37.64	8.00e-107	380.00
IUUC-Opu-083457	Oryza punctata	40.11	9.00e-113	400.00
IUUC-Oru-084960	Oryza rufipogon	37.92	2.00e-102	366.00
IUUC-Osa-085358	Oryza sativa	40.27	1.00e-113	403.00
IUUC-Ola-086420	Oryzias latipes	84.45	0.00e+00	665.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.58	3.00e-64	239.00
IUUC-Oga-088810	Otolemur garnettii	71.64	0.00e+00	833.00
IUUC-Oar-089196	Ovis aries	71.80	0.00e+00	833.00
IUUC-Ptr-090617	Pan troglodytes	71.64	0.00e+00	836.00
IUUC-Pan-092761	Papio anubis	71.64	0.00e+00	836.00
IUUC-Psi-093191	Pelodiscus sinensis	71.95	0.00e+00	826.00
IUUC-Pma-094380	Petromyzon marinus	59.43	0.00e+00	647.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.72	2.00e-73	271.00
IUUC-Ppa-095798	Physcomitrella patens	40.64	1.00e-122	433.00
IUUC-Pfo-096467	Poecilia formosa	85.07	0.00e+00	968.00
IUUC-Pab-098255	Pongo abelii	70.84	0.00e+00	693.00
IUUC-Pop-099722	Populus trichocarpa	39.51	9.00e-123	433.00
IUUC-Pca-100807	Procavia capensis	61.89	1.00e-94	340.00
IUUC-Ppe-101280	Prunus persica	38.98	1.00e-121	429.00
IUUC-Pva-102333	Pteropus vampyrus	69.92	0.00e+00	797.00
IUUC-Pgr-103401	Puccinia graminis	30.13	9.00e-78	284.00
IUUC-Ptt-103889	Puccinia triticina	27.15	4.00e-59	222.00
IUUC-Pte-104355	Pyrenophora teres	35.06	1.00e-86	313.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.24	2.00e-87	316.00
IUUC-Rno-105810	Rattus norvegicus	71.83	0.00e+00	829.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.72	1.00e-31	130.00
IUUC-Sha-106770	Sarcophilus harrisii	76.26	1.00e-131	462.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.08	3.00e-75	275.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.27	3.00e-78	286.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.66	3.00e-67	249.00
IUUC-Smo-109296	Selaginella moellendorffii	40.26	2.00e-119	422.00
IUUC-Sit-110157	Setaria italica	41.90	6.00e-129	454.00
IUUC-Sly-111105	Solanum lycopersicum	37.38	2.00e-116	412.00
IUUC-Stu-112469	Solanum tuberosum	37.57	2.00e-117	416.00
IUUC-Sar-113083	Sorex araneus	54.07	2.00e-168	585.00
IUUC-Sbi-113813	Sorghum bicolor	41.42	4.00e-127	448.00
IUUC-Sre-115058	Sporisorium reilianum	35.78	2.00e-77	283.00
IUUC-Tgu-116772	Taeniopygia guttata	70.21	0.00e+00	791.00
IUUC-Tsy-119111	Tarsius syrichta	69.06	7.00e-115	407.00
IUUC-Tni-120231	Tetraodon nigroviridis	84.33	0.00e+00	936.00
IUUC-Tca-121491	Theobroma cacao	38.42	6.00e-116	410.00
IUUC-Tre-122103	Trichoderma reesei	34.07	3.00e-79	289.00
IUUC-Tvi-122672	Trichoderma virens	35.11	6.00e-76	278.00
IUUC-Tae-125679	Triticum aestivum	40.11	8.00e-123	434.00
IUUC-Tur-126487	Triticum urartu	38.78	2.00e-116	412.00
IUUC-Tme-127097	Tuber melanosporum	37.68	6.00e-96	344.00
IUUC-Ttr-128465	Tursiops truncatus	67.29	0.00e+00	770.00
IUUC-Uma-129645	Ustilago maydis	31.95	8.00e-85	307.00
IUUC-Vda-129989	Verticillium dahliae	30.56	2.00e-54	206.00
IUUC-Vpa-130529	Vicugna pacos	68.80	0.00e+00	791.00
IUUC-Vvi-131059	Vitis vinifera	38.61	7.00e-118	417.00
IUUC-Xtr-132002	Xenopus tropicalis	69.98	0.00e+00	816.00
IUUC-Xma-133930	Xiphophorus maculatus	85.55	0.00e+00	971.00
IUUC-Yli-134505	Yarrowia lipolytica	32.83	9.00e-82	297.00
IUUC-Zma-135619	Zea mays	41.04	2.00e-119	422.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence