iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-066982

Ensembl Protein ID

ENSMLUP00000011198.2

UniProt Accession

G1PK87; G1PK87_MYOLU

Genbank Protein ID

ENSMLUP00000011198

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02037052

Gene Name

WDR62

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000012279.2	ENSMLUT00000012298.2	ENSMLUP00000011198.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-26	91.1	125	162
UBD/Beta-Prp	2.20e-51	174.8	466	722

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs..dDgtikvWDlrtgv 34
           gH+ +v c++f ++ +++vs +  +D ++ vWD++++ 
   Q: 125  GHKYGVACVSFsPNmKHIVSMGyqHDMVLNVWDWKKDI 162
           89**********888*****9989*********98765 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgti.kvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdls.tgkcvhtlkgheds 96
           ++++++spd+++la+g r+g + +++ +++   l +++ h+aev ++++s+ +    +l+++s+Dr+i+v +++ ++   +tl  h++s
   Q: 466  VRVMQVSPDGQHLASGDRSGNLrQLHFMDE---LVKMEAHDAEVLCLEYSKPETgltLLASASRDRLIHVLNVEkNYNLEQTLDDHSSS 551
           67899*****************67777777...789*************99887899**************9997888999******** PP
   S: 97   vlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltg 177
           +++++f  ++   ++s ++d+ i     ++g+   +        ++ +   + ++ ++++++ ++ Dr vr+++    k++k+ +  +g
   Q: 552  ITAIKFAGNRdIQMISCGADKSIYFRSAQQGSDGLHfvrtHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTmngKQKKCYKGSQG 640
           ********885789********998666666555544332112222233446677778****************988888889888898 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW.......dlrs 253
            +++s  ++ +d++g++l++   d+++ + d+ +gec+ ++ gh++ v+ ++f+ +  +l+++s D  ++iW       ++ +
   Q: 641  -DEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWhlgpeitNCMK 722
           .999999999**************************************************************66444444443 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

ARRGQSSPPP SPALRRRTRL PTAPEDTVQN RVSLEKVLGI TAQNSSGLTC DPSTGHVAYL 60
AGCVVVILDP KENKQQHIFN TARKSLSSLA FSPDGKYIVT GENGHRPTVR IWDVDEKSQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGAGAG GCCAGTCCTC CCCGCCCCCT TCTCCAGCGC TCCGCCGGCG GACGCGACTC 60
CCCACGGCGC CCGAGGACAC AGTGCAGAAC CGGGTGAGGA GCGCTTGCCC TGCCCTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR002469--Peptidase_S9B_N
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR030545--WDR62

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0007099--P:centriole replication
GO:0021987--P:cerebral cortex development
GO:0007052--P:mitotic spindle organization
GO:0022008--P:neurogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001371	Ailuropoda melanoleuca	81.73	0.00e+00	2316.00
IUUC-Aca-004935	Anolis carolinensis	69.31	0.00e+00	979.00
IUUC-Afu-008757	Aspergillus fumigatus	22.08	1.00e-29	125.00
IUUC-Bta-013336	Bos taurus	81.32	0.00e+00	2248.00
IUUC-Cja-019094	Callithrix jacchus	75.89	0.00e+00	2105.00
IUUC-Cfa-020529	Canis familiaris	80.28	0.00e+00	2335.00
IUUC-Cpo-021970	Cavia porcellus	85.20	0.00e+00	1575.00
IUUC-Cre-022999	Chlamydomonas reinhardtii	28.38	1.00e-13	72.00
IUUC-Csa-024161	Chlorocebus sabaeus	76.66	0.00e+00	2090.00
IUUC-Cho-024310	Choloepus hoffmanni	83.26	0.00e+00	1122.00
IUUC-Cgl-026454	Colletotrichum gloeosporioides	22.48	3.00e-23	103.00
IUUC-Dno-029933	Dasypus novemcinctus	74.72	0.00e+00	2034.00
IUUC-Dor-031147	Dipodomys ordii	74.60	0.00e+00	1977.00
IUUC-Dse-031501	Dothistroma septosporum	28.86	3.00e-23	104.00
IUUC-Eca-033675	Equus caballus	81.55	0.00e+00	2244.00
IUUC-Fca-035826	Felis catus	80.99	0.00e+00	2361.00
IUUC-Gma-043644	Glycine max	31.54	6.00e-99	355.00
IUUC-Ggo-045152	Gorilla gorilla	78.10	0.00e+00	2097.00
IUUC-Hsa-045891	Homo sapiens	78.21	0.00e+00	2101.00
IUUC-Itr-048019	Ictidomys tridecemlineatus	93.05	0.00e+00	1507.00
IUUC-Lch-049669	Latimeria chalumnae	59.40	0.00e+00	986.00
IUUC-Loc-052488	Lepisosteus oculatus	59.50	0.00e+00	1009.00
IUUC-Laf-053992	Loxodonta africana	77.30	0.00e+00	2155.00
IUUC-Mcc-054994	Macaca mulatta	77.83	0.00e+00	2090.00
IUUC-Meu-056815	Macropus eugenii	79.54	0.00e+00	1394.00
IUUC-Mtr-058383	Medicago truncatula	30.95	3.00e-49	189.00
IUUC-Mmr-060693	Microcebus murinus	75.50	0.00e+00	2074.00
IUUC-Mdo-063007	Monodelphis domestica	61.36	0.00e+00	1725.00
IUUC-Mmu-064067	Mus musculus	73.08	0.00e+00	2002.00
IUUC-Mpu-066532	Mustela putorius furo	81.60	0.00e+00	2359.00
IUUC-Nle-070042	Nomascus leucogenys	81.18	0.00e+00	1813.00
IUUC-Opr-070397	Ochotona princeps	75.13	0.00e+00	2132.00
IUUC-Oan-073119	Ornithorhynchus anatinus	65.94	0.00e+00	858.00
IUUC-Ocu-074274	Oryctolagus cuniculus	76.47	0.00e+00	2078.00
IUUC-Oga-088577	Otolemur garnettii	77.75	0.00e+00	2192.00
IUUC-Oar-090117	Ovis aries	80.28	0.00e+00	2210.00
IUUC-Ptr-090553	Pan troglodytes	78.34	0.00e+00	2128.00
IUUC-Pan-092559	Papio anubis	66.34	0.00e+00	959.00
IUUC-Psi-093710	Pelodiscus sinensis	64.39	0.00e+00	1379.00
IUUC-Pab-098510	Pongo abelii	77.18	0.00e+00	2059.00
IUUC-Pca-100323	Procavia capensis	68.68	0.00e+00	1256.00
IUUC-Pva-102895	Pteropus vampyrus	83.83	0.00e+00	2375.00
IUUC-Rno-105598	Rattus norvegicus	73.81	0.00e+00	2044.00
IUUC-Sha-107013	Sarcophilus harrisii	63.89	0.00e+00	1731.00
IUUC-Smo-109134	Selaginella moellendorffii	37.21	9.00e-132	465.00
IUUC-Sar-113261	Sorex araneus	73.29	0.00e+00	2054.00
IUUC-Ssc-115317	Sus scrofa	80.80	0.00e+00	2220.00
IUUC-Tsy-118799	Tarsius syrichta	89.72	0.00e+00	842.00
IUUC-Tme-127128	Tuber melanosporum	23.46	2.00e-29	124.00
IUUC-Tbe-127555	Tupaia belangeri	93.54	0.00e+00	965.00
IUUC-Ttr-128722	Tursiops truncatus	79.55	0.00e+00	2267.00
IUUC-Vda-129957	Verticillium dahliae	23.04	2.00e-28	121.00
IUUC-Vpa-130392	Vicugna pacos	69.40	2.00e-103	370.00
IUUC-Xtr-131789	Xenopus tropicalis	59.39	0.00e+00	973.00
IUUC-Yli-134437	Yarrowia lipolytica	26.88	1.00e-17	85.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence