iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-016844

Ensembl Protein ID

Bra025434.1-P

UniProt Accession

M4E9H8; M4E9H8_BRARP

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra025434	Bra025434.1	Bra025434.1-P

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	61.92	1.00e-91	333.00	IUUC-Ath-007187

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Brassica rapa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MVGVAETSDE VNGSSSSIPS SQKRKRSSVS SSGDGAKKRS LMLLDSDLLD CPICYEPLTV 60
PIFQCDNGHL ACSSCCPKLS NKCHACASPI GDKRCRAMEN VLESIFTPCP NAKMGCTKNV 120

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Nucleotide Sequence
(Fasta)

ATGGTTGGTG TAGCAGAAAC TTCAGACGAA GTCAATGGGT CGAGCAGCAG CATTCCCTCC 60
TCACAAAAGA GAAAACGCTC CTCAGTATCT TCTTCTGGTG ACGGCGCGAA GAAACGCTCG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005653	Arabidopsis lyrata	66.54	4.00e-95	340.00
IUUC-Ath-007187	Arabidopsis thaliana	61.92	4.00e-95	340.00
IUUC-Bdi-014026	Brachypodium distachyon	30.57	1.00e-27	116.00
IUUC-Bol-016089	Brassica oleracea	59.74	4.00e-76	277.00
IUUC-Cgl-026455	Colletotrichum gloeosporioides	31.07	2.00e-06	47.00
IUUC-Hvu-047394	Hordeum vulgare	33.62	4.00e-24	104.00
IUUC-Mtr-058360	Medicago truncatula	39.65	2.00e-40	159.00
IUUC-Oan-072802	Ornithorhynchus anatinus	35.29	8.00e-05	42.00
IUUC-Opu-083398	Oryza punctata	32.41	1.00e-19	91.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence